Venetoclax
Anter
- Ma mua o ka lawe ʻana i ka venetoclax,
- Hiki i nā Venetoclax ke kumu i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
- Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli a i ʻole nā mea i helu ʻia i ka ʻĀLU MAKAHIKI kūikawā, e kāhea koke i kāu kauka:
Hoʻohana hoʻokahi ʻia ʻo Venetoclax a i ʻole hui pū ʻia me obinutuzumab (Gazyva) a i ʻole rituximab (Rituxan) e mālama ai i kekahi ʻano o ka leukemia lymphocytic mau (CLL; kahi ʻano maʻi ʻaʻai e hoʻomaka i loko o nā hunaola keokeo) a i ʻole kekahi ʻano o ka lymphocytic lymphoma liʻiliʻi (SLL; kahi ʻano maʻi ʻaʻai e hoʻomaka i ka hapa nui o nā lymph node). Hoʻohana pū ʻia ia me ka azacitidine (Vidaza), decitabine (Dacogen), a i ʻole cytarabine ma ke ʻano he lapaʻau mua loa no ka leukemia myeloid koʻikoʻi (AML; kahi ʻano maʻi ʻaʻai e hoʻomaka i nā hunaola keokeo) i ka poʻe 75 mau makahiki a i ʻole. makua, a i ʻole i nā mākua i loaʻa nā kūlana olakino e pale ai iā lākou mai ka mālama ʻia me nā lāʻau chemotherapy ʻē aʻe. Aia ʻo Venetoclax i kahi papa o nā lāʻau i kapa ʻia ʻo B-cell lymphoma-2 (BCL-2) nā mea kāohi. Hana ia ma ka pale ʻana i ka hana o kekahi protein i loko o ke kino e kōkua i nā hunaola maʻi ʻea e ola. Kōkua kēia i ka pepehi ʻana i nā hunaola maʻi ʻaʻai.
Hele mai ʻo Venetoclax ma ke ʻano he papa e lawe ma ka waha. Lawe pinepine ia me kahi meaʻai a me ka wai hoʻokahi i ka lā. Lawe i ka venetoclax ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pololei i ka venetoclax e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.
E ale i nā papa holoʻokoʻa; mai hoʻokaʻawale, a nau aku, a hoka ʻole iā lākou.
Inā ʻoe e luaʻi ma hope o ka lawe ʻana i ka venetoclax, mai hana hou i ka lāʻau. E hoʻomau i kāu papa hana maʻamau.
E hoʻomaka paha kāu kauka iā ʻoe ma kahi haʻahaʻa o ka venetoclax a hoʻonui iki i kāu lāʻau, ʻaʻole ʻoi aku i hoʻokahi manawa i kēlā me kēia pule no nā pule he 5 inā mālama ʻia ʻoe no CLL a i ʻole SLL, a hoʻokahi manawa i ka lā no nā lā 3 a 4 paha i hala. inā mālama ʻia ʻoe no AML.
Pono paha kāu kauka e hoʻopau a hoʻopau paha i kāu lāʻau inā ʻike ʻoe i kekahi mau hopena ʻaoʻao. E haʻi pono i kāu kauka i kou ʻano i kou wā e mālama ai me ka venetoclax. No kekahi mau hopena ʻaoʻao, hiki i kāu kauka ke haʻi iā ʻoe e hoʻomaka i ka lawe ʻana i ka venetoclax ma kahi lāʻau ma lalo.
E hāʻawi aku kāu kauka a mea kauka paha iā ʻoe i ka palapala ʻike hoʻomanawanui o ka mea hana (Kauka Lapaʻau) ke hoʻomaka ʻoe i ka lāʻau me venetoclax a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.
Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.
