Mea Kākau: Peter Berry
Lā O Ka Hana: 12 Iulai 2021
HōʻAno Hou I Ka Lā: 1 Kekemapa 2024
Anonim
How to Inject Orencia (abatacept)
Wikiō: How to Inject Orencia (abatacept)

Anter

He aha ʻo Orencia?

ʻO Orencia kahi lāʻau lapaʻau inoa inoa inoa hoʻohana ʻia e mālama i kēia mau ʻano.

  • Rheumatoid arthritis (RA). Ua ʻae ʻia ʻo Orencia no ka hoʻohana ʻana i nā mākua me ka RA haʻahaʻa. Hiki iā ia ke lawe hoʻokahi a i ʻole ka hui pū ʻana me nā lāʻau ʻē aʻe i hoʻohana ʻia e mālama iā RA.
  • Psoriatic arthritis (PsA). Ua ʻae ʻia ʻo Orencia no ka hoʻohana ʻana i nā mākua me PsA. Hiki iā ia ke lawe hoʻokahi a i ʻole me nā lāʻau ʻē aʻe i hoʻohana ʻia e mālama iā PsA.
  • ʻO ke kuʻi ʻōpiopio ʻōpio (JIA). Ua ʻae ʻia ʻo Orencia no ka hoʻohana ʻana i nā keiki o nā makahiki 2 a ʻoi aku me ka liʻiliʻi a paʻakikī JIA. No kēia kūlana, hiki i Orencia ke hoʻohana hoʻokahi a i ʻole me ka hoʻohui me kahi lāʻau ʻē aʻe i kapa ʻia ʻo methotrexate.

Loaʻa iā Orencia ka lāʻau abatacept, kahi lāʻau biologic. Hana ʻia nā meaolaola mai nā pūnaewele ola (e like me nā mea kanu a holoholona paha) ma mua o nā kemika.

Hele mai ʻo Orencia i ʻelua ʻano: kahi ʻano wai a me kahi ʻano pauda. Hiki iā ʻoe ke lawe i ka lāʻau i kekahi o kēia mau ʻano:


  • Hoʻokomo (IV) infusion. Hoʻohana ʻia ka pauka o Orencia e hana i kahi hopena wai i hoʻokomo ʻia i loko o kāu mau uaua. Loaʻa kēia ʻano ʻo Orencia i hoʻokahi ikaika: 250 milligrams (mg).
  • ʻĀpana ʻāpana. Hoʻokomo ʻia ka wai wai o Orencia ma lalo o kou ʻili. Loaʻa kēia ʻano ʻo Orencia i hoʻokahi ikaika: 125 milligrams i kēlā me kēia milliliter (mg / mL).

Ka hoʻokō ʻana

I nā noiʻi hoʻokolohua, ua maikaʻi ʻo Orencia i ka mālama ʻana i ka haʻahaʻa a RA koʻikoʻi. Ke hui pū ʻia me methotrexate, hana maikaʻi ʻo Orencia i ka hoʻomaikaʻi ʻana i nā hōʻailona o ka maʻi. I kēia mau noiʻi, ua hoʻohana ʻia nā helu ACR (i kapa ʻia ma hope o ke Kulanui ʻAmelika o Rheumatology) e ana i ka pane a ka poʻe i ka lāʻau. Loaʻa i kahi helu ACR o 20 i manaʻo ʻia ua hoʻomaikaʻi ʻia nā ʻōuli RA o ka poʻe e 20%.

ʻO ka poʻe e lawe ana iā Orencia me ka methotrexate, 62% i hōʻea i kahi helu ACR o 20 ma hope o 3 mau mahina. No nā poʻe e lawe ana i ka methotrexate me kahi placebo (lapaʻau me ka lāʻau ʻole hana), 37% ka hopena like.


Ua hana maikaʻi ʻo Orencia i ka poʻe e lawe wale ana iā Orencia, me ka ʻole o ka methotrexate. No ka poʻe e lawe nei iā Orencia wale nō, 53% i hōʻea i kahi helu ACR o 20 ma hope o 3 mau mahina. ʻO ka poʻe i loaʻa ʻole ka lāʻau me Orencia a i ʻole methotrexate akā i lawe i kahi placebo, 31% ka hopena like.

No ka 'ike hou aku e pili ana i ka pono o Orencia no nā kūlana ʻē aʻe, e ʻoluʻolu e ʻike i ka ʻāpana "hoʻohana ʻo Orencia" ma lalo.

ʻO Genera Orencia

Loaʻa ʻo Orencia ma ke ʻano he lāʻau lapaʻau inoa inoa wale nō. ʻAʻole i loaʻa i kēia manawa i ke ʻano biosimilar.

Hoʻohālikelike ʻia kahi lāʻau biosimilar i kahi lāʻau laulaha. ʻO kahi lāʻau laulā kahi kope o kahi lāʻau lapaʻau maʻamau (hoʻokahi i hana ʻia mai nā kemika). Hana ʻia kahi lāʻau biosimilar e like me ka lāʻau biologic (hoʻokahi i hana ʻia mai nā pūnaewele ola).

Loaʻa ka palekana a me ka pono o nā generics a me nā biosimilars like me ka lāʻau i hana ʻia e kope. Eia kekahi, mālama lākou i ke kumukūʻai ma mua o nā inoa inoa inoa inoa.

Nā hopena ʻaoʻao ʻo Orencia

Hiki i Orencia ke hana i nā hopena ʻoluʻolu a koʻikoʻi paha. Loaʻa i nā papa inoa aʻe kekahi o nā hopena ʻaoʻao nui i hiki ke hana ʻia i ka lawe ʻana iā Orencia. ʻAʻole pili kēia mau papa inoa i nā hopena ʻaoʻao āpau.


No ka ʻike hou aku e pili ana i nā hopena ʻē aʻe o Orencia, e kamaʻilio me kāu kauka a kauka paha. Hiki iā lākou ke hāʻawi iā ʻoe i nā ʻōlelo aʻoaʻo e pili ana i ka hana me nā hopena ʻē aʻe e hoʻonāukiuki paha.

Nā hopena ʻaoʻao hou aʻe

Hiki i nā hopena ʻaoʻao maʻamau o Orencia ke hoʻopili:

  • ʻo nā maʻi hanu luna, e like me ke anuanu maʻamau a i ʻole ka maʻi sinus
  • ʻeha poʻo
  • nausea

E hala paha ka hapa nui o kēia mau hopena i loko o kekahi mau lā a i ʻole ʻelua mau pule. Inā ʻoi aku ke koʻikoʻi a i ʻole hele aku, e kamaʻilio me kāu kauka a kauka paha.

Nā hopena hopena koʻikoʻi

ʻAʻole maʻamau nā hopena koʻikoʻi mai Orencia, akā hiki iā lākou ke hana. Kāhea koke i kāu kauka inā loaʻa nā hopena koʻikoʻi. Kāhea iā 911 inā manaʻo kou mau hōʻailona i ka hoʻoweliweli ola a i ʻole inā manaʻo ʻoe e loaʻa ana kahi pilikia olakino.

Nā hopena ʻē aʻe, i kūkākūkā ʻia ma lalo nei i nā "ʻaoʻao kikoʻī hopena," hiki ke hoʻopili i kēia mau mea:

  • nā maʻi kūpilikiʻi, e like me ka niumonia
  • hopena hopena maʻi ʻino
  • hepatitis B mea hoʻomaʻi reactivation (i ka lapalapa o ka mea hoʻomaʻi inā mea ia i loko o kou kino)
  • maʻi ʻaʻai

Nā kikoʻī hopena ʻaoʻao

E noʻonoʻo paha ʻoe i ka pinepine o kekahi mau hopena i hopena ʻia me kēia lāʻau, a i ʻole pili kekahi mau ʻaoʻao iā ia. Eia kekahi mau kikoʻī i nā hopena ʻē aʻe i hiki ʻole i kēia lāʻau ke kumu.

Nā maʻi nui

Hiki paha iā ʻoe ke kiʻekiʻe aʻe i ka loaʻa ʻana o nā maʻi ʻino ke lawe ʻoe iā Orencia. ʻO kēia no ka mea hiki i ka lāʻau lapaʻau ke hoʻemi i ka pale o kou pale pilikino iā ʻoe mai nā maʻi.

I nā noiʻi maʻi, 54% o ka poʻe e lawe ana iā Orencia i loaʻa i nā maʻi maʻi. Ua manaʻo ʻia nā maʻi ʻino i 3% o ka poʻe e lawe ana iā Orencia i loko o nā haʻawina. ʻO ka poʻe i lawe i kahi placebo (lapaʻau me ka lāʻau hoʻohana ʻole), 48% i loaʻa nā maʻi maʻi. Ua manaʻo ʻia nā maʻi ʻino he 1.9% o ka poʻe i lawe i ka placebo. ʻO nā maʻi nui loa e pili ana i nā ake māmā, ka ʻili, nā wahi urinary, kolona, ​​a me nā puʻupaʻa.

Hiki ke loli nā ʻōuli o kahi maʻi, e pili ana i ka ʻāpana o kou kino e hoʻopili ʻia. Pākuʻi ʻia lākou:

  • fiva
  • luhi loa
  • ʻūhā
  • nā ʻōuli like flu
  • mehana, ʻulaʻula, a ʻeha hoʻi nā wahi o kou ʻili

E hoʻomaopopo i kāu kauka inā loaʻa nā ʻōuli o kahi maʻi. Paipai paha lākou i kekahi mau hoʻokolohua e ʻike i ke ʻano o ka maʻi i loaʻa iā ʻoe. Inā pono, e kuhikuhi pū lākou i nā lāʻau e mālama ai i kāu maʻi.

I kekahi mau hihia, paʻakikī paha e mālama i nā maʻi kūpilikiʻi ʻoiai ʻoe e lawe nei iā Orencia. Inā loaʻa ʻoe i kahi maʻi, hiki i kāu kauka ke koi aku iā ʻoe e haʻalele iā Orencia a hiki i ka hala ʻana o kāu maʻi.

Eia kekahi, e makemake ana kāu kauka e hōʻoia ʻaʻohe ou maʻi tuberculosis (TB) ma mua o kou hoʻomaka ʻana e lawe iā Orencia. Hoʻopili ka TB i kou mau māmā, a malia paha ʻaʻole paha e hoʻokumu ʻia nā ʻōuli. Ke kumu ʻole ia o nā hōʻailona, ​​ʻaʻole paha ʻoe e ʻike he maʻi kāu. ʻO ka ʻike inā loaʻa ʻoe i ka maʻi ʻaʻai e kōkua i kāu kauka e hoʻoholo inā palekana ʻo Orencia e hoʻohana ai ʻoe.

Ka hopena hoʻowali

E like me ka nui o nā lāʻau, hiki i kekahi poʻe ke loaʻa i kahi hopena maʻi ma hope o ka lawe ʻana iā Orencia. I nā noiʻi hoʻokolohua, ma lalo o 1% o ka poʻe i lawe iā Orencia i loaʻa i kahi hopena maʻi. Hiki i nā ʻōuli o ke ʻano ʻāpiki mālie ke hoʻopili pū i:

  • ʻāwīwī o ka ʻili
  • ʻumeʻume
  • flushing (hoʻomehana a ʻulaʻula i kou ʻili)

Kākaʻikahi ka hopena maʻi ʻino ʻoi aku ka paʻakikī akā hiki. Hiki i nā ʻōuli o ke kūpilikiʻi ʻāpiki loa ke hoʻopili pū me

  • ʻōhū ma lalo o kou ʻili, maʻamau i kou lihilihi, lehelehe, lima, a mau wāwae paha
  • pehu o kou alelo, waha, a ʻāʻī paha
  • pilikia hanu

Kāhea koke i kāu kauka inā loaʻa iā ʻoe kahi maʻi maʻi ʻeha i Orencia. Kāhea iā 911 inā manaʻo kou mau hōʻailona i ka hoʻoweliweli ola a i ʻole inā manaʻo ʻoe e loaʻa ana kahi pilikia olakino.

Hepatitis B

Inā ua loaʻa ʻoe i ka maʻi hepitis B (HBV) i ka wā ma mua, makaʻu paha ʻoe no ka lele ʻana o ka maʻi (reactivate) ʻoiai ʻoe e lawe nei iā Orencia.

ʻO ka HBV kahi maʻi i loko o kou akepaʻa e ka maʻi maʻi. Lawe pinepine ka poʻe me HBV i nā lāʻau e kāohi ai i ka maʻi. Akā aneane hiki ʻole ke holoi holoʻokoʻa i ka maʻi mai kou kino.

Hoʻokumu paha ʻo Orencia i ka wela ʻana o HBV i kou kino. ʻO kēia no ka mea ua hoʻoliʻiliʻi ʻo Orencia i ka hiki o kāu ʻōnaehana pale pale e hakakā i ka maʻi. Inā hoʻoiho ka virus, hoʻi paha kāu mau ʻōuli o HBV, a e ʻoi aku paha ka maikaʻi o ke ʻano.

