Panobinostat

Anter

• Ma mua o ka lawe ʻana i ka panobinostat,
• Hoʻokumu paha ʻo Panobinostat i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻARlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.
• Hiki i nā ʻōuli o ka overdose ke hoʻopili i kēia mau mea:

Hiki i ka Panobinostat ke kumu i ka palahī a me nā ʻōpū ʻino ʻē aʻe (GI; e pili ana i ka ʻōpū a me nā ʻōpū) nā hopena ʻaoʻao. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke aku i kāu kauka: ʻōpū o ka ʻōpū; noho hakahaka; pāhoehoe; ka luaʻi; a i ʻole ka waha maloʻo, mimi ʻeleʻele, hoʻēmi i ka hou ʻana, ka ʻili maloʻo, a me nā ʻōuli ʻē aʻe o ka make wai. E kamaʻilio me kāu kauka e pili ana i ka mea āu e hana ai inā hoʻomohala ʻoe i ka maʻi pākī i kou wā e mālama ai me ka panobinostat. E kamaʻilio pū me kāu kauka ma mua o ka lawe ʻana i nā laxatives a i ʻole nā ​​palupalu palupalu ʻoiai ʻoe e lawe nei i kēia lāʻau.

Hoʻokumu paha ʻo Panobinostat i nā pilikia puʻuwai koʻikoʻi a i ʻole hoʻoweliweli i ke ola i kāu mālama ʻana. E haʻi i kāu kauka inā loaʻa koke ʻoe i kahi puʻuwai puʻuwai a i ʻole inā loaʻa iā ʻoe kahi maʻi QT lōʻihi (ke ʻano e hoʻonui i ka makaʻu o ka hoʻomohala ʻana i kahi puʻuwai kūpono ʻole e hiki ai ke maʻule a make koke paha), angina (ʻeha o ka umauma), a i ʻole nā ​​pilikia puʻuwai ʻē aʻe. E kauoha kāu kauka i nā hoʻokolohua e like me ka electrocardiogram (ECG; hōʻike e hoʻopaʻa i ka hana uila o ka puʻuwai) ma mua a i kāu wā e hoʻomaʻamaʻa ai e ʻike inā palekana ʻoe e lawe i ka panobinostat. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke aku i kāu kauka: ʻeha ka umauma, wikiwiki, kuʻi, a i ʻole pākuʻi ʻia ka puʻuwai ʻole, ʻālohilohi, ʻano paupauaho, ʻōpau, nā lehelehe polū ʻalani, ka liʻiliʻi o ka hanu, a i ʻole ka pehu ʻana o nā lima, nā lima, nā wāwae, nā kuʻekuʻe wāwae, a me nā wāwae lalo.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua e nānā i ka pane o kou kino i ka panobinostat.

E hāʻawi aku kāu kauka a mea kauka paha iā ʻoe i ka palapala ʻike hoʻomanawanui o ka mea hana (Kauka Lapaʻau) ke hoʻomaka ʻoe i ka mālama ʻana me ka panobinostat a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

E kamaʻilio me kāu kauka e pili ana i ka makaʻu o ka lawe ʻana i ka panobinostat.

Hoʻohana ʻia ʻo Panobinostat me ka bortezomib (Velcade) a me dexamethasone e mālama ai i ka poʻe me ka myeloma maha (kahi ʻano maʻi ʻaʻai o ka iwi iwi) i mālama ʻia i ʻelua mau lāʻau ʻē aʻe, e like me bortezomib (Velcade). Aia ʻo Panobinostat i kahi papa o nā lāʻau i kapa ʻia nā mea kāohi nā histone deacetylase (HDAC). Hana ia ma ka luku ʻana i nā hunaola maʻi ʻaʻai.

Hele mai ʻo Panobinostat ma ke ʻano he capsule e lawe ma ka waha. Lawe pinepine ʻia me a me ka ʻole o ka meaʻai i kēlā me kēia lā ma kekahi mau lā o kahi pōʻaiapuni 21 mau lā. Hiki ke hana hou i ke kaapuni a 16 mau pōʻaiapuni. E lawe i ka panobinostat ma kahi o ka manawa like i kēlā me kēia lā i hoʻopaʻa ʻia. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono i ka panobinostat e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E hoʻopau piha i nā capsule me ke kīʻaha wai; mai haki, nau, a wehe paha. E lawelawe i nā capsule ma kahi liʻiliʻi loa. Inā ʻoe e hoʻopā i kahi capsule panobinostat haki a i ʻole ka lāʻau i loko o ka capsule, holoi i kēlā wahi o kou kino me ke kopa a me ka wai. Inā komo ka lāʻau i loko o ka capsule i kou waha, ihu, a i ʻole nā ​​maka, holoi iā ia me ka nui o ka wai.

Inā ʻoe e luaʻi ma hope o ka lawe ʻana i ka panobinostat, mai lawe i kahi lāʻau ʻē aʻe. E hoʻomau i kāu papa hana maʻamau.

