ʻO Biologics a me Crohn's Disease Remission: He aha kāu e ʻike ai

Anter

• Pehea e hoʻopili ai nā biologics i ka mumū
• Pehea e haʻi ai inā ʻoe i ke kala ʻana
• Pehea nā biologics e mālama ai iā ʻoe i ke kala ʻana
• He aha nā biosimilars?
• Lapaʻau ʻoiai ke kala
• ʻO ka lawe lawe ʻana

Hōʻike Overview

Ma 1932, ua hōʻike aku ʻo Kauka Burrill Crohn a me ʻelua mau hoa i kahi pepa i ka ʻAmelika Hui Pū ʻIa e wehewehe ana i nā kikoʻī o ka mea a mākou e kapa aku nei ʻo Crohn's disease.

Mai ia manawa, ua ulu aʻe nā koho lapaʻau e hoʻopili i nā biologics, ʻo ia nā lāʻau i hana ʻia mai nā pūnaewele ola e hoʻolālā ʻia e hoʻokau i ka puhū.

ʻO ke kuni ke kumu nui o nā maʻi a me nā pilikia o Crohn. Ke waiho nei ʻoe i ke kala ʻana, mae wale kou huhū. Ke ʻike nei ʻoe i kahi lapalapa ahi a Crohn, hoʻi kou hoʻā.

ʻOiai ʻaʻohe lāʻau lapaʻau no Crohn's, ʻo ka pahuhopu o ka mālama ʻana e hoʻoliʻiliʻi i ka mumū e waiho i ka maʻi i loko o ke kala ʻana, a e waiho ma laila.

Pehea e hoʻopili ai nā biologics i ka mumū

Tumor nekrosis factor, a i ʻole TNF, he protein e hoʻohuli i ka mumū ma ke ʻāpana o ka pane o ka pale pale. Hana nā biologics anti-TNF ma ke kuhikuhi ʻana i kēia protein e hoʻoliʻiliʻi i kāna mau mea hoʻoweliweli.

Inā lawe ʻoe iā Remicade (infliximab), Humira (adalimumab), Cimzia (certolizumab), a i ʻole Simponi (golimumab), ke lawe nei ʻoe i kahi biologic anti-TNF.

Me ka maʻi o Crohn, hoʻouna i kāu ʻōnaehana pale kino i nā hunaola keokeo he nui i ka ʻōpū gastrointestinal (GI), kahi e hoʻoulu ai i ka mumū. ʻO kahi ala ʻē aʻe e hoʻopaʻa ai nā biologics i ka lū ma ke kamaʻilio ʻana i ka pilikia o ke keu o nā hunaola keokeo ma ke kaʻe GI.

ʻO Entyvio (vedolizumab) lāua ʻo Tysabri (natalizumab) e hana i kēia ala. Kū lākou i ke kele i ke koko keʻokeʻo e komo i loko o ka ʻōpū. Mālama kēia hana i ka pale ʻana i nā hunaola keʻokeʻo mai ka ʻōpū, kahi e hoʻonā ai lākou i ka wela. Ma ka ʻae, ʻae kēia i ka wahi e hōʻola.

Hiki i nā biologics ke hoʻokau i nā ala ʻē aʻe i loko o ke kino e alakaʻi ai i ka mumū. ʻO Stelara (ustekinumab) kahi mea kāohi interleukin. Hoʻolālā ia i ʻelua mau protein kikoʻī e manaʻo ʻia e hoʻonā i ka wela. Loaʻa i nā poʻe me Crohn nā pae kiʻekiʻe o kēia mau protein i ko lākou kino.

Ma ka māka ʻana i kēia mau protein, poloka ʻo Stelara i ka mumū ma ke ala GI a hoʻemi i nā hōʻailona o ka maʻi o Crohn.

Pehea e haʻi ai inā ʻoe i ke kala ʻana

He mea maʻamau ka loaʻa ʻana o nā lā maikaʻi a me nā lā maikaʻi ʻole ke loaʻa iā Crohn's, no laila pehea ʻoe e ʻike ai inā e kala ana ʻoe a ʻaʻole he mau lā maikaʻi wale nō?

Aia ʻelua ʻaoʻao i ke kala. ʻO ke kala ʻana i ka lāʻau hōʻailona ʻaʻohe ou mau ʻōuli i ʻike ʻia. ʻO ke kala kala ʻana ʻo ia hoʻi ke hōʻike nei nā hōʻike i ka hoʻōla ʻana o kāu mau leona a loaʻa i kou koko nā pae momona maʻamau.

