Statins: hoʻohana, ʻaoʻao hopena, a me nā mea hou aʻe

Anter

• ʻO wai ka mea hiki ke lawe iā lākou
• Pehea lākou e hana ai
• Nā Pōmaikaʻi
• Nā ʻano o nā statins
• Nā pilikia kūpono a me nā hopena ʻē aʻe
• Poino Muscle
• Poino ke ake
• Hoʻonui i ka pilikia o ka maʻi kō
• E kamaʻilio me kāu kauka
• Q&A
• Q:
• A:

He aha nā statins?

ʻO ka Statins kahi hui o nā lāʻau i hoʻohana ʻia e mālama i ke kiʻekiʻe o ke kolesterol. Hana lākou ma ka hōʻemi ʻana i nā pae o ka kolesterol i loko o kou koko, keu hoʻi i ka lipoprotein haʻahaʻa (LDL) a i ʻole ka "ʻino" kolesterol.

Hoʻonui ka pilikia o ka poʻe me ka LDL kolesterol kiʻekiʻe i ka loaʻa ʻana o ka maʻi maʻi ʻōpū. Me kēia kūlana, kūkulu ka kolesterol i loko o kāu mau aʻa a hiki ke alakaʻi i ka angina, ka puʻuwai puʻuwai, a i ʻole ka hahau. No laila, hiki i nā statins ke koʻikoʻi i ka hōʻemi ʻana i kēia mau pilikia.

ʻO wai ka mea hiki ke lawe iā lākou

Paipai ka American Heart Association i nā statins no kekahi poʻe. Pono ʻoe a me kāu kauka e noʻonoʻo i nā statins inā ʻoe:

• loaʻa i kahi pae LDL kolamu o 190 mg / dL a ʻoi paha
• ua loaʻa i ka maʻi maʻi maʻi maʻi
• he 40-75 mau makahiki a ua mahuahua ka makaʻu o ka maʻi maʻi maʻi i loko o 10 mau makahiki e hiki mai ana
• Loaʻa i ka maʻi diabetes, 40 a 75 mau makahiki, a loaʻa ka pae LDL ma waena o 70 a me 189 mg / dL

Pehea lākou e hana ai

Pono maoli kou kino i kahi kolesterol e holo pono. Loaʻa i kou kino ka cholesterol ma ka ʻai ʻana i kekahi meaʻai a ma ka hana ʻana i loko o kou ake. Eia nō naʻe, kū aʻe nā makaʻi ke kiʻekiʻe loa kāu pae kolesterol. Hana nā Statins e hoʻemi i nā pae kolesterol i kou kino.

Hana ʻo Statins i kēia ma ke kāpae ʻana i ka hana o kou kino i kahi enzyme i kapa ʻia ʻo HMG-CoA reductase. ʻO kēia ka enzyme e pono ai i kou ake e hana i ka cholesterol. ʻO ka pale ʻana i kēia enzyme ke kumu e hoʻoliʻiliʻi ai kou ake kōkō, a hoʻoliʻiliʻi hoʻi ia i kāu mau pae kolesterol.

Hana pū ʻo Statins ma o ka hana maʻalahi ʻana i kou kino e omo i ka cholesterol i kūkulu ʻia i loko o kāu mau aʻa.

Nā Pōmaikaʻi

Nui nā keu pono maoli i ka lawe statins, a no ka poʻe he nui, ʻoi aku ka maikaʻi o kēia mau pōmaikaʻi ma mua o ka hopena o nā lāʻau.

Hōʻike nā hoʻokolohua hoʻokolohua hiki i nā statins ke hoʻohaʻahaʻa i nā pae kolamu LDL ma kahi o 50 pakeneka. Hiki i nā Statins ke hōʻemi i kāu makaʻi o ka puʻuwai puʻuwai a me ka hahau. Hoʻohui ʻia, hōʻike kahi 2010 i nā statins i kahi kuleana liʻiliʻi i ka hoʻohaʻahaʻa ʻana i nā pae triglyceride a me ka hāpai ʻana i ka HDL (maikaʻi) kolesterol.

Aia nā Statins i nā waiwai anti-inflammatory e hoʻopili i nā kīʻaha koko, ka puʻuwai, a me ka lolo. Hiki i kēia hopena ke hoʻohaʻahaʻa i ka makaʻu o ke kahe o ke koko, ka puʻuwai puʻuwai, a me ka hahau.

Hiki paha i kēia mau lāʻau ke kōkua i ka hoʻohaʻahaʻa i ka manawa o ka hōʻole ʻana ma hope o ke kolo ʻana o kahi ʻōpala, e like me kahi ʻatikala ma ka Ka Nupepa Hoʻokolohua Hoʻokolohua. Eia naʻe, pono hou ʻia ka noiʻi ʻana ma kēia wahi.

Nā ʻano o nā statins

Loaʻa nā Statins ma lalo o nā ʻano generic a me nā inoa inoa, e like me:

• atorvastatin (Lipitor, Torvast)
• fluvastatin (Lescol)
• lovastatin (Mevacor, Altocor, Altoprev)
• pitavastatin (Livalo, Pitava)
• pravastatin (Pravachol, Selektine)
• rosuvastatin (Crestor)
• simvastatin (Lipex, Zocor)

Loaʻa i kekahi mau lāʻau hoʻohui i statins. Aia i waena o lākou nā:

• amlodipine / atorvastatin (Caduet)
• ezetimibe / simvastatin (Vytorin)

Nā pilikia kūpono a me nā hopena ʻē aʻe

Pono ka poʻe e lawe i nā statins e hōʻalo i ka huaʻulu. Hiki i ka huakeue ke launa pū me kekahi statins a hana i nā ʻaoʻao ʻino i ʻoi aku ka maikaʻi. Heʻoiaʻiʻo loa kēia me ka lovastatin a me ka simvastatin. E heluhelu pono i nā ʻōlelo aʻoaʻo i hiki mai me kāu mau lāʻau. Inā he mau nīnau kāu, e kamaʻilio me kāu kauka a kauka paha. Hiki iā ʻoe ke heluhelu hou aʻe e pili ana i ka grapefruit a me nā statins.

Hiki i ka hapa nui o ka poʻe ke lawe i nā statins me ka ʻole o ka hopena he nui, akā hiki i nā hopena ke kū. He paʻakikī ke ʻōlelo inā hoʻokahi ʻano statin ke kumu o nā hopena ʻē aʻe ma mua o kekahi. Inā loaʻa iā ʻoe nā hopena hopena hoʻomau, hiki i kāu kauka ke hoʻoponopono i kāu mea hana a koi paha i kahi statin ʻokoʻa.

ʻO kekahi o nā hopena ʻaoʻao maʻamau o nā statins e komo pū me:

• kōpaʻa
• pāhoehoe
• nausea

Mālie kēia mau hopena ʻaoʻao. Eia nō naʻe, hiki i nā statins ke kumu i nā hopena ʻino ʻoi aʻe. Pākuʻi ʻia kēia mau mea:

Poino Muscle

Hiki i nā Statins ke hōʻeha i nā ʻeha puʻupuʻu, keu hoʻi i nā koina kiʻekiʻe. I nā hihia maʻamau, hiki iā lākou ke hoʻohiolo i nā pūnaewele mākala. Ke hiki mai kēlā, hoʻokuʻu i nā hunaola mākala i kahi protein i kapa ʻia ʻo myoglobin i loko o kou kahe koko. Kapa ʻia kēia ʻano he rhabdomyolysis. Hiki iā ia ke hoʻopōʻino i kāu mau puʻupaʻa. ʻOi aku ka makaʻu o kēia ʻano inā lawe ʻoe i kekahi mau lāʻau ʻē aʻe me nā statins, ʻo ia hoʻi ʻo lovastatin a i ʻole simvastatin. ʻO kēia mau lāʻau ʻē aʻe:

• kekahi mau antifungals e like me itraconazole a me ketoconazole
• cyclosporine (Restasis, Sandimmune)
• erythromycin (E.E.S., Erythrocin Stearate, a me nā mea ʻē aʻe)
• gemfibrozil (Lopid)
• nefazodone (Serzone)
• niacin (Niacor, Niaspan)

Poino ke ake

ʻO ka hōʻino o ke ake ka hopena hopena ʻē aʻe o statin therapy. ʻO kahi hōʻailona o ka hōʻino o ke ake he hoʻonui i nā enzymes ate. Ma mua o kou hoʻomaka ʻana e lawe i kahi statin, e hana paha kāu kauka i nā hoʻokolohua hana ate e nānā i kāu mau enzymes ate. Hiki paha iā lākou ke hana hou i nā hoʻokolohua inā hōʻike ʻoe i nā ʻōuli o nā pilikia o ke ake ke lawe nei ʻoe i ka lāʻau. Hiki i kēia mau hōʻailona ke hoʻopili i ka jaundice (melemele o kou ʻili a me nā keʻokeʻo o kou mau maka), mimi ʻeleʻele, a me ka ʻeha ma ka ʻaoʻao ʻākau i luna o kou ʻōpū.

Hoʻonui i ka pilikia o ka maʻi kō

Hoʻokumu pū paha ʻo Statins i nā pae glucose (kō) i loko o kou koko e piʻi aʻe. ʻO kēia ke kumu e hoʻonui iki ai i kāu makaʻu o ka maʻi diabetes type 2. Inā hopohopo ʻoe i kēia pilikia, e kamaʻilio me kāu kauka.

E kamaʻilio me kāu kauka

Lawe i kahi statin ʻoiai e ukali nei i ka papaʻai olakino a me ka loaʻa ʻana o ka hoʻoikaika kino he ala maikaʻi ia no nā poʻe he nui e hoʻohaʻahaʻa i kā lākou pae kolesterol. Inā he kolesterol kiʻekiʻe kou, e nīnau i kāu kauka inā he koho maikaʻi kahi statin nou. Nā nīnau āu e nīnau ai i kāu kauka.

• Ke lawe nei wau i nā lāʻau i hiki ke launa pū me kahi statin?
• He aha nā pono ʻē aʻe āu e manaʻo ai e hāʻawi mai kahi statin iaʻu?
• Loaʻa iā ʻoe kahi papaʻai a me nā manaʻo hoʻoikaika e kōkua iaʻu e hoʻohaʻahaʻa i kaʻu kolesterol?

Q&A

Q:

He palekana anei ka hoʻohana pū ʻana i nā statins a me ka waiʻona?

A:

Inā ʻoe e lawe i kahi statin, e ʻike pono e kamaʻilio me kāu kauka no ka palekana inā inu ʻoe i ka ʻalekohola. Inā inu ʻoe i ka nui o ka wai ʻona kaulike a loaʻa i ke akepaʻa olakino, palekana paha ʻoe e hoʻohana pū i ka wai ʻona a me nā statins.

ʻO ka hopohopo nui loa me ka waiʻona a me ka statin hoʻohana ke hele mai inā inu pinepine ʻoe a inu nui paha, a inā he maʻi ate kou. I kēlā mau hihia, hiki i ka hui pū ʻana o ka wai ʻona a me statin ke lilo i mea weliweli a alakaʻi i ka hōʻino nui o ke ake. Inā inu ʻoe a loaʻa paha i ka maʻi maʻi ake, e nīnau pono i kāu kauka no kāu pilikia.