6 mau kumu e hoʻāʻo ai i nā biologics no kāu maʻi o Crohn

Anter

• 1. ʻAʻole ʻoe e pane i nā kuʻuna maʻi maʻi o Crohn
• 2. Loaʻa kāu hōʻoia hou
• 3. ʻIke ʻoe i kahi komplication i kapa ʻia ʻo fistulas
• 4. Makemake ʻoe e mālama i ke kala ʻana
• 5. Hoʻokahi wale nō hana ʻana o ka lāʻau ʻana i kēlā me kēia mahina
• 6. Loaʻa paha nā hopena ʻē aʻe o nā biologics ma mua o nā steroid
• Ke lanakila nei i kāu kānalua
• Ke koho ʻana i kahi biologic

Ma ke ʻano he kanaka e noho nei me ka maʻi o Crohn, ua lohe paha ʻoe e pili ana i nā biologics a ua noʻonoʻo paha e pili ana i ka hoʻohana ʻana iā lākou iho. Inā kāohi kekahi mea iā ʻoe, ua hiki ʻoe i kahi kūpono.

Eia nā kumu ʻeono āu e makemake ai e noʻonoʻo hou i kēia ʻano holomua o ka mālama ʻana, a me nā ʻōlelo aʻoaʻo pehea e hana ai.

1. ʻAʻole ʻoe e pane i nā kuʻuna maʻi maʻi o Crohn

Malia paha ua lawe ʻoe i nā lāʻau ʻokoʻa o ka maʻi ʻo Crohn, e like me nā steroid a me nā immunomodulator, no kekahi manawa i kēia manawa. Eia nō naʻe, ke hoʻomau nei ʻoe i ka lapalapa ʻana i nā manawa he nui i ka makahiki.

Paipai ikaika ke alakaʻi o ke Kulanui ʻAmelika ʻo Gastroenterology (ACG) i ka lawe ʻana i kahi meaola inā loaʻa iā ʻoe ka maʻi Crohn kaulike a koʻikoʻi i kū ʻole i nā steroid a i ʻole nā ​​immunomodulator. E noʻonoʻo paha kāu kauka e hoʻohui i kahi biologic me kahi immunomodulator, ʻoiai inā ʻaʻole ʻoe i hoʻāʻo ʻokoʻa i kēlā mau lāʻau.

2. Loaʻa kāu hōʻoia hou

ʻO ka mea maʻamau, ʻo nā hoʻolālā hoʻomalu no ka maʻi o Crohn i pili i kahi ala i luna. Ua hoʻāʻo mua ʻia nā lāʻau ʻoi aku ka pipiʻi, e like me nā steroid, ʻoiai ʻo nā biologics ʻoi aku ka maikaʻi i hoʻāʻo ʻia.

I kēia mau lā, hoʻolaha nā alakaʻi i kahi ala i luna i lalo i ka lāʻau lapaʻau, e like me nā hōʻike i kuhikuhi i nā hopena kūleʻa me nā lāʻau olaola i nā maʻi hou.

ʻO kahi laʻana, hoʻokahi noiʻi nui o nā ʻikepili koi lapaʻau i loaʻa i ka hoʻomaka ʻana o nā biologics i ka wā mua o ka mālama ʻana no ka maʻi o Crohn e hoʻomaikaʻi ai i ka pane i nā lāʻau.

ʻO ka hui noiʻi i hoʻomaka i ka biologics anti-TNF i ka wā mua he haʻahaʻa haʻahaʻa o ka pono o nā steroid no ka mālama ʻana i nā flare ma luna o nā hui hoʻopaʻa ʻē aʻe. Ua liʻiliʻi lākou i nā ʻoki lāʻau ʻana ma muli o ka maʻi o Crohn.

3. ʻIke ʻoe i kahi komplication i kapa ʻia ʻo fistulas

ʻO nā fistula nā pilina maʻamau ma waena o nā ʻāpana o ke kino. I ka maʻi o Crohn, hiki i kahi fistula ke hana i kahi ulcer e hoʻonui ʻia ma o kou paia ʻōpū, kahi e hoʻopili ai i kou ʻōpū a me kou ʻili, a i ʻole kou ʻōpū a me nā meaola ʻē aʻe.

Inā maʻi ka fistula, hiki ke hoʻoweliweli i ke ola. ʻO nā biologics i kapa ʻia nā mea kāohi TNF hiki ke kuhikuhi ʻia e kāu kauka inā he fistula kāu no ka mea he maikaʻi loa lākou.

Ua ʻae ʻo FDA i nā biologics kikoʻī e mālama pono i ka maʻi o Crohn a mālama i ka pani ʻana o ka fistula.

4. Makemake ʻoe e mālama i ke kala ʻana

ʻIke ʻia nā Corticosteroids e lawe i ke kala akā ʻaʻole hiki ke mālama i kēlā kala. Inā lawe ʻoe i nā steroid no ʻekolu mau mahina a ʻoi paha, hiki i kāu kauka ke hoʻomaka iā ʻoe ma kahi biologic ma kahi. Hōʻike nā noiʻi hoʻokolohua hiki i nā biologics anti-TNF ke mālama i ke kala ʻana i nā mea maʻi me ka maʻi Crohn ʻoi loa.

