He aha ka mea e ʻokoʻa ai ka Mantle Cell Lymphoma mai nā Lymphomas ʻē aʻe?

Anter

• ʻO MCL kahi lymphoma B-cell non-Hodgkin
• Hoʻololi ka MCL i nā kāne makua
• He kākaʻikahi loa ʻo MCL
• Hoʻolahalaha ia mai ka ʻāpana mantle
• Pili ia me nā loli kūpili kikoʻī
• He kūpikipiki a paʻakikī hoʻi e hoʻōla
• Hiki ke mālama ʻia me nā therapies pahuhopu
• ʻO ka lawe lawe ʻana

ʻO Lymphoma kahi maʻi maʻi koko e hoʻomohala i nā lymphocytes, kahi ʻano o ke keʻokeʻo keʻokeʻo. He mea nui ka Lymphocytes i kāu ʻōnaehana pale. Ke lilo lākou i maʻi maʻi maʻi, hoʻonui lākou i ka kaohi ʻole a ulu aʻe i mau tumors.

Nui a hewahewa nā ʻano lymphoma. ʻOkoʻa nā koho lapaʻau a me ka nānā mai kekahi ʻano a i kekahi. E hoʻolōʻihi i kahi manawa e aʻo ai pehea ka hoʻohālikelike ʻana o ka mantle cell lymphoma (MCL) i kekahi ʻano o kēia maʻi.

ʻO MCL kahi lymphoma B-cell non-Hodgkin

Aia ʻelua ʻano nui o ka lymphoma: ʻo Hodgkin's lymphoma a me non-Hodgkin's lymphoma. Aia ma mua o 60 mau subtypes o ka lymphoma non-Hodgkin. ʻO MCL kekahi o lākou.

ʻElua ʻano nui o nā lymphocytes: T lymphocytes (T cells) a me B lymphocytes (B cells). Hoʻopili ka MCL i nā hunaola B.

Hoʻololi ka MCL i nā kāne makua

Wahi a ka American Cancer Society, ʻo Hodgkin's lymphoma pinepine ka hopena i ka poʻe ʻōpio, ʻo ka poʻe hoʻi i ka 20. I ka hoʻohālikelike ʻana, MCL a me nā ʻano like ʻole o ka lymphoma non-Hodgkin ʻoi aku ka maʻamau i nā mākua makua. Hōʻike ka Lymphoma Research Foundation i ka hapa nui o ka poʻe me MCL he mau kāne ma mua o 60 mau makahiki.

Ma ke ʻano holoʻokoʻa, ʻo ka lymphoma kekahi o nā ʻano maʻamau o ka maʻi ʻaʻai e hoʻopili ai i nā keiki a me nā ʻōpio. Akā ʻokoʻa ka ʻano o ka lymphoma, kākaʻikahi loa ʻo MCL i ka poʻe ʻōpio.

He kākaʻikahi loa ʻo MCL

ʻOi aku ka liʻiliʻi o MCL ma mua o kekahi ʻano o ka lymphoma. ʻO ia ka helu no ka 5 pakeneka o nā hihia lymphoma āpau, e like me ka American Cancer Society. ʻO kēia ke kumu o MCL ma kahi o 1 ma 20 lymphomas.

Hoʻohālikelike, ʻo ka ʻano maʻamau o ka lymphoma non-Hodgkin e hoʻolaha ʻia ka lymphoma B-cell nui, kahi e helu ai ma kahi o 1 i 3 lymphomas.

Ma muli o ka mea liʻiliʻi loa, nui ʻole paha ka nui o nā kauka i ka noiʻi hou loa a me ka hoʻokau ʻana no MCL. Ke hiki, ʻoi aku ka maikaʻi e kipa aku i kahi oncologist i loea i ka lymphoma a i ʻole MCL.

Hoʻolahalaha ia mai ka ʻāpana mantle

Loaʻa ka inoa o MCL mai ka ʻoiaʻiʻo o ke ʻano i loko o ka ʻahu mantle o kahi pona lymph. ʻO ke kapa komo ʻo ke apo o nā lymphocytes e hoʻopuni ana i ke kikowaena o kahi pona lymph.

I ka manawa e hōʻoia ʻia ai, ua pālahalaha pinepine ʻo MCL i nā pūnana lymph ʻē aʻe, a me nā mea ʻē aʻe a me nā meaola. ʻO kahi laʻana, e pālahalaha paha ia i kou iwi iwi, ʻeleʻele, a me kou ʻōpū. I nā hihia maʻamau, hoʻopili paha ia i kou lolo a me nā kaula o ka iwi.

Pili ia me nā loli kūpili kikoʻī

ʻO nā pona lymph pehu ka hōʻailona maʻa mau o MCL a me nā ʻano limu ʻē aʻe. Inā kuhi kāu kauka he lymphoma kou, e lawe lākou i kahi mea kiko mai kahi pona lymph pehu a i ʻole nā ​​ʻāpana o kou kino e nānā ai.

