Serum globulin electrophoresis

ʻO ke ana o ka serum globulin electrophoresis hōʻike i nā pae o nā protein i kapa ʻia globulins i ka ʻāpana wai o kahi hāpana koko. Kapa ʻia kēia wai i ke serum.

Pono kahi laʻana koko.

I ka hale hana, hoʻonoho ka ʻenehana i ka laʻana koko ma kahi pepa kūikawā a hoʻopili i kahi kaila uila. Neʻe nā protein i ka pepa a hana i nā band e hōʻike i ka nui o kēlā me kēia protein.

E hāhai i nā ʻōkuhi inā pono ʻoe e hoʻokē ʻai ma mua o kēia hoʻokolohua.

Hiki i kekahi mau lāʻau ke hoʻololi i nā hopena o kēia hōʻike. E haʻi aku kāu mea mālama ola inā pono ʻoe e hōʻoki i ka lawe ʻana i nā lāʻau. Mai kū i kekahi lāʻau i mua o ke kamaʻilio ʻana i kāu mea hāʻawi.

Ke hoʻokomo ʻia ke kui kele e huki i ke koko, manaʻo kekahi poʻe i ka ʻeha kaulike. ʻIke wale kekahi i kahi ʻōniʻu a i ʻole kui. Ma hope, loaʻa paha i kahi kūpikipiki a i ʻole ka ʻūlū iki. Hele koke kēia.

Hana ʻia kēia hōʻike e nānā i nā protein o ka globulin i ke koko. Ke ʻike nei i nā ʻano o nā globulins hiki ke kōkua i ke kuhi ʻana i kekahi mau pilikia olakino.

Māhele ʻemi ʻia nā Globulins i ʻekolu mau pūʻulu: alpha, beta, a me gamma globulins. Hoʻopili nā Gamma globulins i nā ʻano antibodies e like me immunoglobulins (Ig) M, G, a me A.

Pili kekahi mau maʻi i ka hana ʻana i nā immunoglobulins he nui loa. ʻO kahi laʻana, ʻo Waldenstrom macroglobulinemia kahi maʻi ʻaʻai o kekahi mau keʻokeʻo koko keʻokeʻo. Hoʻopili ʻia ia me ka hana ʻana i nā antibodies IgM he nui loa.

ʻO nā pae waiwai maʻamau:

• Serbul globulin: 2.0 a 3.5 gramo i kēlā me kēia deciliter (g / dL) a i ʻole 20 a 35 gram i kēlā me kēia lita (g / L)
• ʻO ka mea IgM: 75 a 300 milligrams i kēlā me kēia deciliter (mg / dL) a i ʻole 750 i 3,000 milligrams i kēlā me kēia lita (mg / L)
• ʻO ka mea IgG: 650 a 1,850 mg / dL a i ʻole 6.5 a i 18.50 g / L
• ʻO ka mea IgA: 90 a 350 mg / dL a i ʻole 900 a 3,500 mg / L

Hiki ke loli iki nā pae waiwai maʻamau i waena o nā hale hana ʻokoʻa. Hoʻohana kekahi mau labs i nā ana like ʻole a i ʻole nā ​​hoʻāʻo i nā laʻana like ʻole. E kamaʻilio i kāu mea hāʻawi e pili ana i ke ʻano o kāu mau hopena hōʻike.

Hiki i nā proteins gamma globulin i hoʻonui ʻia ke hōʻike:

• Maʻi ʻaʻai
• ʻO nā maʻi ʻaʻai koko a me nā iwi pū me ka myeloma maha, a me kekahi mau lymphomas a me nā leukemias
• Nā pilikia maʻi pale maʻi
• ʻO ka maʻi wā lōʻihi (mau) hoʻomāhuahua (e laʻa me, rheumatoid arthritis a me systemic lupus erythematosus)
• Waldenström macroglobulinemia

Aia ka liʻiliʻi o ka makaʻu me ka lawe ʻia o kou koko. ʻOkoʻa nā aʻa a me nā aʻa i ka nui mai kekahi kanaka a i kekahi, a mai kekahi ʻaoʻao o ke kino i kekahi ʻē aʻe. ʻOi aku ka paʻakikī o ka lawe ʻana i ke koko mai kekahi poʻe ma mua o nā poʻe ʻē aʻe.

ʻO nā pilikia ʻē aʻe e pili ana i ke kau ʻana o ke koko he liʻiliʻi, akā hiki ke hoʻopili ʻia:

• Kahe nui ke koko
• Pāleʻale a ʻoluʻolu paha
• Nā punctures he nui e ʻimi i nā uaua
• Hematoma (kūkulu koko ma lalo o ka ʻili)
• Maʻiʻaʻai (i iki kamepiula i kēlā me kēia manawa ka ʻili i haki)

Nā immunoglobulins nui

• Hōʻaʻo koko

Chernecky CC, Berger BJ. Immunoelectrophoresis - serum a me ka mimi. I: Chernecky CC, Berger BJ, hua. Nā Hoʻokolohua Laboratory a me nā kaʻina hana Diagnostic. ʻElua huaʻōlelo St Louis, MO: Elsevier Saunders; 2013: 667-692.

Dominiczak MH, ʻO Fraser WD. ʻO nā protein protein a me ke koko. I: Baynes JW, Dominiczak MH, eds. Lapaʻau Biochemistry. 5th lā. Piladelapia, PA: Elsevier; 2019: chap 40.