Palbociclib

Anter

• Ma mua o ka lawe ʻana i ka palbociclib,
• Hiki i ka Palbociclib ke kumu i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

[Kau ʻia 09/13/2019]

NUI: ʻO ka mea maʻi, ʻoihana olakino, Oncology

ʻĀINA: Ke ao aku nei ʻo FDA i ka palbociclib (Ibrance^®), ribociclib (Kisqali^®), a me abemaciclib (Verzenio^®) hoʻohana ʻia e mālama i kekahi mau mea maʻi me nā maʻi maʻi umauma holomua hiki ke kumu i ka mumū akā ka nui o ka mumū. Ua ʻae ʻo FDA i nā ʻōlelo aʻoaʻo hou e pili ana i kēia pilikia i ka ʻikepili i kākau ʻia a me ka Hoʻomoʻi ʻAoʻao Hoʻomanawanui no ka papa holoʻokoʻa o kēia mau kinakina e pili ana i ka cyclin 4/6 (CDK 4/6) i nā lāʻau lapaʻau. ʻO ka pōmaikaʻi holoʻokoʻa o nā mea kāohi CDK 4/6 ʻoi aku ka nui ma mua o nā pilikia ke hoʻohana ʻia e like me ka mea i kauoha ʻia.

NĀ PONO: ʻO CDK 4/6 mea pāpā he papa ia o nā lāʻau lapaʻau i hoʻohana ʻia e hui pū ʻia me nā therapies hormone e mālama ai i nā mākua me ka receptor hormone (HR) -positive, mea ulu ulu kanaka epidermal 2 (HER2) - neʻe mua a metastatic umauma Ka maʻi ʻaʻai i pāhola ʻia i nā ʻāpana ʻē aʻe o ke kino. Pale nā ​​CDK 4/6 mea kāpae i kekahi mau molekiola i pili i ka hoʻolaha ʻana i ka ulu ʻana o nā hunaola maʻi ʻaʻai. Ua ʻae ʻo FDA i ka palbociclib i ka makahiki 2015, a me nā ribociclib a me nā abemaciclib ma ka makahiki 2017. Ua hōʻike ʻia nā mea pāpālina CDK 4/6 e hoʻomaikaʻi i ka nui o ka manawa ma hope o ka hoʻomaka ʻana o ka lapaʻau ʻana ʻaʻole ulu nui ka maʻi ʻaʻai a ola ka mea maʻi, i kapa ʻia he ola ʻole ʻole holomua. (E nānā i ka papa inoa o ka mea i ʻāpono ʻia e ka CDK 4/6 Inhibitors o FDA ma lalo).

OLELO HOOLAHA:Nā mea maʻi pono e hoʻomaopopo koke i kāu ʻoihana mālama ola inā loaʻa iā ʻoe nā hōʻailona hou a ʻoi aku paha e pili ana i kāu mau māmā, no ka mea e hōʻike paha lākou i kahi ʻano laha akā hoʻoweliweli ola e hiki ai i ka make. Nā ʻōuli e kiaʻi no ka:

• Ka paʻakikī a hōʻoluʻolu ʻole paha me ka hanu ʻana
• Ka hanu ʻana o ka hanu i ka wā hoʻomaha a me ka hana haʻahaʻa

Mai hōʻoki i ka lawe ʻana i kāu lāʻau me ke kamaʻilio mua ʻole ʻana i kāu kauka mālama ola. Loaʻa nā hopena ʻaoʻao āpau i nā lāʻau āpau ke hoʻohana pololei ʻia e like me ka mea i kau ʻia, akā ma ka laulā ʻo nā pōmaikaʻi o ka lawe ʻana i kēia mau lāʻau i ʻoi aku i kēia mau pilikia. He mea nui e ʻike i ka pane ʻokoʻa a ka poʻe i nā lāʻau āpau e pili ana i ko lākou olakino, nā maʻi i loaʻa iā lākou, nā kumu genetic, nā lāʻau ʻē aʻe a lākou e lawe nei, a me nā kumu ʻē aʻe he nui. ʻO nā kumuhana kūpilikiʻi e hoʻoholo ai pehea paha e ʻike ai kekahi kanaka i ka mumū nui i ka lawe ʻole ʻana i ka palbociclib, ribociclib, a i ʻole abemaciclib paha.