Ma lalo o kahi microscope, nānā like nā pūnaewele MCL i kekahi ʻano o ka lymphoma. Akā i ka hapanui o nā hihia, loaʻa i nā hunaola nā hōʻailona genetic i hiki ke kōkua i kāu kauka e aʻo i ke ʻano o ka lymphoma. I mea e hana ai i kahi kuhi, e kauoha ana kāu kauka i nā hoʻokolohua e nānā ai no nā māka genetical kikoʻī a me nā protein.

Kauoha paha kāu kauka i nā hoʻokolohua ʻē aʻe, e like me ka CT scan, e aʻo ai inā ua laha ka maʻi ʻaʻai. Hiki iā lākou ke kauoha i kahi biopsy o kou iwi iwi, ʻōpū, a i ʻole nāʻaʻaʻa ʻē aʻe.

He kūpikipiki a paʻakikī hoʻi e hoʻōla

ʻO kekahi ʻano o ka lymphoma non-Hodgkin haʻahaʻa a palaka hoʻi. ʻO ia ka manaʻo e ulu lohi lākou, akā i ka hapanui o nā hihia ʻaʻole hiki ke hoʻōla ʻia. Hiki i ka mālama ʻana ke kōkua i ka hōʻemi ʻana i ka maʻi ʻaʻai, akā hoʻi ka hoʻi pinepine ʻana o ka lymphoma pae haʻahaʻa, a hoʻi mai paha.

ʻO nā ʻano ʻē aʻe o ka lymphoma non-Hodgkin he pae kiʻekiʻe a kūpikipiki paha. Kūleʻa lākou e ulu wikiwiki, akā hiki ke mālama pinepine ʻia. Ke kūleʻa ka lāʻau lapaʻau mua, ʻaʻole e hoʻi pinepine ka lymphoma kiʻekiʻe.

He mea ʻokoʻa ʻo MCL i ka hōʻike ʻana i nā hiʻohiʻona o nā lymphomas kiʻekiʻe a me nā haʻahaʻa haʻahaʻa. E like me nā lymphomas kiʻekiʻe ʻē aʻe, ulu koke ia. Akā e like me nā lymphomas haʻahaʻa, he mea maʻamau ʻole. ʻO ka hapa nui o ka poʻe me MCL e hele i ke kala ma hope o kā lākou lapaʻau mua ʻana, akā aneane pau ka maʻi ʻaʻai i loko o kekahi mau makahiki.

Hiki ke mālama ʻia me nā therapies pahuhopu

E like me nā ʻano limu ʻē aʻe, hiki ke mālama ʻia ʻo MCL me hoʻokahi a ʻoi paha o kēia mau ʻano:

• kali kakali ana
• lāʻau chemotherapy
• nā kūpuna monoclonal
• hui pū me ka chemotherapy a me ka hoʻomaʻamaʻa antibody i kapa ʻia chemoimmunotherapy
• lāʻau pāhawewe
• transplant cell paʻa

Ua ʻae pū ka Food and Drug Administration (FDA) ʻehā mau lāʻau i kuhikuhi pono iā MCL:

• bortezomib (Velcade)
• lenalidomide (Revlimid)
• ibrutinib (Imbruvica)
• acalabrutinib (Calquence)

Ua ʻae ʻia kēia mau lāʻau āpau no ka hoʻohana i ka wā o ka hoʻi hou ʻana, ma hope o ka hoʻāʻo ʻana o nā lāʻau ʻē aʻe. Ua ʻae ʻia ʻo Bortezomib ma ke ʻano he lālani mua, hiki ke hoʻohana ʻia ma mua o nā hoʻokokoke ʻē aʻe. Ke hoʻomaka nei nā hoʻokolohua hoʻokolohua he nui e hoʻopaʻa i ka hoʻohana o lenalidomide, ibrutinib, a me acalabrutinib e like me nā lapaʻau mua.

E aʻo hou aʻe e pili ana i kāu koho lapaʻau, e kamaʻilio me kāu kauka. ʻO kā lākou papa hana lapaʻau e paulele ʻia i kou makahiki a me ke olakino holoʻokoʻa, a me kahi a pehea e ulu ai ka maʻi ʻaʻai i kou kino.

ʻO ka lawe lawe ʻana

Kākaʻikahi ʻo MCL a paʻakikī hoʻi e mālama. Akā i nā makahiki i hala iho nei, ua hoʻomohala ʻia nā mea hou a ʻae ʻia e māka i kēia ʻano maʻi ʻaʻai. Ua hoʻonui nui kēia mau hoʻoponopono hou i ke ola o ka poʻe i loaʻa iā MCL.

Inā hiki, ʻoi aku ka maikaʻi e kipa aku i kahi loea o ka maʻi ʻaʻai i ʻike i ka mālama ʻana i ka lymphoma, e like me MCL. Hiki i kēia loea ke kōkua iā ʻoe e hoʻomaopopo a kaupaona i kāu koho koho.