He aha nā mea āpau me nā Psoriasis e pono ai e ʻike e pili ana i nā Inhibitors PDE4

Anter

• Hōʻike Overview
• He aha nā mea kāohi PDE4?
• Pehea lākou e hana ai no ka psoriasis?
• Mālama ʻo PDE4 i nā mea hōʻoki vs. nā ʻano lāʻau psoriasis ʻē aʻe
• Nā pono kūpono
• Nā hopena a me nā ʻōlelo aʻoaʻo
• ʻO ka lawe lawe ʻana

Hōʻike Overview

ʻO ka lāʻau plaque kahi ʻano autoimmune mau. ʻO ia, hōʻeha hewa ka ʻōnaehana pale kino i ke kino. Hoʻonui ia i nā ʻulaʻula, scaly patch i ka ʻili. ʻIke paha kēia mau palapū i ka ʻeha a ʻeha paha.

Hoʻolālā nā koho lapaʻau e hōʻemi i kēia mau ʻōuli. Ma muli o ka mumū ma ke aʻa o ka plake psoriasis, ʻo ka pahuhopu o nā lāʻau he nui e hoʻemi i kēia pane ʻōnaehana pale a hana i kahi kaulike maʻamau.

Inā ʻoe e noho nei me ka maʻi maʻamau a koʻikoʻi plake psoriasis, he mea hana maikaʻi paha kahi mea kāohi PDE4 i ka mālama ʻana i nā ʻōuli.

Eia naʻe, ʻaʻole no nā mea āpau ka lāʻau. Pono ʻoe e kūkākūkā i kāu mau koho lapaʻau me kāu kauka.

He aha nā mea kāohi PDE4?

ʻO ka mea kāohi PDE4 kahi lapaʻau hou. Hana lākou e kāohi i ka ʻōnaehana pale, kahi e hoʻēmi ai i ka mumū. Hana lākou i ka pae kelepona e hoʻokū i ka hana ʻana o kahi enzyme overactive i kapa ʻia PDE4.

ʻIke nā kānaka noiʻi ua hoʻohaʻahaʻa nā phospodiesterases (PDEs) i ka cyclic adenosine monophosphate (cAMP). Hāʻawi nui ka cAMP i nā ala hōʻailona ma waena o nā hunaola.

Ma ka hoʻokū ʻana i nā PDE4, hoʻonui ka cAMP.

Wahi a kahi noi 2016, hiki i kēia helu kiʻekiʻe o ka cAMP ke loaʻa i nā hopena anti-inflammatory, kikoʻī i ka poʻe e noho ana me psoriasis a me atopic dermatitis.

Pehea lākou e hana ai no ka psoriasis?

Nā mea hoʻopukapuka PDE4, e like me ka apremilast (Otezla), hana i loko o ke kino e pale ai i ka wela.

Ma ke ʻano he ana pale, he mea pono paha no ka poʻe me ka psoriasis e hoʻokele i ka puhū. Hiki i ka hoʻemi ʻana i ka līlū ke kumu i ka liʻiliʻi pinepine a me ka ʻoi ʻole o ka maʻi.

Kūleʻa a pale paha ia i ka holomua o ka maʻi e hopena i ka psoriatic arthritis (PsA).

ʻO ka poʻe e noho nei me kēlā me kēia ʻano psoriasis, ma kahi o 30 pākēneka e ulu aʻe iā PsA, kahi e ʻeha ai i ka ʻeha ami ami ʻeha. Hiki iā PsA ke hōʻemi i kou ola.

Mālama ʻo PDE4 i nā mea hōʻoki vs. nā ʻano lāʻau psoriasis ʻē aʻe

ʻO Apremilast, kahi mea pāpā PDE4, lawe ʻia e ka waha. Hana pū kekahi ia i kahi ala nui e ka hoʻopau ʻana i ka pane o ka hoʻowahāwahā e hāʻawi ai i nā ʻōuli o ka plake psoriasis.

Hoʻokomo ʻia nā lāʻau biologic e like me adalimumab (Humira), etanercept (Enbrel), a me infliximab (Remicade) i loko o ke kino.

