Pākuʻi Denosumab

Anter

• Hoʻohana ʻia ʻo Denosumab injection (Prolia)
• Hoʻohana ʻia ʻo Denosumab injection (Xgeva) ʻo Denosumab injection i loko o ka papa o nā lāʻau i kapa ʻia ʻo RANK ligand inhibitors. Hana ia e pale i ka nalo ʻana o ka iwi ma ka pale ʻana i kahi mea loaʻa i ke kino e hōʻemi i ka haki o ka iwi. Hana ia e mālama iā GCTB ma ke kāpae ʻana i kahi receptor i loko o nā hunaola tumora e hoʻolohi ai i ka ulu ulu ʻana. Hana ia e mālama i nā kiʻekiʻe o ka calcium ma ka hoʻemi ʻana i ka haki o ka iwi i ka hoʻokuʻu ʻana o ka iwi i ka calcium.
• Ma mua o ka loaʻa ʻana o ka injection denosumab,
• Hoʻokumu paha ka inikua Denosumab i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

Hoʻohana ʻia ʻo Denosumab injection (Prolia)

• e mālama i ka osteoporosis (kahi ʻano e lahilahi a nāwaliwali ai nā iwi a haki maʻalahi) i nā wahine i loaʻa i ka menopause ("loli o ke ola;" ka hopena o nā wā menstrual) ka mea i hoʻonui i ka makaʻala no nā haki (haki nā iwi) a i ʻole ka mea hiki ʻole ke lawe a pane ʻole paha i nā lāʻau lapaʻau ʻē aʻe no ka osteoporosis.
• e mālama i nā kāne i hoʻonui i ka makaʻala no ka haki (haki nā iwi) a i ʻole hiki ke lawe a pane ʻole paha i nā lāʻau lapaʻau ʻē aʻe no ka osteoporosis.
• mālama i ka osteoporosis i hoʻokumu ʻia e nā lāʻau Corticosteroid i nā kāne a me nā wahine e lawe nei i nā lāʻau Corticosteroid no 6 mau mahina a ua nui ka makaʻu no nā haki a i ʻole hiki ke lawe a pane ʻole i nā lāʻau lapaʻau ʻē aʻe no ka osteoporosis.
• e mālama i ka pohō o ka iwi i nā kāne e mālama ʻia no ka maʻi ʻaʻai prostate me kekahi mau lāʻau e hiki ai ke lilo ka iwi.
• e mālama i ka pohō o ka iwi i nā wahine me ka maʻi ʻaʻai umauma e loaʻa ana i kekahi mau lāʻau e hoʻonui i ko lākou makaʻi no nā haki.

Hoʻohana ʻia ʻo Denosumab injection (Xgeva) ʻo Denosumab injection i loko o ka papa o nā lāʻau i kapa ʻia ʻo RANK ligand inhibitors. Hana ia e pale i ka nalo ʻana o ka iwi ma ka pale ʻana i kahi mea loaʻa i ke kino e hōʻemi i ka haki o ka iwi. Hana ia e mālama iā GCTB ma ke kāpae ʻana i kahi receptor i loko o nā hunaola tumora e hoʻolohi ai i ka ulu ulu ʻana. Hana ia e mālama i nā kiʻekiʻe o ka calcium ma ka hoʻemi ʻana i ka haki o ka iwi i ka hoʻokuʻu ʻana o ka iwi i ka calcium.

• e hoʻemi i ka hopena o ka haki i nā poʻe i loaʻa ka myeloma he nui (ka maʻi ʻaʻai e hoʻomaka i nā hunaola plasma a hōʻino ʻia ka iwi), a i ka poʻe i loaʻa kekahi ʻano maʻi ʻaʻai i hoʻomaka i kekahi ʻāpana o ke kino akā ua pāhola i nā iwi.
• i nā mākua a me kekahi mau ʻōpio e mālama i nā tumo pūnaewele nui o ka iwi (GCTB; kahi ʻano iwi iwi) ʻaʻole hiki ke mālama ʻia me ke ʻoki kino.
• e mālama i nā kiʻekiʻe o ka calcium i hoʻokumu ʻia e ka maʻi ʻaʻai i ka poʻe i pane ʻole i nā lāʻau ʻē aʻe.