ʻOihana ʻoihana mālama ola pono e nānā pinepine i nā mea maʻi no nā hōʻailona pulmonary e hōʻike ana i ka maʻi lele interstitial (ILD) a me / a i ʻole pneumonitis. Pākuʻi ʻia paha nā ʻōuli a me nā ʻōuli:

• hypoxia
• ʻūhā
• dyspnea
• infiltrates interstitial ma nā hōʻike radiologic i nā mea maʻi i loko o lākou i kāpae ʻia nā maʻi lele, neoplastic, a me nā kumu ʻē aʻe.

Hoʻokiʻoki i ka lāʻau hoʻomake CDK 4/6 i nā mea maʻi i loaʻa i nā ʻōuli hanu hou a maikaʻi ʻole paha, a hoʻopau mau i ka mālama ʻana i nā mea maʻi me ka ILD koʻikoʻi a me / a i ʻole ka pneumonitis.

No ka ʻike hou aku e kipa aku i ka pūnaewele FDA ma: http://www.fda.gov/Safety/MedWatch/SafetyInformation a me http://www.fda.gov/Drugs/DrugSafety.

Hoʻohana ʻia ʻo Palbociclib me ka anastrozole (Arimidex), exemestane (Aromasin), a i ʻole letrozole (Femara) e mālama ai i kekahi ʻano o ka receptor hormone - maikaʻi, maʻi ʻaʻai umauma maʻi āpau (ka maʻi ʻaʻai umauma e pili ana i nā homone e like me ka ulu ʻana o ka estrogen) a i ʻole ka umauma ʻo ka maʻi ʻaʻai i pālahalaha ʻia i nā ʻāpana ʻē aʻe o ke kino i nā wahine i ʻike i ka menopause (hoʻololi o ke ola; ka hopena o ka manawa o ka menstrual) a i nā kāne Hoʻohana pū ʻia ʻo Palbociclib me ka fulvestrant (Faslodex) e mālama ai i kekahi ʻano o ka receptor hormone – maikaʻi, maʻi ʻaʻai umauma holomua (umauma maʻi ʻaʻai e pili ana i nā homone e like me ka estrogen e ulu ai) a i ʻole ka maʻi ʻaʻai umauma i pāhola ʻia i nā ʻāpana ʻē aʻe o ke kino i ka poʻe i mālama ʻia me kahi lāʻau antiestrogen e like me tamoxifen (Nolvadex). Aia ʻo Palbociclib i kahi papa o nā lāʻau i kapa ʻia ʻo nā kinase inhibitors. Hana ia ma ke kāpae ʻana i ka hana o ka protein pono ʻole e hōʻailona ai i nā hunaola maʻi ʻaʻai e hoʻonui. Kōkua kēia i ka hōʻoki a hoʻolohi paha i ka hoʻolaha ʻana o nā hunaola maʻi ʻaʻai.

Hele mai ʻo Palbociclib ma ke ʻano he capsule e lawe ma ka waha. Lawe ʻia ia me ka meaʻai hoʻokahi manawa i kēlā me kēia lā no nā lā 21 mua o kahi pōʻaiapuni 28 mau lā. E hoʻoholo kāu kauka i nā manawa āu e hana hou ai i kēia pōʻaiapuni. E lawe i ka palbociclib ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono i ka palbociclib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā capsule holoʻokoʻa; mai wehe, nau, a wāwahi paha iā lākou. Mai lawe i nā capsule i haki a haki paha.

Inā luaʻi ʻoe ma hope o ka lawe ʻana i ka palbociclib, mai lawe i kahi lāʻau ʻē aʻe. E hoʻomau i kāu papa hana maʻamau.

Hiki i kāu kauka ke hōʻemi i kāu lāʻau a i ʻole manawa kūmau a paʻa mau paha i kāu lāʻau inā ʻike ʻoe i kekahi mau hopena ʻaoʻao. E haʻi pono i kāu kauka i kou ʻano i kou wā e mālama ai me palbociclib.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka palbociclib,

