ʻO Vemurafenib

Anter

• Ma mua o ka lawe ʻana i vemurafenib,
• Hoʻokumu ʻo Vemurafenib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka:
• Inā ʻoe e ʻike i kekahi o nā ʻōuli o ke ʻano alerika a i ʻole ka ʻili koʻikoʻi, e hooki i ka lawe ʻana i ka vemurafenib a kāhea koke aku i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

Hoʻohana ʻia ʻo Vemurafenib e mālama i kekahi ʻano melanoma (kahi ʻano o ka maʻi ʻaʻai ʻili) ʻaʻole hiki ke mālama ʻia me ke ʻoki a i ʻole ua pāhola aʻe i nā ʻāpana ʻē aʻe o ke kino. Hoʻohana ʻia ia e mālama i kekahi ʻano o ka maʻi Erdheim-Chester (ECD; kahi maʻi e hana i kahi overproduction o kahi ʻano o nā hunaola keʻokeʻo). Aia ʻo Vemurafenib i loko o ka papa o nā lāʻau i kapa ʻia ʻo nā kinase inhibitors. Hana ia ma ke kāpae ʻana i ka hana o kahi protein pono ʻole e hōʻailona ai i nā hunaola maʻi ʻaʻai e hoʻonui. Kōkua kēia i ka hoʻolohi a hoʻopau paha i ka hoʻolaha ʻana o nā hunaola maʻi ʻaʻai.

Hele mai ʻo Vemurafenib ma ke ʻano he papa e lawe ma ka waha. Lawe pinepine ʻia me ka ʻai ʻole a ʻelua paha manawa i ka lā, i ke kakahiaka a me ke ahiahi, ma kahi o 12 mau hola ke kaʻawale. E lawe iā vemurafenib ma nā manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. E lawe pololei i vemurafenib. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka. Mai hōʻoki i ka lawe ʻana i ka vemurafenib me ke kamaʻilio ʻole ʻana me kāu kauka.

E ale i nā papa i ke aniani o ka wai; mai nahu a paopao iā lākou.

Inā luaʻi ʻoe ma hope o kou lawe ʻana i ka vemurafenib, mai lawe koke i kahi lāʻau. E hoʻomau i kāu papa hana maʻamau.

Pono paha kāu kauka e hoʻopau i kahi manawa a kūpaʻa mau paha i kāu lāʻau a hōʻemi paha i kāu lāʻau o vemurafenib i kāu wā e mālama ai. Pili kēia i ka maikaʻi o ka lāʻau lapaʻau iā ʻoe a me nā hopena ʻaoʻao āu e ʻike ai. E pono e haʻi aku i kāu kauka i kou ʻano i kou wā e mālama ai me ka vemurafenib.

E hāʻawi aku kāu kauka a kauka paha iā ʻoe i ka palapala ʻike hoʻomanawanui o ka mea hana (Kauka Lapaʻau) ke hoʻomaka ʻoe i ka lāʻau me vemurafenib a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i vemurafenib,