Hele mai ka injection Denosumab ma ke ʻano he hopena (wai) e ʻoki ʻia subcutaneʻu (ma lalo o ka ʻili) i kou lima o luna, ʻūhā luna, a i ʻole ka ʻōpū. Hoʻokomo pinepine ʻia ia e ke kauka a kahu hānai paha i kahi keʻena lapaʻau a i ʻole kahi keʻena lapaʻau. Hāʻawi pinepine ʻia ʻo Denosumab injection (Prolia) i hoʻokahi manawa i kēlā me kēia 6 mahina. Ke hoʻohana ʻia ka injection denosumab (Xgeva) e hoʻemi i ka makaʻu o nā haki mai ka myeloma maha, a i ʻole ka maʻi ʻaʻai i hohola i nā iwi, hāʻawi pinepine ʻia kēlā me kēia 4 pule. Ke hoʻohana ʻia ka injection denosumab (Xgeva) e mālama i ka tumone pūnaewele nui o ka iwi, a i ʻole nā ​​pae calcium kiʻekiʻe i hoʻokumu ʻia e ka maʻi ʻaʻai, hāʻawi pinepine ʻia ia i kēlā me kēia 7 lā no nā kolamu mua ʻekolu (i ka lā 1, lā 8, a me ka lā 15) a laila hoʻokahi manawa i kēlā me kēia 4 pule e hoʻomaka ana i 2 mau pule ma hope o nā kau mua ʻekolu.

E haʻi aku kāu kauka iā ʻoe e lawe i nā mea hoʻopiha o ka calcium a me ka huaola D ʻoiai ke mālama ʻia ʻoe me ka injection denosumab. E lawe i kēia mau mea hoʻopihapiha e like me ke kuhikuhi.

Ke hoʻohana ʻia ka injection denosumab (Prolia) e mālama ai i ka osteoporosis a i ʻole ka nalo ʻana o ka iwi, e hāʻawi aku kāu kauka a mea lāʻau lapaʻau paha iā ʻoe i ka pepa ʻikepili a ka mea hana (Medication Guide) ke hoʻomaka ʻoe i ka mālama ʻana me ka injection denosumab a i kēlā me kēia manawa e hoʻopiha hou i kāu kuhikuhi. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka loaʻa ʻana o ka injection denosumab,