Ua hoʻoholo ka ACG ʻo nā keu pono o kēia mau lāʻau e mālama i ke kala ʻana ma mua o nā mea hōʻeha no ka hapa nui o nā mea maʻi.

5. Hoʻokahi wale nō hana ʻana o ka lāʻau ʻana i kēlā me kēia mahina

Hoʻoweliweli paha ka manaʻo o kahi injection, akā ma hope o nā kau mua, hāʻawi ʻia ka hapa nui o nā biologics i hoʻokahi manawa wale nō i kēlā me kēia mahina. Ma luna o kēia, he liʻiliʻi loa ka nila, a hoʻokomo ʻia ka lāʻau ma lalo o kou ʻili.

Hāʻawi ʻia ka hapanui o nā biologics i ke ʻano o kahi auto-injector - ʻo ia hoʻi hiki iā ʻoe ke kiʻi i nā injection me ka ʻike ʻole ʻana i ka nila. Hiki iā ʻoe ke hāʻawi iā ʻoe iho i kekahi biologics ma ka home ma hope o kou hoʻomaʻamaʻa pono ʻana pehea e hana ai.

6. Loaʻa paha nā hopena ʻē aʻe o nā biologics ma mua o nā steroid

Hoʻohana ʻia nā Corticosteroids e mālama i ka maʻi o Crohn, e like me prednisone a i ʻole budesonide, hana e kaomi ʻana i ka ʻōnaehana pale pale holoʻokoʻa.

ʻO Biologics, ma ka ʻaoʻao ʻē aʻe, hana i kahi ala i ʻoi aku ke koho ʻia e ka ʻimi ʻana i nā protein kikoʻī i loko o kāu ʻōnaehana pale i hōʻike ʻia e pili ana me ka mumū o Crohn. No kēia kumu, ʻoi aku ka liʻiliʻi o nā hopena o lākou ma mua o ka corticosteroids.

ʻAneʻane pau nā lāʻau i ka hopena o nā hopena. No nā biologics, nā hopena ʻaoʻao maʻamau e pili ana i ka lawelawe ʻana. ʻIke paha ʻoe i ka huhū liʻiliʻi, ʻulaʻula, ʻeha, a i ʻole kahi hopena ma ke kahua o ka injection.

Aia kekahi mea iʻoi aku ka kiʻekiʻe o ka maʻi, akā ʻaʻole kiʻekiʻe ka makaʻi ma mua o nā lāʻau ʻē aʻe, e like me nā corticosteroids.

Ke lanakila nei i kāu kānalua

ʻO ka biologic mua no ka maʻi o Crohn i ʻae ʻia i ka makahiki 1998, no laila he ʻike iki kā ka biologics a me ka hoʻāʻo ʻana i ka palekana e hōʻike iā lākou iho. Ke kānalua nei paha ʻoe e hoʻāʻo i kahi lāʻau biologic no ka mea ua lohe ʻoe he "ikaika" nā lāʻau a i ʻole makaʻu i nā kumukūʻai kiʻekiʻe.

ʻOiai he ʻoiaʻiʻo ua manaʻo ʻia nā biologics he koho lapaʻau hōʻeuʻeu nui aʻe, ʻo nā biologics kekahi mau lāʻau i hoʻomāka ʻia, a hana maikaʻi loa lākou.

ʻAʻole like me kekahi mau mālama kahiko no ka maʻi o Crohn e hoʻonāwaliwali ai i ka ʻōnaehana pale pale holoʻokoʻa, hoʻomoʻa ʻia nā lāʻau biologic i nā protein inflammative kikoʻī i ʻike ʻia e pili ana i ka maʻi o Crohn. I ka hoʻohālikelike ʻana, hoʻopau nā lāʻau corticosteroid i kāu ʻōnaehana pale pale holoʻokoʻa.

Ke koho ʻana i kahi biologic

Ma mua o nā biologics, aia kekahi mau koho lapaʻau e hoʻokaʻawale ʻia mai ke ʻoki ʻana no ka poʻe me ka maʻi maʻi ʻo Crohn. I kēia manawa aia kekahi mau koho:

• adalimumab (Humira, Exemptia)
• certolizumab pegol (Cimzia)
• infliximab (Remicade, Remsima, Inflectra)
• natalizumab (Tysabri)
• ustekinumab (Stelara)
• vedolizumab (Entyvio)

Pono ʻoe e hana me kāu ʻoihana inikua e ʻike inā uhi ʻia kahi biologic ma lalo o kāu hoʻolālā.

Ua akāka ua hoʻomaikaʻi nā lāʻau biologic i ka maka o nā mea hiki ke mālama i ka maʻi o Crohn a me nā pilikia autoimmune ʻē aʻe. Ke hoʻomau nei ka ulu ʻana o ka noiʻi ʻana ma nā meaolaolaola, e loaʻa ana paha nā koho lapaʻau hou aku i ka wā e hiki mai ana.

ʻO ka mea hope loa, ʻo kāu hoʻolālā lapaʻau kahi hoʻoholo i hoʻoholo maikaʻi ʻia me kāu kauka.