Mea Kākau: John Stephens
Lā O Ka Hana: 2 Ianuali 2021
HōʻAno Hou I Ka Lā: 14 Nowemapa 2024
Anonim
GLEEVEC (IMATINIB) MOA
Wikiō: GLEEVEC (IMATINIB) MOA

Anter

He aha ka Gleevec?

ʻO Gleevec kahi lāʻau lapaʻau inoa inoa inoa inoa inoa. Hoʻohana ʻia ia e mālama i kekahi ʻano maʻi ʻaʻai koko i nā mākua a me nā keiki. Hoʻohana ʻia ʻo Gleevec e mālama i kahi ʻano o ka maʻi ʻaʻai ʻili a me kekahi ʻano o ka maʻi ʻaʻai gastrointestinal.

Loaʻa iā Gleevec ka lāʻau imatinib mesylate, no ka papa o nā lāʻau i kapa ʻia nā mea kāohi lāʻau ʻo tyrosine kinase.

Hele mai ʻo Gleevec ma ke ʻano he papa āu e lawe ai ma ka waha. Lawe ʻoe i ka lāʻau i hoʻokahi a i ʻole ʻelua mau manawa i ka lā, ke kaukaʻi ʻia i ke ana o ke kauka.

He aha kāna hana

Ua ʻae ka Food and Drug Administration (FDA) iā Gleevec e mālama i kekahi ʻano o nā maʻi maʻi koko, e like me:

  • ʻO ka chromosome-positive (Ph +) leukemia myeloid maʻi (CML) i nā mākua a me nā keiki
  • Ph + lepemia lymphocytic huehue (ALL) i hoʻi hou ʻia * * a i ʻole refractory * i nā mākua
  • ʻike hou ʻia ʻo Ph + ALL i nā keiki
  • myelodysplastic / myeloproliferative maʻi (nā iwi ʻāʻī iwi) i loko o nā mākua me ka platelet-loaʻa ulu mea receptor (PDGFR) gen rearrangements
  • hypereosinophilic syndrome a i ʻole leukemia eosinophilic mau i nā mākua
  • mastocytosis ʻōnaehana kolohe i nā mākua me ka ʻole o ka D816v c-Kit mutation

* Ua hoʻi mai ka maʻi ʻaʻai kope ma hope o ke kala ʻia ʻana, kahi hōʻemi o nā hōʻailona maʻi ʻaʻai a me nā ʻōuli. ʻAʻole i pane ka maʻi ʻaʻai Refractory i nā mālama maʻi ʻaʻai mua.


ʻAe ʻia ʻo Gleevec e mālama:

  • kahi ʻano maʻi ʻaʻai ʻili i kapa ʻia dermatofibrosarcoma protuberans (DFSP) i nā mākua
  • kahi ʻano o ka maʻi ʻaʻai gastrointestinal i kapa ʻia he Tum-positive gastrointestinal stromal tumors (GIST) i nā mākua

No nā kikoʻī, e ʻike i nā ʻāpana no “Gleevec no CML” a me “Nā hoʻohana ʻē aʻe no Gleevec.”

ʻO ka maikaʻi o Gleevec

Ua loaʻa ka maikaʻi o Gleevec i ka mālama ʻana i nā ʻano maʻi ʻaʻa koko.

I hoʻokahi hoʻokolohua hoʻokolohua, ua lawe nā mākua me CML hou i ka maʻi maʻamau iā Gleevec no ʻehiku mau makahiki. I kēia hui, 96.6% o ka poʻe i pane piha i ka lāʻau. ʻO kēia ka manaʻo ʻaʻole i loaʻa nā hunaola maʻi ʻino i loko o kā lākou koko, a ʻaʻohe o lākou ʻōuli o ke kanesa.

ʻO ka pane piha kahi ala e wehewehe ai i ka helu kūleʻa. I ka hui o ka poʻe i loaʻa ka chemotherapy maʻamau, 56.6% i pane piha.