Pākuʻi ʻia nā ʻōuli o ka maʻi HBV:

  • luhi (nele o ka ikaika)
  • fiva
  • hoʻēmi ʻai
  • nawaliwali ana
  • ʻeha ma kou mau ami a i ʻole nā ​​mākala
  • hōʻoluʻolu i kou ʻōpū (ʻōpū)
  • mimi ʻeleʻele
  • jaundice (melemele o kou ʻili a i ʻole nā ​​keʻokeʻo o kou mau maka)

E hoʻomaopopo koke i kāu kauka inā loaʻa nā ʻōuli o HBV. Makemake paha kāu kauka e hōʻoia iā ʻoe no ka maʻi hepa B ma mua o kou hoʻomaka ʻana iā Orencia. Inā loaʻa iā ʻoe ka HBV, e mālama paha lākou i ka maʻi ma mua o ka hoʻomaka ʻana iā Orencia. ʻO ka mālama ʻana i ka HBV e kōkua pū i kāu maʻi e hele aku.

Kanesa

Hiki paha iā ʻoe ke hoʻonui i ka makaʻu o ka maʻi ʻaʻai inā lawe ʻoe iā Orencia. Hiki i kēia lāʻau ke hoʻololi i ke ʻano o ka hana ʻana o kāu mau pūnaewele a hoʻonui paha i ka wikiwiki o ka ulu ʻana o kāu mau pūnaewele a hoʻonui (e hoʻonui i nā pūnaewele.) Hiki i kēia mau hopena ke kumu i ka maʻi ʻaʻai.

I nā noiʻi maʻi, 1.3% o ka poʻe e lawe ana iā Orencia i ulu i ka maʻi ʻaʻai. ʻO ka poʻe i lawe ʻole iā Orencia, akā nāna i lawe kahi placebo (lapaʻau me ka lāʻau ʻole), 1.1% ka hopena like. I ka hapanui o nā hihia, ua kū ka maʻi ʻaʻai i nā māmā a me nā koko o nā kānaka.

ʻAʻole ʻike ʻia inā ua hoʻokumu ʻia ka maʻi ʻaʻai e ka hoʻohana ʻana iā Orencia. He mea hiki i nā mea ʻē aʻe ke hoʻokani i kāna hana.

Hiki ke loli nā ʻōuli o ke kanesa ma muli o ka wahi o kou kino i hoʻopili ʻia. Pākuʻi ʻia paha nā ʻōuli:

  • nā hoʻololi neurological (e like me ke poʻo o ke poʻo, ka hopu ʻana i ka maka, ka ʻike a i ʻole ka hoʻolohe ʻana i nā pilikia, a i ʻole ke lule ʻia i kou alo)
  • ʻoi aku ka maʻalahi o ke kahe ʻana a i ʻole ka palapū ʻana ma mua o ka maʻamau
  • ʻūhā
  • luhi (nele o ka ikaika)
  • fiva
  • pehu
  • puʻupuʻu
  • loaʻa kaupaona a hoʻemi kino paha

E haʻi i kāu kauka inā loaʻa iā ʻoe kekahi mau ʻōuli o ka maʻi ʻaʻai. Paipai lākou i kekahi mau hoʻokolohua e ʻike inā ua ulu ʻoe i ka maʻi ʻaʻai. Inā loaʻa ʻoe i ka maʻi ʻaʻai, e ʻōlelo lākou i ka lāʻau lapaʻau no ia. E kūkākūkā pū lākou me ʻoe inā paha he palekana ia nou e lawe iā Orencia.

ʻ Skinhū ʻili

I nā noiʻi hoʻokolohua, ʻaʻole pili ka ʻili i ka hopena koʻikoʻi i ka poʻe e lawe ana iā Orencia. ʻO nā poʻe me RA nāna i lawe iā Orencia, 4% i loaʻa kahi ʻōpala i ka wā o ke aʻo ʻana. ʻO ka poʻe i lawe i ka placebo (lapaʻau me ka lāʻau lapaʻau ʻole), 3% ka hū. Hiki ke hana i kahi ʻili māmā i kahi o kou kino kahi i pahu ʻia ai ʻo Orencia.

I kekahi mau hihia, hiki i ka ʻili ke lilo i hōʻailona o ka hopena maʻi. (E ʻike i ka ʻāpana "Allergic react" ma luna.)

Inā loaʻa iā ʻoe kahi ʻili o ka ʻili e hele ʻole a ke hoʻohana nei ʻoe iā Orencia, e haʻi i kāu kauka. E kamaʻilio lākou me ʻoe e pili ana i ka mea e hoʻonāukiuki ai kou ʻili. E nīnau paha lākou inā he mau hōʻailona kāu o ka hopena maʻi kūpilikiʻi koʻikoʻi. Inā loaʻa iā ʻoe kahi hopena maʻi ahulau, e kauoha ana kāu kauka i nā lāʻau e hōʻemi i kāu mau hōʻailona allergy, a ua hoʻokau paha lākou iā ʻoe me ka hoʻohana ʻana iā Orencia.

Kaumaha hoʻonui (ʻaʻole kahi hopena)

I ka wā o nā noiʻi haukapila, ʻaʻole ka hopena o ke kaumaha i ka poʻe e lawe ana iā Orencia.

Inā ʻoe e hopohopo e pili ana i ka loaʻa ʻana o ke kaumaha i ka wā e hoʻohana ana iā Orencia, e kamaʻilio me kāu kauka.

Lilo ka lauoho (ʻaʻole kahi hopena)

I nā noiʻi lapaʻau, ʻaʻole ka hopena o ka lauoho i ka poʻe e lawe ana iā Orencia. Akā hiki ke hāʻule ka lauoho i ka poʻe me kekahi ʻano o ka arthritis, me nā mea e hoʻohana ʻia ai ʻo Orencia e mālama ai.

E hoʻomaopopo i kāu kauka inā hopohopo ʻoe e pili ana i ka nalo ʻana o ka lauoho, a i ʻole inā he lauoho lauoho kāu e hoʻohana nei iā Orencia. Paipai paha lākou i nā hoʻokolohua e hoʻāʻo e ʻike i ke kumu o ka hana ʻana a hāʻawi i nā ala e kōkua ai iā ʻoe e kūleʻa i ka hopena ʻaoʻao.

Ka luhi (ʻaʻole kahi hopena)

ʻO ka luhi (nele o ka ikehu) ʻaʻole ia he hopena i ka poʻe e lawe ana iā Orencia i ka wā o nā noiʻi maʻi. Akā ʻo kekahi poʻe me nā ʻano like ʻole o ka arthritis (e like me ka mea i hoʻohana ʻia ʻo Orencia e mālama ai) e ʻike paha i ka luhi.

E haʻi i kāu kauka inā he luhi kou e hele ʻole ke hoʻohana nei ʻoe iā Orencia. Paipai lākou i kekahi mau hoʻokolohua e kōkua ai e ʻike i ke kumu o kou luhi. Inā pono, kauoha paha lākou i nā lāʻau e kōkua i ka hoʻoluhi i kou luhi.

ʻO ke ana ʻo Orencia

ʻO ka lāʻau Orencia i kuhikuhi ʻia e kāu kauka e pili ana i nā kumu he nui. Pākuʻi ʻia kēia mau mea:

  • ke ʻano a me ke koʻikoʻi o ke ʻano āu e hoʻohana nei iā Orencia e mālama ai
  • kou kaumaha
  • ke ʻano o Orencia āu e lawe ai

ʻO ka maʻamau, e hoʻomaka ke kauka iā ʻoe ma ka maʻa maʻamau. A laila e hoʻoponopono lākou iā ia i ka manawa e hiki ai i ka nui e kūpono iā ʻoe. E kauoha kauka loa i kāu kauka liʻiliʻi e hāʻawi i ka hopena i makemake ʻia.

Hōʻike ka ʻikepili aʻe i nā lāʻau i hoʻohana pinepine ʻia a koi ʻia paha. Eia nō naʻe, e mālama pono i nā lāʻau a ke kauka i kuhikuhi ai nāu. E hoʻoholo kāu kauka i ke ana ʻoi loa e kūpono i kāu mau pono.

Nā ʻano lāʻau a me nā ikaika

Hele mai ʻo Orencia i ʻelua ʻano: ka pauka a me ka wai. He mau ikaika ʻokoʻa ko kēia mau ʻano.

Pepa pauka

ʻO ka pauka:

  • loaʻa i hoʻokahi ikaika: 250 mg (milligrams)
  • ua hui ʻia me ka wai e hana i kahi hopena i hāʻawi ʻia iā ʻoe ma ke ʻano he infravenous (IV) infusion (kahi inikomo i kou aa i hāʻawi ʻia i ka manawa)

ʻAno wai

Ke ʻano wai:

  • loaʻa i hoʻokahi ikaika: 125 mg / mL (milligrams per milliliter)
  • Hāʻawi ʻia iā ʻoe ma ke ʻano he subcutaneous injection (kahi injection ma lalo o kou ʻili)
  • hele mai i nā syringes aniani prefilled e paʻa ana i 0.4 mL, 0.7 mL, a me 1.0 mL o ka wai
  • hele mai hoʻi i loko o kahi kīʻaha 1-mL i hoʻonoho ʻia i loko o kahi hāmeʻa i kapa ʻia ʻo ClickJect autoinjector

Nā hana no ka rheumatoid arthritis

ʻO ke ana o Orencia no ka rheumatoid arthritis (RA) ma muli o ka lawe ʻana i ka lāʻau. Hana ʻia nā hana no ka infravenous (IV) infusion a me subcutaneed injection i lalo.

Hoʻomoʻo intravenous

ʻO ke ana o Orencia no kēlā me kēia infusion IV e pili i ka kaupaona o kou kino. ʻO ka mahele maʻamau o Orencia ka:

  • 500 mg no ka poʻe kaupaona ma lalo o 60 kilokilo (ma kahi o 132 paona)
  • 750 mg no ka poʻe kaupaona 60 a 100 mau kilokilo (ma kahi o 132 a 220 mau paona)
  • 1,000 mg no ka poʻe kaupaona ma mua o 100 kilokilo (ma kahi o 220 paona)

E mālama ana kēlā me kēia IV infusion ma kahi o 30 mau minuke.

Ma hope o kāu mahele mua o Orencia, hāʻawi ʻia ʻoe i ʻelua mau lāʻau i kēlā me kēia 2 mau pule. Ma hope o kēlā, hāʻawi ʻia kēlā me kēia lāʻau kēlā me kēia 4 mau pule.

ʻĀpana ʻāpana

ʻO ka mahele maʻamau o Orencia no ka subcutaneous injection: 125 mg i kēlā me kēia pule.

ʻAʻole paha e hāʻawi ʻia kāu ʻāpana subcutaneus ma hope o ka loaʻa ʻana o kahi lāʻau ma mua o Orencia ma o ka infusion IV. Inā loaʻa iā ʻoe ka infusion IV o Orencia, lawe mau ʻoe i kāu inikopa subcutanea mua o ka lāʻau i ka lā ma hope o kāu lapaʻau IV.

Nā hana no ka psoriatic arthritis

ʻO ka mahele o Orencia no ka psoriatic arthritis (PsA) ma muli o ka lawe ʻana i ka lāʻau. Hana ʻia nā hana no ka infravenous (IV) infusion a me nā subcutaneous injection i lalo.

Hoʻomoʻo intravenous

ʻO ke ana o Orencia no kēlā me kēia infusion IV e pili i ka kaupaona o kou kino. ʻO ka mahele maʻamau o Orencia ka:

  • 500 mg no nā mea kaupaona ma lalo o 60 kilokilo (ma kahi o 132 mau paona)
  • 750 mg no nā mea kaupaona 60 a 100 mau kilokilo (ma kahi o 132 a 220 mau paona)
  • 1,000 mg no nā mea kaupaona ma mua o 100 kilokilo (ma kahi o 220 paona)

E mālama ana kēlā me kēia IV infusion ma kahi o 30 mau minuke.

Ma hope o kāu mahele mua o Orencia, hāʻawi ʻia ʻoe i ʻelua mau lāʻau i kēlā me kēia 2 mau pule. Ma hope o kēlā, hāʻawi ʻia kēlā me kēia lāʻau kēlā me kēia 4 mau pule.

ʻĀpana ʻāpana

ʻO ka mahele maʻamau o Orencia no ka subcutaneous injection he 125 mg hoʻokahi i kēlā me kēia pule.

Nā hana no ka ʻōpio idiopathic arthritis

ʻO ke ana o Orencia no ka ʻōpio idiopathic arthritis (JIA) ma muli o ka lawe ʻana i ka lāʻau. Hana ʻia nā hana no ka infravenous (IV) infusion a me nā subcutaneous injection i lalo.

Hoʻomoʻo intravenous

ʻO ke ana o Orencia no kēlā me kēia infusion IV hiki ke hilinaʻi i kāu kaumaha o kāu keiki a i kāu keiki paha. ʻO ke ana maʻamau o Orencia i nā keiki mai nā makahiki 6 a ʻoi paha:

  • 10 mg / kg (milligrams o ka lāʻau i kēlā kilogram o ke kaumaha o ke kino) no ka mea kaupaona ma lalo o 75 kilokilo (ma kahi o 165 paona)
  • 750 mg no nā mea kaupaona 75 kilokilo a me 100 kilokilo (ma kahi o 165 paona a i 220 paona)
  • 1,000 mg no ka poʻe kaupaona ma mua o 100 kg (ma kahi o 220 paona)

ʻO kahi laʻana, kahi mea kaupaona i 50 kilokilo (ma kahi o 110 paona) e lawe iā 500 mg o Orencia. ʻO 10 milligrams kēia o ka lāʻau no kēlā me kēia kilokilo o ko lākou kino kaupaona.

