Viagra no nā Wahine: Pehea e holo ai, a palekana?

Anter

• Addyi vs. Viagra
• Kumu a me nā pono
• Pehea e hana ai ʻo flibanserin
• Ka hoʻokō ʻana
• I nā wahine postmenopausal
• Nā hopena ʻaoʻao
• Nā ʻōlelo aʻoaʻo a ka FDA: Ma ka maʻi akepaʻa, nā mea hoʻowahāwahā, a me ka waiʻona
  
• Nā ʻōlelo aʻoaʻo a me nā launa pū
• Addyi a me ka waiʻona
• Nāʻaʻa o ka ʻae ʻia
• ʻO ka lawe lawe ʻana

Hōʻike Overview

ʻO Flibanserin (Addyi), kahi lāʻau like me Viagra, i ʻae ʻia e ka Food and Drug Administration (FDA) i ka makahiki 2015 no ka mālama ʻana i ka wahine a me ka wahine arousal (FSIAD) i nā wahine ma mua o ka wahine.

ʻIke ʻia ʻo FSIAD ma ke ʻano he maʻi moe kolohe hypoactive (HSDD).

I kēia manawa, loaʻa wale ʻo Addyi ma o kekahi mau kauka a me nā kauka lāʻau. Kau ʻia e nā mea hoʻolako i ʻae ʻia i ka ʻaelike ma waena o ka mea hana a me ka FDA. Pono e hōʻoia ʻia kahi mea kākau e ka mea hana e hoʻokō i kekahi mau koi a ka FDA.

Lawe ʻia hoʻokahi manawa i kēlā me kēia lā, i ka wā moe.

ʻO Addyi ka lāʻau HSDD mua loa i ʻae ʻia e ka FDA. I Iune 2019, bremelanotide (Vyleesi) i lilo i lua. He pilamu ʻo Addyi i kēlā me kēia lā, ʻoiai ʻo Vyleesi kahi injectable nona iho i hoʻohana ʻia e pono ai.

Addyi vs. Viagra

ʻAʻole i ʻae ka FDA iā Viagra (sildenafil) iā ia iho e hoʻohana ai nā wahine. Eia naʻe, ua kau ʻia ma luna o ka lepili hōʻailona no nā wahine me ka holo haʻahaʻa o ka wahine.

ʻO ka hoʻohana ʻana i ka lāʻau lapaʻau i hōʻailona ʻia ʻo kahi lāʻau i ʻae ʻia e ka FDA no hoʻokahi kumu i hoʻohana ʻia no kahi kumu ʻē aʻe i ʻae ʻole ʻia. Eia nō naʻe, hiki i ke kauka ke hoʻohana i ka lāʻau no ia kumu. ʻO kēia no ka mea hoʻoponopono ka FDA i ka hoʻāʻo a me ka ʻae ʻana o nā lāʻau, akā ʻaʻole pehea e hoʻohana ai nā kauka i nā lāʻau e mālama ai i kā lākou mau maʻi. No laila, hiki i kāu kauka ke kuhikuhi i kahi lāʻau akā manaʻo lākou ʻoi aku ka maikaʻi no kāu mālama.

Hoʻohui ʻia nā hōʻike o kona hopena i ka maikaʻi. ʻO kahi o nā hoʻāʻo o Viagra i loko o nā wahine i manaʻo ʻia e mālama ʻia nā hopena maikaʻi e pili ana i ka hoʻāla kino. Eia naʻe, ʻaʻole kēia ka hihia no ka ʻoi aku ka paʻakikī o ka FSIAD.

ʻO kahi laʻana, ua kikoʻī ka loiloi i kahi noiʻi i hāʻawi iā Viagra i 202 wahine postmenopausal me FSIAD mua.

Nānā nā kānaka noiʻi i ka hoʻonui ʻia o nā sensation arousal, lubrication ʻele, a me ka orgasm i nā mea hoʻopaʻa haʻawina. Eia nō naʻe, ʻo nā wahine me nā maʻi ʻelua e pili ana i ka FSIAD (e like me ka sclerosis (MS) a me ka maʻi diabetic) hōʻike ʻole ka hoʻonui ʻana o ka makemake a ʻoluʻolu paha.

