ʻO Hormone vs. Non-Hormone Therapies no ka maʻi ʻaʻa Prostate ʻoi loa

Anter

• Nā hōʻailona Hormone no ka maʻi ʻaʻai prostate holomua
• Pehea e holo ai ka hoʻomaʻamaʻa hormone?
• Nā hōʻailona hormonone i ʻae ʻia
• Nā Pahuhopu o ka lapaʻau
• Pehea e mālama ai i nā mālama?
• ʻO wai ka moho?
• Nā hopena ʻaoʻao maʻamau
• Nā hana ʻoniʻoni ʻole no ka maʻi ʻaʻai prostate holomua
• Ua ʻāpono ʻia nā lāʻau lapaʻau ʻoka ʻole
• Nā Pahuhopu o ka lapaʻau
• ʻO wai ka moho?
• Pehea e mālama ai i nā mālama?
• Nā hopena ʻaoʻao maʻamau
• Ke laina lalo

Inā piʻi ka maʻi ʻaʻai prostate i kahi pae holomua a ua pāhola ʻia nā hunaola maʻi maʻi i nā ʻāpana ʻē aʻe o ke kino, pono ka mālama ʻana. ʻAʻole ke koho ke kali ʻana i ke ala, inā ʻo ia ka papa ʻike o kāu hana me kāu kauka.

ʻO ka mea pōmaikaʻi, ʻo nā kāne me ka maʻi ʻaʻai prostate holomua i kēia manawa ua loaʻa nā koho lapaʻau ma mua o ka wā ma mua. Pākuʻi ʻia kēia mau mea i nā ʻano ʻāpono ʻelua o ka hormone a me nā koho pono ʻole ʻoneoneone. ʻO ka mālama pololei ʻana āu e loaʻa ai ma muli o kāu pae o ka maʻi ʻaʻai prostate a me nā ʻano kumu i loaʻa iā ʻoe. E hoʻomanaʻo he hiki ke ʻokoʻa loa kāu ʻike lapaʻau mai kekahi.

E hoʻoholo i kahi lapaʻau, pono ʻoe e noʻonoʻo i ka pahuhopu nui o ka mālama ʻana, nā hopena ʻaoʻao, a inā paha he moho maikaʻi ʻoe. ʻO ka hoʻomaopopo ʻana e pili ana i nā lapaʻau i loaʻa e hiki ke kōkua iā ʻoe a me kāu kauka e hoʻoholo i kahi lapaʻau, a i ʻole ka hui ʻana o nā lapaʻau.

Nā hōʻailona Hormone no ka maʻi ʻaʻai prostate holomua

Hoʻomaopopo pū ʻia ʻo Hormone therapy ma ke ʻano androgen deprivation therapy (ADT). Hōʻike pinepine ʻia ma ke ʻano he kumu nui no ka mālama ʻana i ka maʻi ʻaʻai prostate metastatic.

Pehea e holo ai ka hoʻomaʻamaʻa hormone?

Hana ka Hormone therapy ma ka hoʻemi ʻana i nā pae o nā hormones (androgens) i loko o ke kino. Hoʻokomo pū nā Androgens i ka testosterone a me dihydrotestosterone (DHT). Paipai kēia mau hormones i ka maʻi ʻaʻai prostate e hoʻonui. Me ka ʻole o androgens, lohi ka ulu ʻana o ka tumo a hele aku paha ka maʻi ʻaʻai i loko o ke kala.

Nā hōʻailona hormonone i ʻae ʻia

Nui a hewahewa nā mālama ʻana i ka hormone no ka maʻi ʻaʻai prostate. Pākuʻi ʻia kēia mau mea:

• ʻO nā agonists GnRH, e like me leuprolide (Eligard, Lupron) a me goserelin (Zoladex). Hana kēia mau mea ma ka hoʻohaʻahaʻa ʻana i ka nui o ka testosterone i hana ʻia e nā testicle.
• Nā anti-androgens, e like me nilutamide (Nilandron) a me enzalutamide (Xtandi). Hoʻohui pinepine ʻia kēia i nā agonists GnRH e kōkua ai i ka pale ʻana i ka testosterone mai ka hoʻopili ʻana i nā hunaola tumora.
• ʻO kekahi ʻano agonist GnRH i kapa ʻia ʻo degarelix (Firmagon), kahi e ālai ai i nā hōʻailona mai ka lolo i nā hōʻike i hoʻōki ʻia ka hana ʻana o androgens.
• ʻO ke keʻena hana e wehe i nā testicle (orchiectomy). I ka hopena, e hōʻoki kēia i ka hana o nā kāne kāne.
• ʻO Abiraterone (Zytiga), kahi antagonist LHRH e hana nei ma ke kāpae ʻana i kahi enzyme i kapa ʻia ʻo CYP17 e hoʻōki i ka hana ʻana o androgens e nā hunaola i loko o ke kino.