Ma hope o kāu a i kāu keiki i ka hopena mua o Orencia, hāʻawi ʻia i ʻelua mau lāʻau i kēlā me kēia 2 mau pule. Ma hope o kēlā, hāʻawi ʻia kēlā me kēia lāʻau kēlā me kēia 4 mau pule.

ʻAʻole koi ʻia ka hoʻomalu IV o Orencia i nā keiki ʻōpio ma mua o 6 mau makahiki.

ʻĀpana ʻāpana

ʻO ka mahele o Orencia no ka subcutaneous injection e kaukaʻi ʻia i kāu a i kāu keiki i ke kaumaha o ke kino. ʻO ka mahele maʻamau o Orencia i nā keiki mai 2 mau makahiki a ʻoi paha:

  • 50 mg no ka poʻe kaupaona 10 kilokika i lalo o 25 kilokilo (ma kahi o 22 paona a emi ma lalo o 55 paona)
  • 87.5 mg no nā mea kaupaona he 25 mau kilokika a emi iho ma mua o 50 kilokilo (ma kahi o 55 mau paona a emi iho ma kahi o 110 mau paona)
  • 125 mg no nā mea kaupaona 50 kilokika a ʻoi (ma kahi o 110 paona a ʻoi paha)

I ka poʻe makahiki 6 a ʻoi paha, hiki ke hāʻawi ʻia i kā lākou ʻoki mua ʻana iā Orencia ma hope o ka loaʻa ʻana iā IV i ka lāʻau. Inā ua hāʻawi ʻia kahi infusion IV o Orencia, hāʻawi pinepine ʻia ka subcutaneous injection i ka lā ma hope o ka IV infusion.

ʻĀpana pēpē

Hoʻololi ka mea maʻamau i koi ʻia o Orencia ma muli o ka lawe a me ke kino o ke kanaka e lawe ana. No ka ʻike hou aku e pili ana i ka mahele lāʻau i nā keiki, e ʻike i ka paukū “Dosage for juvenile idiopathic arthritis” ma luna.

He aha inā e haʻo wau i kahi lāʻau?

ʻO ka mea āu e hana ai no kahi mahele lāʻau hala e pili ana i ka lawe ʻana iā Orencia. Akā no nā hihia ʻelua, hiki i nā mea hoʻomanaʻo i nā lāʻau ke kōkua e hōʻoia ʻaʻole ʻoe e nalo i kahi lāʻau.

Hoʻomoʻo intravenous

Inā ua hala ʻoe i kahi manawa no kāu infusion IV o Orencia, e kelepona koke aku i kāu keʻena olakino. E hoʻolālā lākou i kahi manawa hou no ʻoe e loaʻa ai kāu lāʻau Orencia IV.

ʻĀpana ʻāpana

Inā ua hala ʻoe i kahi kaomi subcutaneous o Orencia, e kāhea koke aku i kāu kauka. E kōkua lākou iā ʻoe e hana i kahi papa hana maʻa hou e hāhai ai.

Pono wau e hoʻohana i kēia lāʻau lōʻihi?

Hiki paha iā ʻoe. Hoʻohana ʻia nā kūlana ʻo Orencia e mālama ai i nā maʻi mau (wā lōʻihi). Hiki paha ke hoʻohana ʻia ʻo Orencia i ka wā lōʻihi no ka hoʻomaʻamaʻa inā manaʻo ʻoe a me kāu kauka he palekana a maikaʻi kāu lāʻau.

Hoʻohana ʻo Orencia

Ua ʻae ka Food and Drug Administration (FDA) i nā lāʻau i kuhikuhi ʻia e like me Orencia e mālama i kekahi mau ʻano. Ua ʻae ʻia ʻo Orencia e mālama i ʻekolu mau ʻano ʻāpala: rheumatoid arthritis, psoriatic arthritis, and juvenile idiopathic arthritis.

ʻO Orencia no ka rheumatoid arthritis

Ua ʻae ʻia ʻo Orencia e mālama i ka rheumatoid arthritis (RA) ʻeleu i nā mākua. Hoʻohana ʻia ia i ka hapanui o nā mākua i loaʻa mau nā ʻōuli o ka maʻi.

ʻO RA kahi maʻi maʻi autoimmune nāna e hoʻopōʻino i kāu mau ami. Hiki i nā ʻōuli o RA ke hoʻopili i ka ʻeha, ka pehu ʻana, a me ka ʻoʻoleʻa i loko o kou kino.

Paipai ʻia ʻo Orencia e ka poʻe loea ma ke ʻano he lapaʻau no RA. Makemake paha kāu kauka iā ʻoe e hoʻohana hoʻokahi a i ʻole ka hui pū ʻana me nā lāʻau ʻē aʻe, e like me ka methotrexate. Kapa ʻia kēia mau lāʻau ʻē aʻe i kekahi manawa i nā maʻi antirheumatic (DMARD) e hoʻololi ai i ka maʻi.

Ka hopena no ka rheumatoid arthritis

I hoʻokahi hoʻokolohua hoʻokolohua, hāʻawi ʻia ʻo Orencia me ka methotrexate i ka poʻe 424 me ka RA kaulike a koʻikoʻi. Hāʻawi ʻia ʻo Orencia e ka infravenous (IV) infusion (kahi hoʻokomo i nā veins o nā kānaka). ʻO ka poʻe e lawe ana iā Orencia, 62% o ka poʻe i loaʻa ma kahi liʻiliʻi he 20% hōʻemi i kā lākou RA hōʻailona ma hope o 3 mau mahina o ka mālama ʻana. ʻO ka poʻe e lawe ana i kahi placebo (lapaʻau me ka lāʻau hana ʻole) me ka methotrexate, he 37% ka hopena like.

Ua nānā ʻia kahi noiʻi lapaʻau ʻē aʻe i ka mālama ʻana iā Orencia i ka poʻe me RA. Hāʻawi ʻia ka poʻe iā Orencia a me ka methotrexate. Akā i loko o kēia noi ʻana, ua hāʻawi ʻia ka hui pū ʻana o nā lāʻau lapaʻau e ka ʻāpana subcutaneus (kahi kuʻi ʻana ma lalo o ka ʻili o ka poʻe) i hoʻokahi hui. A hāʻawi ʻia kahi hui ʻē aʻe i nā lāʻau e IV infusion.

Ma hope o 3 mau mahina o ka mālama ʻana, 68% o ka poʻe e lawe ana i nā lāʻau e ka inikopa subcutaneus ma kahi o 20% e hoʻemi ana i kā lākou hōʻailona RA. Hoʻohālikelike ʻia kēia i ka 69% o ka poʻe i lawe i nā lāʻau i loko o ka infusion intravenous.

Orencia no ka psoriatic arthritis

Ua ʻae ʻia ʻo Orencia e mālama i nā mākua me ka psoriatic arthritis (PsA). Hoʻohana ʻia ia i ka hapanui o ka poʻe me nā ʻōuli hoʻomau o ka maʻi. ʻO ka ʻoiaʻiʻo, nā ʻōlelo koi a ka poʻe loea i kēia manawa e ʻōlelo nei e hoʻohana ana iā Orencia i kēia mau poʻe.

ʻO PsA kahi ʻano o ka maʻi kōpaʻa e kū i ka poʻe me psoriasis. ʻO nā ʻōuli o ke ʻano e komo pū me nā ʻulaʻula, ʻili, a me nā ʻeha pūhū.

Ka hopena no ka psoriatic arthritis

I hoʻokahi hoʻokolohua hoʻokolohua, hāʻawi ʻia ʻo Orencia i 40 mau kānaka me PsA e hoʻohana nei i ka infravenous (IV) infusion (kahi injection i loko o kā lākou uaua). Ma hope o 24 mau pule o ka mālama ʻana, 47.5% o ka poʻe e lawe ana iā Orencia ma kahi liʻiliʻi he 20% hōʻemi i kā lākou hōʻailona PSA. ʻO ka poʻe e lawe ana i kahi placebo (lapaʻau me ka lāʻau lapaʻau ʻole), 19% ka hopena like.

I loko o kahi noi hoʻokolohua ʻē aʻe, hāʻawi ʻia ʻo Orencia i ka 213 poʻe me PsA e hoʻohana ana i ka subcutaneous injection (kahi injection ma lalo o ko lākou ʻili). Ma hope o 24 mau pule o ka mālama ʻana, 39.4% o ka poʻe i lawe iā Orencia i loaʻa ma kahi o 20% ka hoʻēmi o kā lākou hōʻailona PSA. ʻO ka poʻe e lawe ana i kahi placebo (lapaʻau me ka lāʻau lapaʻau ʻole), 22.3% ka hopena like.

Orencia no ka ʻōpio idiopathic arthritis

Ua ʻae ʻia ʻo Orencia e hoʻomaʻamaʻa i ke ʻano o ke ʻano o ka ʻōpio idiopathic ʻōpio koʻikoʻi (JIA). ʻO kēia ʻano ke ʻano maʻamau o ka arthritis i nā keiki. Kuhi ia i ka ʻeha pū, ka pehu ʻana, a me ka ʻoʻoleʻa.

E hoʻohana ʻia ʻo Orencia i nā keiki kahi a JIA e hoʻopili ai i nā hapa nui o ko lākou kino. Ua ʻae ʻia no ka hoʻohana ʻana i nā keiki o nā makahiki 2 a ʻoi paha.

Paipai nā loea i kēia manawa e hoʻohana ana iā Orencia i kēia mau poʻe. Hiki ke hoʻohana ʻia ka lāʻau i hoʻokahi a i ʻole me ka methotrexate.

Ka hopena no ka ʻōpio idiopathic arthritis

I hoʻokahi hoʻokolohua hoʻokolohua, hāʻawi ʻia ʻo Orencia i nā keiki 190 me JIA i piha i nā makahiki 6 a 17 mau makahiki. Loaʻa nā kamaliʻi iā Orencia ma o ka infravenous (IV) infusion (kahi injection i loko o kā lākou uaua). ʻO ka hapa nui o nā keiki i loaʻa ka methotrexate. Ma ka hopena o ke aʻo ʻana, 65% o nā keiki e lawe ana iā Orencia ma ka liʻiliʻi he 30% hōʻemi i kā lākou mau hōʻailona JIA.

I loko o kahi noi hoʻokolohua ʻē aʻe, hāʻawi ʻia ʻo Orencia ma ke ʻano he subcutaneous injection (kahi kuʻi ʻana ma lalo o ko lākou ʻili) i nā keiki he 205 me JIA. Ua loaʻa nā keiki i nā lāʻau ʻē aʻe e mālama i kā lākou JIA, akā loaʻa nō naʻe iā lākou nā ʻōuli o ke ʻano. Ma ka hopena o ke aʻo ʻana, ua hoʻokō ʻo Orencia i ka hōʻemi ʻana i nā ʻōuli o JIA. Ua like nā hopena o kēia noi me nā hopena o ka noi IV infusion.

Orencia no nā kūlana ʻē aʻe

Mahalo paha ʻoe inā hoʻohana ʻia ʻo Orencia no nā kūlana ʻē aʻe. Ma lalo nā kūlana i hoʻohana ʻia ai ʻo Orencia i kahi manawa i kahi lepili e mālama ai. ʻO ka hoʻohana ʻana i ka lepili hōʻailona ʻo ia ka hoʻohana ʻana i ka lāʻau e mālama ai i kahi kūlana ʻoiai ʻaʻole ʻae ʻia e FDA e hana pēlā.

Orencia no ka lupus (hoʻohana inoa ʻole ʻia)

ʻAʻole ʻae ʻia ʻo Orencia e ka lāʻau lapaʻau i ka lupus, akā i kekahi manawa hoʻohana ʻia ka lepili no kēia ʻano.

Manaʻo kekahi poʻe loea hiki i Orencia ke kōkua i ka hōʻemi ʻana i nā hōʻailona o ka lupus. Akā ʻaʻole i hiki i nā noiʻi hoʻokolohua hou ke hōʻike i ka hoʻomaikaʻi ʻana o Orencia i kēia ʻano. Pono nā ʻike hou aku e ʻike pono inā palekana a maikaʻi ʻo Orencia e hoʻohana ai i ka poʻe me ka lupus.

E kamaʻilio me kāu kauka inā he lupus kou a hoihoi ʻoe e lawe iā Orencia. E kūkākūkā lākou i kāu mau koho lapaʻau me ʻoe a kuhikuhi i kahi lāʻau i palekana a maikaʻi hoʻi nāu.

Orencia no ka ankylosing spondylitis (ma lalo o ke aʻo ʻana)

ʻAʻole i ʻae ʻia ʻo Orencia e ka lāʻau e mālama i ka spondylitis ankylosing (AS). Eia kekahi, ʻaʻole koi ka poʻe loea i ka hoʻohana ʻana i ka lāʻau e mālama ai i kēia maʻi.

Akā ke hana ʻia nei kekahi mau noiʻi e loiloi i ka maikaʻi o ka mālama ʻana a Orencia iā AS. Pono e ʻike hou i ka ʻike hou inā he palekana a maikaʻi hoʻi ka lāʻau e mālama iā AS.

E kamaʻilio me kāu kauka inā he AS kāu a hoihoi ʻoe e lawe iā Orencia. E kūkākūkā lākou i kāu mōʻaukala lapaʻau a koi i ka lāʻau maikaʻi loa nāu.

