ʻO Abemaciclib

Anter

• Ma mua o ka lawe ʻana i abemaciclib,
• Hiki i ka Abemaciclib ke kumu i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli a i ʻole i kekahi ma ka ʻĀINA HUAKAI SPECIAL, e kāhea koke i kāu kauka:

[Kau ʻia 09/13/2019]

NUI: ʻO ka mea maʻi, ʻoihana olakino, Oncology

ʻĀINA: Ke ao aku nei ʻo FDA i ka palbociclib (Ibrance^®), ribociclib (Kisqali^®), a me abemaciclib (Verzenio^®) hoʻohana ʻia e mālama i kekahi mau mea maʻi me nā maʻi maʻi umauma holomua hiki ke kumu i ka mumū akā ka nui o ka mumū. Ua ʻae ʻo FDA i nā ʻōlelo aʻoaʻo hou e pili ana i kēia pilikia i ka ʻikepili i kākau ʻia a me ka Hoʻomoʻi ʻAoʻao Hoʻomanawanui no ka papa holoʻokoʻa o kēia mau kinakina e pili ana i ka cyclin 4/6 (CDK 4/6) i nā lāʻau lapaʻau. ʻO ka pōmaikaʻi holoʻokoʻa o nā mea kāohi CDK 4/6 ʻoi aku ka nui ma mua o nā pilikia ke hoʻohana ʻia e like me ka mea i kauoha ʻia.

NĀ PONO: ʻO CDK 4/6 mea pāpā he papa ia o nā lāʻau lapaʻau i hoʻohana ʻia e hui pū ʻia me nā therapies hormone e mālama ai i nā mākua me ka receptor hormone (HR) -positive, mea ulu ulu kanaka epidermal 2 (HER2) - neʻe mua a metastatic umauma Ka maʻi ʻaʻai i pāhola ʻia i nā ʻāpana ʻē aʻe o ke kino. Pale nā ​​CDK 4/6 mea kāpae i kekahi mau molekiola i pili i ka hoʻolaha ʻana i ka ulu ʻana o nā hunaola maʻi ʻaʻai. Ua ʻae ʻo FDA i ka palbociclib i ka makahiki 2015, a me nā ribociclib a me nā abemaciclib ma ka makahiki 2017. Ua hōʻike ʻia nā mea pāpālina CDK 4/6 e hoʻomaikaʻi i ka nui o ka manawa ma hope o ka hoʻomaka ʻana o ka lapaʻau ʻana ʻaʻole ulu nui ka maʻi ʻaʻai a ola ka mea maʻi, i kapa ʻia he ola ʻole ʻole holomua. (E nānā i ka papa inoa o ka mea i ʻāpono ʻia e ka CDK 4/6 Inhibitors o FDA ma lalo).

OLELO HOOLAHA:Nā mea maʻi pono e hoʻomaopopo koke i kāu ʻoihana mālama ola inā loaʻa iā ʻoe nā hōʻailona hou a ʻoi aku paha e pili ana i kāu mau māmā, no ka mea e hōʻike paha lākou i kahi ʻano laha akā hoʻoweliweli ola e hiki ai i ka make. Nā ʻōuli e kiaʻi no ka:

• Ka paʻakikī a hōʻoluʻolu ʻole paha me ka hanu ʻana
• Ka hanu ʻana o ka hanu i ka wā hoʻomaha a me ka hana haʻahaʻa

Mai hōʻoki i ka lawe ʻana i kāu lāʻau me ke kamaʻilio mua ʻole ʻana i kāu kauka mālama ola. Loaʻa nā hopena ʻaoʻao āpau i nā lāʻau āpau ke hoʻohana pololei ʻia e like me ka mea i kau ʻia, akā ma ka laulā ʻo nā pōmaikaʻi o ka lawe ʻana i kēia mau lāʻau i ʻoi aku i kēia mau pilikia.He mea nui e ʻike i ka pane ʻokoʻa a ka poʻe i nā lāʻau āpau e pili ana i ko lākou olakino, nā maʻi i loaʻa iā lākou, nā kumu genetic, nā lāʻau ʻē aʻe a lākou e lawe nei, a me nā kumu ʻē aʻe he nui. ʻO nā kumuhana kūpilikiʻi e hoʻoholo ai pehea paha e ʻike ai kekahi kanaka i ka mumū nui i ka lawe ʻole ʻana i ka palbociclib, ribociclib, a i ʻole abemaciclib paha.