Ma mua o ka lawe ʻana i ka venetoclax,
- e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka venetoclax, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā papa venetoclax. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
- e haʻi i kāu kauka inā ʻoe e lawe i ka clarithromycin, conivaptan (Vaprisol), indinavir (Crixivan), itraconazole (Onmel, Sporanox), ketoconazole, lopinavir (i Kaletra), posaconazole (Noxafil), ritonavir (Norvir, i Kaletra, Technivie ), a i ʻole voriconazole (Vfend). E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe i ka venetoclax inā ʻoe e lawe i hoʻokahi a ʻoi paha o kēia mau lāʻau.
- e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau a me nā lāʻau ʻole i kuhikuhi ʻole ʻia, nā wikamina a me nā mea hoʻopihaʻaiʻai āu e lawe nei a hoʻolālā paha e lawe. E hoʻomaopopo pono e ʻōlelo i kekahi o kēia mau mea: amiodarone (Nexterone, Pacerone), bosentan (Tracleer), captopril, carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), carvedilol (Coreg), ciprofloxacin (Cipro), cyclosporine (Gengraf, Neoral, Sandimmune), digoxin (Lanoxin), diltiazem (Cardizem, Cartia XT, Diltzac, Taztia, Tiazac), dronedarone (Multaq), efavirenz (Sustiva, i Atripla), erythromycin (EES, Eryc, Erypedry, Eryin, ), etravirine (Intelence), everolimus (Afinitor, Zortress), felodipine, fluconazole (Diflucan), modafinil (Nuvigil, Provigil), nafcillin (Nallpen), phenytoin (Dilantin, Phenytek), quinidine (i Nuedextaane), ranolazine , rifampin (Rifadin, Rimactane, ma Rifamate, Rifater), sirolimus (Rapamune), ticagrelor (Brilinta), verapamil (Calan, Verelan, ma Tarka), a i ʻole warfarin (Coumadin, Jantoven). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Hiki paha i nā lāʻau ʻē aʻe ke launa pū me ka venetoclax, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
- e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, keu hoʻi i ka quercetin a i ʻole ka wort o St.
- e haʻi i kāu kauka inā loaʻa a loaʻa paha iā ʻoe kekahi mau pilikia me kāu mau pae o ka potassium, phosphorus, a i ʻole calcium i loko o kou koko; nā pae kiʻekiʻe o ka uric acid i kou koko; gout (kahi ʻano o ka maʻi lūlū e hoʻokumu ʻia e nā aniani i waiho ʻia i loko o nā hono); aiʻole ka maʻi puʻuwai a i ʻole ate.
- e haʻi i kāu kauka inā hāpai ʻoe a i ʻole hoʻolālā e hāpai. Inā hiki iā ʻoe ke hāpai, pono ʻoe e loaʻa kahi hōʻike hāpai ma mua o ka hoʻomaka ʻana o ka mālama ʻana me ka venetoclax. ʻAʻole ʻoe e hāpai i kou wā lapaʻau a no 30 mau lā ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā ʻano hana hānau hiki iā ʻoe ke hoʻohana i kāu wā o kāu mālama ʻana. Inā hāpai ʻoe i ka lawe ʻana i ka venetoclax, e kāhea i kāu kauka.
- e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū. Mai hānai i ka wā e lawe ana i ka venetoclax a no 1 mau pule ma hope o kāu hopena hope loa.
- pono ʻoe e ʻike i kēia lāʻau i hoʻemi ai i ka momona i nā kāne. E kamaʻilio me kāu kauka e pili ana i nā makaʻu o ka lawe ʻana i ka venetoclax.
- ʻaʻohe o nā lāʻau āpau ma mua, i ka wā, a ma hope paha o ka mālama ʻana me venetoclax me ke kamaʻilio ʻole ʻana me kāu kauka.