Ua loaʻa ka maikaʻi o Gleevec i ka mālama ʻana i nā tumomoma stromal gastrointestinal (GIST) i loko o nā noiʻi maʻi. ʻO ka helu ola holoʻokoʻa ma kahi o ʻehā mau makahiki. ʻO kēia ka manaʻo o ka hapalua o ka poʻe i hoʻopaʻa ʻia i noho ma kahi o ʻehā mau makahiki ma hope o ko lākou hoʻomaka ʻana e lawe iā Gleevec. ʻO ka poʻe i lawe iā Gleevec ma hope o ka hana ʻoki ʻana e ola ana ma kahi o ʻelima mau makahiki ma hope o ka hoʻomaka ʻana o ka lāʻau.


E aʻo ai i ka maikaʻi o ka Gleevec i ka mālama ʻana i nā ʻano maʻi ʻē aʻe, e ʻike i ka ʻāpana "Nā hoʻohana ʻē aʻe no Gleevec".

ʻO Generic Gleevec

Loaʻa ʻo Gleevec ma ke ʻano he lāʻau inoa inoa inoa a me ke ʻano he generic form.

Loaʻa iā Gleevec ka lāʻau hana imatinib mesylate.

Nā hopena ʻaoʻao Gleevec

Hiki i ka Gleevec ke hana i nā hopena ʻoluʻolu a koʻikoʻi paha. Loaʻa i nā papa inoa aʻe kekahi o nā hopena ʻaoʻao nui i hiki ke hana ʻia i ka wā e lawe ana iā Gleevec. ʻAʻole pili kēia mau papa inoa i nā hopena āpau āpau.

No ka ʻike hou aku e pili ana i nā hopena pili o Gleevec, e kamaʻilio me kāu kauka a kauka paha. Hiki iā lākou ke hāʻawi iā ʻoe i nā ʻōlelo aʻoaʻo e pili ana i ka hana me nā hopena ʻē aʻe e hoʻonāukiuki paha.

Nā hopena ʻaoʻao hou aʻe

Hiki i nā hopena ʻaoʻao maʻamau o Gleevec ke hoʻopili:

  • pāhoehoe
  • ʻeha ka ʻōpū
  • luhi (nele o ka ikaika)
  • edema (ka pehu ʻana, maʻamau i kou mau wāwae, nā kuʻekuʻe wāwae, a i ʻole nā ​​wāwae a puni kou mau maka)
  • puʻupuʻu ʻili a ʻeha paha
  • nausea
  • ka luaʻi
  • hūwī

Hiki ke hele aku ka hapa nui o kēia mau hopena i loko o kekahi mau lā a i ʻole ʻelua mau pule. Inā ʻoi aku ke koʻikoʻi a i ʻole hele aku, e kamaʻilio me kāu kauka a kauka paha.


Nā hopena hopena koʻikoʻi

ʻAʻole maʻamau nā hopena koʻikoʻi mai Gleevec, akā hiki iā lākou ke hana. Kāhea koke i kāu kauka inā loaʻa nā hopena koʻikoʻi. Kāhea iā 911 inā manaʻo kou mau hōʻailona i ka hoʻoweliweli ola a i ʻole inā manaʻo ʻoe e loaʻa ana kahi pilikia olakino.

Hiki i nā hopena ʻē aʻe a me kā lākou mau hōʻailona ke hoʻohui i kēia:

  • ʻO ka paʻa ʻana o ka wai nui (ka nui o ka wai a wai paha) i loko a puni o kou puʻuwai, nā māmā (pleural effusion), a me ka ʻōpū (ascites). Hiki i nā ʻōuli ke hoʻohui pū:
    • ka mea i manaʻo ʻole ʻia, loaʻa ke kaupaona wikiwiki
    • ʻeha ka umauma
    • pokole o ka hanu
    • pilikia i ka hanu ʻana
    • pilikia i ka hanu ke moe ʻoe i lalo
    • ʻūhū maloʻo
    • ʻōpū pehu
  • Nā maʻi o ke koko, me ka anemia (nā pae haʻahaʻa o nā hunaola ʻulaʻula), neutropenia (nā pae haʻahaʻa o nā hunaola keokeo), a me ka thrombositopenia (nā pae haʻahaʻa o nā platelet). Hiki i nā ʻōuli ke hoʻohui pū:
    • luhi (nele o ka ikaika)
    • kōmi puʻuwai wikiwiki
    • pokole o ka hanu
    • nā maʻi pinepine
    • fiva
    • ʻū wale
    • gums kahe
    • ke koko i ka mimi a i ʻole ka noho
  • Hewa puʻuwai Congestive a me nā pilikia puʻuwai ʻē aʻe, e like me ka maikaʻi ʻole o ka puʻuwai hema. Hiki i nā ʻōuli ke hoʻohui pū:
    • loaʻa ke kaumaha i manaʻo ʻole ʻia
    • edema (hāhā o kou mau wāwae, nā kuʻekuʻe wāwae, a me nā wāwae)
    • ka helu o ka puʻuwai a i ʻole ka ritim (kuʻi ka puʻuwai i wikiwiki loa, lohi, a i ʻole kaulike)
    • ʻeha ka umauma
    • pokole o ka hanu
  • Ka hōʻino o ke ake a me ke kūleʻa ʻole o ke ake. Hiki i nā ʻōuli ke hoʻohui pū:
    • nausea
    • pāhoehoe
    • nalo ʻai ʻole
    • ʻili ʻili
    • jaundice (kala melemele o kou ʻili a keʻokeʻo o kou mau maka)
    • edema (hāhā o kou mau wāwae, nā kuʻekuʻe wāwae, a me nā wāwae)
    • ascites (hoʻoulu wai i kou ʻōpū)
    • ʻāpā pinepine
    • kahe pinepine ʻana o ke kahe
  • ʻO ka hemorrhage koʻikoʻi (kahe koko e kū ʻole), pinepine i kou ʻōpū. Hiki i nā ʻōuli ke hoʻohui pū:
    • koko i ka noho
    • noho ʻeleʻele a lōʻihi paha
    • luhi (nele o ka ikaika)
    • e kahe ana ke koko
    • e ʻū ana i ka lepo ʻeleʻele
    • nausea
    • ʻōpū o ka ʻōpū
  • Nā pilikia Gastrointestinal, me nā perforations (waimaka) i kou ʻōpū a i ʻole nā ​​ʻōpū. Hiki i nā ʻōuli ke hoʻohui pū:
    • nausea
    • ka luaʻi
    • ʻeha nui i kou ʻōpū
    • fiva
    • pokole o ka hanu
    • puʻuwai wikiwiki
  • Nā pilikia ʻili ʻino. Hiki i nā ʻōuli ke hoʻohui pū:
    • erythema multiforme (ʻulaʻula a palu paha, pinepine ma nā kapuwaʻi o kou mau wāwae a i ʻole nā ​​poho o kou mau lima)
    • ʻO Stevens-Johnson Syndrome (ke kuni; ʻeha ʻeha ma kou waha, ʻāʻī, maka, genitalia, a i ʻole ke kino holoʻokoʻa)
    • fiva
    • ʻeha ke kino
  • ʻO ka hypothyroidism (pae pae thyroid haʻahaʻa) i ka poʻe i hemo i kā lākou thyroid a ke lawe nei i kāu lāʻau hou. Hiki i nā ʻōuli ke hoʻohui pū:
    • luhi (nele o ka ikaika)
    • kōpaʻa
    • kaumaha
    • ʻano anuanu
    • ʻili maloʻo
    • loaʻa kaupaona
    • pilikia pilikia hoʻomanaʻo
  • Hoʻonui lohi i nā keiki. Hiki i nā ʻōuli ke hoʻohui pū:
    • ʻaʻole e ulu ana i ka uku maʻamau
    • ʻoi aku ka liʻiliʻi ma mua o nā keiki ʻē aʻe o kā lākou mau makahiki
  • Tumor lysis syndrome (ke hoʻokuʻu nā hunaola maʻi ʻino i loko o kou koko). Hiki i nā ʻōuli ke hoʻohui pū:
    • luhi (nele o ka ikaika)
    • nausea
    • ka luaʻi
    • pāhoehoe
    • ʻūpē mākala
    • ka puʻuwai puʻuwai maikaʻi ʻole (kuʻi ka puʻuwai i wikiwiki loa, lohi, a i ʻole maʻamau)
    • ka hopu ʻana
  • Poino hakuʻala. Hiki i nā ʻōuli ke hoʻohui pū:
    • emi iho ka mimiki ma mua o ka mau
    • edema (hāhā o kou mau wāwae, nā kuʻekuʻe wāwae, a me nā wāwae)
    • luhi (nele o ka ikaika)
    • nausea
    • huikau
    • kahe koko kiʻekiʻe
  • Nā hopena i hiki ke alakaʻi i nā ulia kaʻa kaʻa. Hiki i nā ʻōuli ke hoʻohui pū:
    • ʻūpā
    • hiamoe
    • ʻike hihi ʻole