• e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka denosumab (Prolia, Xgeva), nā lāʻau ʻē aʻe, latex, a i ʻole kekahi o nā mea hana i ka denosumab injection. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
• pono ʻoe e ʻike i ka loaʻa ʻana o ka injection denosumab ma lalo o nā inoa ʻo Prolia a me Xgeva. ʻAʻole pono ʻoe e loaʻa ma mua o hoʻokahi huahana i loaʻa ka denosumab i ka manawa like. E pono e haʻi aku i kāu kauka inā mālama ʻia ʻoe me kekahi o kēia mau lāʻau.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe.E hoʻomaopopo pono e haʻi i kekahi o kēia mau mea: angiogenesis nā mea kāohi e like me axitinib (Inlyta), bevacizumab (Avastin), everolimus (Afinitor, Zortress), pazopanib (Votrient), sorafenib (Nexavar), a sunitinib (Sutent); bisphosphonates e like me alendronate (Binosto, Fosamax), etidronate, ibandronate (Boniva), pamidronate, risedronate (Actonel, Atelvia), zoledronic acid (Reclast); nā lāʻau chemotherapy chemotherapy; nā lāʻau e kāohi i ka ʻōnaehana pale e like me azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), methotrexate (Otrexup, Rasuvo, Trexall, Xatmep), sirolimus (Rapamune), a me tacrolimus (Astagraf XL, Envarsus, Prograf) ; nā steroid e like me dexamethasone, methylprednisolone (A-Methapred, Depo-Medrol, Medrol, Solu-Medrol), a me prednisone (Rayos); aiʻole nā ​​lāʻau i hoʻohana ʻia e hoʻohaʻahaʻa i kāu mau pae calcium, e like me cinacalcet (Sensipar). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• e haʻi i kāu kauka inā loaʻa a loaʻa paha iā ʻoe kahi pae haʻahaʻa o ka calcium i loko o kou koko. E nānā paha kāu kauka i ke kiʻekiʻe o ka calcium i loko o kou koko ma mua o kou hoʻomaka ʻana i ka lāʻau lapaʻau a e ʻōlelo paha iā ʻoe ʻaʻole e loaʻa i ka injection denosumab inā haʻahaʻa loa ka pae.
• e haʻi i kāu kauka inā e loaʻa ana iā ʻoe nā lāʻau dialysis a i ʻole inā he anemia kou a i ʻole (ke ʻano i lawe ʻole ʻia nā hunaola ʻulaʻula i nā ʻāpana āpau o ke kino); maʻi ʻaʻai; kekahi ʻano maʻi, ʻoi loa i kou waha; nā pilikia me kou waha, nā niho, nā gum, a me nā niho niho; ʻoki niho a haʻi waha paha (wehe ʻia nā niho, hoʻokomo ʻia nā niho); i kekahi ʻano e hōʻoki i kou koko mai ka hoʻopili ʻana maʻamau; i kekahi kūlana e hōʻemi ana i ka hana o kāu ʻōnaehana pale maʻi; ke kahakaha ma kāu gland thyroid a i ʻole ka parathyroid gland (ka liʻiliʻi liʻiliʻi ma ka ʻāʻī); ʻoki kino e hemo i kahi hapa o kou ʻōpū liʻiliʻi; nā pilikia me kou ʻōpū a i ʻole kou ʻōpū e paʻakikī i kou kino e komo i nā mea momona; polymyalgia rheumatica (maʻi e hōʻeha ai i ka ʻeha a me nāwaliwali); diabetes, aiʻole parathyroid a maʻi maʻi maʻi paha.
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Pono ʻoe e loaʻa i kahi hōʻoia hāpai maikaʻi ʻole ma mua o ka hoʻomaka ʻana o ka mālama ʻana me ka injection denosumab. ʻAʻole pono ʻoe e hāpai i ka wā e loaʻa ana iā ʻoe ka injection denosumab. Pono ʻoe e hoʻohana i kahi ʻano hilinaʻi o ka kaohi hānau e pale ai i ka hāpai ʻana ʻoiai ke loaʻa ʻana iā ʻoe ka pahu denosumab a no 5 mau mahina ma hope o kāu hopena hope loa. Inā hāpai ʻoe i ka loaʻa ʻana o ka injection denosumab, a i ʻole ma waena o 5 mau mahina o kāu mālama ʻana, e kāhea koke i kāu kauka. Hiki iā Denosumab ke hōʻeha i ka fetus.
• pono ʻoe e ʻike i ka hoʻopili ʻana o denosumab i kumu osteonecrosis o ka ʻāʻī (ONJ, kahi kūlana koʻikoʻi o ka iwi ā), keu hoʻi inā he ʻoki niho ʻoe a i ʻole ke mālama ʻana ke loaʻa ʻoe i kēia lāʻau. Pono kahi kauka niho e nānā pono i kou mau niho a hana i nā hana e pono ai, e like me ka hoʻomaʻemaʻe a hoʻoponopono ʻana paha i nā niho pono ʻole, ma mua o kou hoʻomaka ʻana e loaʻa ka pahu kui denosumab. E nānā pono e palaki i kou mau niho a hoʻomaʻemaʻe i kou waha pono ʻoiai ʻoe e loaʻa ana i ka injection denosumab. E kamaʻilio me kāu kauka ma mua o ka loaʻa ʻana o nā lāʻau lapaʻau iā ʻoe ke loaʻa nei kēia lāʻau.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

Inā haʻalele ʻoe i kahi manawa e loaʻa ai kahi injection o denosumab, pono ʻoe e kelepona i kāu kauka lawelawe i ka wā hiki. E hāʻawi ʻia ka mahele lāʻau i hala ke hiki ke hoʻonohonoho hou ʻia. Ke hoʻohana ʻia ka injection denosumab (Prolia) no ka osteoporosis a i ʻole ka nalo ʻana o ka iwi, ma hope o kou loaʻa ʻana o ka huina i hala, pono e hoʻonohonoho ʻia kāu ʻoki aʻe 6 mau mahina mai ka lā o kāu pahu hope loa