ʻO Orencia no nā keiki

Ua ʻae ʻia ʻo Orencia e hoʻohana ʻia i nā keiki me ka liʻiliʻi a koʻikoʻi i ka maʻi ʻōpiopio idiopathic (JIA). No ka ʻike hou aku, e ʻike i ka ʻāpana ʻo "Orencia no ka ʻōpio idiopathic arthritis" ma luna.

Hoʻohana ʻo Orencia me nā lāʻau ʻē aʻe

Hiki ke hoʻohana wale ʻia ʻo Orencia a i ʻole hui pū ʻia me nā lāʻau ʻē aʻe. Paipai kāu kauka inā pono ʻoe e lawe i nā lāʻau ʻē aʻe me Orencia e mālama ai i kou ʻano. ʻOi aku paha kēia i ka poʻe me ka rheumatoid arthritis a i ʻole ka ʻōpio idiopathic ʻōpio.

ʻO Orencia me nā lāʻau ʻē aʻe no ka rheumatoid arthritis

Ua ʻae ʻia ʻo Orencia e mālama i nā mākua me ke kaulike a koʻikoʻi hoʻi i ka rheumatoid arthritis (RA). Hiki ke hoʻohana wale ʻia ka lāʻau lapaʻau a i ʻole me ka hui pū ʻana me nā lāʻau ʻē aʻe. Eia nō naʻe, inā e hoʻohana ʻia me nā lāʻau ʻē aʻe, ʻaʻole pono kēlā mau lāʻau i ka hui o nā lāʻau i kapa ʻia anti-TNF. (E ʻike i ka ʻāpana "Orencia interactions" ma lalo no nā kikoʻī hou aku.)

I ke aʻo ʻana i ka lāʻau lapaʻau, ua hana maikaʻi ʻo Orencia ke lawe ʻia me nā lāʻau ʻē aʻe e nā mākua me ka RA haʻahaʻa. ʻO nā lāʻau lapaʻau maʻamau i hāʻawi ʻia me Orencia nā lāʻau e hoʻololi ai i nā maʻi antirheumatic (DMARDs), me methotrexate.

ʻO Orencia me nā lāʻau ʻē aʻe no nā ʻōpio idiopathic ʻōpio

Ua ʻae ʻia ʻo Orencia e mālama i nā keiki me ka ʻōpio idiopathic arthritis (JIA). Ua ʻae ʻia ka lāʻau no ka hoʻohana wale a i ʻole me ka methotrexate.

I nā noiʻi hoʻokolohua, hana maikaʻi ʻo Orencia e mālama iā JIA i nā keiki ke hāʻawi ʻia ka lāʻau me ka methotrexate. A ʻo kahi hopena, koi nā poʻe loea i kēia manawa e hoʻohana ʻia ʻo Orencia me ka methotrexate ma mua o ka lawelawe ʻana iā JIA.

Nā koho ʻē aʻe iā Orencia

Loaʻa nā lāʻau ʻē aʻe i hiki ke mālama i kou ʻano. Kūpono paha kekahi iā ʻoe ma mua o nā poʻe ʻē aʻe. Inā makemake ʻoe i ka ʻimi ʻana i kahi ʻokoʻa i Orencia, e kamaʻilio me kāu kauka. Hiki iā lākou ke haʻi iā ʻoe e pili ana i nā lāʻau ʻē aʻe i hana maikaʻi iā ʻoe.

Kaha: Hoʻohana ʻia kekahi o nā lāʻau i helu ʻia ma aneʻi i ka lepili e mālama ai i kēia mau ʻano kikoʻī.

Nā koho ʻē aʻe no ka rheumatoid arthritis

Nā laʻana o nā lāʻau ʻē aʻe i hiki ke hoʻohana ʻia e mālama ai i ka rheumatoid arthritis (RA) me:

  • methotrexate (Otrexup, Rasuvo, Trexall, Xatmep)
  • sulfasalazine (Azulfidine, Azulfidine EN)
  • hydroxychloroquine (Plaquenil)
  • adalimumab (Humira)
  • certolizumab pegol (Cimzia)
  • etanercept (Enbrel)
  • golimumab (Simponi)
  • infliximab (Remicade, Inflectra, Renflexis)
  • tofacitinib (Xeljanz)

Nā koho ʻē aʻe no ka maʻi psoriatic

ʻO nā laʻana o nā lāʻau ʻē aʻe i hiki ke hoʻohana ʻia e mālama i ka psoriatic arthritis (PsA) me:

  • methotrexate (Otrexup, Rasuvo, Trexall, Xatmep)
  • sulfasalazine (Azulfidine, Azulfidine EN)
  • cyclosporine (Gengraf, Neoral, Sandimmune)
  • leflunomide (Arava)
  • apremilast (ʻOtezla)
  • adalimumab (Humira)
  • certolizumab pegol (Cimzia)
  • etanercept (Enbrel)
  • golimumab (Simponi)
  • infliximab (Remicade, Inflectra, Renflexis)
  • ustekinumab (Stelara)
  • secukinumab (Cosentyx)
  • ixekizumab (Taltz)
  • brodalumab (Siliq)
  • tofacitinib (Xeljanz)

Nā koho ʻē aʻe no nā ʻōpio idiopathic ʻōpio

Nā laʻana o nā lāʻau ʻē aʻe i hiki ke hoʻohana ʻia e mālama i nā ʻōpio idiopathic ʻōpio (JIA) me:

  • methotrexate (Otrexup, Rasuvo, Trexall, Xatmep)
  • sulfasalazine (Azulfidine, Azulfidine EN)
  • leflunomide (Arava)
  • adalimumab (Humira)
  • etanercept (Enbrel)
  • golimumab (Simponi)
  • infliximab (Remicade, Inflectra, Renflexis)
  • tocilizumab (Actemra)

ʻO Orencia vs. Humira

Mahalo paha ʻoe pehea e hoʻohālikelike ai ʻo Orencia i nā lāʻau ʻē aʻe i kuhikuhi ʻia no nā hoʻohana like. Maanei mākou e nānā ai pehea e like ai a ʻokoʻa ai hoʻi ʻo Orencia lāua ʻo Humira.

Generala

Loaʻa iā Orencia ka lāʻau abatacept. Loaʻa iā Humira ka lāʻau adalimumab. Hana ʻokoʻa kēia mau lāʻau i kou kino, a pili lākou i nā papa like ʻole o nā lāʻau.

Hoʻohana

Ua ʻae ʻia ʻo Orencia lāua ʻo Humira e ka Food and Drug Administration (FDA) e mālama i ke ʻano o ka rheumatoid arthritis (RA) a me psoriatic arthritis (PsA) i nā mākua. ʻAe ʻia kēia mau lāʻau e mālama i ka ʻōpio idiopathic arthritis (JIA) i nā keiki he 2 makahiki a ʻoi paha.

Ua ʻae ʻia ʻo Humira e mālama i nā ʻano aʻe:

  • ankylosing spondylitis i nā mākua
  • ʻO ka maʻi o Crohn i nā mākua a me nā keiki o nā makahiki 6 a ʻoi paha
  • ulcerative colitis i nā mākua
  • plaque psoriasis i nā mākua
  • hidradenitis suppurativa i nā mākua a me nā keiki o ka makahiki 12 a ʻoi paha
  • uveitis i nā mākua a me nā keiki o nā makahiki 2 a ʻoi paha

Nā ʻano lāʻau a me ka hoʻoponopono ʻana

Hele mai ʻo Orencia i ʻelua mau ʻano, i loaʻa nā ikaika ʻokoʻa. Penei kēia ʻano:

  • pepa pauka
    • loaʻa i hoʻokahi ikaika: 250 mg (milligrams)
    • ua hui ʻia me ka wai e hana i kahi hopena i hāʻawi ʻia iā ʻoe ma ke ʻano he infravenous (IV) infusion (kahi inikomo i kou aa i hāʻawi ʻia i ka manawa)
  • ʻano wai
    • loaʻa i hoʻokahi ikaika: 125 mg / mL (milligrams per milliliter)
    • Hāʻawi ʻia iā ʻoe ma ke ʻano he subcutaneous injection (kahi injection ma lalo o kou ʻili)
    • hele mai i nā syringes aniani prefilled e paʻa ana i 0.4 mL, 0.7 mL, a me 1.0 mL o ka wai
    • hele mai hoʻi i loko o kahi kīʻaha 1-mL i hoʻonoho ʻia i loko o kahi hāmeʻa i kapa ʻia ʻo ClickJect autoinjector

Hele mai ʻo Humira ma ke ʻano he hopena i hāʻawi ʻia e ka subcutaneed injection (kahi iniki ma lalo o kou ʻili). Loaʻa ia i nā ikaika ʻelua aʻe:

  • 100 mg / mL: hele mai i loko o nā hue i paʻa i 0.8 mL, 0.4 mL, 0.2 mL, a me 0.1 mL o ka hopena
  • 50 mg / mL: hele mai i loko o nā hue i paʻa i 0.8 mL, 0.4 ML, a me 0.2 mL o ka hopena

Nā hopena a me nā pilikia

Loaʻa i loko o Orencia lāua ʻo Humira nā lāʻau like ʻole. Akā pili nā lāʻau ʻelua i ka hana a kāu ʻōnaehana pale. No laila, hiki i nā lāʻau ʻelua ke hana i nā hopena ʻaoʻao like loa. Ma lalo nā hiʻohiʻona o kēia mau hopena ʻaoʻao.

Nā hopena ʻaoʻao hou aʻe

Aia i loko o kēia mau papa inoa nā laʻana o nā hopena ʻē aʻe i hiki ke hana ʻia me Orencia, me Humira, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me Orencia:
    • nausea
  • Hiki iā Humira:
    • ka hopena o ka ʻili ma kahi e puni ana i kāu pūnaewele injection
    • ʻāwīwī o ka ʻili
  • Hiki ke hana me Orencia a me Humira:
    • ʻo nā maʻi hanu luna, e like me ke anuanu maʻamau a i ʻole ka maʻi sinus
    • ʻeha poʻo

Nā hopena hopena koʻikoʻi

Loaʻa i kēia mau papa inoa nā laʻana o nā hopena ʻino e hiki ke hana me Orencia, me Humira, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me Orencia:
    • nā maʻi kūpilikiʻi, e like me ka niumonia
  • Hiki iā Humira:
    • nā pilikia me kāu ʻōnaehana ʻōnaehana (numbness a tingling paha, hoʻololi i kāu ʻike, nāwaliwali i kou mau lima a me kou mau wāwae, a i ʻole ka ʻōpala)
    • nā pae haʻahaʻa o kekahi mau huna koko, e like me nā hunaola keokeo a me nā platelet
    • nā pilikia puʻuwai, e like me ka maikaʻi ʻole o ka puʻuwai
    • nā maʻi ʻino, e like me ka maʻi puʻu (TB) *
    • nā pilikia o ke ake, e like me ke kō ʻole o ke ake
  • Hiki ke hana me Orencia a me Humira:
    • nā maʻi kūpilikiʻi
    • maʻi ʻaʻai *
    • hepatitis B mea hoʻomaʻi reactivation (flare-i o ka mea hoʻomaʻi inā ka mea, ua i loko o kou kino)
    • hopena hopena maʻi ʻino

Ka hoʻokō ʻana

Ua ʻae ʻia ʻo Orencia lāua ʻo Humira e mālama i ka rheumatoid arthritis, psoriatic arthritis, a me ka ʻōpio idiopathic arthritis. Hoʻohālikelike ʻia ka hopena o nā lāʻau ʻelua i ka mālama ʻana i kēia mau ʻano ma lalo.

Ka hopena i ka mālama ʻana i ka maʻi rumatika

Ua hoʻohālikelike pololei ʻia ʻo Orencia lāua ʻo Humira i kahi noiʻi hoʻokolohua ma ke ʻano he koho lapaʻau no ka rheumatoid arthritis (RA).

I kēia noi ʻana, he 646 mau mākua me ka RA kaulike a paʻakikī paha e lawe ana iā Orencia a i ʻole Humira: 318 poʻe i lawe iā Orencia, ʻoiai he 328 poʻe i lawe iā Humira. Lawe pū nā hui ʻelua o ka poʻe i ka methotrexate. Ma hope o 2 mau makahiki o ka mālama ʻana, like ka hopena o nā lāʻau ʻelua i ka mālama ʻana iā RA.

No nā poʻe e lawe ana iā Orencia, 59.7% o ka poʻe i loaʻa he 20% hōʻemi loa i kā lākou RA hōʻailona. No nā poʻe e lawe nei iā Humira, 60.1% i loaʻa ka hopena like.

Ka hopena i ka mālama ʻana i ka psoriatic arthritis

ʻAʻole hoʻohālikelike pololei ʻo Orencia lāua ʻo Humira i nā hoʻokolohua hoʻokolohua ma ke ʻano he koho lapaʻau no ka psoriatic arthritis (PsA). Akā ua loaʻa i kahi noiʻi ʻokoʻa ka maikaʻi o nā lāʻau ʻelua e mālama ai i ke ʻano.

Ka hopena i ka mālama ʻana i ka ʻōpio idiopathic ʻōpio

Ua hoʻohālikelike ʻia ʻo Orencia lāua ʻo Humira i kahi loiloi o nā noiʻi e like me nā koho lapaʻau no ka ʻōpio idiopathic arthritis (JIA). Ma hope o kēia loiloi, ʻike ka poʻe loea i ka like o ka palekana a me ka pono o nā lāʻau ʻelua.

