ʻO Riociguat

Anter

• Ma mua o ka lawe ʻana i riociguat,
• Hoʻokumu paha ʻo Riociguat i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli a i ʻole kēlā mau mea i ka ʻĀKAHI MAKAHIKI ʻāpana, e kelepona koke i kāu kauka a i ʻole e kiʻi i nā lāʻau lapaʻau pilikia

Mai lawe i ka riociguat inā hāpai ʻoe a hoʻolālā paha e hāpai. Hiki iā Riociguat ke hōʻeha i ka fetus. Inā hana kolohe ʻoe a hiki i ka hāpai ʻana, ʻaʻole pono ʻoe e hoʻomaka i ka riociguat a hiki i ka hōʻike ʻana o kahi hōʻike hāpai keiki ʻaʻole ʻoe hāpai. Pono ʻoe e hoʻohana i nā ʻano pono o ka kaohi hānau i ka wā o ka mālama ʻana a no hoʻokahi mahina ma hope o ka kū ʻana o riociguat. Mai moe kolohe. E kamaʻilio me kāu kauka e pili ana i nā hana kaohi hānau e kūpono a e holo pono nāu. Kāhea koke i kāu kauka inā ʻike ʻoe i kahi wā menstrual a manaʻo paha ʻoe e hāpai ana ʻoiai ʻoe e lawe nei i riociguat.

Inā he makua a kahu paha ʻoe no ka wahine ʻaʻole i oʻo i ka wā ʻōpio, e nānā pinepine i kāu keiki e ʻike inā ke ulu nei ʻo ia i nā ʻōuli o ka ʻōpio (ʻōpuʻu umauma, lauoho pubic) a hōʻike i kāna kauka e pili ana i nā loli. Hiki i kāu keiki ke oʻo i ka wā ʻōpio ma mua o ka loaʻa ʻana o kāna wā menstrual mua.

Ma muli o ka makaʻu o ka hānau hānau, loaʻa wale ka riociguat ma o kahi papahana hoʻokaʻawale palena papaha. Ua hoʻonohonoho ʻia kahi papahana i kapa ʻia ʻo Adempas Risk Evaluation and Mitigation Strategies (REMS) no nā mea maʻi wahine āpau e hōʻoia ua hoʻāʻo ʻia lākou no ka hāpai keiki i kēlā me kēia mahina ma ka hoʻomaʻamaʻa ʻana a no 1 mahina ma hope o ka pau ʻana o riociguat. Hiki i nā mea maʻi wahine ke loaʻa riociguat inā lākou hoʻopaʻa inoa ʻia me ka Polokalamu Adempas REMS. Ma ke kau inoa ʻana e koho ʻoe i kahi lāʻau lapaʻau kūikawā i hōʻoia ʻia e hoʻouna i kāu lāʻau iā ʻoe. E nīnau i kāu kauka inā he nīnau kāu e pili ana pehea e loaʻa ai kāu lāʻau.

E hāʻawi aku kāu kauka a kauka paha iā ʻoe i ka palapala ʻike hoʻomanawanui o ka mea hana (Kauka Kuhi) ke hoʻomaka ʻoe i ka lāʻau me riociguat a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) e kiʻi i ke alakaʻi Medication.

E kamaʻilio me kāu kauka e pili ana i nā pilikia o ka lawe ʻana i riociguat.

Hoʻohana ʻia ʻo Riociguat e mālama i ka hypertension pulmonary arterial (PAH; ke kiʻekiʻe o ke koko i loko o nā kīʻaha e lawe i ke koko i nā akemāmā). Hoʻohana ʻia ʻo Riociguat e mālama i ke kiʻekiʻe o ka pulmonary thromboembolic hypertension (CTEPH; ke kiʻekiʻe o ke koko i loko o nā aʻa māmā i hana ʻia e nā kahe o ke koko e hoʻopaʻa a ālai paha i ke kahe o ke koko) pae pae ma hope o ka ʻoki kino. Hiki paha iā Riociguat ke hoʻomaikaʻi i ka hiki ke hoʻoikaika kino i ka poʻe me PAH a me CTEPH a lohi paha i ka hōʻeha ʻana o nā ʻōuli i ka poʻe me PAH. Aia ʻo Riociguat i loko o ka papa o nā lāʻau i kapa ʻia he stimulus guanylate cyclase (sGC) stimulator. Hana ia e ka hoʻomaha ʻana i nā kīʻaha koko i nā akemāmā e ʻae i ke kahe o ke koko e maʻalahi.

Hele mai ʻo Riociguat ma ke ʻano he papa e lawe ma ka waha. Lawe pinepine ʻia me a me ka ʻole o ka meaʻai 3 mau manawa i ka lā. Lawe iā riociguat ma kahi o ka manawa like (s) i kēlā me kēia lā a kau i kāu kau ma kahi o 6 a 8 mau hola ke kaʻawale. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pololei i ka riociguat. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

Inā ʻaʻole hiki iā ʻoe ke ale i ka papapihi āpau, hiki iā ʻoe ke haki i ka papa a hoʻohuihui i nā ʻike me kahi wai liʻiliʻi a i ʻole kahi meaʻai palupalu e like me ka ʻomaʻoma. E ale pono i ka hui ma hope o kou kāwili ʻana.