Hoʻokumu paha ka inikua Denosumab i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• ʻulaʻula, maloʻo, a ʻili ʻili paha
• ʻōniʻu a huehue paha i ka ʻili
• ʻili peeling
• ʻeha kua
• ʻeha ma kou mau lima
• pehu o nā lima a mau wāwae paha
• ʻehaʻeha a ʻeha pū paha
• nausea
• pāhoehoe
• kōpaʻa
• abdominal eha
• ʻeha poʻo

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• ʻoʻoleʻa o ka mākala, twitching, cramp, a i ʻole spasms
• numbness a kani paha i kou mau manamana lima, manamana wāwae, a puni paha kou waha
• hives, ʻāwīwī, ʻili, paʻakikī i ka hanu ʻana a me ka ale ʻana paha, ka pehu ʻana o ka maka, nā maka, ka ʻāʻī, ke alelo a i ʻole nā ​​lehelehe,
• ke kunu a i ʻole ke anuanu
• ʻulaʻula, palupalu, pehu a mehana o kahi ʻili
• fiva, uha, pōkole o ka hanu
• kahe ka pepeiao a ʻeha paha ka pepeiao pepeiao
• Pono pinepine a i ʻole koi nui e mimi, wela ke ahi i ka wā e mimi ai ʻoe
• ʻeha nui i ka ʻōpū
• ʻeha a pehu paha, hoʻokuʻu i nā niho, numbness a i ʻole kaumaha kaumaha i ka iwi ā, hoʻōla maikaʻi ʻole o ka iwi ā
• kahe koko ʻole ʻana a palapū paha
• nausea, luaʻi, headache, a hoʻemi i ka makaʻala ma hope o ke kū ʻana o denosumab a no 1 mau makahiki ma hope

Hiki i ka inikua Denosumab ke hoʻonui i ka makaʻu e haki ʻoe i kou mau ʻūhā (s) ʻeha paha ʻoe i kou pūhaka, ʻūlū, a i ʻole nā ​​ʻūhā no nā pule he nui a mau mahina paha ma mua o ka haki ʻana o ka iwi, a ʻike paha ʻoe i hoʻokahi a i ʻole ʻelua paha ua haki kou mau iwi ʻūhā ʻoiai ʻaʻole ʻoe i hāʻule a i ʻole ʻike i kahi trauma ʻē aʻe. He mea maʻamau ʻole ka haki ka iwi o ka ʻūhā i ka poʻe olakino, akā ʻo ka poʻe i loaʻa ka osteoporosis e haki paha kēia iwi inā ʻaʻole lākou e loaʻa i ka ʻume denosumab. Hiki i ke kuikahi Denosumab ke kumu i nā iwi haʻi e hoʻōla mālie a hōʻino paha i ka ulu ʻana o ka iwi a pale i nā niho mai ke komo kūpono ʻana i nā keiki. E kamaʻilio me kāu kauka e pili ana i nā pilikia o ka loaʻa ʻana o ka injection denosumab.

Hoʻokumu paha ʻo Denosumab injection i nā hopena ʻē aʻe. Kāhea i kāu kauka inā loaʻa iā ʻoe kekahi pilikia maʻamau i ka loaʻa ʻana o kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. Mai hoʻoluliluli i ka pahu kui denosumab. E mālama iā ia i loko o ka pahu hau a pale iā ia mai ka mālamalama. Mai paʻa hau. Hiki ke mālama ʻia ka pahu kui Denosumab i ka mahana wela no 14 mau lā.

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha aku kāu kauka i kekahi mau hoʻokolohua e ʻike pono ka palekana no ʻoe e loaʻa i ka ʻume denosumab a e nānā i ka pane o kou kino i ka hoʻopiʻi denosumab.

Mai ʻae i kekahi e hoʻohana i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Prolia^®
• Xgeva^®