Nā kumukūʻai

ʻO Orencia lāua ʻo Humira nā lāʻau lapaʻau inoa inoa ʻelua. ʻAʻohe o nā ʻano biosimilar o Orencia i loaʻa i kēia manawa. Hoʻohālikelike ʻia kahi lāʻau biosimilar i kahi lāʻau laulaha. ʻO kahi lāʻau laulā kahi kope o kahi lāʻau lapaʻau maʻamau (hoʻokahi i hana ʻia mai nā kemika). Hana ʻia kahi lāʻau biosimilar e like me ka lāʻau biologic (hoʻokahi i hana ʻia mai nā pūnaewele ola).

Loaʻa kahi lāʻau biosimilar iā Humira i kahi ʻano i hāʻawi ʻia e ka infravenous (IV) infusion. Paipai nā loea i ka hoʻohana ʻana i nā biosimilars e mālama iā RA, PsA, a me JIA ke palekana a maikaʻi hoʻi ia no kāu maʻi. E kamaʻilio me kāu kauka e ʻike inā kūpono kahi biosimilar no ʻoe.

ʻOi aku ke kumu kūʻai o nā lāʻau lapaʻau inoa inoa ma mua o ke kumu kūʻai biosimilar.

Wahi a nā koho ma GoodRx.com, ʻoi aku ka uku o Humira ma mua o Orencia. ʻO ke kumukūʻai maoli āu e uku ai no kēlā me kēia lāʻau e pili ana i kāu hoʻolālā ʻinikua, kou wahi, a me ka lāʻau kūʻai āu e hoʻohana ai.

Orencia vs. Enbrel

Mahalo paha ʻoe pehea e hoʻohālikelike ai ʻo Orencia i nā lāʻau ʻē aʻe i kuhikuhi ʻia no nā hoʻohana like. Maanei mākou e nānā ai pehea e like ai a ʻokoʻa ai hoʻi ʻo Orencia lāua ʻo Enbrel.

Generala

Loaʻa iā Orencia ka lāʻau abatacept. Loaʻa iā Enbrel ka lāʻau etanercept. Pili kēia mau lāʻau i nā papa like ʻole o nā lāʻau, a hana ʻokoʻa lākou i kou kino.

Hoʻohana

Ua ʻae ʻia ʻo Orencia a me Enbrel e ka Food and Drug Administration (FDA) e mālama i ka rheumatoid arthritis (RA) a me ka psoriatic arthritis (PsA) i nā mākua. Ua ʻae ʻia nā lāʻau ʻelua e mālama i ka ʻōpio idiopathic arthritis (JIA) i nā keiki he 2 makahiki a ʻoi paha.

Ua ʻae ʻia ʻo Enbrel e mālama i nā kūlana ʻē aʻe ʻelua:

  • ankylosing spondylitis i nā mākua
  • plaque psoriasis i nā mākua a me nā keiki o nā makahiki 4 a ʻoi

Nā ʻano lāʻau a me ka hoʻoponopono ʻana

Hele mai ʻo Orencia i ʻelua mau ʻano, i loaʻa nā ikaika ʻokoʻa. Penei kēia ʻano:

  • pepa pauka
    • loaʻa i hoʻokahi ikaika: 250 mg (milligrams)
    • ua hui ʻia me ka wai e hana i kahi hopena i hāʻawi ʻia iā ʻoe ma ke ʻano he infravenous (IV) infusion (kahi inikomo i kou aa i hāʻawi ʻia i ka manawa)
  • ʻano wai
    • loaʻa i hoʻokahi ikaika: 125 mg / mL (milligrams per milliliter)
    • Hāʻawi ʻia iā ʻoe ma ke ʻano he subcutaneous injection (kahi injection ma lalo o kou ʻili)
    • hele mai i nā syringes aniani prefilled e paʻa ana i 0.4 mL, 0.7 mL, a me 1.0 mL o ka wai
    • hele mai hoʻi i loko o kahi kīʻaha 1-mL i hoʻonoho ʻia i loko o kahi hāmeʻa i kapa ʻia ʻo ClickJect autoinjector

Hāʻawi ʻia ʻo Enbrel ma o ka injection subcutaneous. Hele mai ia i nā ʻano aʻe:

  • pepa pauka
    • loaʻa i hoʻokahi ikaika: 25 mg
    • hui ʻia me ka wai e hana i kahi hopena
  • ʻano wai
    • loaʻa i hoʻokahi ikaika: 50 mg / mL
    • hele mai i loko o nā kīʻaha e paʻa ana i 0.5 mL a me 1.0 mL o ka wai

Nā hopena a me nā pilikia

Loaʻa nā lāʻau ʻokoʻa i ʻO Orencia lāua ʻo Enbrel. Akā hana kēia mau lāʻau ʻelua i kāu ʻōnaehana pale. No laila, hiki i nā lāʻau ʻelua ke hana i nā hopena ʻaoʻao like loa. Ma lalo nā hiʻohiʻona o kēia mau hopena ʻaoʻao.

Nā hopena ʻaoʻao hou aʻe

Aia i loko o kēia mau papa inoa nā laʻana o nā hopena ʻē aʻe i hiki ke hana ʻia me Orencia a me Enbrel.

  • Hiki ke hana me Orencia:
    • nā maʻi, e like me ke anuanu maʻamau a i ʻole ka maʻi sinus
    • ʻeha poʻo
    • nausea
  • Hiki ke hana me Enbrel:
    • ka hopena o ka ʻili ma kahi e puni ana i kāu pūnaewele injection
  • Hiki ke hana me Orencia a me Enbrel:
    • ʻaʻohe hopena pili like

Nā hopena hopena koʻikoʻi

Aia i loko o kēia mau papa inoa nā laʻana o nā hopena ʻino e hiki ke hana ʻia me Orencia, me Enbrel, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me Orencia:
    • ʻaʻohe hopena koʻikoʻi koʻikoʻi
  • Hiki ke hana me Enbrel:
    • nā pilikia me kāu ʻōnaehana hopohopo (sclerosis he nui, ka hopu ʻana, ka pehu ʻana o nā ʻalolo)
    • nā pae haʻahaʻa o kekahi mau huna koko, e like me nā hunaola keokeo a me nā platelet
    • nā pilikia puʻuwai, e like me ka maikaʻi ʻole o ka puʻuwai
    • nā pilikia o ke ake, e like me ke kō ʻole o ke ake
    • nā maʻi ʻino, e like me ka maʻi puʻu (TB) *
  • Hiki ke hana me Orencia a me Enbrel:
    • maʻi ʻaʻai *
    • hepatitis B mea hoʻomaʻi reactivation (flare-i o ka mea hoʻomaʻi inā ka mea, ua i loko o kou kino)
    • nā maʻi kūpilikiʻi, e like me ka niumonia
    • hopena hopena maʻi ʻino

Ka hoʻokō ʻana

Ua ʻae ʻia ʻo Orencia lāua ʻo Enbrel e hoʻomaʻamaʻa i ka rheumatoid arthritis, psoriatic arthritis, a me ka ʻōpio idiopathic arthritis. Hoʻohālikelike ʻia ka hopena o nā lāʻau ʻelua i ka mālama ʻana i kēia mau ʻano ma lalo.

Ka hopena i ka mālama ʻana i ka maʻi rumatika

ʻAʻole i hoʻohālikelike pololei ʻia kēia mau lāʻau i nā hoʻokolohua hoʻokolohua. Akā ua loaʻa nā ʻimi ʻokoʻa i ka maikaʻi o Orencia a me Enbrel i ka mālama ʻana i ka rheumatoid arthritis (RA).

Ka hopena i ka mālama ʻana i ka psoriatic arthritis

ʻAʻole i hoʻohālikelike pololei ʻia kēia mau lāʻau i nā hoʻokolohua hoʻokolohua. Akā ua loaʻa i kahi ʻimi noiʻi ʻokoʻa he maikaʻi nā Orencia a me Enbrel i ka mālama ʻana i ka psoriatic arthritis (PsA).

Ka hopena i ka mālama ʻana i ka ʻōpio idiopathic ʻōpio

Ua nānā kahi loiloi o nā noiʻi i ka maikaʻi o ka hana a Orencia a me Enbrel e mālama ai i ka ʻōpio idiopathic arthritis (JIA) i nā keiki. I ka hopena o ka loiloi, ua ʻae ka poʻe loea i ka like o ka palekana a me ka pono o nā lāʻau ʻelua i ka mālama ʻana i kēia ʻano.

Nā kumukūʻai

ʻO Orencia lāua ʻo Enbrel nā lāʻau lapaʻau inoa inoa ʻelua. ʻAʻohe o nā ʻano biosimilar o Orencia i loaʻa i kēia manawa. Hoʻohālikelike ʻia kahi lāʻau biosimilar i kahi lāʻau laulaha. ʻO kahi lāʻau laulā kahi kope o kahi lāʻau lapaʻau maʻamau (hoʻokahi i hana ʻia mai nā kemika). Hana ʻia kahi lāʻau biosimilar e like me ka lāʻau biologic (hoʻokahi i hana ʻia mai nā pūnaewele ola).

Loaʻa kahi lāʻau biosimilar iā Enbrel i kahi ʻano i hāʻawi ʻia e ka infravenous (IV) infusion. Paipai nā loea i ka hoʻohana ʻana i nā biosimilars e mālama iā RA, PsA, a me JIA ke palekana a maikaʻi hoʻi ia no kāu maʻi. E kamaʻilio me kāu kauka e ʻike inā kūpono kahi biosimilar no ʻoe.

ʻOi aku ke kumu kūʻai o nā lāʻau lapaʻau inoa inoa ma mua o ke kumu kūʻai biosimilar.

Wahi a nā kuhi ma GoodRx.com, e uku ʻo Enbrel ma mua o Orencia. ʻO ke kumukūʻai maoli āu e uku ai no nā lāʻau ʻelua e pili ana i kāu hoʻolālā ʻinikua, kou wahi, a me ka lāʻau kūʻai āu e hoʻohana ai.

ʻO Orencia a me ka waiʻona

ʻAʻohe mea i ʻike ʻia ma waena o Orencia a me ka waiʻona. Akā ʻo ka inu nui ʻana i ka waiʻona e hoʻopōʻino paha i kāu mau hōʻailona arthritis a me ka holomua o ka maʻi. Eia kekahi, hiki ke launa pū ka waiʻona me nā lāʻau ʻē aʻe āu e lawe nei.

E kamaʻilio me kāu kauka e pili ana i ka nui o ka palekana o ka waiʻona iā ʻoe e inu ai. E kūkākūkā lākou i kāu hoʻoponopono ʻana o ka maʻi o kēia manawa a aʻoaʻo inā palekana ka ʻalekiko iā ʻoe e ʻai ai.

Nā launa pū ʻO Orencia

Hiki iā Orencia ke launa pū me nā lāʻau ʻē aʻe. Hiki iā ia ke launa pū me kekahi mau mea hoʻopihapiha a me kekahi mau meaʻai.

Hiki i nā launa like ʻole ke kumu i nā hopena like ʻole. ʻO kahi laʻana, hiki i kekahi mau pilina ke hoʻopilikia me ka maikaʻi o ka hana ʻana o ka lāʻau. Hiki i nā pilina ʻē aʻe ke hoʻonui i nā hopena a i ʻole e hoʻonui i ke koʻikoʻi.

Orencia a me nā lāʻau ʻē aʻe

Ma lalo nā papa inoa o nā lāʻau i hiki ke launa pū me Orencia. ʻAʻole i loko o kēia mau papa inoa nā lāʻau a pau e launa pū me Orencia.

Ma mua o ka lawe ʻana iā Orencia, e kamaʻilio me kāu kauka a me kāu kauka lāʻau. E haʻi iā lākou e pili ana i nā kuhikuhi āpau, nā mea kūʻai aku, a me nā lāʻau ʻē aʻe āu e lawe ai. E haʻi pū iā lākou e pili ana i nā wikamina, nā mea kanu, a me nā mea hoʻopiha āu e hoʻohana ai. Hiki ke kōkua i ka hāʻawi ʻana i kēia ʻike iā ʻoe e hōʻalo i nā launa ʻole.

Inā he mau nīnau kāu e pili ana i nā launa lāʻau e hoʻopili iā ʻoe, e nīnau i kāu kauka a kauka paha.

Nā anti-TNF

ʻO nā anti-TNF kahi hui o nā lāʻau i hoʻohana mau ʻia e mālama i ka rheumatoid arthritis (RA), psoriatic arthritis (PsA), a me ka ʻōpio idiopathic arthritis (JIA). Hana kēia mau lāʻau i ka hoʻopili ʻana a me ka pale ʻana i ka hana o kahi protein i kapa ʻia ʻo tumrosis factor (TNF).

Eia kekahi laʻana o nā lāʻau anti-TNF:

  • adalimumab (Humira)
  • etanercept (Enbrel)
  • infliximab (Remicade)

ʻO Orencia a me anti-TNF e hoʻohaʻahaʻa i ka hiki i kou kino e hakakā i nā maʻi hou a i ʻole nā ​​maʻi e kū nei.ʻO ka lawe pū ʻana i kēia mau lāʻau i hiki ke hoʻonui hou aʻe i kou makaʻu i ka loaʻa ʻana o nā maʻi hou a hoʻemi i kou hiki ke hakakā i nā maʻi i loko o kou kino.