E hoʻomaka paha kāu kauka iā ʻoe ma kahi haʻahaʻa o riociguat a hoʻonui iki i kāu lāʻau, ʻaʻole ʻoi aku i hoʻokahi manawa i kēlā me kēia 2 pule. Hiki i kāu kauka ke hōʻemi i kāu lāʻau inā ʻike ʻoe i nā hopena ʻaoʻao.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i riociguat,

• e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka riociguat, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā papa riociguat. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka inā lawe a lawe paha ʻoe i kahi nitrate e like me isosorbide dinitrate (Isordil, in BiDil), isosorbide mononitrate (Monoket), a i ʻole nitroglycerin (Nitro-Dur, Nitromist, Nitrostat, Minitran, Rectiv, a me nā mea ʻē aʻe),; nā mea kūpale phosphodiesterase (PDE-5) e like me avanafil (Stendra), sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), a i ʻole vardenafil (Levitra, Staxyn); aiʻole inā e lawe ana ʻoe i ka dipyridamole (Persantine, i Aggrenox), a i ʻole theophylline (Theo-24, Theochron, Theolair, a me nā mea ʻē aʻe). E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe i ka riociguat inā ʻoe e lawe i kēia aʻoi aku paha o kēia mau lāʻau. Mai lawe i ka riociguat i loko o 24 mau hola ma mua a ma hope paha o ka lawe ʻana i sildenafil a i ʻole ma loko o 24 mau hola ma mua a i ʻole 48 mau hola ma hope o ka lawe ʻana i kā tadalafil.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E ʻike pono i kekahi o kēia mau mea: kekahi antifungals e like me itraconazole (Onmel, Sporanox) a me ketoconazole (Extina, Nizoral, Xolegel); Nā mea hoʻopuka protease HIV me ritonavir (Norvir, ma Kaletra); kekahi mau lāʻau no ka hopu ʻana e like me ka carbamazepine (Epitol, Equetro, Tegretol, a me nā mea ʻē aʻe), phenobarbital, a me phenytoin (Dilantin, Phenytek); a me nā lāʻau no ke koko kiʻekiʻe. Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• inā ʻoe e lawe i nā antacids i loko o ka aluminium hydroxide a i ʻole magnesium hydroxide (Maalox, Mylanta, Tums, a me nā mea ʻē aʻe), lawe iā lākou i hoʻokahi hola ma mua a i ʻole 1 hola ma hope o ka lawe ʻana i riociguat.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St.
• e haʻi i kāu kauka inā loaʻa iā ʻoe kahi kiʻekiʻe o ka pulmonary me ka pulupona interstitial idiopathic (PH-IIP; maʻi maʻi). E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe iā riociguat.
• e haʻi i kāu kauka inā puhipaka ʻoe i kēia manawa a hoʻomaka a kū paha i ka puhipaka i ka wā o ka lāʻau. E haʻi pū aku i kāu kauka inā loaʻa koke ʻoe i ka maʻi pākī, ka luaʻi, a i ʻole ka hou ʻana i ka nui o ka wai i kumu i ka make wai (nalowale o kahi nui o nā wai o ke kino); nā kahe koko ʻana mai kāu (mau) māmā; inā loaʻa iā ʻoe kahi kaʻina hana e kāpae iā ʻoe mai ka uha ʻana i ke koko; inā loaʻa ʻoe i ke kahe haʻahaʻa, ka maʻi veno-occlusive pulmonary (kahi paʻa o nā uaua i nā akemāmā); aiʻole ka puʻuwai, ka puʻuwai, a me nā maʻi ate.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū. Mai hānai i ka wā e lawe ana ʻoe i riociguat.
• pono ʻoe e ʻike he hiki i ka riociguat ke hoʻonāukiuki a me ka lightheadedness. Mai hoʻokele i kahi kaʻa a hana i nā mīkini a ʻike ʻoe i ka hopena o kēia lāʻau iā ʻoe.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

E haʻalele i ka lāʻau i haʻalele ʻia a hoʻomau i kāu papa hana maʻamau. Inā makemake ʻoe e lawe i riociguat ma mua o 3 mau lā, e kāhea i kāu kauka. Makemake paha kāu kauka e hoʻomaka hou i kāu lāʻau i kahi mahele haʻahaʻa.

Hoʻokumu paha ʻo Riociguat i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• ʻeha poʻo
• kōpaʻa
• puʻuwai puʻuwai
• hoʻohuhū ʻōpū
• nausea
• ka luaʻi
• pāhoehoe
• ka pehu o kou mau lima, nā wāwae, nā wāwae, a me nā kuʻekuʻe wāwae

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli a i ʻole kēlā mau mea i ka ʻĀKAHI MAKAHIKI ʻāpana, e kelepona koke i kāu kauka a i ʻole e kiʻi i nā lāʻau lapaʻau pilikia

• ke kuʻi nei i ka poni, ka huʻi a me ke koko
• maule ana
• ʻeha ka umauma
• pokole o ka hanu

Hoʻokumu paha ʻo Riociguat i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Mālama i nā manawa āpau me kāu kauka. E nānā pinepine kāu kauka i kou kaomi koko i kou wā e mālama ai me riociguat.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Adempas^®