Tisagenlecleucel ka pahu kui

Anter

• Ma mua o ka loaʻa ʻana o ka injection tisagenlecleucel,
• Hoʻokumu paha ka injection Tisagenlecleucel i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻARlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

Hoʻokumu paha ka injection Tisagenlecleucel i kahi hopena koʻikoʻi a weliweli paha i kapa ʻia cytokine hoʻokuʻu syndrome (CRS). E nānā pono kahi kauka a kahu hānai paha iā ʻoe i kāu infusion a no 4 mau pule ma hope. E haʻi i kāu kauka inā loaʻa ʻoe i kahi maʻi hōʻeha a i ʻole inā manaʻo a manaʻo paha ʻoe he ʻano maʻi paha kāu i kēia manawa. Hāʻawi ʻia ʻoe i nā lāʻau i 30 a 60 mau minuke ma mua o kou hoʻokomo ʻana e kōkua i ka pale ʻana i nā hopena i ka tisagenlecleucel. Inā ʻoe e ʻike i kekahi o nā ʻōuli ma hope a ma hope o kou hoʻopili ʻana, e haʻi koke aku i kāu kauka: ke kuni, ka haʻalulu, ka luliluli ʻana, ka uha, ka make ʻole o ka makemake, ka palahī, ka ʻeha a i ʻole ka ʻeha pū, ka luhi, ka paʻakikī o ka hanu ʻana, ka hanu ʻole ʻana, ka huikau, kaho , ka luaʻi, lū, a i ʻole ka ʻūlū.

Tisagenlecleucel ka pahu kui hiki i ke koʻikoʻi a hoʻoweliweli ola i nā ʻōnaehana ʻōnaehana. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e haʻi koke aku i kāu kauka: ʻeha poʻo, hoʻomaha ʻole, huikau, hopohopo, paʻakikī e hiamoe a hiamoe paha, haʻalulu ʻole i kahi ʻāpana o ke kino, nalowale o ka ʻike, huikau, hoʻonāukiuki, ʻeha, ʻeha a numbness i ka lima a i ʻole ka wāwae, nalo o ke kaulike, paʻakikī i ka hoʻomaopopo ʻana, a i ʻole paʻakikī e ʻōlelo.

Loaʻa wale ka pahu kui Tisagenlecleucel ma o kahi papahana hoʻokaʻawale i kaupalena ʻia. Ua hoʻonohonoho ʻia kahi papahana i kapa ʻia ʻo Kymriah REMS (Risk Evaluation and Mitigation Strategy) ma muli o nā pilikia o CRS a me nā mea ʻona neurological. Hiki iā ʻoe ke loaʻa nā lāʻau mai ke kauka a me nā lawelawe mālama ola e komo i ka papahana.E nīnau i kāu kauka inā he nīnau kāu e pili ana i kēia polokalamu.

E hāʻawi aku kāu kauka a kauka paha iā ʻoe i ka ʻikepili ʻike hoʻomanawanui o ka mea hana (Kauka Lapaʻau) ke hoʻomaka ʻoe i ka lapaʻau me tisagenlecleucel. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

Hoʻohana ʻia ka injection Tisagenlecleucel e mālama i kekahi leukemia lymphoblastic huikau (ALL; i kapa ʻia hoʻi he leukemia lymphoblastic huikau a me ka leukemia lymphatic huehue; kahi ʻano maʻi ʻaʻai e hoʻomaka ana i nā hunaola keokeo) i ka poʻe 25 makahiki a ʻoi paha i hoʻi mai a pane ʻole paha iā nā lapaʻau ʻē aʻe (s). Hoʻohana ʻia ia e mālama i kekahi ʻano o ka lymphoma non-Hodgkin (ʻano o ka maʻi ʻaʻai e hoʻomaka i kahi ʻano o nā hunaola keokeo e hakakā maʻamau i ka maʻi) i nā poʻe mākua i hoʻi a pane ʻole paha ma hope o ka mālama ʻana me ʻelua mau lāʻau ʻē aʻe. ʻO ka injection Tisagenlecleucel i loko o ka papa o nā lāʻau i kapa ʻia autologous cellular immunotherapy, kahi ʻano o ka lāʻau i hoʻomākaukau ʻia me ka hoʻohana ʻana i nā hunaola mai ke koko ponoʻī o ka mea maʻi. Hana ia e ke kumu o ke kino o ke kino (kahi hui o nā hunaola, nāʻaʻaʻa, a me nā mea i pale i ke kino mai ka hoʻouka ʻia ʻana e nā koʻohune, nā mea ʻino, nā hunaola maʻi ʻaʻai, a me nā mea like ʻē aʻe e hōʻeha i nā maʻi) e hakakā me nā hunaola maʻi ʻaʻai.

Hele mai ʻo Tisagenlecleucel injection ma ke ʻano he wehe (wai) e hoʻokomo ʻiʻo ʻia (i loko o ke aa) e ke kauka a kahu wahine paha i ke keʻena kauka a i ʻole ke kikowaena infusion. Hāʻawi pinepine ʻia ia ma kahi o 60 mau minuke ma ke ʻano he mahele manawa hoʻokahi. Ma mua o ka loaʻa ʻana o kāu lāʻau tisagenlecleucel, na kāu kauka a kahu hānai paha e lawelawe i nā lāʻau chemotherapy ʻē aʻe e hoʻomākaukau ai i kou kino no ka tisagenlecleucel.

Ma kahi o 3 a 4 mau pule ma mua o ka hāʻawi ʻia ʻana o ka lāʻau o tisagenlecleucel injection, e lawe ʻia kahi laʻana o kou mau keʻokeʻo keʻokeʻo ma kahi kikowaena ohi cell e hoʻohana ana i kahi hana i kapa ʻia ʻo leukapheresis (kahi hana e lawe i nā keokeo keokeo mai ke kino) E hana ana kēia hana ma kahi o 3 a 6 mau hola a pono paha e hana hou. Ma muli o ka hana ʻia ʻana o kēia lāʻau i kou mau huna ponoʻī, pono e hāʻawi ʻia iā ʻoe wale nō. He mea nui ia ma ka manawa kūpono a mai haʻalele i kāu koho ʻana i ka ʻohiʻohi a hoʻonohonoho ʻia a i ʻole e loaʻa i kāu mahele lāʻau. Pono ʻoe e hoʻolālā e noho ma waena o 2 mau hola o ka wahi kahi i loaʻa ai iā ʻoe kāu lapaʻau tisagenlecleucel no 4 mau pule ma hope o kāu kau lāʻau. E nānā kāu mea olakino e ʻike inā e hana ana kāu lāʻau a nānā iā ʻoe no nā hopena ʻē aʻe. E kamaʻilio me kāu kauka e pili ana pehea e hoʻomākaukau ai no ka leukapheresis a me ka mea e kali ai i ka wā a ma hope o ke kaʻina hana.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka loaʻa ʻana o ka injection tisagenlecleucel,

