ʻO ka hyperlipidemia hui pū ʻia

ʻO ka hyperlipidemia hui pū ʻia ʻo familial kahi maʻi i hoʻoili ʻia i waena o nā ʻohana. Hoʻonui ia i ke kiʻekiʻe o ke kolesterol a me nā triglycerides koko kiʻekiʻe.

ʻO ka hyperlipidemia hui pū ʻia ʻo familial ka maʻi maʻamau maʻamau e hoʻonui ai i nā momona o ke koko. Hiki iā ia ke kumu i nā hōʻeha puʻuwai mua.

ʻO ka maʻi diabetes, ka wai ʻona, a me ka hypothyroidism e hoʻonui ai i ke ʻano. ʻO nā kumu pilikia e pili ana i ka moʻolelo ʻohana o ka cholesterol kiʻekiʻe a me nā maʻi o ke aʻa koko.

I nā makahiki mua, ʻaʻohe paha ʻōuli.

Ke ʻike ʻia nā ʻōuli, pili pū paha lākou:

• ʻO ka ʻeha o ka umauma (angina) a i ʻole nā ​​hōʻailona ʻē aʻe o ka maʻi coronary artery hiki ke loaʻa i ka wā ʻōpio.
• ʻO ka cramping o hoʻokahi a i ʻole ʻelua mau keiki bipi ke hele wāwae.
• Nā ʻeha ma nā manamana wāwae e hoʻōla ʻole ai.
• ʻO nā ʻōuli e like me ka hahau ʻana, e like me ka ʻōlelo ʻana i ka pilikia, hāʻule ʻana ma kekahi ʻaoʻao o ka maka, nāwaliwali o ka lima a me ka wāwae, a me ka nalo ʻana o ke kaulike.

Hiki i nā poʻe me kēia ʻano ke hoʻomohala i nā kiʻekiʻe kolesterol a i ʻole nā ​​pae triglyceride kiʻekiʻe ma ke ʻano he ʻōpio. Kuhi ʻia nō hoʻi ke ʻano ke 20 a 30 mau makahiki ka poʻe. Mau ke kiʻekiʻe o nā pae i ke ola holoʻokoʻa. ʻO ka poʻe me ka hyperlipidemia hui pū ʻia ka ʻohana i hoʻonui i ka makaʻu o ka maʻi coronary artery a me nā hōʻeha puʻuwai. Loaʻa iā lākou nā helu kiʻekiʻe o ka momona a ʻoi aku ka nui o ka hoʻomanawanui ʻole o ka glucose.

E hana ʻia nā hoʻokolohua koko e nānā i kāu pae o ka kolesterol a me nā triglycerides. E hōʻike ʻia nā hoʻokolohua:

• Hoʻonui ʻia ka LDL kolesterol
• Hoemi i ka HDL kolesterol
• Hoʻonui i nā triglycerides
• Hoʻonui i ka apolipoprotein B100

Loaʻa ka hoʻāʻo genetic no kekahi ʻano o ka hyperlipidemia hui pū ʻia o ka ʻohana.

ʻO ka pahuhopu o ka mālama ʻana e hōʻemi i ka makaʻu o ka maʻi puʻuwai atherosclerotic.

NA OLELO OLA

ʻO ka hana mua e hoʻololi i ka mea āu e ʻai ai. ʻO ka hapanui o ka manawa, e hoʻāʻo ʻoe i nā loliʻai no kekahi mau mahina ma mua o ka paipai ʻana o kāu kauka i nā lāʻau. Hoʻololi nā meaʻai i ka hoʻoliʻiliʻi i ka nui o ka momona momona a me ke kō i hoʻomaʻemaʻe ʻia.

Eia kekahi mau hoʻololi i hiki iā ʻoe ke hana:

• ʻAi liʻiliʻi ka pipi, ka moa, ka puaʻa, a me ka hipa
• Hoʻohuli i nā huahana waiū momona momona momona no nā mea momona piha
• Hōʻalo i nā kuki pūʻolo a me nā mea i hoʻomoʻa ʻia i piha nā momona trans
• E hoʻēmi i ka cholesterol āu e ʻai ai ma ka kaohi ʻana i nā yolks a me nā ʻiʻo aʻa

Paipai pinepine ʻia ka ʻōlelo aʻoaʻo e kōkua i ka poʻe e hoʻololi i kā lākou ʻano ʻai. Hiki ke kōkua i ka hōʻemi ʻana a me ka hoʻoikaika mau i ka hoʻohaʻahaʻa ʻana i kāu pae kolesterol.