ʻO kahi noiʻi ʻelua i kūkā ʻia i loko o ka loiloi i ʻike ʻia ʻaʻole hōʻike nā wahine premenopausal ʻelua a me nā wahine postmenopausal i nā pane maikaʻi i ka hoʻohana ʻana iā Viagra.

Kumu a me nā pono

Nui nā kumu e ʻimi ai nā wahine i kahi lāʻau like Viagra. I ko lākou hoʻokokoke ʻana i ka makahiki waena a ma ʻō aku, ʻaʻole ia he mea mau no ka nānā ʻana o nā wahine i ka emi ʻana o kā lākou wahine holoʻokoʻa.

Hiki ke hoʻomaka ʻia kahi hōʻemi o ka hoʻokele wahine mai nā pilikia o kēlā me kēia lā, nā hanana ola nui, a i ʻole nā ​​kūlana mau e like me MS a i ʻole diabetes.

Eia nō naʻe, ʻike kekahi mau wahine i ka hoʻoliʻiliʻi a i ʻole ka hemo ʻana o ka pākeke ma muli o FSIAD. Wahi a kekahi mākaukau loiloi a me ka loiloi, manaʻo ʻia ʻo FSIAD e hoʻopili ma kahi o 10 pakeneka o nā wahine makua.

Hoʻohālikelike ʻia e nā ʻōuli penei:

• nā manaʻo moekolohe palena ʻole a i ʻole moeʻuhane paha
• hoʻemi a ʻae ʻole paha i ka pane o ka makemake i nā kuhi moekolohe a i ʻole stimulate
• lilo o ka hoihoi a i ʻole hiki ʻole ke mālama i ka hoihoi i nā hana moekolohe
• manaʻo nui o ka ukiuki, kūpono ʻole, a hopohopo paha i ka nele o ka moekolohe a i ʻole ke ala ʻana

Pehea e hana ai ʻo flibanserin

Ua hoʻomohala mua ʻia ʻo Flibanserin ma ke ʻano he antidepressant, akā ua ʻae ʻia e ka FDA no ka mālama ʻana iā FSIAD ma 2015.

ʻO kāna ʻano hana e pili ana iā FSIAD ʻaʻole i maopopo maikaʻi. Hoʻomaopopo ʻia ka hāpai mau ʻana i ka flibanserin i nā manawa he nui e piʻi ai ka kiʻekiʻe o ka dopamine a me ka norepinephrine i ke kino. I ka manawa like, hoʻohaʻahaʻa ia i nā pae o ka serotonin.

He mea nui ka dopamine a me ka norepinephrine no ka pīhoihoi i ka moekolohe. He kuleana ko Dopamine i ka hoʻoikaika ʻana i ka makemake moekolohe. He kuleana ko Norepinephrine i ka hāpai i ka hoʻāla ʻana i ka moekolohe.

Ka hoʻokō ʻana

Ua hoʻokumu ʻia ka ʻae ʻia o ka flibanserin e ka FDA ma nā hopena o nā hoʻokolohua hoʻokolohua ʻekolu pae III. ʻO kēlā me kēia hoʻokolokolo he 24 mau pule a loiloi i ka hopena o flibanserin i hoʻohālikelike ʻia i kahi placebo i nā wahine premenopausal.

Ua kālailai nā mea noiʻi a me ka FDA i nā hopena o nā hoʻokolokolo ʻekolu. Ke hoʻololi ʻia no ka pane placebo, ua hōʻike ka poʻe komo i kahi kūlana "hoʻomaikaʻi nui" a i ʻole "hoʻomaikaʻi loa" i nā wiki hoʻokolokolo 8 a 24. He hoʻomaikaʻi haʻahaʻa kēia ke hoʻohālikelike ʻia me Viagra.

Ua paʻi ʻia kahi loiloi i ʻekolu mau makahiki ma hope o ka ʻae ʻia a Viagra's FDA no ka mālama ʻana i ka hana erectile (ED) hōʻuluʻulu i nā pane o ka honua holoʻokoʻa i ka lāʻau. Ma ʻAmelika Hui Pū ʻIa, no ka laʻana, ua pane maikaʻi nā poʻe i komo. Hoʻohālikelike ʻia kēia me ka 19 pākēneka pane maikaʻi no ka poʻe e lawe ana i kahi placebo.