Nā Pahuhopu o ka lapaʻau

ʻO ka pahuhopu o ka hoʻōla hormonone ke kala. ʻO ke kala ke kumu o ka hele aku o nā hōʻailona āpau a me nā ʻōuli o ka maʻi ʻaʻai prostate. ʻO nā poʻe i loaʻa ke kala ʻana ʻaʻole "hoola ʻia," akā hiki iā lākou ke hele i nā makahiki he nui me ka hōʻike ʻole ʻana i nā hōʻailona o ka maʻi ʻaʻai.

Hiki paha ke hoʻohana ʻia ka Hormone therapy e hōʻemi ai i ka hopena o ka hoʻi hou ʻana ma hope o ka hoʻomaʻamaʻa mua ʻana i nā kāne i hiki ke piʻi hou.

Pehea e mālama ai i nā mālama?

Hoʻokomo ʻia a waiho ʻia nā agonists GnRH ma ke ʻano he implants liʻiliʻi ma lalo o ka ʻili. Lawe ʻia nā anti-androgens ma ke ʻano he pill hoʻokahi i kēlā me kēia lā. Hāʻawi ʻia ʻo Degarelix ma ke ʻano he injection. Hoʻohana ʻia kekahi lāʻau chemotherapy i kapa ʻia ʻo docetaxel (Taxotere) i kekahi manawa me ka hui pū ʻana me kēia mau hōmona.

Lawe ʻia ʻo Zytiga e ka waha hoʻokahi i kēlā me kēia lā i ka hui pū me kahi steroid i kapa ʻia ʻo prednisone.

Hiki ke hana i kahi ʻoki e wehe i nā testicle ma ke ʻano he hana ma waho. Hiki iā ʻoe ke hoʻi i ka home i kekahi mau hola ma hope o kahi orchiectomy.

ʻO wai ka moho?

ʻO ka hapa nui o nā kāne me ka maʻi ʻaʻai prostate holomua nā moho no ka hoʻomaʻamaʻa hormonone. Manaʻo pinepine ʻia ke pālahalaha ʻia ka maʻi ʻaʻai prostate ma ʻō aku o ka prostate, a ʻaʻole hiki ke hana hou i ke kahakaha e hoʻoneʻe ai i ka tumo.

Ma mua o ka hoʻomaka ʻana o ka mālama ʻana, pono ʻoe e loaʻa kahi hoʻokolohua hana ate me ka hoʻāʻo ʻana i ke koko e hōʻoia i hiki i kou ake ke wāwahi pono i nā lāʻau.

I kēia manawa, ʻae wale ʻia ʻo enzalutamide (Xtandi) no ka hoʻohana ʻana i nā kāne me ka maʻi ʻaʻai prostate i pāhola ʻia i nā ʻāpana ʻē aʻe o ke kino, a pane hou ʻole i nā lāʻau lapaʻau a lāʻau lapaʻau paha e hoʻohaʻahaʻa i nā pae testosterone.

I kekahi mau hihia, hiki i nā hunaola maʻi ʻaʻai prostate ke pale aku i nā mālama ʻana o ka hōmona a hoʻonui pinepine i ka loaʻa ʻole o nā homone kāne. Kāhea ʻia kēia ʻo ka maʻi ʻaʻai prostate kūʻē (a i ʻole castration-resistant). ʻAʻole nā ​​moho me ka maʻi ʻaʻai prostate kūpaʻa pale i moho no ka hoʻomaʻamaʻa hou o ka hormone.

Nā hopena ʻaoʻao maʻamau

ʻO nā hopena ʻaoʻao maʻamau o nā hoʻoponopono hormonone e like me:

• uila uila
• lahilahi, nā iwi palupalu (osteoporosis) no ka mea ʻo nā pae testosterone haʻahaʻa ke kumu o ka nalo ʻana o ka puna
• loaʻa kaupaona
• nalo o ka nui o nā mākala
• ka hana erectile
• lilo o ka hoʻokele moekolohe

Nā hana ʻoniʻoni ʻole no ka maʻi ʻaʻai prostate holomua

Inā ʻaʻole e hana ana ka hoʻomaʻamaʻa ʻana o ka hōmona a ulu paha paha kou maʻi ʻaʻai a hoʻolaha koke, hiki ke ʻōlelo ʻia me ke koho ʻana me nā koho non-hormone ʻē aʻe.

Ua ʻāpono ʻia nā lāʻau lapaʻau ʻoka ʻole

ʻO nā mālama pono ʻole ʻana no ka maʻi ʻaʻai prostate me:

• ʻO Chemotherapy, e like me docetaxel (Taxotere), cabazitaxel (Jevtana), a me mitoxantrone (Novantrone). Hāʻawi ʻia ʻo Chemotherapy i kekahi manawa me ka steroid i ʻike ʻia ʻo prednisone.
• ʻO ka radiation radiation, kahi e hoʻohana ai i nā kaola ikaika nui a i ʻole nā ​​hua radioactive e hoʻopau ai i nā tumors. Hoʻohana mau ʻia ka pāhawewe me ka chemotherapy.
• Immunotherapy, me sipuleucel-T (Provenge). Hana ka Immunotherapy i ka hoʻohana ʻana i ka ʻōnaehana pale pilikino o ke kino e pepehi i nā hunaola maʻi ʻaʻai.
• ʻO Radium Ra 223 (Xofigo), nona ka liʻiliʻi o ka radiation a hoʻohana ʻia e luku i nā hunaola maʻi ʻaʻai prostate i pāhola ʻia i ka iwi.