NA LAAU LAPAAU

Inā hoʻololi ʻole ka nohona i kāu mau pae kolesterol a i ʻole he makaʻu nui loa ʻoe no ka maʻi puʻuwai atherosclerotic, e ʻōlelo paha kāu mea mālama ola e lawe ʻoe i nā lāʻau. Nui a hewahewa nā ʻano lāʻau e kōkua e hoʻohaʻahaʻa i ke kiʻekiʻe o ke kō kolesterol.

Hana nā lāʻau i nā ʻano like ʻole e kōkua iā ʻoe e hoʻokō i nā pae lipid olakino. ʻOi aku ka maikaʻi o kekahi i ka hoʻohaʻahaʻa ʻana i ka LDL cholesterol, maikaʻi kekahi i ka hoʻohaʻahaʻa ʻana i nā triglycerides, ʻoiai kōkua kekahi e hoʻonui i ka HDL kolesterol.

ʻO nā lāʻau i hoʻohana pinepine ʻia, a me nā lāʻau lapaʻau maikaʻi loa no ka mālama ʻana i ka LDL kolesterol kiʻekiʻe ua kapa ʻia he statins. Hoʻopili lākou i ka lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), fluvastatin (Lescol), atorvastatin (Lipitor), rosuvastatin (Crestor), a me pitivastatin (Livalo).

ʻO nā lāʻau e hoʻohaʻahaʻa ana i ka kolesterol me:

• ʻO nā resins acid-sequestering bile.
• ʻO Ezetimibe.
• Fibrates (e like me gemfibrozil a me fenofibrate).
• ʻAkika nikotinikika.
• Nā mea kāohi iā PCSK9, e like me alirocumab (Praluent) a me evolocumab (Repatha) Hōʻike kēia mau mea i kahi papa lāʻau hou e mālama ai i ke kiʻekiʻe o ke kolesterol.

Maikaʻi kāu hilinaʻi ʻana:

• Pehea ka wanaʻao e ʻike ʻia ai ke ʻano
• Ke hoʻomaka ʻoe i ka lāʻau
• Pehea kou maikaʻi e ukali ai i kāu hoʻolālā hoʻomaʻamaʻa

Me ka ʻole o ka lapaʻau ʻana, hōʻeha ka puʻuwai a i ʻole hahau paha i kumu e make koke ai.

ʻOiai me ka lāʻau, hiki i kekahi poʻe ke hoʻomau i ka loaʻa o nā kiʻekiʻe lipid kiʻekiʻe e hoʻonui ai i ko lākou pilikia no ka hōʻeha puʻuwai.

Komo pū nā pilikia:

• ʻO ka maʻi puʻuwai atherosclerotic mua
• Maʻi hohola
• Hahau

E ʻimi koke i ka lāʻau lapaʻau inā loaʻa iā ʻoe ka ʻeha o ka umauma a i ʻole nā ​​hōʻailona ʻē aʻe o ka hōʻeha puʻuwai.

Kāhea i kāu mea hāʻawi inā loaʻa iā ʻoe kahi moʻolelo pilikino a ʻohana paha o nā kiʻekiʻe kolesterol.

ʻO ka papaʻai haʻahaʻa i ka kolesterol a me ka momona momona e kōkua i ka mālama ʻana i nā pae o ka LDL i ka poʻe pilikia nui.

Inā loaʻa kēia ʻano i kekahi o kou ʻohana, makemake paha ʻoe e noʻonoʻo i ka kānana genetika ʻana iā ʻoe iho a i kāu mau keiki paha. I kekahi manawa, loaʻa i nā keiki ʻōpio ka hyperlipidemia akahai.

He mea nui ka mālama ʻana i nā kumu pilikia ʻē aʻe no ka hōʻeha puʻuwai mua ʻana, e like me ka puhipaka.

Hyperlipidemia-ʻano lipoprotein-type

• Ka paʻa artery coronary
• Papaʻai olakino

ʻO Genest J, Libby P. Nā maʻi lipoprotein a me nā maʻi maʻi ʻōpū. I: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. ʻO ka maʻi puʻuwai ʻo Braunwald: He puke aʻo no ka lāʻau Cardiovascular. 11th hua. Piladelapia, PA: Elsevier; 2019: chap 48.

Robinson JG. Nā maʻi o ka lipid metabolism. I: Goldman L, Schafer AI, eds. ʻO ka lāʻau lapaʻau Goldman-Cecil. 26th ed. Piladelapia, PA: Elsevier; 2020: chap 195.