E kamaʻilio me kāu kauka inā ʻoe e lawe a hoʻolālā paha e hoʻomaka i ka lawe ʻana i kahi lāʻau anti-TNF ke hoʻohana nei ʻoe iā Orencia. Hiki i kāu kauka ke kūkākūkā i kāu pono e pono ai a koi i nā lāʻau i palekana no ʻoe e lawe.

Nā lāʻau lapaʻau rumatika ʻē aʻe

ʻO Orencia a me nā lāʻau rheumatic ʻē aʻe, e like me Xeljanz, e hoʻopili i kāu ʻōnaehana pale. Hoʻoemi kēia mau lāʻau i kou hiki ke pale aku i nā maʻi. ʻO ka lawe ʻana iā Orencia me nā lāʻau rumatika ʻē aʻe e hoʻohaʻahaʻa nui loa i ka hiki o kāu ʻōnaehana pale. Hiki i kēia ke hoʻonui i kou makaʻi i nā maʻi.

E haʻi i kāu kauka inā lawe ʻoe i nā lāʻau rumatika ʻē aʻe ma waho o Orencia. Hiki i kāu kauka ke kauoha i nā hoʻokolohua e nānā ai i ka maikaʻi o ka hana ʻana o kāu ʻōnaehana pale kino a paipai i ka papa hana lapaʻau maikaʻi loa nāu.

ʻO Orencia a me nā mea kanu a me nā mea hoʻopili

ʻAʻole nā ​​mea kanu a hoʻopili paha i ʻike i ka launa pū ʻana me Orencia. Eia nō naʻe, pono ʻoe e nānā me kāu kauka a kauka paha ma mua o ka hoʻohana ʻana i nā mea hoʻopihapiha ʻoiai ʻoe e lawe ana iā Orencia.

Pehea e hana ai ʻo Orencia

Ua ʻae ʻia ʻo Orencia e mālama i kekahi mau maʻi autoimmune. Hana ia i kou kino e kōkua i ka hōʻemi ʻana i nā ʻōuli a hoʻolōʻihi i ka holomua (ʻoi aku ka maikaʻi) o kēia mau maʻi.

He aha nā maʻi autoimmune?

Pale kāu ʻōnaehana pale pale i kou kino i nā maʻi. Hana ia i kēia ma ka hoʻouka ʻana i nā koʻohune a me nā mea ʻino e komo i loko a i ʻole i loko o kou kino.

Akā i kekahi manawa huikau kāu ʻōnaehana pale, a hoʻomaka ia e hoʻouka i kāu mau pūnaewele ponoʻī. Inā kū ʻole ia, kumu ia nā maʻi autoimmune. Me kēia mau maʻi, hoʻouka kāu ʻōnaehana pale pale i nā hunaola e hana i nā kiko a me nā kino o kou kino.

Rheumatoid arthritis (RA), psoriatic arthritis (PsA), a me ka ʻōpio idiopathic arthritis (JIA) nā ʻano autoimmune āpau. ʻO kēia ke loaʻa iā ʻoe kēia mau ʻano, ke hoʻouka nei kāu ʻōnaehana pale pale i kou kino ponoʻī.

He aha ka hana a Orencia?

Hana ʻo Orencia ma ka hoʻopili ʻana i ʻelua protein (i kapa ʻia ʻo CD80 a me CD86) i loaʻa ma kekahi mau ʻōnaehana pale pale. Hoʻoikaika nā proteins CD80 a me CD86 i kahi ʻano ʻē aʻe o ke kikowaena pūnaewele immune, i kapa ʻia nā pūnaewele T. ʻO kāu mau pūnaewele T kahi ʻano kikoʻī o ke kikoʻī e kōkua i kāu ʻōnaehana pale pale i nā maʻi.

Ma ka hoʻopili ʻana i kēia mau protein, hoʻopau ʻo Orencia i nā pūnaewele T mai ka hana kūpono ʻana. Pale kēia i kāu ʻōnaehana pale pale mai ka hoʻouka ʻana i kāu mau huna iho, nāʻaʻaʻa, a me nā ʻokena.

Kōkua ʻo Orencia i ka lohi o ka holomua (worsening) o ka rheumatoid arthritis, psoriatic arthritis, a me ka ʻōpio idiopathic arthritis. Hoʻoemi ka lāʻau i nā ʻōuli o kēia mau ʻano, hōʻoluʻolu iā ʻoe.

Pehea ka lōʻihi o ka hana?

E hoʻomaka ʻo Orencia e hana i kou kino ke hoʻomaka ʻoe e lawe. Akā ʻo ka rheumatoid arthritis, psoriatic arthritis, a me nā ʻōpio idiopathic ʻōpio kahi ʻano e hoʻolōʻihi i ka manawa e mālama ai. I nā noiʻi hoʻokolohua, ua hoʻomaikaʻi ka poʻe i ko lākou pae ʻeha a me ka hana holoʻokoʻa ma waena o 3 mau mahina o ka hoʻomaka ʻana i ka lāʻau. Eia nō naʻe, e kū hoʻokahi ka pane a kēlā me kēia kanaka iā Orencia.

Lawe ʻia ʻo Orencia i lāʻau lapaʻau no ka wā lōʻihi. Hana ia i kēlā me kēia lā i kou kino e mālama i kāu ʻano. Inā kū ʻoe i ka lawe ʻana me ka wikiwiki, hoʻi hou paha kāu mau ʻōuli.

Mai hōʻoki i ka lawe ʻana iā Orencia ma hope o ka pau ʻana o kāu mau hōʻailona. Inā makemake ʻoe e haʻalele i ka lawe ʻana i kēia lāʻau, e kamaʻilio me kāu kauka. E loiloi lākou i kou kūlana a ʻike inā pono ʻoe e lawe iā Orencia.

ʻO Orencia a me ka hāpai ʻana

ʻAʻole lawa nā haʻawina i nā kānaka e ʻike pono inā palekana ʻo Orencia e hoʻohana ai i ka wā hāpai. Hōʻike nā haʻawina holoholona e pili paha iā Orencia i kahi fetus ulu inā hoʻohana ʻia i ka wā hāpai. Akā ʻaʻole kuhi mau ka noiʻi ʻana i nā holoholona i ka mea e hiki i nā kānaka.

E hoʻomaopopo i kāu kauka inā hāpai ʻoe a hāpai paha ʻoiai ʻoe e hoʻohana ana iā Orencia. E kūkākūkā lākou i kāu mau koho lapaʻau a hōʻoia inā palekana ka hoʻohana ʻana iā Orencia iā ʻoe e hana ai i ka wā o ka hāpai ʻana.

Loaʻa kahi papa inoa hāpai no nā wahine i lawe a i ʻole e lawe nei iā Orencia i ka wā hāpai. Inā hāpai ʻoe a lawe iā Orencia, hiki i kāu kauka ke noi iā ʻoe e hoʻopaʻa inoa. Hāʻawi ka papa inoa i nā kauka e hōʻiliʻili i ka ʻike e pili ana i ka palekana o ka hoʻohana ʻana ʻo Orencia i nā wahine hāpai. No ka ʻike ʻana i ka ʻike hou aku e pili ana i ke kākau inoa, kāhea iā 877-311-8972 a i ʻole kipa i ka pūnaewele kikoʻī.

ʻO Orencia a me ka kaohi hānau

ʻAʻole ʻike ʻia inā palekana ʻo Orencia i ka wā hāpai. Inā hiki iā ʻoe a i ʻole kāu ipo wahine ke hāpai, e kamaʻilio me kāu kauka e pili ana i kāu pono hānau pono ke hoʻohana nei ʻoe i kēia lāʻau.

ʻO Orencia a me ka hānai waiū

ʻAʻohe o nā noiʻi i loko o nā kānaka i nānā i ka palekana o ka hoʻohana ʻana o Orencia i nā wahine e hānai ana. Ua hōʻike ʻia nā noiʻi i nā holoholona i ka hele ʻana ʻo Orencia i ka waiū umauma o nā holoholona i hāʻawi ʻia i ka lāʻau. Akā ʻaʻole ʻike ʻia inā pili ka lāʻau i nā holoholona e ʻai i kēlā waiū umauma.

E hoʻomanaʻo i nā aʻo ʻana i nā holoholona ʻaʻole wānana mau i ka mea e hiki i nā kānaka.

E haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū a i ʻole ke hoʻolālā nei i ka hānai ʻana iā ʻoe e lawe ana iā Orencia. E paipai lākou i ke ala palekana loa iā ʻoe e hānai ai i kāu keiki.

ʻO ke kumukūʻai ʻo Orencia

E like me nā lāʻau āpau, hiki ke hoʻololi ke kumukūʻai o Orencia.

ʻO ke kumukūʻai maoli āu e uku ai ma muli o kāu hoʻolālā ʻinikua, kou wahi, a me ka lāʻau kūʻai āu e hoʻohana ai.

Kōkua kālā a me nā ʻinikua

Inā makemake ʻoe i kākoʻo kālā e uku no Orencia, a inā ʻoe e kōkua i ka hoʻomaopopo ʻana i kāu ʻinikua uhi, loaʻa ke kōkua.

Hāʻawi ʻo Bristol-Myers Squibb, ka mea hana o Orencia, i kahi papahana copay no ka poʻe e hoʻohana nei i ka ʻano injected ponoʻī o Orencia. No ka ʻike hou aku a e ʻike inā ua kūpono ʻoe no ke kākoʻo, kāhea iā 800-ORENCIA (800-673-6242) a i ʻole kipa i ka pūnaewele pūnaewele.

Inā ʻoe e loaʻa ana iā Orencia ma o nā infusions intravenous (IV), hiki iā ʻoe ke hoʻokaʻaʻike i ke kime kākoʻo kākoʻo ʻo Bristol-Myers Squibb Access e aʻo e pili ana i nā koho mālama kālā. No ka ʻike ʻana i ka ʻike hou aku, e kāhea iā 800-861-0048 a i ʻole kipa i ka pūnaewele pūnaewele.

Pehea e lawe ai iā Orencia

Pono ʻoe e lawe iā Orencia e like me kāu kauka a i ʻole nā ​​ʻōlelo aʻoaʻo mālama ola.

ʻO Orencia e ka hoʻokomo intravenous

I kekahi mau hihia, hiki i kāu kauka ke koi aku iā ʻoe e loaʻa iā Orencia ma o ka infravenous (IV) infusion (kahi injection i loko o kou aa i hāʻawi ʻia i ka manawa).

I kēia hihia, pono ʻoe e hoʻonohonoho i kahi manawa i kou keʻena mālama ola. Ke hele nei ʻoe i ke keʻena lapaʻau no kāu infusion, e lawe nā limahana lapaʻau iā ʻoe i kahi lumi ʻoluʻolu. E hoʻokomo lākou i kahi nila i loko o kou aa a hoʻopili i ka nila i kahi ʻeke i piha me ka wai i loaʻa iā Orencia.

E hoʻolōʻihi kāu infusion ma kahi o 30 mau minuke. I kēia manawa, e neʻe ka wai i loaʻa iā Orencia mai ka ʻeke IV, ma o ka nila, a i loko o kou aa.

Ma hope o kou loaʻaʻana i nā wai a pau o Orencia, e hoʻoneʻe ʻia ka nila mai kou aʻa. Makemake paha kāu kauka e nānā iā ʻoe no kekahi manawa ma mua o kou haʻalele ʻana i ke keʻena maʻi. Hana ʻia kēia e hōʻoia i ka loaʻa ʻole o nā hopena koʻikoʻi ma hope o kou loaʻa ʻana iā Orencia.

ʻO Orencia i lawe ʻia e ka injection subcutaneus

Hiki i kāu kauka ke koi aku iā ʻoe e loaʻa iā Orencia ma o kahi subcutaneed injection (kahi ʻoki i lalo o kou ʻili).

I ka manawa mua, makemake paha kāu mea mālama ola e hāʻawi iā ʻoe i kāu injection Orencia. ʻAe kēia iā lākou e wehewehe i ke kaʻina hana injection a hōʻike pololei iā ʻoe pehea e hana ai. Ma hope o ka hōʻike ʻana o kāu kauka iā ʻoe pehea e hana ai i nā inekiko Orencia, noi paha lākou iā ʻoe e hoʻomaka e hāʻawi iā ʻoe iho i nā injection o ka lāʻau.

Hiki ke hana ʻia i kēlā me kēia Orencia injection ma o nā ʻokoʻa ʻelua: kahi syringe i hoʻomākaukau ʻia a i ʻole kahi Clickinect autoinjector i hoʻomākaukau ʻia. E hele mai kēlā me kēia hāmeʻa me ke kiko kikoʻī o Orencia a kāu kauka i kau ai. ʻAʻole pono ʻoe e ana i kāu mahele lāʻau o Orencia no kēlā me kēia injection. E hāʻawi aku kāu mau kauka olakino iā ʻoe i nā ʻōkuhi a me nā kaʻina hana i ka hoʻohana ʻana i ka hāmeʻa i hāʻawi ʻia iā ʻoe.