ʻOihana ʻoihana mālama ola pono e nānā pinepine i nā mea maʻi no nā hōʻailona pulmonary e hōʻike ana i ka maʻi lele interstitial (ILD) a me / a i ʻole pneumonitis. Pākuʻi ʻia paha nā ʻōuli a me nā ʻōuli:

• hypoxia
• ʻūhā
• dyspnea
• infiltrates interstitial ma nā hōʻike radiologic i nā mea maʻi i loko o lākou i kāpae ʻia nā maʻi lele, neoplastic, a me nā kumu ʻē aʻe.

Hoʻokiʻoki i ka lāʻau hoʻomake CDK 4/6 i nā mea maʻi i loaʻa i nā ʻōuli hanu hou a maikaʻi ʻole paha, a hoʻopau mau i ka mālama ʻana i nā mea maʻi me ka ILD koʻikoʻi a me / a i ʻole ka pneumonitis.

No ka ʻike hou aku e kipa aku i ka pūnaewele FDA ma: http://www.fda.gov/Safety/MedWatch/SafetyInformation a me http://www.fda.gov/Drugs/DrugSafety.

Hoʻohana ʻia ʻo Abemaciclib me ka fulvestrant (Faslodex) e mālama ai i kekahi ʻano o ka hormone receptor-positive, cancer cancer mua (ka maʻi ʻaʻai umauma e pili ana i nā hormones e like me ka estrogen e ulu ai) a i ʻole ka maʻi ʻaʻai umauma i pāhola ʻia i nā ʻāpana ʻē aʻe o ke kino ma hope o ka lapaʻau me kahi lāʻau antiestrogen e like me tamoxifen (Nolvadex). Hoʻohana pū ʻia ʻo Abemaciclib me ka anastrozole (Arimidex), exemestane (Aromasin), a i ʻole letrozole (Femara) ma ke ʻano he lapaʻau mua o ka receptor-positive, cancer cancer a i ʻole ka maʻi ʻaʻai umauma i pāhola ʻia i nā ʻāpana ʻē aʻe o ke kino. Hoʻohana wale ʻia ʻo Abemaciclib e mālama i kekahi ʻano o ka receptor-positive, ka maʻi ʻaʻai umauma holomua a i ʻole ka maʻi ʻaʻai umauma i pāhola ʻia i nā ʻāpana ʻē aʻe o ke kino i ka poʻe i mālama mua ʻia me ka lāʻau antiestrogen a me ka chemotherapy. Aia ʻo Abemaciclib i kahi papa o nā lāʻau i kapa ʻia ʻo nā kinase inhibitors. Hana ia ma ke kāpae ʻana i ka hana o kahi protein pono ʻole e hōʻailona ai i nā hunaola maʻi ʻaʻai e hoʻonui. Kōkua kēia i ka hoʻolohi a hoʻopau paha i ka hoʻolaha ʻana o nā hunaola maʻi ʻaʻai.

Hele mai ʻo Abemaciclib ma ke ʻano he papa e lawe ma ka waha. Lawe pinepine ʻia ia i ʻelua mau lā me ka ʻai ʻole. E lawe i ka abemaciclib ma nā manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe i ka abemaciclib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā papa holoʻokoʻa; mai hoʻokaʻawale, a nau aku, a hoka ʻole iā lākou. Mai lawe i nā papa i haki, ʻāhaʻi, a i ʻole hōʻino ʻia i kekahi ʻano.

Inā ʻoe e luaʻi ma hope o ka lawe ʻana i ka abemaciclib, mai lawe i kahi lāʻau ʻē aʻe. E hoʻomau i kāu papa hana maʻamau.

