ʻO ka Lymphoid Leukemia maʻi: he aha ia, nā ʻōuli a me nā lāʻau

Anter

• Nā ʻōuli ʻo LLC
• Pehea e hana ʻia ai ke kuhi
• Hoʻolapa kino ʻo LLC

ʻO ka Lymphoid Leukemia maʻi, i ʻike ʻia ʻo LLC a i ʻole leukemia lymphocytic mau, kahi ʻano leukemia i hōʻike ʻia e ka hoʻonui ʻana i ka nui o nā lymphocytes makua i ke koko peripheral, me ka hoʻonui ʻana i nā lymph node, ka pohō kaumaha a me ka luhi nui, ʻo kahi laʻana .

Hoʻomaopopo pinepine ʻia ʻo LLC mai ka makahiki 65, no ka mea lohi ka ulu ʻana o ka maʻi, a ʻike pinepine ʻia nā ʻōuli ke hele a kahi maʻi i kahi pae holomua. Ma muli o ka lohi o ke ʻano o nā ʻōuli, ʻike pinepine ʻia ka maʻi i ka wā o nā hoʻokolohua koko maʻamau, ʻo ia hoʻi ka helu o ke koko, kahi e ʻike ʻia ai ka hoʻonui ʻana i ka nui o nā lymphocytes.

Nā ʻōuli ʻo LLC

Hoʻolālā ka LLC i nā mahina a i ʻole mau makahiki, a no laila, ʻike lōkahi nā ʻōuli, a ʻike pinepine ʻia ka maʻi ke hele i kahi wā ʻoi aku ka maikaʻi. ʻO nā hōʻailona hōʻailona o LLC ʻo:

• Hoʻonui i nā lymph node a me nā lymph node;
• Māluhiluhi;
• Ka liʻiliʻi o ka hanu i ka wā o ke kino;
• Hoʻonui ākea, kāhea ʻia hoʻi splenomegaly;
• Hepatomegaly, ʻo ia ka hoʻonui ʻana o ke ake;
• Nā maʻi hou o ka ʻili, ka mimi a me nā akemāmā;
• Kaumaha emi.

ʻAʻole hōʻike ka maʻi i nā ʻōuli i kāna pae mua, hiki ke ʻike ʻia ka LLC ma hope o ka hana ʻana i nā hoʻokolohua maʻamau, kahi e ʻike ʻia ai ka hoʻonui ʻana i ka nui o nā lymphocytes a me nā leukosit i ke hoʻokolohua koko.

Pehea e hana ʻia ai ke kuhi

Hana ʻia ke kuhi o ka Chronic Lymphoid Leukemia mai ke kālailai ʻia ʻana o nā hunaola koko ma o ka hopena o ka helu piha o ke koko, i hana ʻia mai ke kālailai ʻana i kahi hāpana koko. I ka helu piha o ka LLC hiki ke ʻike ʻia ka leukositosis, ma mua o 25,000 a / mm cells o ke koko, a me ka lymphocytosis paʻa mau, ma mua o 5000 lymphocytes / mm³ o ke koko. Hoʻohui ʻia, loaʻa kekahi o nā mea maʻi i ka anemia a me ka thrombocytopenia, kahi e hoʻemi ana i ka nui o nā platelet i ke koko. E ʻike i ke ʻano o ka waiwai kuhi koko keʻokeʻo.

ʻOiai makua, ʻo ka lymphocytes e noho nei i ke koko peripheral he liʻiliʻi a palupalu a, no laila, i ka manawa o ka hana ʻana i ke koko e hiki iā lākou ke haki a hāpai i nā aka nukelea, i kapa ʻia hoʻi nā aka Gumprecht, a noʻonoʻo ʻia no ka piha ka hōʻailona

ʻOiai ua lawa ka helu o ke koko e hoʻopau ai i ke kuhi ʻana o ka leukemia lymphocytic mau, pono nā hoʻokolohua immunophenotyping e ʻike i ke alo o nā māka e hōʻoia he leukemia ia e pili ana i ka hoʻonui ʻia ʻana o nā ʻano lymphocytes B a he maʻi mau ia. Manaʻo ʻia ʻo Immunophenotyping ke kūlana gula o ka ʻike ʻana ʻaʻole wale no LLC akā no nā ʻano leukemia ʻē aʻe.

I kekahi mau hihia, hiki i ke kauka ke noi i kahi myelogram, kahi hōʻike i hana ʻia e kālailai i nā hunaola i loaʻa i ka iwi iwi, ma kahi o LLC i ʻoi aku ma mua o 30% o nā lymphocytes makua. ʻAʻole noi ʻia kēia hoʻokolohua e hōʻoia i ka maʻi, akā e hōʻoia i ka evolution, infiltration pattern of the lymphocytes a wehewehe i ka wānana. Hoʻomaopopo pehea e hana ʻia ai ka myelogram.

Hoʻolapa kino ʻo LLC

Hana ʻia ʻo LLC e like me ka pae o ka maʻi.

• Palena haʻahaʻa: kahi i ʻike ʻia ai nā leukositosis a me nā lymphocytosis wale nō, me ka ʻole o nā ʻōuli ʻē aʻe. No laila, hele pū ke kauka me ka mea maʻi a ʻaʻole pono e hoʻokō i ka lāʻau;
• Pilikia waena: kahi lymphocytosis, hoʻonui ʻia o nā lymph nodes a me ke ake a i ʻole splenomegaly e hōʻoia ʻia, e koi ana i ka ukali olakino e nānā i ka ulu ʻana o ka maʻi a me ka mālama ʻana me chemo a i ʻole radiotherapy;
• Kūlana kiʻekiʻe: kahi e ʻike ʻia ai nā ʻōuli ʻano o CLL, me ka hoʻohui o ka anemia a me ka thrombositopenia, a e hoʻomaka koke ʻia ka lāʻau ʻana. ʻO ka lāʻau lapaʻau i koi nui ʻia i kēia hihia ka hoʻoneʻe iwi o ka iwi, a he mea pono hoʻi e hana i ka chemo a me ka radiotherapy.

Ke ʻike ʻia ka hoʻonui ʻana i ka nui o nā lymphocytes i ke koko ākea, he mea nui e nānā ke kauka i ke kūlana maʻamau o ka mea maʻi i hōʻoia ʻia ka hōʻoia o CLL a hiki ke hoʻomaka ʻia ka lapaʻau a hōʻalo ʻia ka holomua o ka maʻi.

Hiki i nā radiotherapy a me chemotherapy ke hoʻonāwaliwali loa a hoʻopilikia i ka ola o ke kanaka. No laila, hoihoi ka loaʻa ʻana o kahi papaʻai olakino a kaulike e hōʻoia i ka manaʻo o ke olakino a hōʻemi i nā ʻōuli e pili ana i kēia ʻano lapaʻau. E nānā i ka wikiō aʻe e pili ana i nā meaʻai maikaʻi e hōʻoluʻolu i nā hopena o ka chemotherapy: