ʻO Cobicistat

Anter

• Ma mua o ka lawe ʻana i ka cobicistat,
• Hoʻokumu paha ʻo Cobicistat i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kēia ʻōuli a hele ʻole paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka:

Hoʻohana ʻia ʻo Cobicistat e hoʻonui i ka nui o atazanavir (Reyataz, ma Evotaz) i nā mākua a me nā keiki e kaupaona ana ma kahi o 77 paona (35 kg) a i ʻole darunavir (Prezista, ma Prezcobix) i nā mākua a me nā keiki e kaupaona ana ma kahi o 88 paona (40 kg) i ke koko ke hoʻohana ʻia kēia mau lāʻau e mālama ai i ka maʻi pale maʻi kanaka (HIV). Aia ʻo Cobicistat i loko o ka papa o nā lāʻau i kapa ʻia he mau mea hoʻohiki cytochrome P450 3A (CYP3A). Hana ia ma ka hoʻonui ʻana i ka nui o atazanavir a i ʻole darunavir i ke kino i hiki iā lākou ke loaʻa ka hopena nui aʻe.

Hele mai ʻo Cobicistat ma ke ʻano he papa e lawe ma ka waha. Lawe ʻia ia me nā meaʻai i hoʻokahi manawa i ka lā me ka atazanavir a i ʻole darunavir. E lawe i ka cobicistat me atazanavir a i ʻole darunavir ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe i ka cobicistat e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

He mea nui e lawe mau i ka cobicistat i ka manawa like ma atazanavir a i ʻole darunavir.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka cobicistat,

