Hepatitis C Genotype 2: He aha e manaʻo ai

Anter

• No ke aha he mea nui iaʻu he genotype 2?
• Pehea e mālama ʻia ai ka genotype hepatitis C 2?
• ʻO Glecaprevir a me pibrentasvir (Mavyret)
• ʻO Sofosbuvir a me velpatasvir (Epclusa)
• Daclatasvir (Daklinza) a me sofosbuvir (Sovaldi)
• Pehea e mālama ʻia ai nā genotypes ʻē aʻe
• He aha nā pilikia kūpono?
• Outlook

Hōʻike Overview

Ke loaʻa ʻoe i kahi maʻi hepitis C, a ma mua o kou hoʻomaka ʻana i ka lāʻau, pono ʻoe i kahi hoʻokolohua koko hou e hoʻoholo ai i ka genotype o ka maʻi. Aia he ʻeono mau genotypes i hoʻokumu pono ʻia (nā kānana) o ka hepatitis C, a ʻoi aku ma mua o 75 mau subtypes.

Hāʻawi nā hōʻike koko i nā ʻike kikoʻī e pili ana i ka nui o ka maʻi i kēia manawa i kou kahe koko.

ʻAʻole pono e hana hou i kēia hōʻike no ka mea ʻaʻole loli ka genotype. ʻOiai he mea mau ʻole ia, hiki ke maʻi i nā genotype ma mua o hoʻokahi. Kapa ʻia kēia he superinfection.

Ma ʻAmelika Hui Pū ʻIa, ma kahi o 13 a 15 mau pākēneka o ka poʻe me ka maʻi hepa C he genotype 2. ʻO Genotype 1 ka a hoʻopili i 75 pakeneka o ka poʻe me ka maʻi hepitis C.

ʻO ka ʻike ʻana i kāu genotype ka hopena i kāu ʻōlelo aʻoaʻo.

No ke aha he mea nui iaʻu he genotype 2?

Ke ʻike nei iā ʻoe he genotype 2 hāʻawi i ka ʻike nui e pili ana i kāu koho lapaʻau a pehea e maikaʻi ai.

Ma muli o ka genotype, hiki i nā kauka ke hoʻohaʻahaʻa i nā kauka e kūpono a me ka lōʻihi e lawe ai iā lākou. Hiki i kēia ke pale iā ʻoe mai ka hoʻonele ʻana i ka manawa no ka hōʻino kūpono ʻole a i ʻole ka lawe ʻana i nā lāʻau i lōʻihi ma mua o kāu.

ʻ respondlelo ʻokoʻa kekahi mau genotypes i ka lapaʻau ma mua o nā mea ʻē aʻe. A pehea ka lōʻihi e pono ai ʻoe e lawe i ka lāʻau i hiki ke ʻokoʻa ma muli o kāu genotype.

Eia nō naʻe, ʻaʻole hiki i ka genotype ke haʻi i nā kauka i ka wikiwiki e holo ai ke ʻano, pehea ke koʻikoʻi o kāu mau ʻōuli, a i ʻole inā e maʻi mau ka maʻi maʻi.

Pehea e mālama ʻia ai ka genotype hepatitis C 2?

ʻAʻole maopopo ke kumu, akā hoʻomaʻemaʻe ka poʻe i ka maʻi hepatitis C me ka ʻole o ka lāʻau. ʻOiai ʻaʻohe ala o ka ʻike ʻana i ka mea e hāʻule i kēia mahele, i kahi maʻi ʻino, e paipai ka kauka no ke kali ʻana no 6 mau mahina e mālama ai i ka maʻi, ʻoiai e hoʻomaʻemaʻe wale paha ia.

Mālama ʻia ʻo Hepatitis C me nā lāʻau antiviral e hoʻomaʻemaʻe i kou kino o ka maʻi maʻi a pale a hōʻemi paha i ka hōʻino o kou ake. I ka manawa pinepine, e lawe ʻoe i kahi hui o nā lāʻau antiviral ʻelua no 8 mau pule a ʻoi paha.

Loaʻa kahi manawa kūpono e loaʻa iā ʻoe kahi pane virologic hoʻomau (SVR) i ka lāʻau lāʻau lāʻau. I nā huaʻōlelo ʻē aʻe, hiki ke curable kiʻekiʻe loa. ʻO ka helu SVR no ka nui o nā hoʻohui lāʻau hepatitis C hou e like me 99 pakeneka.