E haʻi pono i kāu kauka i kou ʻano i kou wā e mālama ai. Hiki i kāu kauka ke hōʻemi i kāu lāʻau o panobinostat a i ʻole hoʻokū i kāu lāʻau lapaʻau no kekahi manawa a mau paha, inā ʻike ʻoe i nā hopena o ka lāʻau.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka panobinostat,

• e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka panobinostat, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā capsule panobinostat. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E ʻike pono i kekahi o kēia mau mea: amiodarone (Cordarone, Nexterone, Pacerone); nā antifungals e like me itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), a me voriconazole (Vfend); atomoxetine (Strattera); bepridil (Vascor; ʻaʻole loaʻa hou ma ka U.S.); boceprevir (Victrelis); carbamazepine (Carbatrol, Tegretol, Teril, nā mea ʻē aʻe); chloroquine (Aralen); clarithromycin (Biaxin, i PrevPac); konivaptan (Vaprisol); desipramine (Norpramin); dextromethorphan; disopyramide (Norpace); dolasetron (Anzemet); kekahi mau lāʻau no ka HIV e like me indinavir (Crixivan), lopinavir / ritonavir (Kaletra), nelfinavir (Viracept), ritonavir (Norvir, ma Kaletra, ma Viekira Pak), saquinavir (Invirase); methadone (Dolophine, Methadose); metoprolol (Lopressor, Toprol-XL); moxifloxacin (Avelox); nebivolol (Bystolic); nefazodone; ondansetron (Zofran, Zuplenz); perphenazine; pimozide (Orap); phenobarbital; phenytoin (Dilantin, Phenytek); procainamide; quinidine (i Nuedexta); rifampin (Rifadin, Rimactane, ma Rifamate, ma Rifater); sotalol (Betapace, Sorine, Sotylize); telaprevir (Incivek; ʻaʻole loaʻa hou ma U.S.); telithromycin (Ketek); thioridazine; tolterodine (Detrol); a me ka venlafaxine (Effexor). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St John.
• e haʻi i kāu kauka inā loaʻa ʻoe i ka maʻi ʻaʻai a i ʻole loaʻa paha iā ʻoe nā pilikia kahe o ke kahe a i ʻole nā ​​maʻi ate.
• e haʻi i kāu kauka inā hāpai ʻoe a i ʻole hoʻolālā e hāpai. Hoʻopilikia paha ʻo Panobinostat i ka fetus. E hoʻohana i ka kaohi hānau e pale i ka hāpai ʻana i ka wā o kāu mālama ʻana me ka panobinostat a no ka liʻiliʻi o 1 mau mahina ma hope o ka hopena hope loa. Inā he kāne ʻoe a hiki i kāu pakanā ke hāpai, pono ʻoe e hoʻohana i kahi condom i ka lawe ʻana i kēia lāʻau a 90 mau lā ma hope o ka pau ʻana o kāu lapaʻau. E nīnau i kāu kauka inā he mau nīnau kāu e pili ana i ke ʻano o ka kaohi hānau e holo pono nāu. Inā hāpai ʻoe i ka lawe ʻana i ka panobinostat, e kāhea koke i kāu kauka.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū. ʻAʻole pono ʻoe e hānai i ka wā e lawe ana i ka panobinostat.
• inā ke ʻoki nei ʻoe, e like me ke kaha ʻana o ka niho, e haʻi i ke kauka a i ʻole kauka niho paha e lawe ana ʻoe i ka panobinostat.

Mai ʻai i ka pomeraite, grapefruit a i nā hua hōkū paha a i ʻole inu i ka huaʻōlani a i ʻole ka wai pomegranate i ka wā e lawe ana i kēia lāʻau.

Inā he 12 mau hola a ʻoi aku paha o ka liʻiliʻi mai kou wā i hoʻonohonoho ʻia ai e lawe i ka lāʻau, lawe i ka lāʻau i hala i kou hoʻomanaʻo ʻana iā ia. Inā ʻoi aku ma mua o 12 mau hola mai kāu kau palena papaha, e lele i ka lāʻau a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i nalo.

Hoʻokumu paha ʻo Panobinostat i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• Kaumaha emi
• ʻeha poʻo

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻARlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• ʻeleʻele, hoʻolōʻihi, a i ʻole nā ​​noho noho koko
• luaʻi koko a i luaʻi paha e like me ke kope
• ʻāpā ʻaʻano ʻole a hoʻokahe koko paha
• mimi ʻākala a ʻeleʻele paha
• koko i ka phlegm
• huikau
• nā hoʻololi i kāu haʻiʻōlelo
• ke kuni, ka hū, ka haʻalulu, ka hou ʻana a i ʻole nā ​​hōʻailona ʻē aʻe o ka maʻi
• ʻili mae
• nausea, luaʻi, nalo o ka makemake ʻole, mimi ʻeleʻele, ʻeha o ka ʻōpū, luhi nui loa, nele i ka ikaika, a me ka melemele ʻana o ka ʻili a keʻokeʻo o nā maka.

Hoʻokumu paha ʻo Panobinostat i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a mamao aku mai ka mālamalama, ka wela a me ka momona o ka wela (ʻaʻole i loko o ka lua.

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Hiki i nā ʻōuli o ka overdose ke hoʻopili i kēia mau mea:

• pāhoehoe
• nausea
• ka luaʻi
• hoʻēmi ʻai

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Farydak^®