He aha nā koho ʻē aʻe i hoʻokomo ʻia i Statins?

Anter

• E pili ana i nā Inhibitors PCSK9
• Nā Hana Hou Mea Hou
• ʻImi Hou
• Kumukūʻai
• ʻO ka wā e hiki mai ana o PCSK9 Inhibitors

Wahi a ka, ma kahi o 610,000 poʻe e make i ka maʻi puʻuwai maʻAmelika Hui Pū ʻIa i kēlā me kēia makahiki. ʻO ka maʻi puʻuwai ke kumu nui o ka make no nā kāne a me nā wahine.

No ka mea he pilikia nui ka kolesterol kiʻekiʻe, aia nā lāʻau hou i nā hana e kōkua i ka kaohi a mālama iā ia. ʻO nā mea kāohi iā PCSK9 ka lālani hou loa o nā lāʻau i ke kaua kūʻē i ka maʻi maʻi maʻi maʻi.

Ke hana nei kēia mau kolamu hoʻohaʻahaʻa kolesterol e hoʻonui i ka hiki i kou ake ke hemo i ka "maikaʻi" LDL cholesterol mai kou koko a pēlā e hōʻemi ai i kāu makaʻi o ka puʻuwai a i ʻole ka hahau.

E hoʻomau i ka heluhelu ʻana e kiʻi i nā mea hou loa ma nā mea kāohi iā PCSK9, a pehea lākou e pōmaikaʻi ai iā ʻoe.

E pili ana i nā Inhibitors PCSK9

Hiki ke hoʻohana ʻia nā mea kāohi PCSK9 me ka ʻole o ka hoʻohui o kahi statin, akā hiki iā lākou ke kōkua i ka hōʻemi ʻana i ka LDL kolokole ma kahi o 75 pakeneka ke hoʻohana ʻia me ka lāʻau statin.

He mea maikaʻi paha kēia no nā mea hiki ʻole ke hoʻomanawanui i nā ʻehaʻeha a me nā hopena ʻē aʻe o nā statins a i ʻole nā ​​mea hiki ʻole ke kiʻi i kā lākou kolesterol ma ka hoʻohana ʻana i nā statins wale nō.

ʻO ka mahele hoʻomaka hoʻomaka ʻia he 75 mg i injected hoʻokahi i kēlā me kēia pule ʻelua. E hoʻonui ʻia paha kēia ana i 150 mg i kēlā me kēia pule ʻelua inā manaʻo kāu kauka ʻaʻole pane maikaʻi kāu pae LDL i ka lāʻau liʻiliʻi.

ʻOiai he mea hou loa nā noiʻi a me nā hopena hoʻokolohua me kēia mau lāʻau hoʻōki, hōʻike hoʻohiki lākou.

Nā Hana Hou Mea Hou

ʻO Praluent (alirocumab) a me Repatha (evolocumab) i ʻae ʻia i hōʻaiho hou ʻia, ʻo nā kolokolo mua e hoʻohaʻahaʻa kolesterol i ka papa hou o nā mea kāohi iā PCSK9. Hoʻolālā ʻia lākou e hoʻohana ʻia me ka statin therapy a me nā loli dietary.

ʻO Praluent a Repatha no nā mākua me ka heterozygous familial hypercholesterolemia (HeFH), kahi ʻano hoʻoilina e hoʻokumu i nā kiʻekiʻe o ka LDL kolesterol i ke koko, a me nā mea me ka maʻi maʻi maʻi maʻi.

ʻO kēia mau lāʻau lapaʻau he antibodies i hoʻokumu i kahi protein i ke kino i kapa ʻia ʻo PCSK9. Ma ka pāpā ʻana i ka hiki i ka PCSK9 ke hana, hiki i kēia mau mea ʻino ke kāpae i ka LDL cholesterol mai ke koko a hoʻemi i ka nui o nā kiʻekiʻe kolamu LDL.

ʻImi Hou

Ua hōʻike ʻia nā hopena maikaʻi a me nā noiʻi no Praluent a me Repatha. I kahi hoʻokolokolo hou ma Repatha, nā mea komo me HeFH a me nā mea ʻē aʻe me nā kumu kiʻekiʻe no ka hōʻeha puʻuwai a i ʻole hahau i hoʻohaʻahaʻa ʻia i kā lākou LDL kolamu ma ka awelika o.

ʻO nā hopena i hōʻike pinepine ʻia o Repatha ʻo:

• maʻi maʻi maʻi luna o luna
• nasopharyngitis
• ʻeha kua
• flu
• a me ka palapū, ʻulaʻula, a i ʻole ʻeha ma ka pūnaewele injection

Nānā ʻia nā hopena pāhoeho, me nā hives a me ka hū.

Ua hōʻike ʻia kekahi mau hoʻokolokolo me ka hoʻohana ʻana iā Praluent i nā hopena maikaʻi. ʻO kēia mau mea i komo, e hoʻohana nei i ka statin therapy a loaʻa iā HeFH a i ʻole hoʻonui i ka makaʻu o ka maʻi ahulau a i ʻole ka puʻuwai puʻuwai, ʻike i kahi hāʻule o ka LDL kolesterol.

mai Praluent hoʻohana like me Repatha, me:

• ʻeha a me ka ʻeha ma ke kahua o ka injection
• nā ʻōuli like flu
• nasopharyngitis
• nā hopena āpau, e like me ka vasculitis hypersensitivity

Kumukūʻai

E like me ka hihia me ka hapanui o nā lāʻau lapaʻau holomua, e hele mai kēia mau lāʻau hoʻōla hou me kahi kumukūʻai nui. ʻOiai ke kumukūʻai no nā mea maʻi e pili ana i kā lākou hoʻolālā ʻinikua, hoʻomaka nā kumukūʻai nui ma $ 14,600 i kēlā me kēia makahiki.

I ka hoʻohālikelike ʻana, kūʻai ʻia nā lāʻau lapaʻau statin inoa $ 500 wale nō i $ 700 i kēlā me kēia makahiki, a hāʻule nui kēlā mau helu inā kūʻai i ka palapala statin generic.

Ke manaʻo nei nā loiloi e hele i mua nā lāʻau i ke kūlana maikaʻi loa i ka manawa hoʻopaʻa a lawe mai i mau piliona kālā i nā kūʻai hou.

ʻO ka wā e hiki mai ana o PCSK9 Inhibitors

Ke hoʻomau nei nā hoʻokolohua e pili ana i ka hopena o kēia mau lāʻau hoʻōla. Hopohopo kekahi mau luna olakino hiki i nā lāʻau hou ke hiki i nā pōʻino neurocognitive, ma muli o kekahi o nā haumāna e hoʻopaʻa haʻawina ana e hōʻike nei i nā pilikia me ka huikau a me ka hiki ʻole ke hoʻolohe.

E hoʻopau ʻia nā hoʻokolohua hoʻokolohua nui ma 2017. A hiki i kēlā manawa koi ikaika ka poʻe loea no ka mea he manawa pōkole nā ​​hoʻokolohua i mālama ʻia a maopopo ʻole inā hiki i nā mea hoʻopale PCSK9 ke hōʻemi maoli i ka makaʻi o ka maʻi puʻuwai a hoʻolōʻihi i nā ola.