ʻO nā lāʻau olaola ʻē aʻe i hoʻopili ʻia:

• Ustekinumab (IL-12/23 mea kāohi)
• secukinumab (IL-17A mea kāohi)
• ixekizumab (IL-17A mea kāohi)
• guselkumab (IL-23 mea kāohi)
• risankizumab (IL-23 mea kāohi)

ʻO Tofacitinib kahi mea kāohi ʻo Janus kinase (JAK) i ʻae ʻia ma ke ʻano he lapaʻau waha.

ʻO Abatacept kahi mea hoʻowalewale T-cell activation i hāʻawi ʻia ma ke ʻano he infravenous (IV) infusion a i ʻole kahi injection.

Nā pono kūpono

Paipai ʻia ʻo Apremilast no ka poʻe e noho ana me ka psoriasis kaulike a koʻikoʻi hoʻi ka poʻe moho no ka systemic therapy a i ʻole phototherapy.

I, ʻo ka hapa nui o ka poʻe e lawe ana i ka apremilast i helu maikaʻi ʻia ma nā helu helu ʻelua o ka Kauka (sPGA) a me ka Area Psoriasis a me Severity Index (PASI) i ka poʻe e lawe ana i kahi placebo.

Nā hopena a me nā ʻōlelo aʻoaʻo

ʻOiai ʻo PDE4 mea hōʻoki e hōʻike i ka hoʻohiki nui, ʻaʻole ia na ka poʻe āpau. ʻAʻole i ho'āʻo ʻia ʻo Apremilast i nā wahine hāpai a hānai paha. I kēia manawa, ʻae wale ʻia no nā mākua.

He mea nui nō hoʻi e kaupaona i nā pilikia a me nā pono o nā mea kūpale PDE4.

Hele mai ʻo Apremilast me kekahi mau pilikia ʻike ʻia.

E ʻike paha ka poʻe e lawe ana i ka apremilast i nā hopena e like me:

• nausea
• pāhoehoe
• maʻi maʻi maʻi luna o luna
• ʻeha poʻo

ʻIke kekahi poʻe i ka pohō kaumaha nui.

Hiki i ka Apremilast ke hoʻonui i ka manaʻo kaumaha a me nā manaʻo o ka pepehi kanaka.

No ka poʻe me ka mōʻaukala kaumaha a i ʻole ka hana suicidal, ua ʻōlelo ʻia e kamaʻilio pū lākou me kā lākou kauka e kōkua pono iā lākou e kaupaona pono i nā pono kūpono o ka lāʻau e kūʻē i nā pilikia.

Inā ʻike ʻoe i nā hopena ʻē aʻe, hiki i kāu kauka ke koi aku e hōʻoki i ka lāʻau.

ʻO ka lawe lawe ʻana

He maʻi hoʻomau ʻo Psoriasis - akā hiki ke mālama ʻia - kūlana. ʻO ka hana a ka mumū ka mea nui o ka mālama ʻana a me ka noiʻi ʻana.

Inā hoʻoholo kāu kauka i kāu lāʻau plaque psoriasis akahai a mālama maikaʻi ʻia paha, ʻōlelo paha lākou i nā lāʻau anti-inflammatory nonsteroidal (NSAID). Paipai paha lākou i nā mālama kumuhana.

E hoʻāʻo paha lākou i kēia mau ʻōlelo aʻoaʻo ʻelua ma mua o ka noʻonoʻo ʻana i ka hoʻohana ʻana o kahi mea kāohi PDE4 a i ʻole nā ​​modulator pale ʻē aʻe.

Ua ʻike nā mea noiʻi i nā mea hou aʻe e pili ana i nā ʻano hana i loko o ke kino e hoʻonā ai i ka mumū. Ua kōkua kēia ʻike i ka hoʻomohala ʻana i nā lāʻau hou i hiki ke hāʻawi i ke kōkua no ka poʻe e noho ana me ka psoriasis.

ʻO nā mea kāohi PDE4 nā mea hou loa, akā hele mai lākou me nā pilikia. Pono ʻoe a me kāu kauka e noʻonoʻo pono i kēia mau mea ma mua o ka hoʻomaka ʻana i kahi ʻano lapaʻau hou.