• e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka palbociclib, i nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā capsule palbociclib. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E ʻike pono i kekahi o kēia mau mea: antifungals e like me itraconazole (Onmel, Sporanox, Tolsura), ketoconazole, posaconazole (Noxafil), a me voriconazole (Vfend); kekahi mau lāʻau e mālama ai i ka hopu ʻana e like me ka carbamazepine (Carbatrol, Equetro, Epitol, Tegretol, a me nā mea ʻē aʻe) a me phenytoin (Dilantin, Phenytek); clarithromycin; enzalutamide (Xtandi); ergot alkaloids e like me dihydroergotamine (D.H.E 45, Migranal) a me ergotamine (Ergomar, ma Cafergot, ma Migergot); kekahi mau lāʻau no ka maʻi pale maʻi (HIV) a i ʻole ka maʻi maʻi maʻi loaʻa (AIDS) me indinavir (Crixivan), lopinavir (ma Kaletra), nelfinavir (Viracept), ritonavir (Norvir, ma Kaletra, ma Viekira Pak), saquinavir (Invirase), a me telaprevir (ʻaʻole loaʻa hou ma ka US); fentanyl (Abstral, Fentora, Lazanda, Subsys, nā mea ʻē aʻe); nā immunosuppressants e like me cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), a me tacrolimus (Astagraf XL, Envarsus XR, Prograf); midazolam; nefazodone; pimozide (Orap); quinidine (i Nuedexta); rifampin (Rimactane, Rifadin, ma Rifater, ma Rifamate); a me telithromycin (Ketek). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Pili pū paha nā lāʻau ʻē aʻe he nui me ka palbociclib, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• e haʻi i kāu kauka a me kāu kauka lāʻau he aha nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St.
• e haʻi i kāu kauka inā loaʻa ʻoe i ka maʻi ʻaʻai a inā he maʻi ate paha a i ʻole loaʻa paha iā ʻoe.
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a inā ʻoe e hoʻolālā i ka hānau keiki ʻana. Inā he wahine ʻoe, pono ʻoe e lawe i kahi hōʻike hāpai keiki ma mua o kou hoʻomaka ʻana i ka mālama ʻana a hoʻohana i ka kaohi hānau e pale ai i ka hāpai ʻana i kāu wā lapaʻau a no 3 mau pule ma hope o kāu hopena hope loa. Inā he kāne ʻoe, pono ʻoe a me kāu pakanā e hoʻohana i ka kaohi hānau i ka wā o kāu mālama ʻana me palbociclib a no 3 mau mahina ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā ʻano hana hānau hiki iā ʻoe ke hoʻohana i kāu wā o kāu mālama ʻana. Inā hāpai ʻoe a ʻo kāu hoa paha i ka lawe ʻana i ka palbociclib, e kāhea koke i kāu kauka. Hoʻopilikia paha ʻo Palbociclib i ka fetus.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū. ʻAʻole pono ʻoe e hānai i ka wā e lawe ana ʻoe i ka palbociclib a no 3 mau pule ma hope o ka hopena hope loa.
• inā ke ʻoki nei ʻoe, e like me ke kaha ʻana o nā niho, e haʻi i ke kauka a i ʻole kauka niho paha e lawe ana ʻoe i ka palbociclib.
• pono ʻoe e ʻike i kēia lāʻau i hoʻemi ai i ka momona i nā kāne. E kamaʻilio me kāu kauka e pili ana i ka makaʻu o ka lawe palbociclib.

Mai ʻai i ka hua waina a i ʻole inu i ka wai huaʻulu i ka wā e lawe ana i kēia lāʻau.

E haʻalele i ka lāʻau i haʻalele ʻia a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua i ka lā like e pani no kahi mea i hala.

Hiki i ka Palbociclib ke kumu i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• nausea
• pāhoehoe
• ka luaʻi
• hoʻēmi ʻai
• hoʻololi i ka ʻono
• luhi
• numbness a i ʻole ke kani ʻana i kou mau lima, nā lima, nā wāwae, a me nā wāwae
• ʻeha ma nā lehelehe, waha, a ʻāʻī paha
• lahilahi lauoho lauoho a lauoho lauoho
• ʻili maloʻo
• hūwī

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• ke kuni, ke anu, a me nā hōʻailona o ka maʻi
• pokole o ka hanu
• ʻūpā
• wikiwiki, kūlike ʻole, a kuʻi paha i ka puʻuwai puʻuwai
• nāwaliwali
• kahe koko ʻole ʻana a palapū paha
• ihu ihu

Hiki i ka Palbociclib ke kumu i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi.E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha paha kāu kauka i kekahi mau hoʻokolohua lab a ma mua a i kou wā e mālama ai e nānā i ka pane o kou kino iā palbociclib.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Hebera^®