Ka nele Prothrombin

ʻO ka hemahema Prothrombin kahi maʻi i hoʻokumu ʻia e ka nele o kahi protein i ke koko i kapa ʻia ʻo prothrombin. Alakaʻi ia i nā pilikia me ke kō ʻana o ke koko (coagulation). ʻO Prothrombin kahi i ʻike ʻia ma ke ʻano he helu II (ʻelua ʻelua).

Ke kahe nei ʻoe i ke kahe, hana ʻia kahi hopena o nā hopena i loko o ke kino e kōkua ai i ke kōkō ʻana o ke koko. Kapa ʻia kēia hana ke cascade coagulation. Pili ia i nā proteins kūikawā i kapa ʻia ka coagulation, a i ʻole ke kāʻei ʻana, nā kumu. Loaʻa paha iā ʻoe kahi manawa kiʻekiʻe o ke kahe ʻana o ke kahe inā e nalowale ana hoʻokahi a ʻoi paha o kēia mau kumu a hana ʻole paha e like me ka mea e pono ai.

ʻO Prothrombin, a i ʻole kekona II, kekahi ʻano coagulation. Holo ka hemahema Prothrombin i loko o nā ʻohana (hoʻoilina) a kākaʻikahi loa ia. Pono i nā mākua ʻelua ke ʻae e hoʻoili i ka maʻi i kā lākou keiki. ʻO kahi moʻolelo ʻohana o kahi maʻi kahe e hiki ke lilo i mea pilikia.

Hiki ke loaʻa ka hemahema Prothrombin ma muli o kekahi ʻano a hoʻohana ʻana paha i kekahi mau lāʻau. Kāhea ʻia kēia mea ʻo ka loaʻa prothrombin deficience. Hiki ke kumu ʻia e:

• Ka nele o ka wikamina K (hānau ʻia kekahi mau pēpē me ka lawa ʻole o ka wikamina K)
• Maʻi maʻi ʻeha nui
• Hoʻohana i nā lāʻau e pale ai i ka hoʻopili ʻana (anticoagulants e like me warfarin)

Pākuʻi ʻia paha nā ʻōuli i kekahi o kēia mau mea:

• Kahe koko ʻole ma hope o ka hānau ʻana
• Kahe nui ka haehae
• Kahe ma hope o ke kahakaha ʻana
• Kahe i hope o ka ʻeha
• Māmā maʻalahi
• Nā Nosebleeds e kū mālie ʻole
• Kahe ʻana ke kaula uila ma hope o ka hānau ʻana

ʻO nā hoʻāʻo e hana ʻia ana paha:

• ʻIke kumu II
• Manawa thromboplastin manawa
• Ka manawa Prothrombin (PT)
• Hoʻohui aʻoaʻo (kahi hōʻike PTT kūikawā e hōʻoia i ka hemahema prothrombin)

Hiki ke kāohi ʻia ke kahe ʻana e ka loaʻa ʻana o ka infravenous (IV) infusions o ka plasma a i ʻole nā ​​concentrates o nā kumu hoʻopili. Inā nele ʻoe i ka wikamina K, hiki iā ʻoe ke lawe i kēia huaora e ka waha, ma o nā hoʻopili ʻana ma lalo o ka ʻili, a i ʻole ma o kahi aa (intravenously).

Inā loaʻa kēia maʻi kolohe iā ʻoe, e pono e:

• E haʻi aku i kāu poʻe mālama ola ma mua o kāu loaʻa ʻana i kekahi ʻano o ke kaʻina hana, e like me ka hana ʻoki ʻana a me nā hana niho.
• E haʻi i nā ʻohana o kou ʻohana no ka mea he maʻi like paha kā lākou akā ʻaʻole ʻike ia manawa.

Hiki i kēia mau kumuwaiwai ke hāʻawi i ka ʻike hou aku e pili ana i ka hemahema o Factor VII:

• National Hemophilia Foundation: Nā Mea Kūpono ʻē aʻe - www.hemophilia.org/Bleeding-Disorder/Types-of-Bleeding-Disorders/Other-Factor-Deficiencies
• NIH Genetic and Rare Diseases Information Center - rarediseases.info.nih.gov/diseases/2926/prothrombin-deficiency

Maikaʻi ka hopena me ka lapaʻau kūpono.

ʻO ka hemahema prothrombin hoʻoilina kahi ʻano o ke ola holoʻokoʻa.

ʻO ka nānā no ka loaʻa ʻole o ka prothrombin hemahema ma muli o ke kumu. Inā kumu ʻia e ka maʻi akepau, pili ka hopena i ka maikaʻi e mālama ʻia ai kou maʻi ate. ʻO ka lawe ʻana i nā mea kōkua Kaminamina K e mālama pono ai i ka wikamina K.

Hiki ke hana i ke kahe nui i nā ʻōpū.

E kiʻi koke i ka lāʻau ulia pōpilikia inā ʻaʻole ʻoe i wehewehe a i ʻole ka lilo o ke koko lōʻihi, a i ʻole inā ʻaʻole hiki iā ʻoe ke kaohi i ke kahe ʻana.

ʻAʻohe pale e ʻike ʻia no ka hemahema prothrombin hoʻoilina. Ke loaʻa ʻole ka huaʻai K i ke kumu, hoʻohana i ka wikamina K hiki ke kōkua.

Hypoprothrombinemia; Ka hemahema o ka ʻoihana II; Dysprothrombinemia

• Hoʻomaʻamaʻa koko
• Huʻi koko

ʻO Gailani D, Wheeler AP, Neff AT. Nā hemahema coagulation ololi. I: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Nā Kumumanaʻo a me ka Hoʻomeheu. ʻEpekema 7 Piladelapia, PA: Elsevier; 2018: chap 137.

Halelu JE. Hemostasis a me ka coagulation koko. I: Hall JE, hoʻoponopono. ʻO Guyton a me Hall Textbook of Medical Physiology. 13th ed. Piladelapia, PA: Elsevier Saunders; 2016: chap 37.

ʻO Ragni MV. Nā maʻi hemorrhagic: deficiencies factor coagulation. I: Goldman L, Schafer AI, eds. ʻO ka lāʻau lapaʻau Goldman-Cecil. 25th hua. Piladelapia, PA: Elsevier Saunders; 2016: chap 174.