Lawe i nā Biologics a me ka mālama hou ʻana i kāu mana o Psoriatic

Anter

• He aha nā meaolaolaola?
• Nā ʻano biologics
• Abatacept
• Adalimumab
• ʻO Certolizumab pegol
• Etanercept
• Golimumab
• ʻO Infliximab
• ʻO Ustekinumab
• Hoʻohui hoʻohui hoʻohui
• Nā hopena a me nā ʻōlelo aʻoaʻo
• ʻO Biologics kekahi ʻāpana o kahi hoʻolālā hoʻomalu PsA

Hōʻike Overview

ʻO Psoriatic arthritis (PsA) kahi ʻano mau, a pono ka mālama ʻana e pono ai e pale i ka hōʻino pū o nā hui pū. Hiki i ka lāʻau lapaʻau kūpono ke hōʻoluʻolu i ka helu o nā mumū o ke ākea.

ʻO Biologics kahi ʻano lāʻau wale nō i hoʻohana ʻia e mālama iā PsA. Hana kēia mau mea ma ke kāohi ʻana i kāu ʻōnaehana pale no laila kū ia i ka hōʻeha ʻana i nā hono olakino a me ka hōʻeha ʻana i ka ʻeha a me ka hōʻino.

He aha nā meaolaolaola?

ʻO nā biologics he subtypes o ka hoʻololi ʻana i nā lāʻau antirheumatic (DMARDs). Hoʻopau nā DMARD i kāu ʻōnaehana pale maʻi mai ka hoʻoulu ʻana i ka huhū o PsA a me nā kūlana autoimmune ʻē aʻe.

ʻO ka hōʻemi ʻana i ka mumū he ʻelua kumu nui:

• Heʻuʻuku paha ka ʻeha ma muli o ka mumū ma nā pūnaewele hui ke kumu o ka hui.
• Hoʻoemi ʻia paha ka pohō.

Hana nā biologics i ka pale ʻana i nā protein immune system e hoʻohua i ka mumū. ʻAʻole like me kekahi DMARD, lawelawe ʻia nā meaolaolaola e ka infusion a i ʻole ka injection wale nō.

Kau ʻia nā biologics ma ke ʻano he lālani mua no ka poʻe me PsA hana. Inā ka biologic mua āu e hoʻāʻo ai ʻaʻole ia e hoʻomaha i kāu mau ʻōuli, hiki i kāu kauka ke hoʻololi iā ʻoe i kahi lāʻau ʻokoʻa i kēia papa.

Nā ʻano biologics

Hoʻohana ʻia nā ʻano biologics ʻehā e mālama iā PsA:

• tumzeris factor-alpha (TNF-alpha) nā mea kūpale: adalimumab (Humira), certolizumab pegol (Cimzia), etanercept (Enbrel), golimumab (Simponi Aria), infliximab (Remicade)
• interleukin 12/23 (IL-12/23) nā mea kūpale: ustekinumab (Stelara)
• interleukin 17 (nā mea kūloko IL-17): ixekizumab (Taltz), secukinumab (Cosentyx)
• Nā kūpili cell T: abatacept (Orencia)

Pākuʻi paha kēia mau lāʻau i kekahi mau protein ponoʻī e hōʻailona i kāu ʻōnaehana pale pale e hoʻouka i nā hunaola olakino, a i ʻole nā ​​pahuhopu pale pale i hoʻopili ʻia i ka pane o ka mumū. ʻO ka pahuhopu o kēlā me kēia ʻano biologic ka mea e pale ai i ke kaʻina hana hōʻino mai ka hoʻomaka ʻana.

Loaʻa he mau biologics. ʻO nā mea aʻe i kuhikuhi pinepine ʻia no PsA.