• e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka cobicistat, i nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā papa cobicistat. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka inā lawe ʻoe i kekahi o nā lāʻau aʻe: alfuzosin (Uroxatral); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol); cisapride (Propulsid) (ʻaʻole loaʻa ma ka U.S.); colchisin (Colcrys, Mitigare, ma Col-Probenecid); dronedarone (Multaq); nā lāʻau lapaʻau ergot e like me dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar, ma Cafergot, ma Migergot), a me methylergonovine (Methergine); lomitapide (Juxtapid); lovastatin (Altoprev); lurasidone (Latuda); midazolam (Versed) e ka waha; phenobarbital; phenytoin (Dilantin, Phenytek); pimozide (Orap); ranolazine (Ranexa); rifampin (Rimactane, Rifadin, ma Rifamate, ma Rifater); sildenafil (ʻo ka inoa Revatio wale nō i hoʻohana ʻia no ka maʻi puʻupuʻu); simvastatin (Flolipid, Zocor); St. John's wort; aiʻole triazolam (Halcion). Inā ʻoe e lawe ana i ka atazanavir me cobicistat, e haʻi aku i kāu kauka inā ʻoe e lawe ana i ka drospirenone a me ka ethinyl estradiol (kekahi mau mea pale waha e like me Beyaz, Safyral, Yasmin, Yaz, a me kekahi poʻe ʻē aʻe) indinavir (Crixivan), irinotecan (Camptosar), a i ʻole nevirapine (Viramune). E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe i ka cobicistat inā lawe ʻoe i kekahi o kēia mau lāʻau.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E hoʻomaopopo pono e ʻōlelo i kekahi o kēia mau mea: anticoagulants ('blood thinners') e like me apixaban (Eliquis), betrixaban (Bevyxxa), dabigatran (Pradaxa), edoxaban (Savaysa), rivaroxaban (Xarelto), a me warfarin (Coumadin, Jantoven) ; nā lāʻau antiplatelet e like me clopidogrel (Plavix) a me ticagrelor (Brilinta); atorvastatin (Lipitor, ma Caduet); nā benzodiazepines e like me diazepam (Valium), estazolam, midazolam i hāʻawi ʻia i loko o ke aniani (i loko o ke aa), a me zolpidem (Ambien, Edluar, Intermezzo); beta blockers e like me carvedilol (Coreg), metoprolol (Lopressor), a me timolol; boceprevir (Victrelis) (ʻaʻole loaʻa ma ka U.S.); bosentan (Tracleer); buprenorphine (Belbuca, Butrans, Probuphine); buprenorphine a me naloxone (Suboxone, Zubsolv); buspirone; nā poloka channel calcium e like me amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Tiazac, a me nā mea ʻē aʻe), felodipine, nifedipine (Adalat, Afeditab, Procardia), a me verapamil (Calan, Verelan, a me nā mea ʻē aʻe); clarithromycin (Biaxin, i PrevPac); corticosteroids e like me beclomethasone (Beconase AQ), budesonide (Rhinocort Aqua), ciclesonide (Omnaris), dexamethasone (Decadron), fluticasone (Flonase, Flovent), methylprednisolone (Medrol), momentasone (Flonase), a me triamcinolone (Nasacolone); dasatinib (Sprycel); efavirenz (Sustiva, i Atripla); erythromycin (E.E.S, Erytab, nā mea ʻē aʻe); etravirine (Intelence); fentanyl (Abstral, Actiq, Fentora, nā mea ʻē aʻe); itraconazole (Onmel, Sporanox); ketoconazole; nā lāʻau no ke kaumaha e like me amitriptyline, desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Brisdelle, Paxil, Pexeva), a me trazodone; nā lāʻau no ke kuʻi puʻuwai ʻole e like me amiodarone (Cordarone, Nexterone, Pacerone), digoxin (Lanoxin), disopyramide (Norpace), flecainide, mexiletine, propafenone (Rythmol), a me quinidine (i Nuedexta); nā lāʻau no ka hopu ʻana e like me clonazepam (Klonopin), eslicarbazepine (Aptiom), a me oxcarbazepine (Trileptal); nā lāʻau e kāohi i ka ʻōnaehana pale e like me cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), a me tacrolimus (Astagraf, Envarsus XR, Prograf); lopinavir (i Kaletra); maraviroc (Selzentry); methadone (Dolophine, Methadose); nilotinib (Tasigna); nā pale pale waha (nā pā kaohi hānau); perphenazine; kekahi mau mea hoʻopale ph phodiodiesterase (PDE5) e like me avanafil (Stendra), sildenafil (Viagra), tadalafil (Adcirca, Cialis), a me vardenafil (Levitra); quetiapine (Seroquel); rifabutin (Mycobutin); risperidone (Risperdal); ritonavir (Norvir, ma Kaletra); rivaroxaban (Xarelto); rosuvastatin; salmeterol (Serevent, ma Advair); simeprevir (Olysio); telaprevir (Incivek) (ʻaʻole loaʻa ma ka U.S.); telithromycin (Ketek); tenofovir (Viread, i Atripla, Complera, Truvada, kekahi), thioridazine; tramadol (Conzip, Ultram, ma Ultracet); vinblastine; vincristine (Pahu Marqibo); a me voriconazole (Vfend). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Nui paha nā lāʻau ʻē aʻe e launa pū paha me ka cobicistat no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• inā ʻoe e lawe i ka cobicistat me atazanavir a ke lawe pū nei ʻoe i nā antacids (Maalox, Mylanta, Tums, a me nā mea ʻē aʻe), lawe iā lākou i 2 mau hola ma mua a i ʻole 2 mau hola ma hope o cobicistat a me atazanavir.
• inā ʻoe e lawe nei i ka cobicistat me atazanavir a ke lawe pū nei ʻoe i kahi lāʻau no ka palaka ʻole ʻana, ka puʻuwai puʻuwai, a i ʻole nā ​​maʻi puʻupuʻu (H₂ blockers) e like me ka cimetidine, famotidine (Pepcid, ma Duexis), nizatidine (Axid), a i ʻole ranitidine (Zantac), lawe iā lākou i ka manawa like a i ʻole 10 mau hola ma hope o ka lawe ʻana i ka H₂ poloka.
• inā ʻoe e lawe ana i ka cobicistat me ka atazanavir a ke lawe pū nei ʻoe i ka lāʻau no ka palaka ʻole ʻana, ka puʻuwai puʻuwai, a i ʻole nā ​​ulcer (proton pump inhibitors) e like me esomeprazole (Nexium, ma Vimovo), lansoprazole (Prevacid), omeprazole (Prilosec, i Zegerid), pantoprazole (Protonix), a i ʻole rabeprazole (AcipHex) lawe iā lākou ma ka liʻiliʻi he 12 mau hola ma hope o ka lawe ʻana i ka mea kūpale proton pump.
• e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole loaʻa paha iā ʻoe ka maʻi puʻuwai a i ʻole ate.
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā hāpai ʻoe i ka lawe ʻana i ka cobicistat, e kāhea i kāu kauka. ʻAʻole pono ʻoe e hānai i ka hānai inā loaʻa ʻoe i ka maʻi HIV a inā ʻoe e lawe ana i ka cobicistat.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

Inā loaʻa kāu mahele lāʻau aʻe i 12 mau hola a ʻoi paha, e lawe i ka lāʻau i hala i kou hoʻomanaʻo ʻana iā ia. Eia nō naʻe, inā e lawe ʻia ka lāʻau aʻe ma lalo o 12 mau hola, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu paha ʻo Cobicistat i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kēia ʻōuli a hele ʻole paha:

• nausea

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka:

• melemele o ka ʻili a me nā maka
• hūwī
• hoʻemi urination

Hoʻokumu paha ʻo Cobicistat i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua lab a ma mua a i kou wā e mālama ai e nānā i ka pane o kou kino i ka cobicistat.

E mālama i kahi lako o ka lāʻau i ka lima. Mai kali a hiki i ka pau ʻana o kāu lāʻau e hoʻopiha hou i kāu kuhikuhi.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• ʻO Tybost^®

• ʻO Evotaz^® (loaʻa ʻo Atazanavir, Cobicistat)
• Prezcobix^® (loaʻa iā Cobicistat, Darunavir)