Nā Pahuhopu o ka lapaʻau

ʻO ka pahuhopu o ka chemotherapy, radiation, a me nā mālama pono ʻole ʻoneʻone e hoʻolohi i ka ulu ʻana o ka maʻi ʻaʻai a hoʻolōʻihi i ke ola o ke kanaka. ʻAʻole hiki i ka Chemotherapy a me nā mea hana ʻoneʻone ʻole ke hōʻola i ka maʻi ʻaʻai, akā hiki iā lākou ke hoʻolōʻihi i ke ola o nā kāne me ka maʻi ʻaʻai prostate metastatic.

ʻO wai ka moho?

Hiki paha iā ʻoe ke moho no nā hōʻailona non-hormone e like me chemotherapy a i ʻole radiation inā:

• ke piʻi wikiwiki nei kāu pae PSA no ka mālama ʻana i ka hōmona e kāohi iā ia
• ke hoʻolaha laha nei kou maʻi ʻaʻai
• ke piʻi nei kou mau hōʻailona
• ʻAʻole holo pono nā mālama ʻana o ka hōmona
• ua pālahalaha ka maʻi ʻaʻai i kou mau iwi

Pehea e mālama ai i nā mālama?

Hāʻawi pinepine ʻia ʻo Chemotherapy i nā pōʻaiapuni. Kū mau kēlā me kēia pōʻai i kekahi mau pule. Pono paha ʻoe i mau puni o ka lapaʻau, akā maʻa mau kahi manawa hoʻomaha i waena. Inā kū kekahi ʻano chemotherapy, hiki i kāu kauka ke koi aku i nā koho chemotherapy ʻē aʻe.

Hāʻawi ʻia ʻo Sipuleucel-T (Provenge) ma ke ʻano he ʻekolu infusions i loko o kahi aa, me ʻelua mau pule ma waena o kēlā me kēia infusion.

Hāʻawi ʻia ʻo Radium Ra 223 ma ke ʻano he injection.

Nā hopena ʻaoʻao maʻamau

ʻO nā hopena ʻē aʻe o ka chemotherapy e:

• poho lauoho
• nausea a me ka luaʻi
• pāhoehoe
• luhi
• nalo ʻai ʻole
• haʻahaʻa keokeo keena (neutropenia) a kiekie ae kamepiula o ka maʻiʻaʻai
• nā hoʻololi i ka hoʻomanaʻo
• numbness a ʻūlū paha i nā lima a me nā wāwae
• paopao maʻalahi
• ʻeha nā waha

Hiki i nā hana hoʻomāliʻi uila ke hōʻemi i ka helu o ke kaola ʻulaʻula a hana i ka anemia. Hoʻokumu ʻo Anemia i ka luhi, dizziness, headache, a me nā ʻōuli ʻē aʻe. Hiki i ke kauā uila ke alakaʻi i ka nalo ʻana o ke kaohi o ka maʻi ʻaʻa (incontinence) a me ka hana erectile.

Ke laina lalo

Hoʻonohonoho pinepine ʻia nā hoʻoponopono Hormone a me nā ʻoki ʻana e mālama mua i ka maʻi ʻaʻai prostate holomua. Hiki ke hoʻohana ʻia lākou me ka chemotherapy. Akā ma hope o kekahi manawa, hiki i nā maʻi ʻaʻai prostate ke kūʻē i ka hoʻōla hormonone. Ua lilo nā koho non-hormone i koho maikaʻi loa no nā kāne me ka maʻi ʻaʻai prostate metastatic e pane hou ʻole i nā mālama ʻana o ka hormone a me ka chemotherapy.

ʻOiai me ka mālama ʻana, ʻaʻole hiki ke hoʻōla ʻia nā hihia āpau o ka maʻi ʻaʻai prostate holomua, akā hiki i nā mālama ʻana ke hoʻolohi i ka ulu ʻana o ka maʻi ʻaʻai, hōʻemi i nā ʻōuli, a hoʻomaikaʻi i ke ola. Noho nā kāne he nui i mau makahiki me ka maʻi ʻaʻai prostate holomua.

ʻO ka hoʻoholo ʻana e pili ana i nā mālama ʻana hiki ke huikau a paʻakikī hoʻi no ka mea he nui nā mea e noʻonoʻo ai. E hoʻomanaʻo ʻaʻole pono ʻoe e hoʻoholo wale. Me ke alakaʻi ʻana mai kāu oncologist a me kāu hui olakino, hiki iā ʻoe ke hoʻoholo i ka hoʻolālā lapaʻau maikaʻi loa nāu.