Abatacept

ʻO Abatacept (Orencia) kahi mea kāohi cell T. ʻO nā hunaola T he mau keʻokeʻo koko keʻokeʻo. Pāleo lākou i ka pale o ke kino, a me ka hoʻonāukiuki ʻana i ka lī. Hoʻolālā ʻo Orencia i nā pūnaewele T e lawe i lalo i ka mumū.

Mālama pū ʻo Orencia i ka rheumatoid arthritis (RA) a me ka ʻōpio idiopathic arthritis (JIA). Loaʻa iā ia ma ke ʻano he infusion ma o kahi aa, a i ʻole ke ʻoki kuʻi āu e hāʻawi ai iā ʻoe iho.

Adalimumab

Hana ʻo Adalimumab (Humira) ma ke kāpae ʻana iā TNF-alpha, kahi protein e hoʻolauna i ka mumū. Hana ka poʻe me PsA i ka nui o ka TNF-alpha i ko lākou ʻili a me nā hono.

ʻO Humira kahi lāʻau hoʻomake. Kau ʻia nō ia no ka maʻi o Crohn a me nā ʻano ʻano ʻē aʻe o ka arthritis.

ʻO Certolizumab pegol

ʻO Certolizumab pegol (Cimzia) kekahi lāʻau lapaʻau TNF-alpha. Hoʻonohonoho ʻia e mālama i nā ʻano kūpikipiki o PsA, a me ka maʻi o Crohn, RA, a me ka ankylosing spondylitis (AS).

Hāʻawi ʻia ʻo Cimzia ma ke ʻano he injection ponoʻī.

Etanercept

ʻO Etanercept (Enbrel) kekahi lāʻau lapaʻau TNF-alpha. Aia ia i waena o nā lāʻau i ʻae ʻia no ka mālama ʻana iā PsA, a hoʻohana ʻia e mālama i nā ʻano ʻē aʻe o ka maʻi kō.

Hoʻopiʻi pono ʻia ʻo Enbrel i hoʻokahi i ʻelua mau manawa i kēlā me kēia pule.

Golimumab

ʻO Golimumab (Simponi) kahi lāʻau lapaʻau TNF-alpha i hoʻolālā ʻia e mālama iā PsA hana. Kau ʻia hoʻi no RA kaulike-i-koʻikoʻi, kolitis ulcerative ulcerative (UC), a me AS paʻa.

Lawe ʻoe iā Simponi i hoʻokahi manawa i ka mahina ma o ka hoʻopili ʻana iā ʻoe iho.

ʻO Infliximab

ʻO Infliximab (Remicade) kahi ʻano infusion o kahi lāʻau TNF-alpha. Loaʻa iā ʻoe ka infusion ma ke keʻena o ke kauka i ʻekolu mau manawa i loko o ʻeono pule. Ma hope o nā hana mua, hāʻawi ʻia nā infusions i kēlā me kēia ʻelua mau mahina.

Mālama pū ʻo Remicade i ka maʻi o Crohn, UC, a me AS. Kauoha paha nā kauka no RA, me ka methotrexate.

Ixekizumab

ʻO Ixekizumab (Taltz) kahi mea kāohi iā IL-17. Pale iā IL-17, i pili i ka pane o ke kino i ka pane.

Loaʻa iā ʻoe ʻo Taltz ma ke ʻano he injection i lalo o ka ʻili i kēlā me kēia pule ʻelua, a laila i kēlā me kēia pule ʻehā.

ʻO Secukinumab

ʻO Secukinumab (Cosentyx) kekahi mea kāohi iā IL-17. Ua ʻae ʻia no ka mālama ʻana iā psoriasis a me PsA, a me AS.

Lawe ʻoe iā ia ma ke ʻano he kī ma lalo o kou ʻili.

ʻO Ustekinumab

ʻO Ustekinumab (Stelara) kahi mea kūloko IL-12/23. Pale ia i nā protein IL-12 a me IL-23, ke kumu o ka lū ma PsA. Ua ʻae ʻia ʻo Stelara e mālama i ka PsA ikaika, ka lāʻau plaque, a me ka maʻi Crohn kaulike a koʻikoʻi.