E noi i kāu kauka inā ʻaʻole maopopo iā ʻoe e pili ana pehea e hika ai iā ʻoe iho iā Orencia. E nānā lākou i ke kaʻina me ʻoe. Hiki iā ʻoe ke kipa i ka pūnaewele Orencia e heluhelu hou aku ai e pili ana i ka hoʻopili ʻana iā ʻoe iho i ka lāʻau.

I ka manawa hea e lawe ai

Ke hoʻomaka nei ʻoe e lawe iā Orencia no ka manawa mua, e loaʻa iā ʻoe kahi papa hana hana. E lawe ʻoe iā Orencia e like me kēlā papa manawa.

Hiki i nā hoʻomanaʻo hoʻomanaʻo ʻana ke kōkua i ka mālama ʻana i kāu papa kuhikuhi.

ʻO nā nīnau maʻamau e pili ana iā Orencia

Eia nā pane i kekahi mau nīnau e nīnau pinepine ʻia e pili ana iā Orencia.

Hiki iaʻu ke lawe iā Orencia inā he COPD kaʻu?

Hiki paha iā ʻoe. Paipai ʻia ʻo Orencia i kekahi manawa no ka hoʻohana ʻana i ka poʻe me nā ʻano o ka maʻi ʻōpala i loaʻa pū kekahi i ka maʻi pulmonary obstructive maʻi (COPD). Akā e nānā pono ʻia kēia poʻe i ka hoʻohana ʻana i ka lāʻau.

Inā loaʻa iā COPD, hiki i ka lawe ʻana iā Orencia ke hoʻonui i kou makaʻu i ka loaʻa ʻana o kekahi mau hopena ʻaoʻao. I ka ʻoiaʻiʻo, hiki ke hoʻonui i kou makaʻu i ka loaʻa ʻana o ka paʻakikī koʻikoʻi me ka hanu ʻana. Inā loaʻa iā ʻoe ka COPD a ke hoʻohana nei ʻoe i kēia lāʻau, hiki i kāu kauka ke nānā pono iā ʻoe e mālama pono iā Orencia.

E haʻi i kāu kauka inā he COPD kāu a pilikia ʻoe i ka hanu ʻana ke lawe ʻoe iā Orencia. (E ʻike i ka ʻāpana "Kaʻi" ma lalo nei no ka ʻike hou aku.) Hiki i kāu kauka ke ʻōlelo inā palekana ʻo Orencia e hoʻohana ai ʻoe. Inā palekana ʻole ia, e kuhikuhi lākou i nā lāʻau ʻē aʻe i ʻoi aku ka palekana iā ʻoe.

Hiki iaʻu ke loaʻa i nā lāʻau āpau ke hoʻohana nei wau iā Orencia?

Hiki paha iā ʻoe ke loaʻa i kekahi mau lāʻau ākea i ka mālama ʻana o Orencia. Eia nō naʻe, ʻaʻole pono ʻoe e loaʻa nā lāʻau lapaʻau ola ke lawe ʻoe iā Orencia, a i ʻole no 3 mau mahina ma hope o kāu kau hope loa.

Loaʻa nā lāʻau āpau i kahi ʻano nāwaliwali o ka maʻi hoʻomaʻemaʻe a i ʻole ka bacteria. ʻOiai e lawe nei iā Orencia, ʻaʻole hiki i kāu ʻōnaehana pale pale ke pale aku i nā maʻi e like me ka maʻamau. Inā loaʻa iā ʻoe kahi lāʻau lapaʻau ola i ka wā e lawe ana ʻoe iā Orencia, loaʻa paha iā ʻoe ka maʻi i pale ʻia ka lāʻau lapaʻau iā ʻoe mai.

Inā loaʻa iā ʻoe kahi lāʻau lapaʻau ola ʻole i ka wā o Orencia lapaʻau, ʻaʻole maikaʻi paha ia e pale aku ai iā ʻoe mai ka maʻi i manaʻo ʻia. Akā ʻae ʻia ʻoe e kiʻi i kēia ʻano o nā lāʻau lapaʻau i ka wā o ka mālama ʻana.

E nānā pono nā mea āpau āpau āpau a i ʻole ʻo kāu keiki ma mua o ka hoʻomaka ʻana o ka hoʻomaʻamaʻa Orencia. Inā he nīnau kāu e pili ana i nā lāʻau āpau e pono ai, e kamaʻilio me kāu kauka. E paipai lākou inā hiki ke hoʻopaneʻe ʻia ka pale ʻana.

Inā loaʻa wau i kahi maʻi i ka wā e hoʻohana ana iā Orencia, hiki iaʻu ke lawe i kahi antibiotic?

Ae. ʻAʻohe mea i ʻike ʻia ma waena o Orencia a me nā lāʻau ʻaloʻalo.

Inā loaʻa ʻoe i kahi maʻi hou i ka wā e lawe ana ʻoe iā Orencia, e nīnau i kāu kauka inā pono ʻoe e lawe i kahi lāʻauʻaeʻa. Hiki iā lākou ke kuhikuhi i kahi antibiotic e holo pono ke lawe ʻia me Orencia.

Hiki iaʻu ke lawe iā Orencia ma ka home?

Aia ia i ka mea a kāu kauka e koi ai iā ʻoe e lawe iā Orencia.

Makemake paha kāu kauka iā ʻoe e lawe iā Orencia ma o kahi infravenous (IV) infusion. ʻO kēia ka mea e hāʻawi i kahi mea mālama ola i kahi nila i kou aa, a e loaʻa iā ʻoe ka lāʻau i loko o ke kui kele ma ke ʻano he infusion. I kēia hihia, ʻaʻole hiki iā ʻoe ke lawe iā Orencia ma ka home. Pono ʻoe e kipa i kahi keʻena olakino no kāu mālama ʻana.

Inā ʻole, makemake paha kāu kauka iā ʻoe e lawe iā Orencia ma o kahi subcutaneous injection. I kēia hihia, e injected ʻia ʻo Orencia me kahi nila ma lalo o kou ʻili. Pono e hana i ka ʻoki mua ma kahi keʻena mālama ola e nā limahana olakino. Akā ma hope o kēia, hiki iā ʻoe ke hoʻokomo iā Orencia iā ʻoe iho i ka home.

Hiki iaʻu ke hoʻohana iā Orencia inā loaʻa ka maʻi diabetes?

ʻAe, akā pono ʻoe e akahele inā ʻoe e lawe iā Orencia ma o ka infravenous (IV) infusion. I kēia hihia, hāʻawi ʻia ʻo Orencia ma ke ʻano he injection i loko o kou aa.

ʻO ke ʻano o Orencia i hoʻohana ʻia no nā infusions IV i loaʻa ka maltose. ʻAʻole holo kēia mea i loko o kou kino e mālama i kou ʻano, akā pili ia i ke ana ʻana o kekahi mau hāmeʻa i kāu mau kō kō kō. Ke hōʻike ʻia i ka maltose, e hōʻike paha kekahi mau mea nānā glucose (ke kō i ke kō) he ʻoi aku kou kiʻekiʻe o ke kō kō ma mua o kāu maoli.

E hoʻomaopopo i kāu kauka inā he maʻi diabetes ʻoe a ke lawe nei ʻoe iā Orencia ma o IV infusions. E paipai lākou i ke ala ʻoi loa no ʻoe e ana i kou mau kō kō i ka wā o ka lapaʻau.

Hiki iā Orencia ke kōkua me ka nalo ʻana o ka lauoho?

ʻAʻole i hōʻoia maikaʻi ʻo Orencia i ka hoʻōki ʻana i ka nalo ʻana o ka lauoho. ʻOiai ua loiloi kahi noiʻi hoʻokolohua i kona hoʻohana ʻana no ka nalo ʻana o ka lauoho, ua liʻiliʻi ka hoʻopaʻa ʻana a he 15 wale nō ka poʻe i komo.

E kamaʻilio me kāu kauka inā hopohopo ʻoe e pili ana i ka nalo ʻana o ka lauoho. E aʻo lākou iā ʻoe pehea e kū ai me ia a kauoha paha i ka lāʻau e kāohi iā ia.

Hiki iaʻu ke huakaʻi inā lawe wau iā Orencia?

ʻAe, hiki iā ʻoe ke huakaʻi, akā pono ʻoe e ʻike pono ʻaʻole ʻoe e haʻalele i kekahi o kāu mau kaha Orencia.

Inā ʻoe e loaʻa ana iā Orencia ma kahi keʻena mālama ola, e kamaʻilio me kāu kauka no kāu hoʻolālā huakaʻi. E ʻike lākou i ka papa hana o kāu hana keakea ʻole i kāu huakaʻi.

Inā hoʻokomo ʻoe iā ʻoe iho iā Orencia, e ʻike pono hiki iā ʻoe ke lawe pū me ʻoe i ka lāʻau inā pono ʻoe i kāu lāʻau i kou wā e haʻalele ai i ka home. E noi i kāu kauka a kauka paha e pili ana pehea e ʻūlū ai mālama iā Orencia ʻoiai ʻoe e huakaʻi nei.

Pono wau i kahi ʻae ma mua e kiʻi iā Orencia?

Aia ia i kāu hoʻolālā ʻinikua. Noi nā hoʻolālā ʻinikua he nui i kahi ʻae ma mua o ka loaʻa ʻana o kahi ʻinikua pilikino no Orencia.

No ke noi ʻana i ka ʻae ma mua, e hoʻopiha kāu kauka i nā palapala no kāu ʻoihana inikua. A laila e nānā hou ka ʻoihana ʻinikua i kēia palapala a e hōʻike iā ʻoe inā e uhi kāu hoʻolālā iā Orencia.

Nā palekana o Orencia

Ma mua o ka lawe ʻana iā Orencia, e kamaʻilio me kāu kauka e pili ana i kāu mōʻaukala olakino. ʻAʻole kūpono paha ʻo Orencia iā ʻoe inā loaʻa iā ʻoe kekahi ʻano olakino a i ʻole nā ​​mea ʻē aʻe e hoʻopili i kou olakino. Pākuʻi ʻia kēia mau mea:

  • Hoʻohana o nā lāʻau anti-TNF. Inā ʻoe e lawe i nā lāʻau anti-TNF (ʻo Humira, Enbrel, a me Remicade) me Orencia, hiki ke hoʻoliʻiliʻi nui ʻia ka hiki o kāu ʻōnaehana pale pale i nā maʻi. Hoʻonui kēia i kou makaʻi i nā mea ʻino, a i kekahi manawa hoʻoweliweli i nā ola. E kamaʻilio me kāu kauka e pili ana i nā lāʻau āpau āu e lawe nei ma mua o ka hoʻomaka ʻana iā Orencia.
  • Mōʻaukala o nā maʻi hou a latent paha. Inā loaʻa ʻoe i nā maʻi kūlohelohe (nā maʻi i hoʻi pinepine mai), ʻo ka lawe ʻana iā Orencia e hoʻonui ai i kou makaʻi o ka hoʻi pinepine ʻana. Inā loaʻa iā ʻoe nā maʻi latent (nā maʻi me ka ʻole o nā ʻōuli), hiki i ka lawe ʻana iā Orencia ke hoʻonui i kou makaʻu i ka loaʻa ʻana o kahi maʻi maʻi. ʻO nā maʻi latent maʻamau ka maʻi tuberculosis (TB) a me ka maʻi hepitis B. E kamaʻilio me kāu kauka e pili ana i kāu mōʻaukala o nā maʻi ma mua o ka hoʻomaka ʻana iā Orencia.
  • Pono no nā lāʻau āpau. Inā loaʻa iā ʻoe nā lāʻau lapaʻau ʻoiai ʻoe e lawe ana iā Orencia, ʻaʻole holo pono paha nā lāʻau lapaʻau i kou kino. E kamaʻilio me kāu kauka e pili ana i nā lāʻau āpau āu e pono ai ma mua o kou hoʻomaka ʻana e lawe iā Orencia.
  • ʻO ka maʻi pulmonary obstructive maʻi (COPD). Inā loaʻa iā ʻoe ka COPD, lawe paha ʻo Orencia i mea e hōʻino ai i kāu mau hōʻailona COPD. Ma muli o kēia, pono paha ʻoe e nānā pono inā lawe ʻoe i kēia lāʻau. Inā loaʻa iā ʻoe kahi moʻolelo o COPD, e kamaʻilio me kāu kauka ma mua o kou hoʻomaka ʻana e lawe iā Orencia.
  • ʻO ka hopena maʻi ʻino loa iā Orencia. ʻAʻole pono ʻoe e lawe iā Orencia inā loaʻa iā ʻoe kahi hopena maʻi ʻino i ka lāʻau i ka wā i hala. Inā kānalua ʻole ʻoe inā ua loaʻa iā ʻoe kahi maʻi maʻi ʻino nui, e kamaʻilio me kāu kauka ma mua o ka hoʻomaka ʻana iā Orencia.
  • Hapai keiki. ʻAʻole i aʻo ʻia ka hoʻohana ʻana ʻo Orencia i ka wā hāpai. E kamaʻilio me kāu kauka e pili ana inā palekana ʻo Orencia e hoʻohana i ka wā o ka hāpai ʻana. No ka 'ike hou aku, e nānā i ka mahele "Orencia a hāpai" ma luna.
  • Hānai umauma. ʻAʻole maopopo leʻa inā palekana ʻo Orencia i ka wā e hānai ana ʻoe. No ka ʻike hou aku, e ʻoluʻolu e ʻike i ka ʻāpana "Orencia a me ka hānai ʻana" ma luna.