I nā wahine postmenopausal

ʻAʻole ʻae ʻia ʻo Flibanserin e hoʻohana ʻia i nā wahine postmenopausal. Eia nō naʻe, ua loiloi ʻia ka hopena o flibanserin i kēia heluna kanaka i hoʻokahi hoʻokolokolo.

Ua hōʻike ʻia nā mea e like me ka mea i hōʻike ʻia i nā wahine premenopausal. Pono kēia e hana hou i nā hoʻokolohua hou aʻe no ka mea e ʻae ʻia no nā wahine postmenopausal.

Nā hopena ʻaoʻao

ʻO nā hopena ʻaoʻao maʻamau o flibanserin me:

• ʻūpā
• pilikia i ka hiamoe ʻana a i ʻole ka hiamoe mau ʻana
• nausea
• waha maloo
• luhi
• haʻahaʻa ke koko, a ʻike ʻia ʻo hypotension
• maʻule a nalowale paha o ka ʻike

Nā ʻōlelo aʻoaʻo a ka FDA: Ma ka maʻi akepaʻa, nā mea hoʻowahāwahā, a me ka waiʻona

• Ua kau ʻia nā lāʻau lapaʻau i kēia lāʻau ʻO kēia nā ʻōlelo aʻoaʻo koʻikoʻi nui loa mai ka Food and Drug Administration (FDA). ʻO ka leka hoʻomaopopo e hōʻike i nā kauka a me nā mea maʻi e pili ana i nā hopena lāʻau e weliweli paha.
• Hiki i ka Flibanserin (Addyi) ke hoʻonāwaliwali a i ʻole ke kūpikipiki nui ke lawe ʻia e nā poʻe me nā maʻi ate a i ʻole ka ʻaoʻao o kekahi mau lāʻau, e like me ka waiʻona.
• ʻAʻole pono ʻoe e hoʻohana iā Addyi inā ʻoe e lawe i kahi mea hoʻopale CYP3A4 kaulike a ikaika paha. Hoʻopili kēia hui o nā mea hoʻopōkole i ka enzyme i nā antibiotics, antifungals, a me nā lāʻau HIV, a me nā ʻano lāʻau ʻē aʻe. ʻO ka wai hua waina kekahi mea hoʻopōkō CYP3A4 kaulike.
• I mea e pale aku ai i kēia mau hopena ʻaoʻao, pono ʻoe e hōʻole i ka inu ʻana i ka waiʻona no ʻelua mau hola ma mua o ka lawe ʻana i kāu hopena o Addyi i ka pō. Ma hope o kou lawe ʻana i kāu lāʻau, pono ʻoe e hōʻole i ka inu ʻana i ka ʻalekohola a kakahiaka. Inā ʻoe i inu i ka wai ʻona ma mua o ʻelua mau hola ma mua o ka manawa o kou hiamoe ʻana, pono ʻoe e lele ma kahi o ka hopena o kēlā pō.

Nā ʻōlelo aʻoaʻo a me nā launa pū

ʻAʻole pono e hoʻohana ʻia ʻo Flibanserin i ka poʻe me nā pilikia o ke ake.

E kamaʻilio me kāu kauka e pili ana i nā lāʻau a me nā mea hoʻopihapiha āu e lawe nei ma mua o ka hoʻomaka ʻana o flibanserin. ʻAʻole pono ʻoe e lawe i ka flibanserin inā ʻoe e lawe i kekahi o nā lāʻau aʻe a i ʻole nā ​​mea hoʻopili.

• kekahi mau lāʻau i hoʻohana ʻia e mālama ai i nā kūlana maʻi puʻuwai, e like me diltiazem (Cardizem CD) a me verapamil (Verelan)
• kekahi mau antibiotic, e like me ciprofloxacin (Cipro) a me erythromycin (Ery-Tab)
• nā lāʻau e mālama ai i nā maʻi fungal, e like me fluconazole (Diflucan) a me itraconazole (Sporanox)
• Nā lāʻau HIV, e like me ritonavir (Norvir) a me indinavir (Crixivan)
• nefazodone, kahi antidepressant
• nā mea hoʻopihapiha e like me St. John's wort

ʻO ka hapa nui o kēia mau lāʻau i loko o kahi hui o nā mea hoʻopōpili enzyme i kapa ʻia ʻo CYP3A4 mea kāohi.

ʻO ka mea hope loa, ʻaʻole pono ʻoe e inu i ka wai kawa i ka lawe ʻana i ka flibanserin. He mea kāohi pū kekahi iā CYP3A4.

Addyi a me ka waiʻona

I ka wā i ʻae ʻia ʻo Addyi i ka FDA, ua aʻo ka FDA i ka poʻe e hoʻohana ana i ka lāʻau e hōʻole i ka waiʻona no ka makaʻu o ka poniuniu a me ka manaʻo nui. Eia naʻe, ʻo ka FDA i ʻApelila 2019.

Inā kuhikuhi ʻoe iā Addyi, ʻaʻole pono ʻoe e hōʻalo loa i ka waiʻona. Eia nō naʻe, ma hope o kou lawe ʻana i kāu lāʻau i ka pō, pono ʻoe e hōʻole i ka inu ʻana i ka ʻalekohola a kakahiaka.

E hōʻole hoʻi ʻoe i ka inu lama ʻana ma kahi o ʻelua mau hola ma mua lawe ana i kāu kau lāʻau i ka pō. Inā ʻoe i inu i ka wai ʻona ma lalo o ʻelua mau hola ma mua o ka manawa o kou hiamoe ʻana, pono ʻoe e lele ma hope o ka hopena o Addyi.

Inā ʻoe e nalo i kahi lāʻau o Addyi no nā kumu, mai lawe i kahi lāʻau e hana ai no ke kakahiaka aʻe. E kali a ahiahi aʻe a hoʻomaka hou i kāu papa hana maʻamau.

Nāʻaʻa o ka ʻae ʻia

He ala paʻakikī ʻo Flibanserin i ka ʻae ʻia o FDA.

Ua nānā ka FDA i ka lāʻau i ʻekolu mau manawa ma mua o ka ʻae ʻia. Aia kekahi hopohopo e pili ana i kona hopena ke hoʻohālikelike ʻia me nā hopena maikaʻi ʻole. ʻO kēia mau hopohopo nā kumu nui i koi ai ka FDA e hōʻole i ka ʻae ʻia ma hope o nā loiloi mua ʻelua.

Aia kekahi mau nīnau lohi e pili ana i ka mālama ʻia ʻana o ka wahine e ka wahine. Paʻa paʻakikī ka hoʻokalakupua wahine. Aia kekahi mahele o ke kino a me ka psychological.

Hana ʻo Flibanserin a me sildenafil i nā ʻano like ʻole. ʻO Sildenafil, no ka laʻana, ʻaʻole e hoʻonui i ka hoʻonāukiuki i ka kāne. Ma ka ʻaoʻao ʻē aʻe, hana ʻo flibanserin e hoʻāla i nā kiʻekiʻe o ka dopamine a me ka norepinephrine e hāpai i ka makemake a me ka hoʻāla ʻana.

No laila, kau ʻia hoʻokahi pill i kahi hiʻohiʻona o ke kino o ka moekolohe. Hoʻokumu nā mea ʻē aʻe i nā manaʻo o ka hoʻāla a me ka makemake, kahi pilikia paʻakikī.

Ma hope o ke kolu o ka loiloi, ua ʻae ʻo FDA i ka lāʻau ma muli o nā pono olakino pono ʻole. Eia nō naʻe, ua mau ka hopohopo e pili ana i nā hopena. ʻO kahi hopohopo nui ka manaʻo nui i ʻike ʻia ke lawe ʻia ʻo flibanserin me ka wai ʻona.

ʻO ka lawe lawe ʻana

Nui nā kumu o ka hoʻohaʻahaʻa moekolohe haʻahaʻa, mai ka pilikia i kēlā me kēia lā a i FSIAD.

Ua ʻike ʻo Viagra i nā hopena huikau i nā wahine ma ka laulā, a ʻaʻole i loaʻa ka maikaʻi no nā wahine me FSIAD. Hiki i nā wahine Premenopausal me FSIAD ke ʻike i kahi hoʻomaikaʻi haʻahaʻa i ka makemake a me ka hoʻāla ma hope o ka lawe ʻana iā Addyi.

E kamaʻilio me kāu kauka inā makemake ʻoe e lawe iā Addyi. E noʻonoʻo pono e kūkākūkā i kāu mau lāʻau ʻē aʻe a i ʻole nā ​​mea hoʻopihapiha me kāu kauka ma mua o ka hoʻohana ʻana iā Addyi.