Hele mai ʻo Stelara ma ke ʻano he injection. Ma hope o ke kuikahi mua, lawelawe hou ʻia ia ma hope o ʻehā pule, a laila hoʻokahi manawa i kēlā me kēia 12 pule.

Hoʻohui hoʻohui hoʻohui

No ka maʻamau a paʻakikī PSA, pono nā biologics i ka mālama ʻana i nā ʻōuli a me nā pilikia wā lōʻihi. Eia nō naʻe, koi paha kāu kauka i nā lāʻau lapaʻau ʻē aʻe.

Kau kauka i kau kauka anti-inflammatory nonsteroidal (NSAIDs) no ka ʻeha pū. Hoʻoemi kēia i ka pehu. Loaʻa ākea nā mana over-the-counter (OTC), e like me ibuprofen (Advil), a me nā formulate ikaika.

Ma muli o ka hoʻohana wā lōʻihi hiki ke hoʻonui i ka hopena o ke kahe ʻana o ka ʻōpū, nā pilikia o ka puʻuwai, a me ka hahau ʻana, pono e hoʻohana iki ʻia nā NSAID a me ka mahele haʻahaʻa e hiki ai.

Inā loaʻa iā ʻoe ka psoriasis ma mua o PsA, a laila pono ʻoe i nā therapies e kōkua ai e hōʻemi i nā ʻili a me nā pilikia kui. ʻO nā koho lapaʻau kūpono me nā corticosteroids, light therapy, a me nā hamo kuhikuhi.

Nā hopena a me nā ʻōlelo aʻoaʻo

ʻO nā hopena maʻa mau o nā biologics he hopena o ka ʻili (e like me ka ʻulaʻula a me ka hū) ma ke kahua o ka injection. Ma muli o ka mālama ʻana o nā biologics i kāu ʻōnaehana pale, hiki i ka nui o ka makaʻu no ka hoʻomohala ʻana i nā maʻi.

ʻOi aku ka liʻiliʻi, akā koʻikoʻi, nā hopena ʻē aʻe i:

• ʻoi aku ka maikaʻi o psoriasis
• maʻi hanu o luna
• maʻi puʻu
• nā ʻōuli like lupus (e like me ka ʻeha a me ka ʻeha pū, ke kuni, a me ka nalo ʻana o ka lauoho)

E kamaʻilio me kāu rheumatologist e pili ana i kēia mau hopena hopena, a nānā pono i kou ʻano. Kāhea koke aku inā manaʻo ʻoe he hopena maikaʻi ʻole kāu i kāu mau lāʻau.

Eia kekahi, ʻo nā wahine hāpai a hoʻolālā paha i ka hāpai ʻana e hoʻohana i nā biologics me ka mālama.

ʻOiai ʻaʻole maopopo iki nā hopena ma kahi pēpē e ulu ana, aia ka hiki i nā pilikia me ka hāpai keiki. Kaukaʻi ʻia i ka paʻakikī o PsA, paipai kekahi mau kauka e hōʻoki i ka mālama ʻana i ka wā hāpai.

ʻO Biologics kekahi ʻāpana o kahi hoʻolālā hoʻomalu PsA

Lawe ka biologics i ka manaʻolana no ka poʻe he nui me PsA. ʻAʻole wale nā ​​biologics e kōkua i ka mālama ʻana i nā hōʻailona PsA, hoʻemi lākou i ke ʻano luku o ka hoʻohaʻahaʻa o ke kumu.

Eia nō naʻe, he mea nui e hoʻomanaʻo i nā biologics kahi ʻāpana o kāu hoʻolālā hoʻokele PsA lōʻihi. E kamaʻilio me kāu kauka e pili ana i nā loli nohona a me nā lāʻau ʻē aʻe i hiki ke kōkua.