• e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka tisagenlecleucel, nā lāʻau ʻē aʻe, dimethyl sulokside (DMSO), dextran 40, a i ʻole nā ​​mea hoʻohui ʻē aʻe i ka inikū tisagenlecleucel. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E ʻōlelo pono i kekahi o kēia mau mea: nā steroid e like me dexamethasone, methylprednisolone (Medrol), prednisolone, a me prednisone (Rayos). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• e haʻi i kāu kauka inā ua loaʻa iā ʻoe nā hopena mai nā hoʻomaʻamaʻa chemotherapy ma mua e like me nā pilikia hanu a i ʻole ke kuʻi puʻuwai ʻole. Eia kekahi, e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole loaʻa i ka maʻi ākea, nā konā, ka puʻuwai, a i ʻole nā ​​maʻi ate.
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Pono ʻoe e hana i kahi hōʻike hāpai ma mua o kou hoʻomaka ʻana i ka hoʻomaʻamaʻa tisagenlecleucel. Inā hāpai ʻoe i ka loaʻa ʻana o ka inikuma tisagenlecleucel, e kelepona koke i kāu kauka. Hiki i ke kuikahi Tisagenlecleucel ke hōʻeha i ka fetal.
• pono ʻoe e ʻike i ka hoʻoluhi ʻana o tisagenlecleucel e hiamoe ai ʻoe a hoʻolilo i ka huikau, nāwaliwali, ʻū, a me nā ʻūlū. Mai hoʻokele i kahi kaʻa a hana i nā mīkini ma kahi o 8 mau pule ma hope o kāu kaho tisagenlecleucel.
• mai hāʻawi manawaleʻa i ke koko, nā ʻōpala, nā aʻa, a i ʻole nā ​​hunaola no ke kanu ʻana ma hope o kou loaʻa ʻana o ka injection tisagenlecleucel.
• nānā me kāu kauka e ʻike inā pono ʻoe e loaʻa i nā lāʻau āpau. Mai loaʻa i nā lāʻau āpau me ke kamaʻilio ʻole ʻana me kāu kauka no 2 mau pule ma mua o ka hoʻomaka ʻana o ka chemotherapy, i ka wā o kāu hoʻomaʻamaʻa tisagenlecleucel, a hiki i ka haʻi ʻana o kāu kauka iā ʻoe ua ola kāu ʻōnaehana pale.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

Inā haʻalele ʻoe i ka manawa e hōʻiliʻili ai i kāu mau hunaola, pono ʻoe e kāhea koke i kāu kauka a me ke kikowaena hōʻiliʻili. Inā ʻike ʻoe i kahi manawa e loaʻa ai kāu lāʻau tisagenlecleucel, pono ʻoe e kelepona koke i kāu kauka.

Hoʻokumu paha ka injection Tisagenlecleucel i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• kōpaʻa
• ʻeha ka ʻōpū
• ʻeha kua

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻARlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• kahe koko ʻole ʻana a palapū paha
• koko i ka mimi
• hoʻemi i ke alapine urination a i ʻole ka nui
• ka pehu o nā maka, ka maka, ka lehelehe, ka elelo, ka ʻāʻī, ka lima, ka lima, ka wāwae, nā kuʻekuʻe wāwae, a me nā wāwae lalo
• paʻakikī i ka ale ʻana
• hūwī
• hives
• ʻūlili

Hiki ke hoʻonui i ka hopena o Tisagenlecleucel i kāu pilikia i ka hoʻomohala ʻana i kekahi mau maʻi maʻi maʻi. E kamaʻilio me kāu kauka e pili ana i ka makaʻu o ka loaʻa ʻana o kēia lāʻau.

Hoʻokumu paha ka injection Tisagenlecleucel i nā hopena ʻē aʻe. Kāhea i kāu kauka inā loaʻa iā ʻoe kekahi pilikia maʻamau i ka loaʻa ʻana o kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i nā manawa a pau me kāu kauka, ke kikowaena ohi cell, a me ka hale hana. Hiki paha i kāu kauka ke kauoha i kekahi mau hoʻokolohua lab ma mua, i ka wā, a ma hope o kāu mālama ʻana e nānā i ka pane o kou kino i ka tisagenlecleucel injection.

Ma mua o ka hoʻāʻo ʻana i kahi lumi hoʻokolohua, e haʻi i kāu kauka a me nā limahana o ke keʻena hoʻokolohua ke loaʻa nei ʻoe i ka ʻume tisagenlecleucel. Hiki i kēia lāʻau ke hoʻololi i nā hopena o kekahi mau hoʻokolohua hoʻokolohua.

E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka injection tisagenlecleucel.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Kymriah^®