Hiki i kāu kauka ke hōʻemi i kāu lāʻau a i ʻole manawa kūmau a paʻa mau paha i kāu lāʻau inā ʻike ʻoe i kekahi mau hopena ʻaoʻao. Aia kēia i ka maikaʻi o ka hana ʻana o ka lāʻau iā ʻoe a me nā hopena ʻē aʻe āu e ʻike ai. E haʻi pono i kāu kauka i kou ʻano i kou wā e mālama ai me ka abemaciclib.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i abemaciclib,

• e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka abemaciclib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā papa abemaciclib. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E haʻi pono i kekahi o kēia mau mea: clarithromycin (Biaxin, ma Prevpac), diltiazem (Cardizem, Tiazac, a me nā mea ʻē aʻe), itraconazole (Sporanox), ketoconazole (Nizoral), rifampin (Rifadin, Rimactane, ma Rifater), a me verapamil (Calan , Verelan, haʻi ʻē aʻe). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Nui paha nā lāʻau ʻē aʻe e launa pū paha me ka abemaciclib, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• e haʻi i kāu kauka inā he kuni ʻoe, haʻalulu, a i ʻole nā ​​hōʻailona ʻē aʻe o kahi maʻi a inā i loaʻa a loaʻa paha iā ʻoe ka maʻi ate a me nā puʻupaʻa.
• e haʻi i kāu kauka inā hāpai ʻoe a i ʻole hoʻolālā e hāpai. Pono ʻoe e lawe i kahi hōʻike hāpai ma mua o kou hoʻomaka ʻana i ka lāʻau lapaʻau a pono e hoʻohana i ka kaohi hānau e pale ai i ka hāpai ʻana i kāu wā lapaʻau a no 3 mau pule ma hope o kāu hopena hope loa. Inā hāpai ʻoe i ka lawe ʻana i ka abemaciclib, e kāhea koke i kāu kauka. Hoʻopilikia paha ʻo Abemaciclib i ka fetus.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū a i ʻole hoʻolālā e hānai. ʻAʻole pono ʻoe e hānai i ka wā e lawe ana i ka abemaciclib a no 3 mau pule ma hope o kāu hopena hope loa.
• pono ʻoe e ʻike i kēia lāʻau i hoʻemi ai i ka momona i nā kāne. E kamaʻilio me kāu kauka e pili ana i ka makaʻu o ka lawe abemaciclib.
• pono ʻoe e ʻike ʻo ka abemaciclib ke kumu pinepine i ka maʻi diarrhea, a hiki ke koʻikoʻi. E haʻi paha kāu kauka iā ʻoe e inu i nā wai a inu i nā lāʻau anti-diarrhea i mea e pale aku ai i ka make wai (ka nui o ka wai mai kou kino) ke ʻike mua ʻoe i ka palahī a i ʻole nā ​​pahu hemo. Kāhea koke i kāu kauka inā ʻike ʻoe i kekahi o nā ʻōuli ma hope o ka make wai: make wai loa, waha maloʻo a ʻili paha, hoʻoliʻiliʻi ka urination, a me ka puʻuwai wikiwiki.

Mai ʻai i ka hua waina a i ʻole inu i ka wai huaʻulu i ka wā e lawe ana i kēia lāʻau.

E haʻalele i ka lāʻau i haʻalele ʻia a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hiki i ka Abemaciclib ke kumu i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• nausea
• ka luaʻi
• ʻeha ka ʻōpū
• kōpaʻa
• ʻeha ma nā lehelehe, waha, a ʻāʻī paha
• hoʻēmi ʻai
• Kaumaha emi
• poho lauoho
• ʻūlili
• hūwī
• ʻeha poʻo
• hoʻololi i ka ʻono
• ʻūpā
• ʻeha pū

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli a i ʻole i kekahi ma ka ʻĀINA HUAKAI SPECIAL, e kāhea koke i kāu kauka:

• luhi
• ʻeha ma ka ʻaoʻao ʻākau o luna o ka ʻōpū
• melemele o ka ʻili a me nā maka
• nalo ʻai ʻole
• kahe kahe ʻana a palapū wale paha
• ʻeha ma nā lima a me nā wāwae
• pehu o nā lima, nā wāwae, nā wāwae a me nā kuʻekuʻe wāwae
• pokole o ka hanu
• ʻeha ka umauma
• hanu wikiwiki
• wikiwiki, kūlike ʻole, a kuʻi paha i ka puʻuwai puʻuwai
• ke kuni, ke anu, ka ʻū a i ʻole nā ​​hōʻailona ʻē aʻe o ka maʻi
• ʻili mae

Hoʻokumu paha ʻo Abemaciclib i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha paha kāu kauka i kekahi mau hoʻokolohua lab a ma mua a i kou wā e mālama ai e nānā i ka pane o kou kino i ka abemaciclib.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Verzenio^®