Ke koho ʻana i nā lāʻau a hoʻoholo i ka lōʻihi o kāu e lawe ai iā lākou, e noʻonoʻo pinepine kāu kauka i kēia mau mea:

• kou olakino holoʻokoʻa
• ehia nā maʻi i loaʻa i kāu ʻōnaehana (viral load)
• inā he cirrhosis paha kāu a i ʻole nā ​​mea ʻino ʻē aʻe i kou ake
• inā ua mālama mua ʻia ʻoe no ka maʻi hepa C, a ʻo ke ʻano hea kāu

ʻO Glecaprevir a me pibrentasvir (Mavyret)

Kau ʻia paha ʻoe i kēia hui inā inā hou ʻoe i ka lāʻau lapaʻau a i ʻole mālama ʻia ʻoe me ka peginterferon plus ribavirin a i ʻole sofosbuvir plus ribavirin (RibaPack) a ʻaʻole ia i hoʻōla iā ʻoe. ʻO ka mahele lāʻau he ʻekolu papa, hoʻokahi manawa i ka lā.

Pehea ka lōʻihi e lawe ai ʻoe i ka lāʻau:

• inā ʻaʻohe ou cirrhosis: 8 mau pule
• inā he cirrhosis ʻoe: 12 mau pule

ʻO Sofosbuvir a me velpatasvir (Epclusa)

ʻO kēia hui pū kekahi koho ʻē aʻe no ka poʻe hou i ka lapaʻau, a i ʻole nā ​​mea i mālama ʻia ma mua. E lawe ʻoe i hoʻokahi papa i ka lā no 12 mau pule. Ua like ka mahele lāʻau, inā he cirrhosis paha kāu.

Daclatasvir (Daklinza) a me sofosbuvir (Sovaldi)

Ua ʻae ʻia kēia regimen no ka maʻi hepitis C 3. ʻAʻole ʻae ʻia e mālama i ka genotype 2, akā hiki i nā kauka ke hoʻohana iā ia i ka lepili no kekahi poʻe me kēia genotype.

ʻO ka mahele lāʻau hoʻokahi papa daclatasvir a hoʻokahi papa sofosbuvir i hoʻokahi manawa i ka lā.

Pehea ka lōʻihi e lawe ai ʻoe i ka lāʻau:

• inā ʻaʻohe ou cirrhosis: 12 mau pule
• inā he cirrhosis ʻoe: 16 a 24 mau pule

E hōʻike ke kahe ʻana o ke koko ukali i ka maikaʻi o kāu pane ʻana i ka lāʻau.

Kahakaha: ʻO ka hoʻohana ʻana i ka lāʻau lapaʻau i kapa ʻia ka inoa ʻo ia ka lāʻau i ʻae ʻia e ka FDA no hoʻokahi kumu e hoʻohana ʻia no kahi kumu ʻē aʻe i ʻae ʻole ʻia. Eia nō naʻe, hiki i ke kauka ke hoʻohana i ka lāʻau no ia kumu. ʻO kēia no ka mea hoʻoponopono ka FDA i ka hoʻāʻo a me ka ʻae ʻana o nā lāʻau, akā ʻaʻole pehea e hoʻohana ai nā kauka i nā lāʻau e mālama ai i kā lākou mau maʻi. No laila, hiki i kāu kauka ke kuhikuhi i kahi lāʻau akā manaʻo lākou ʻoi aku ka maikaʻi no kāu mālama. E aʻo hou aʻe e pili ana i ka hoʻohana ʻana i ka lāʻau lapaʻau i waho o ka lepili.

Pehea e mālama ʻia ai nā genotypes ʻē aʻe

ʻO ka mālama ʻana i nā genotypes 1, 3, 4, 5, a me 6 e pili pū kekahi i nā ʻano like ʻole e like me ka viral viral a me ka nui o ka hōʻino o ke ake. ʻOi aku ka liʻiliʻi o nā genotypes 4 a me 6, a kākaʻikahi nā genotypes 5 a me 6 ma United States.