Hoʻohana kāu kauka i kahi mea i kapa ʻia ʻo ka Crohn's disease activity index (CDAI) e ana i ke kēkelē e hana ai kāu Crohn a i ʻole ke kala. Hoʻomaopopo ka CDAI i kāu mau hōʻailona, ​​e like me ka helu o ka ʻōpū a me pehea ʻoe e manaʻo nei.

Lawe pū ia i nā pilikia o ka maʻi o Crohn a me nā hopena o kāu mau hoʻāʻo.

ʻOiai ke kala nei ʻoe, he mea mau ia no kahi biopsy e hōʻike i nā loli microscopic i kāu kiko e hōʻike ai i ka pehu mua. I kekahi manawa, i ka hihia o ka hoʻolōʻihi lōʻihi ʻana a me ka hohonu, maʻamau nā hopena biopsy, akā ʻaʻole maʻamau kēia ka hihia.

Pehea nā biologics e mālama ai iā ʻoe i ke kala ʻana

Mālama ʻo Biologics iā ʻoe i ke kala ʻia ʻana e ka pale ʻana i ka hopena o ka mumū o kou ʻōnaehana pale. Inā hele ʻoe i kāu lāʻau i ka wā e kala ai, ʻoi aku ka makaʻu no ka hopena ʻana i kahi mea hoʻomaka me ka lapalapa.

I kekahi manawa paʻakikī ka wānana. ʻOi aku ka maʻalahi o kekahi e like me kēia:

• loli dietary
• puhipaka
• loli ka lāʻau
• hoʻoluhi
• haumia ea

Inā ʻoe ma ka lāʻau i ka wā e hōʻike ʻia i nā trigger, e hoʻoneʻe ʻia ka maʻi o Crohn.

He aha nā biosimilars?

ʻO nā biosimilars nā mana o nā biologics me nā ʻano like, palekana, a me ka pono. ʻAʻole lākou he mana generic o nā biologics kumu. Ma kahi o, he kope lākou o nā biologics kumu i hala nā patent.

ʻOi aku ka liʻiliʻi o kā lākou kumukūʻai a maikaʻi hoʻi no ka mālama ʻana i ke kala.

Lapaʻau ʻoiai ke kala

Ke kala hou nei ʻoe, e hoʻowalewale ʻia paha ʻoe e hoʻōki i ka lāʻau. Inā ʻoe e hana, pilikia ʻoe i ka ʻike ʻana i kahi lapalapa hou.

Inā kū ʻoe i ka lawe ʻana i kāu lāʻau, aia paha hiki ʻole ke holo pono i ka manawa hou e loaʻa ai kahi uila. ʻO kēia no ka mea ke hōʻoki ʻoe i ka lawe ʻana i kahi biologic, hiki i kou kino ke ulu i nā mea pale e kūʻē i ka lāʻau, a ʻoi aku ka maikaʻi o ka hopena i ka wā e hiki mai ana.

Hiki iā ia ke alakaʻi i nā hopena maikaʻi ʻole.

Hoʻopau nā biologics i kāu ʻōnaehana pale, kahi e waiho ai iā ʻoe i ka makaʻu no ka maʻi. Ma muli o kēia, aia kekahi mau hanana kahi e aʻoaʻo ai kāu kauka iā ʻoe e lawe i kahi haʻihaʻi lāʻau. Pākuʻi ʻia kēia mau mea:

• ʻoki kino
• ʻōpū
• hāpai keiki

Inā ʻole, ʻo ka hana i koi ʻia e noho mau i ka lāʻau ʻoiai ke kala ʻia ʻoe.

Ua hōʻike ʻia nā noiʻi e pili ana i ka hapalua o ka poʻe i hooki i ka hoʻohana ʻana i ko lākou anti-TNF biologic ʻoiai ke kala ʻana e noho mau nei i ke kala no ʻelua mau makahiki, a ke emi nei kēlā helu me ka manawa.

ʻO ka lawe lawe ʻana

ʻO ka pahuhopu no kāu mālama ʻana ʻo Crohn e kiʻi a hoʻomau i ke kala. Hiki i nā lāʻau i hala ke alakaʻi i nā lapalapa ahi. He mea nui e hana pū me kāu kauka e hoʻokumu i ka hoʻolālā maikaʻi loa no ka noho ʻana i ke kala ʻana. Hoʻopili kēia i ka nānā mau ʻana a me ka mālama ʻana i kāu regimen lāʻau.