Kaha: No ka ʻike hou aku e pili ana i nā hopena maikaʻi ʻole o Orencia, e ʻike i ka ʻāpana "ʻaoʻao Orencia" ma luna.

ʻO Ordosis overdose

ʻO ka hoʻohana ʻana i nā mea i ʻoi aku i ka lāʻau i koi ʻia o Orencia hiki ke alakaʻi i nā hopena ʻino. No ka ʻike hou aku e pili ana i nā hopena koʻikoʻi, e ʻoluʻolu e ʻike i ka ʻāpana "Orencia ʻaoʻao" ma luna aʻe.

He aha e hana ai inā he overdose

Inā manaʻo ʻoe ua lawe nui ʻoe i kēia lāʻau, e kāhea i kāu kauka. Hiki iā ʻoe ke kāhea i ka ʻAmelika Hui Pū ʻIa o nā Poison Control ma 800-222-1222 a i ʻole hoʻohana i kā lākou mea hana pūnaewele. Akā inā koʻikoʻi kāu mau ʻōuli, e kāhea iā 911 a i ʻole e hele koke i kahi lumi pilikia kokoke.

Pau ʻO Orencia, mālama, a hoʻolei

Ke kiʻi ʻoe iā Orencia mai ka hale kūʻai lāʻau, e hoʻohui ka kauka i kahi lā palena pau i ka lepili ma ka ʻōmole. ʻO kēia lā he 1 mau makahiki ia mai ka lā a lākou i hāʻawi ai i ka lāʻau.

Kōkua ka lā palena i ka hōʻoia ʻana i ka maikaʻi o nā lāʻau i kēia manawa. ʻO ke kūlana o ka Food and Drug Administration (FDA) i kēia manawa e hōʻalo i ka hoʻohana ʻana i nā lāʻau i make. Inā loaʻa iā ʻoe kahi lāʻau i hoʻohana ʻole ʻia i hala i ka lā palena pau, e kamaʻilio me kāu kauka lāʻau e pili ana inā hiki paha iā ʻoe ke hoʻohana.

Waihona

Pehea ka lōʻihi o ka maikaʻi o ka lāʻau e hiki ai ke hilinaʻi i nā kumu he nui, e like me pehea a ma hea ʻoe e mālama ai i ka lāʻau.

Pono e mālama ʻia ʻo Orencia i loko o ka pahu hau ma kahi mahana o 36 ° F a 46 ° F (2 ° C a 8 ° C). Pono ʻoe e mālama i ka lāʻau i pale ʻia mai ka mālamalama a mālama ʻia i loko o nā ʻōpala kumu. ʻAʻole ʻoe e ʻae iā Orencia (i loko o nā syringes prefilled a i ʻole ClickJect autoinjectors) e paʻa.

Hoʻolei

Inā ʻaʻole ʻoe e pono hou e lawe iā Orencia a loaʻa nā lāʻau i koe, he mea nui ia e hoʻolei aku me ka palekana. Kōkua kēia i ka pale aku i nā poʻe ʻē aʻe, e like me nā keiki a me nā holoholona, ​​mai ka lawe lāʻau ʻana ʻole. Mālama pū kekahi ia i ka lāʻau mai hōʻino i ke kaiapuni.

Hāʻawi ka pūnaewele FDA i nā ʻōlelo aʻoaʻo e pili ana i ka hoʻolāʻau lāʻau. Hiki iā ʻoe ke nīnau i kāu kauka lāʻau no ka ʻike e pili ana i ka hoʻolilo ʻana i kāu lāʻau.

ʻO ka ʻike ʻoihana no Orencia

Hāʻawi ʻia ka ʻike aʻe no nā kauka lapaʻau a me nā ʻoihana ola.

Nā Hōʻike

ʻO Orencia kahi lāʻau biologic i hōʻike ʻia no ka mālama ʻana i:

  • ʻeleu, lōpū a hiki i ka nui rheumatoid arthritis (RA) i nā mākua
  • ʻeleu psoriatic arthritis (PsA) i nā mākua
  • ʻeleu, haʻahaʻa a koʻikoʻi i ka polyarticular juvenile idiopathic arthritis (JIA) i nā keiki he 2 makahiki a ʻoi paha

No ka hoʻomaʻamaʻa RA, hiki i Orencia ke hoʻohana hoʻokahi, a i ʻole polytherapy inā hoʻohui ʻia me nā lāʻau antirheumatic (DMARD) e hoʻololi ai i ka maʻi. No ka mālama ʻana iā JIA, hiki i Orencia ke hoʻohana hoʻokahi a i ʻole me ka methotrexate.

Nānā ʻole ʻia i ke ʻano i mālama ʻia, ʻaʻole pono e lawelawe pū ʻia ʻo Orencia me kahi lāʻau anti-TNF.

Mekanism o ka hana

Hoʻopili ʻo Orencia i ka cell-proteins CD80 a me CD86, i loaʻa i ka membrane pūnaewele o nā cell antenting presenting. Hoʻopili kēia paʻa i ka hoʻonāukiuki o ka protein CD28. Pono ka CD28 e hoʻāʻo i nā T-lymphocytes. ʻO ka hoʻoulu ʻana o T-lymphocytes he mea nui i ka hopena o RA a me PsA.ʻO ka pale ʻana i kēia hoʻoulu ʻana e hoʻemi ana i ka holomua o kēia mau maʻi.

Hōʻike nā noiʻi i loko o ka vitro i ka paʻa ʻana i CD80 a me CD86 i loaʻa nā hopena pūnaewele hou aʻe. Ma ka māka ʻana i nā T-lymphocytes, hoʻemi ʻo Orencia i kā lākou hoʻolaha ʻana. Hoʻopili pū ia i ka hana ʻana o nā cytokine kī i mea nui no nā hopena pale pale. ʻO kēia mau cytokine me TNF-alpha, INF-gamma, a me IL-2.

Eia kekahi, ua hōʻike nā hiʻohiʻona holoholona i nā hopena hou aʻe i nānā ʻia ma hope o ka hoʻoponopono ʻana o Orencia. Ua hōʻike ʻia nā noiʻi e hiki iā Orencia ke kāohi i ka mumū a hoʻemi i ka hana ʻana o nā meaola i kūʻē i ka collagen Hiki iā ia ke kaupalena i ka hana ʻana o nā antigens i māka INF-gamma. Inā paha he mea nui kēia mau hana no ka pono olakino o Orencia i ʻike ʻole ʻia.

Pharmacokinetics a me ka metabolism

Hoʻololi nā lāʻau lapaʻau a me nā metabolism o Orencia e pili ana i ke ʻano o ka mālama ʻana. Hoʻololi pū kekahi lākou i ke ala o ka hoʻokele.

Hōʻike nā noiʻi i nā lāhui hoʻomanawanui āpau i ke ʻano o ka ʻae ʻana i nā lāʻau ʻoi aku me ke kaumaha o ke kino. Eia nō naʻe, ʻaʻohe loli nui o ka ʻae i hōʻike ʻia ma waena o ka hoʻohana i nā poʻe o nā makahiki a i ʻole ke kāne. I nā noiʻi ʻana, ʻaʻole hoʻohana ka methotrexate, anti-TNFs, NSAIDs, a i ʻole corticosteroids i kahi ʻano nui i ka ʻae.

RA: Hoʻokele i loko o ka huhū

ʻO nā hana he nui o 10 mg / kg i nā mea maʻi me ka rheumatoid arthritis (RA) i alakaʻi ʻia i kahi kiʻekiʻe kiʻekiʻe o 295 mcg / mL. ʻIke ʻia ka hapalua ola Terminal ma ka lā 13.1, me ka ʻae o 0.22 mL / h / kg.

I nā mea maʻi me RA, ua hoʻonui like ʻo Orencia ma waena o nā mea hana a me ka noʻonoʻo nui. ʻO ka pilina ma waena o nā mea hana a me nā wahi ma lalo o ka piko (AUC) e ukali i ke ʻano like. Eia kekahi, piʻi ka nui o ka mahele i ka lakio o 0,07 L / kg.

Ma hope o nā mahele lāʻau he 10 mg / kg, ʻike ʻia ke kūlana paʻa i ka lā 60. ʻO ka paʻa paʻa paʻa i hōʻea i 24 mcg / mL.

ʻAʻole mālama ka malama o Orencia i ka hōʻuluʻulu ʻōnaehana o ka lāʻau.

RA: Ka lawelawe ʻana ma lalo o ka ʻāina

Ke mālama ʻia ma lalo o ka honua, hiki i Orencia i ka palena iki a me nā kiʻekiʻe kiʻekiʻe o 32.5 mcg / mL a me 48.1 mcg / mL, i kēlā me kēia lā, ma ka lā 85 2.

Hōʻea ka ʻae pūnaewele i 0.28 mL / h / kg, me ka nui o ka lakio hoʻokaʻawale o 0.11 L / kg. ʻO ka bioavailability subcutaneous ka 78.6%., Me kahi hapa hapalua o ke ola o 14.3 mau lā.

PsA: Ka lawelawe kūwaho

Hōʻike ʻo Orencia i nā pharmacokinetics linear ma nā lāʻau ma waena o 3 mg / kg a me 10 mg / kg. Ke lawelawe ʻia ma 10 mg / kg, hiki ʻo Orencia i nā paʻa paʻa paʻa i ka lā 57. ʻO ke kikowaena ʻōnaehana geometric ʻo 24.3 mcg / mL i ka lā 169.

PsA: ʻOihana hoʻokele

ʻO ka hoʻokele subcutaneous pule o Orencia 125 mg ke alakaʻi i kahi kikowaena geometric o 25.6 mcg / mL i ka lā 169. Ua hiki ke kūlana paʻa i ka lā 57.

JIA: Hoʻokele intravenous

I nā keiki mai 6 a 17 mau makahiki, ua hōʻea ʻo Orencia i ka palena iki a me nā kiʻekiʻe kiʻekiʻe o 11.9 mcg / mL a me 217 mcg / mL, ma ke kūlana paʻa. ʻO 0.4 ka mL / h / kg ka ʻae ʻana.

ʻAʻole loaʻa nā aʻo ʻana o ka Pharmacokinetics no nā keiki ma lalo o 6 mau makahiki e like me Orencia ma o ka infravenous infusion i ʻae ʻia no ka hoʻohana ʻana i kēia heluna kanaka.

JIA: ʻOihana hoʻokele

I nā keiki mai 2 a 17 mau makahiki, hoʻokau ka subcutaneous pule o Orencia i kahi kūlana paʻa i ka lā 85.

ʻOkoʻa ka manaʻo nui o Orencia ma muli o nā ana. I ka lā 113, ua hōʻea ʻo Orencia i nā kukuna o 44.4 mcg / mL, 46.6 mcg / mL, a me 38.5 mcg / mL ma nā mahele lāʻau o 50 mg, 87.5 mg, a me 125 mg.

Nā Kūʻai Kūʻai

ʻAʻohe contraindications no ka hoʻohana o Orencia. Eia nō naʻe, pono e mālama i kekahi o nā akaʻi i mua a i ka wā o kāna hoʻokele. No ka 'ike hou aku, e nānā i ka mahele "Orencia precautions" ma luna.

Waihona

Ke hāʻawi ʻia ma kahi vial me ka pauka lyophilized, pono e hoʻomaʻamaʻa ʻia ʻo Orencia i kahi mahana o 36 ° F a 46 ° F (2 ° C a 8 ° C). E mālama ʻia ka ipu i loko o kāna pūʻolo kumu a pale ʻia mai ka mālamalama e hōʻalo ai i ka hoʻohaʻahaʻa.

ʻO nā syringes prefilled a i ʻole ClickJect autoinjectors o Orencia e pono e hoʻomaʻalili ʻia i ka mahana o 36 ° F a 46 ° F (2 ° C a 8 ° C). Pono e kāohi i nā mahana e pale i ka paʻahau o ka hopena. Eia kekahi, pono e mālama ʻia kēia mau hāmeʻa i loko o kā lākou ʻōpala kumu a pale ʻia mai ka mālamalama e hōʻalo ai i ka hoʻohaʻahaʻa.

Hoʻolaha: Ua hana ʻo Nūhou Lapaʻau i kēia mau lā e hōʻoia i ka pololei, ka laulā, a me ka lā hou o nā ʻike āpau. Eia nō naʻe, ʻaʻole pono e hoʻohana i kēia ʻatikala i pani no ka ʻike a me ka mākaukau o kahi loea mālama ola laikini. E nīnau mau ʻoe i kāu kauka a i ʻole ʻoihana olakino ʻē aʻe ma mua o ka lawe ʻana i nā lāʻau. Hiki ke loli i ka ʻike o ka lāʻau i loko a ʻaʻole i manaʻo ʻia e uhi i nā hoʻohana a pau, nā kuhikuhi, ka mālama ʻana, nā ʻōlelo aʻoaʻo, nā launa lāʻau, nā hopena maʻi ʻaʻai, a me nā hopena maikaʻi ʻole. ʻO ka loaʻa ʻole o nā ʻōlelo aʻoaʻo a i ʻole nā ​​ʻike ʻē aʻe no kahi lāʻau i hāʻawi ʻia ʻaʻole ia e hōʻike i ka palekana o ka lāʻau a lāʻau paha i kūpono no nā mea maʻi āpau a i ʻole nā ​​hoʻohana kikoʻī āpau.

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