• e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka vemurafenib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā papa vemurafenib. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E ʻike pono i kekahi o kēia mau mea: kekahi antifungals e like me itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), a me voriconazole (Vfend); clarithromycin (Biaxin, i PrevPac); kekahi mau lāʻau no ka maʻi pale maʻi (HIV) a i ʻole loaʻa mai kahi maʻi maʻi maʻi maʻi (AIDS) e like me indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, ma Kaletra), a me saquinavir (Invirase); kekahi mau lāʻau no ka hopu ʻana e like me ka carbamazepine (Carbatrol, Epitol, Tegretol, a me nā mea ʻē aʻe), phenobarbital, a me phenytoin (Dilantin, Phenytek); nefazodone; rifampin (Rifadin, Rimactane, ma Rifamate, ma Rifater); tizanidine; a me warfarin (Coumadin, Jantoven). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Nui paha nā lāʻau ʻē aʻe e launa pū me vemurafenib, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole kekahi ʻano o ka maʻi ʻaʻai ʻili; kahi wā QT hoʻolōʻihi (kahi pilikia puʻuwai laha ʻole e hiki ai ke hōʻeha i ka puʻuwai ʻole, maʻule, a make koke paha); puʻuwai puʻuwai; kahi pae haʻahaʻa o ka puna, magnesium, a pāhare potassium paha i kou koko; puʻuwai, puʻuwai, a i ʻole maʻi maʻi ate. Eia kekahi, e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole ke hoʻolālā nei e loaʻa ka radiation radiation.
• e haʻi i kāu kauka inā hāpai ʻoe a i ʻole hoʻolālā e hāpai. ʻAʻole pono ʻoe e hāpai i ka wā e lawe ana ʻoe i ka vemurafenib. Pono ʻoe e hoʻohana i ka kaohi hānau e pale ai i ka hāpai ʻana i kāu mālama ʻana me vemurafenib a no 2 mau pule ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā hana kaohi hānau e holo pono nāu. Inā hāpai ʻoe i ka lawe ʻana i vemurafenib, e kāhea i kāu kauka. Hiki iā Vemurafenib ke hōʻeha i ka fetus.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū. ʻAʻole pono ʻoe e hānai i ka wā e lawe ana i ka vemurafenib a no 2 mau pule ma hope o kāu hopena hope loa.
• inā ke ʻoki nei ʻoe, e like me ke kaha ʻana o nā niho, e haʻi i ke kauka a i ʻole kauka niho paha ʻoe e lawe nei i ka vemurafenib.
• hoʻolālā e hōʻalo i ka pono ʻole a hoʻolōʻihi ʻia paha i ka lā a komo i nā lole pale, nā aniani aniani, nā lehelehe lepe a me ka sunscreen (SPF 30 a ʻoi aku). Hoʻomaopopo ʻo Vemurafenib i kou ʻili i ka lā o ka lā.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia nō naʻe, inā aia ia i loko o 4 mau hola o kāu kau palena hope e hoʻolālā ʻia, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu ʻo Vemurafenib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• luhi
• ami, mākala, lima, wāwae, a ʻeha hoʻi
• ʻulaʻula a pehu paha i nā lima, ka wāwae, nā kuʻekuʻe wāwae, a me nā wāwae lalo
• loli i ke ʻano o ka ʻono
• ʻeha poʻo
• poho lauoho
• ʻili maloʻo a ʻili paha
• pāhoehoe
• kōpaʻa
• ʻūhā

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka:

• hoʻololi i ka helehelena o ka ʻili
• wart hou
• ʻeha ka ʻili a ʻulaʻula paha e hoʻokahe ke koko a hoʻōla ʻole paha
• e hoʻololi i ka nui a me ke kala o kahi mole
• luhi loa
• ʻāpā ʻaʻano ʻole a hoʻokahe koko paha
• nausea
• ka luaʻi
• nalo ʻai ʻole
• ʻeha ma ka ʻaoʻao ʻākau o luna o ka ʻōpū
• melemele o ka ʻili a me nā maka
• ʻike maka i ka mālamalama
• ʻulaʻula maka a ʻeha paha
• loli ka hihiʻo
• ʻokoʻa ka mānoanoa o nā poho lima
• ke hoʻokū nei i nā manamana i loko i ka palama
• ʻano lahilahi ʻole o nā kapuaʻi, ʻeha paha

Inā ʻoe e ʻike i kekahi o nā ʻōuli o ke ʻano alerika a i ʻole ka ʻili koʻikoʻi, e hooki i ka lawe ʻana i ka vemurafenib a kāhea koke aku i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• pilikia i ka hanu ʻana a i ʻole ke ale ʻana
• wikiwiki, kūlike ʻole, a kuʻi paha i nā puʻuwai puʻuwai
• maule ana
• ʻehu a ʻulaʻula paha ma ke kino holoʻokoʻa
• hives
• ʻili a ʻili paha i ka ʻili
• fiva

Hiki i ka Vemurafenib ke hoʻonui i ka makaʻu e hoʻomohala ʻoe i nā maʻi ʻē aʻe. E kamaʻilio me kāu kauka e pili ana i kēia pilikia.

Hoʻokumu paha ʻo Vemurafenib i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua lab e nānā i ka pane o kou kino iā vemurafenib. E nānā kāu kauka i kou ʻili ma mua o ka hoʻomaka ʻana i ka lāʻau, i kēlā me kēia 2 mau mahina i kou wā e hoʻomaʻamaʻa ai, a hiki i 6 mau mahina ma hope o ka mālama.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• ʻO Zelboraf^®