- pono ʻoe e ʻike e ʻike paha ʻoe i ka maʻi tumo lysis syndrome (TLS; kahi kumu i hoʻokumu ʻia e ka wikiwiki o ka haki ʻana o nā hunaola maʻi ʻaʻai e hiki ai ke hōʻeha i nā puʻupaʻa a me nā pilikia ʻē aʻe) i kāu mālama ʻana me venetoclax. Hiki ke hana kēia i ka hoʻomaka mua ʻana o ka lāʻau, a i kēlā me kēia manawa e hoʻonui ʻia kāu lāʻau. I mea e hōʻemi ai i kou makaʻu i ka loaʻa ʻana iā TLS pono ʻoe e inu ma ka liʻiliʻi he 6 a 8 mau aniani (48 a 64 auneke) o ka wai i hoʻokahi lā no 2 mau lā ma mua a ma ka lā o kāu kau mua, a i kēlā me kēia manawa e hoʻonui ʻia kāu mahele lāʻau. Hoʻohui ʻia e hāʻawi aku kāu kauka iā ʻoe i ka lāʻau e lawe ma mua o ka hoʻomaka ʻana a i kāu wā e hoʻomaʻamaʻa ai e pale ai i kēia hopena ʻaoʻao. Inā ʻoe e ʻike i kekahi o nā ʻōuli o TLS e kāhea koke aku i kāu kauka: fever, chills, nausea, luaʻi, huikau, ka hanu ʻana o ka hanu, ka hopu ʻana i ka puʻuwai puʻuwai ʻole, ka mimi ʻeleʻele a me ke ao, ka luhi ʻole, a i ʻole ka ʻeha a ʻeha pū paha.
Mai ʻai i ka huaora, ka ʻalani, a i ʻole nā alani Seville (hoʻohana ʻia i kekahi manawa i nā marmalades), a inu ʻole i ka wai huaʻulu i ka wā e lawe ana i kēia lāʻau.
Inā hoʻomanaʻo ʻoe i ka mahele lāʻau i hala ma loko o 8 mau hola o ka manawa āu i hoʻonohonoho ʻia ai e lawe, lawe koke i ka lāʻau i nalo ʻia. Eia nō naʻe, inā ua hala ma mua o 8 mau hola mai ka manawa āu e maʻa mau ai i ka venetoclax, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.
Inā makemake ʻoe e lawe i ka venetoclax ma mua o 7 mau lā, pono ʻoe e kāhea i kāu kauka ma mua o ka lawe ʻana i nā lāʻau hou aʻe. Makemake paha kāu kauka e hoʻomaka hou i kāu lāʻau i kahi mahele haʻahaʻa.
Hiki i nā Venetoclax ke kumu i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
- pāhoehoe
- kōpaʻa
- nausea
- ka luaʻi
- hoʻēmi ʻai
- luhi loa
- pehu o kou mau lima a lima paha
- ʻeha kua
- iwi, ʻami, a ʻeha pū paha
- abdominal eha
- pehu a ʻeha paha i ka waha
- ʻeha ka waha a ʻeha paha
- ʻeha poʻo
- ihu ihu a mahu paha
- pokole o ka hanu
- ʻūpā
- hūwī
- paʻakikī e hiamoe a hiamoe paha
Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli a i ʻole nā mea i helu ʻia i ka ʻĀLU MAKAHIKI kūikawā, e kāhea koke i kāu kauka:
- ke kuni wale a i ʻole me ka ʻāʻī ʻeha, ka ʻū, ka haʻalulu, mehana, ʻulaʻula, ʻeha a pehu paha ka ʻili, wikiwiki, pinepine, a i ʻole ka mimiki ʻeha, a me nā ʻōuli ʻino ʻē aʻe.
- hoʻemi urination
- ka pehu ʻana o kou mau wāwae, nā kuʻekuʻe wāwae, a me nā wāwae
- ʻokoʻa a kaumaha paha ke kahe ʻana a i ʻole ʻūpā
- ʻili mae, ka pōkole o ka hanu, ʻōpau, ka luhi nui, kuʻi puʻuwai wikiwiki
Hiki i nā Venetoclax ke kumu i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.
Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).
E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. Hana ʻaʻole hoʻoili i ka lāʻau i kahi ipu ʻokoʻa. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.
He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org
Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.
I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.
E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua lab a ma mua a i kou wā e mālama ai e nānā i ka pane o kou kino i ka venetoclax.
Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.
He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.
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