ʻAcromegaly

ʻO Acromegaly kahi kūlana i nui ka nui o ka hormone ulu (GH) i ke kino.

ʻO Acromegaly kahi ʻano laha ʻole. Hoʻokumu ʻia ia ke hana ka pituitary gland i ka nui o ka ulu o ka hormone. ʻO ka pituitary gland he wahi endocrine liʻiliʻi i pili i ka lalo o ka lolo. Mālama ia, hana, a hoʻokuʻu i kekahi mau homona, e like me ka ulu ʻana o ka hormone.

ʻO ka maʻa mau kahi tumo noncancerous (benign) o ka pituitary gland e hoʻokuʻu i ka nui o ka ulu ulu. I nā hihia kakaikahi, hiki ke hoʻoilina ʻia nā pituitary tumors.

I nā keiki, ʻo ka nui o GH ke kumu o gigantism ma mua o ka acromegaly.

Hiki i nā ʻōuli o ka acromegaly ke hoʻopili i kekahi o kēia mau mea:

• Pilau kino
• Koko i loko o ka pahu
• Carpal tunnel maʻi maʻi
• Hoʻoemi i ka ikaika o ka mākala (nāwaliwali)
• Hoemi i ka hihio ākea
• Ka luhi maʻalahi
• Ke kiʻekiʻena kiʻekiʻe (ke hoʻomaka ka hana GH nui i ka wā kamaliʻi)
• Nui ka hou ʻana i ka hou
• ʻEha poʻo
• Hoʻonui i ka puʻuwai, kahi e hiki ai ke maʻule
• Hoarseness
• ʻEha ʻeha
• ʻEha hui, kaupalena neʻe hui ʻana, pehu o nā iwi iwi a puni o kahi ami
• ʻO nā iwi nui o ka maka, ka iwi ā nui, a me ke elelo, nā niho ākea
• Nā wāwae nui (hoʻololi i ka nui o nā kāmaʻa), nā lima nui (hoʻololi i ke apo a i ka nui o ka lima)
• Nunui i loko o ka ʻili (sebaceous glands) e hana ana i ka ʻili aila, ka mānoanoa o ka ʻili, nā ʻili ʻili (ulu)
• ʻAlena moe
• ʻO nā manamana lima a me nā manamana wāwae paha, me ka pehu ʻana, ʻulaʻula, a me ka ʻeha

Nā ʻōuli ʻē aʻe i hiki ke loaʻa me kēia maʻi.

• Nā polyps kolonā
• ʻO ka ulu nui ʻana o ka lauoho i nā wahine (hirsutism)
• Piʻi koko kiʻekiʻe
• ʻAno 2 diabetes
• Hoʻonui ākea thyroid
• Kaumaha hoʻonui

E hana ka mea mālama ola i kahi hoʻokolohua kino a nīnau e pili ana i kāu mau hōʻailona.

E kauoha ʻia nā hoʻokolohua aʻe e hōʻoia i ka hōʻoia ʻana o ka acromegaly a nānā i nā pilikia.

• Glucose koko
• ʻO ka hoʻoneoneo ulu ulu a hoʻāʻo hoʻi e kāohi i ka hoʻāʻo
• ʻO ka ulu ulu ulu ʻana ʻo Insulin 1 (IGF-1)
• ʻO Prolactin
• Spine x-ray
• MRI o ka lolo, me ka pituitary gland
• ʻEchocardiogram
• Kolonekia
• Haʻawina hiamoe

E kauoha ʻia paha nā hōʻike ʻē aʻe e nānā inā e hana maʻamau ke koena o ka pituitary gland.

ʻO ke ʻoki e wehe i ka tumo pituitary ke kumu o kēia ʻano e hoʻoponopono pinepine i ka GH maʻamau. I kekahi manawa, nui loa ka tumo e hoʻoneʻe loa ʻia a hoʻōla ʻole ʻia ʻo acromegaly. I kēia hihia, hiki ke hoʻohana i nā lāʻau a me ka radiation (radiotherapy) e mālama ai i ka acromegaly.

ʻO kekahi poʻe me nā tumors paʻakikī loa e hemo e ka ʻokiʻoki mālama ʻia me nā lāʻau ma kahi o ke ʻoki. Hiki paha i kēia mau lāʻau ke pale i ka hana o GH mai ka pituitary gland a pale paha i ka hana a GH i nā ʻāpana ʻē aʻe o ke kino.

Ma hope o ka hoʻomaʻamaʻa, pono ʻoe e ʻike pinepine i kāu mea e hoʻolako pono e hōʻoia i ka hana maʻamau o ka pituitary gland a hoʻi ʻole ka acromegaly. Paipai ʻia nā loiloi makahiki.

Hāʻawi paha kēia mau kumuwaiwai i ka ʻike hou aʻe e pili ana i ka acromegaly:

• National Institute of Diabetes and Digestive and Kidney Diseases - www.niddk.nih.gov/health-information/endocrine-diseases/acromegaly
• National Organization for Rare Disorder - rarediseases.org/rare-diseases/acromegaly

Kūleʻa ke kahakaha pituitary i ka hapanui o ka poʻe, kaukaʻi ʻia i ka nui o ka tumo a me ka ʻike o ka neurosurgeon me nā pituitary tumors

Me ka mālama ʻole ʻia, e māhuahua loa nā ʻōuli. ʻO nā kūlana e like me ke kiʻekiʻe o ke koko, diabetes, a me nā maʻi puʻuwai e hopena paha.

Kāhea i kāu mea hāʻawi inā:

• Loaʻa iā ʻoe nā ʻōuli o ka acromegaly
• ʻAʻole hoʻomaikaʻi kāu mau ʻōuli me ka lāʻau

ʻAʻole hiki ke pale ʻia ʻo Acromegaly. Hiki i ka mālama mua ʻana ke pale i ka maʻi mai ka ʻino a kōkua i ka pale ʻana i nā pilikia.

Somatotroph adenoma; ʻOi aku ka nui o ka hormone ulu; ʻO ka hormone ulu e hūnā ana i ka adituoma pituitary; Pilikua Pituitary (i ka wā kamaliʻi)

• Nānā Endocrine

Katznelson L, Laws ER Jr, Melmed S, et al. Acromegaly: kahi papa hana hoʻomaʻamaʻa hana kaiaulu endocrine. ʻO J Clin Endocrinol Metab. 2014; 99 (11): 3933-3951. PMID: 25356808 www.ncbi.nlm.nih.gov/pubmed/25356808.

Klein I. Nā maʻi Endocrine a me nā maʻi maʻi ʻōpū. I: Mann DL, Zipe DP, Libby P, Bonow RO, Braunwald E, nā hua. ʻO ka maʻi puʻuwai ʻo Braunwald: kahi puke o ka lāʻau Cardiovascular. 10 o ka lā. Piladelapia, PA: Elsevier Saunders; 2015: chap 81.

Melmed S. Acromegaly. I: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Makua a Pediatric. ʻEpekema 7 Piladelapia, PA: Elsevier Saunders; 2016: chap 12.