Cerebral amyloid angiopathy

ʻO ka cerebral amyloid angiopathy (CAA) kahi ʻano i kūkulu ʻia nā protein i kapa ʻia ʻo amyloid ma nā paia o nā aʻa i ka lolo. Hoʻonui ka CAA i ka makaʻu no ka hahau ʻana ma muli o ke kahe ʻana a me ke dementia.

Loaʻa i ka poʻe me CAA nā waihona o ka protein amyloid i loko o nā paia o nā kīʻaha koko i ka lolo. ʻAʻole waiho ʻia ka protein i nā wahi ʻē aʻe o ke kino.

ʻO ka mea nui weliweli e hoʻonui nei i ka makahiki. ʻIke pinepine ʻia ʻo CAA i ka poʻe ma mua o 55. I kekahi manawa, hoʻoili ʻia i waena o nā ʻohana.

Hiki i ka CAA ke kumu i ke kahe ʻana i ka lolo. Kū pinepine ke kahe ʻana i nā ʻaoʻao o waho o ka lolo, i kapa ʻia ʻo ka piko, ʻaʻole nā ​​wahi hohonu. Kū nā ʻōuli ma muli o ke kahe ʻana o ka lolo i loko o ka lolo e hōʻeha ai i kaʻiʻo o ka lolo. Loaʻa i kekahi poʻe nā pilikia hoʻomanaʻo pākī. Ke hoʻopau ʻia kahi CT scan, aia nā hōʻailona aia lākou i kahe ʻia o ke kahe i ka lolo ʻaʻole lākou i ʻike.

Inā nui ke kahe o ke kahe, kū koke nā ʻōuli a like me ka hahau. Loaʻa kēia mau ʻōuli:

• Hiamoe
• Headache (maʻamau i kekahi ʻāpana o ke poʻo)
• Hoʻololi nā ʻōnaehana hopohopo e hoʻomaka koke paha, e like me ka huikau, ka hilahila, ka ʻike pālua, ka hoʻoliʻiliʻi ʻike, nā loli sensation, nā pilikia kamaʻilio, nāwaliwali, a i ʻole ka lolo.
• Ka hopu ʻana i nā maʻi
• Kanalua a koma (kākaʻikahi)
• ʻO ka luaʻi

Inā ʻaʻole koʻikoʻi a ākea paha ke kahe ʻana, hiki i nā ʻōuli ke komo pū me:

• Episodes o ka huikau
• Headache e hele mai a hele
• Ka nalowale o ka hana noʻonoʻo (dementia)
• Nāwaliwali a ʻano ʻē paha i hele a hele, a hoʻopili i nā wahi liʻiliʻi
• Ka hopu ʻana i nā maʻi

He paʻakikī ka CAA e hōʻoia me ka ʻole me kahi laʻana o kaʻiʻo o ka lolo. Hana ʻia kēia ma hope o ka make ʻana a i ʻole ke hana ʻia kahi biopsy o nā kīʻaha koko o ka lolo.

Hiki ke maʻamau ka hoʻokolohua kino inā liʻiliʻi ka kahe. E loli paha kahi hana o ka lolo. He mea nui i ke kauka e nīnau i nā nīnau kikoʻī e pili ana i nā ʻōuli a me ka mōʻaukala. ʻO nā ʻōuli a me nā hopena o ka hoʻāʻo kino a me nā hoʻokolohua kiʻi hiki ke manaʻo ke kauka iā CAA.

ʻO nā hoʻokolohua kiʻi o ke poʻo e hiki ke hana ʻia e:

• CT scan a scan MRI paha e nānā i ke kahe ʻana o ka lolo i ka lolo
• MRA scan e nānā no nā kahe nui a haʻalele i nā kumu ʻē aʻe o ke kahe ʻana
• Nānā ʻo PET e nānā i nā waihona amyloid i ka lolo

ʻAʻohe lāʻau lapaʻau maikaʻi i ʻike ʻia. ʻO ka pahuhopu o ka mālama ʻana e hōʻoluʻolu i nā ʻōuli. I kekahi mau hihia, pono ka hoʻoponopono hou ʻana no ka nāwaliwali a i ʻole clumsiness. Hiki i kēia ke hoʻopili i ke olakino, ʻoihana hana, a i ʻole haʻi ʻōlelo.

I kekahi manawa, hoʻohana ʻia nā lāʻau e kōkua i ka hoʻomaikaʻi ʻana i ka hoʻomanaʻo, e like me nā mea no ka maʻi ʻo Alzheimer.

ʻO ka hopu ʻana, i kapa ʻia hoʻi he mau kilokilo amyloid, hiki ke mālama ʻia me nā lāʻau anti-seizure.

E hele mālie ka maʻi.

Komo pū nā pilikia o CAA:

• Dementia
• Hydrocephalus (kākaʻikahi)
• Ka hopu ʻana i nā maʻi
• Nā paukū hou o ke kahe ʻana o ka lolo i ka lolo

E hele i ka lumi pilikia a kāhea paha i ka helu kūloko kūloko (e like me 911) inā loaʻa koke iā ʻoe ka neʻe ʻana, ke ʻano, ka ʻike, a me ka haʻiʻōlelo paha.

ʻO Amyloidosis - cerebral; CAA; ʻO ka angiopathy Congophilic

• ʻO Amyloidosis o nā manamana lima
• Nā aʻa o ka lolo

Charidimou A, Boulouis G, Gurol ME, et al. Nā manaʻo e kupu mai nei i ka sporadic cerebral amyloid angiopathy. Lolo. 2017; 140 (7): 1829-1850. PMID: 28334869 pubmed.ncbi.nlm.nih.gov/28334869/.

Greenberg SM, Charidimou A. Diagnosis o ka cerebral amyloid angiopathy: ka ulu ʻana o nā pae hoʻohālikelike o Bosetona. Hahau. 2018; 49 (2): 491-497. PMID: 29335334 pubmed.ncbi.nlm.nih.gov/29335334/.

Kase CS, Shoamanesh A. Hoʻokena hemachage Intracerebral. I: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, eds. ʻO Bradley's Neurology i ka hana lapaʻau. ʻEpekema 7 Piladelapia, PA: Elsevier; 2016: chap 66.