Hiki i nā lāʻau anttiviral ke hoʻopili i kēia mau lāʻau a hui pū paha o lākou:

• daclatasvir (Daklinza)
• elbasvir / grazoprevir (Zepatier)
• glecaprevir / pibrentasvir (Mavyret)
• ledipasvir / sofosbuvir (Harvoni)
• ombitasvir / paritaprevir / ritonavir (Technivie)
• ombitasvir / paritaprevir / ritonavir a me dasabuvir (Viekira Pak)
• simeprevir (Olysio)
• sofosbuvir (Sovaldi)
• sofosbuvir / velpatasvir (Epclusa)
• sofosbuvir / velpatasvir / voxilaprevir (Vosevi)
• ribavirin

Hiki ke loli ke lōʻihi o ka mālama ʻana e ka genotype.

Inā lawa ka hōʻino o ke ake, e paipai ʻia kahi transplant ate.

He aha nā pilikia kūpono?

Hepatitis C genotype 2 hiki ke mālama pinepine ʻia. Akā hiki i ka maʻi mau ke alakaʻi i nā pilikia koʻikoʻi.

ʻO ka hapa nui o ka poʻe me ka maʻi hepitis C ʻaʻohe o nā ʻōuli a i ʻole nā ​​ʻōuli palupalu wale nō, ʻoiai ke ʻeha nei ke ake.

ʻO nā mahina ʻeono mua ma hope o ka maʻi ʻana ua wehewehe ʻia e like me ka maʻi hepatitis C koʻikoʻi. He ʻoiaʻiʻo kēia inā he hōʻailona kou a ʻaʻole paha. Me ka lāʻau, a i kekahi manawa me ka ʻole o ka lapaʻau, nui ka poʻe e hoʻomaʻemaʻe i ka maʻi i kēia manawa.

ʻAʻole paha ʻoe e hōʻino nui i ke ake i ka wā koʻikoʻi, ʻoiai i nā hihia kakaikahi hiki ke ʻike i ka holomua o ka ate fulminant.

Inā loaʻa iā ʻoe ka maʻi ma kāu ʻōnaehana ma hope o ʻeono mau mahina, loaʻa ʻoe i ka maʻi hepatitis C mau. ʻOiai, he mau makahiki ka maʻi e holo i mua. Hiki i nā pilikia koʻikoʻi ke hoʻopili i ka cirrhosis, ka maʻi ʻaʻai ate, a me ka holo pono ʻole o ke ake.

Ua nele nā ​​helu helu no nā pilikia o ka genotype 2 iā ia iho.

No nā ʻano hepatitis C āpau i ʻAmelika Hui Pū ʻIa, ke koho ʻia:

• 75 a 85 i waho o 100 mau kānaka i loaʻa i ka maʻi e hoʻomaka i ka maʻi maʻi mau
• 10 i ka 20 e hoʻomohala i ka cirrhosis o ke akepaʻa ma waena o 20 a 30 mau makahiki

Ke hoʻomohala nā kānaka i ka cirrhosis, holo lākou i ka loaʻa ʻana i ka maʻi ʻaʻai ate i kēlā me kēia makahiki.

Outlook

ʻO ka mea ma mua e loaʻa ai ka lāʻau, ʻo ka ʻoi aku ka maikaʻi o kou pale ʻana i nā hōʻino o ke ake nui. Ma waho aʻe o ka lāʻau lapaʻau, pono ʻoe i nā hoʻokolohua koko hope e ʻike i ka maikaʻi o ka hana.

ʻO ka nānā aku no ka maʻi hepitis C genotype 2 maikaʻi loa. ʻOiaʻiʻo nō inā ʻoe e hoʻomaka i ka hoʻomaʻamaʻa kakahiaka, ma mua o ka loaʻa ʻana o ka maʻi i ka maʻi ma ke ake.

Inā hoʻomaʻemaʻe maikaʻi ʻoe i ka genotype hepatitis C 2 mai kāu ʻōnaehana, loaʻa iā ʻoe nā mea ʻāpala e kōkua i ka pale ʻana iā ʻoe mai nā hoʻouka hou aku. Akā hiki iā ʻoe ke lilo i maʻi me nā ʻano hepatitis a i ʻole genotype ʻē aʻe o ka hepatitis C.