Nā kikoʻī hopena ʻaoʻao

E noʻonoʻo paha ʻoe i ka pinepine o kekahi mau hopena i hopena ʻia me kēia lāʻau, a i ʻole pili kekahi mau ʻaoʻao iā ia.Eia kekahi mau kikoʻī i nā hopena ʻē aʻe i hiki ʻole i kēia lāʻau ke kumu.

Ka hopena hoʻowali

E like me ka nui o nā lāʻau, hiki i kekahi poʻe ke loaʻa i kahi hopena maʻi ma hope o ka lawe ʻana iā Gleevec. Hiki i nā ʻōuli o ke ʻano ʻāpiki mālie ke hoʻopili pū i:

  • ʻāwīwī o ka ʻili
  • ʻumeʻume
  • flushing (hoʻomehana a ʻulaʻula i kou ʻili)

Kākaʻikahi ka hopena maʻi ʻino ʻoi aku ka paʻakikī akā hiki. Hiki i nā ʻōuli o ke kūpilikiʻi ʻāpiki loa ke hoʻopili pū me

  • angioedema (hāhā ma lalo o kou ʻili, maʻamau i kou mau lihilihi, nā lehelehe, nā lima, a me nā wāwae)
  • pehu o kou alelo, waha, a ʻāʻī paha
  • pilikia hanu

Kāhea koke i kāu kauka inā loaʻa iā ʻoe kahi maʻi maʻi ʻino loa iā Gleevec. Kāhea iā 911 inā manaʻo kou mau hōʻailona i ka hoʻoweliweli ola a i ʻole inā manaʻo ʻoe e loaʻa ana kahi pilikia olakino.

Nā hopena ʻaoʻao lōʻihi

ʻO kekahi o nā hopena i ʻike ʻia ma nā noiʻi maʻi hiki ke hana me ka hoʻohana lōʻihi o Gleevec. Hoʻopili kēia i nā pilikia puʻuwai, e like me ka puʻuwai puʻuwai congestive a me ka maikaʻi ʻole o ka puʻuwai hema.

Ma kahi noiʻi hoʻokolohua, ʻoi aku ma mua o 500 mau kānaka i lawe iā Gleevec no ka maʻi myeloid leukemia (CML) i ukali ʻia a 11 mau makahiki. ʻO ka poʻe i loko o kēia noi wā lōʻihi he nui nā hopena pili like i hōʻike ʻia i nā noiʻi pōkole. Eia nō naʻe, ua hoʻomaikaʻi ʻia kēia mau hopena i ka holo ʻana o ka manawa.

ʻIke ʻia nā hopena koʻikoʻi me ka hoʻohana wā lōʻihi:

  • nā maʻi koko koʻikoʻi (nā pae haʻahaʻa o nā hunaola ʻulaʻula, nā hunaola keokeo, a i ʻole nā ​​platelet) i nā kānaka ʻeono
  • nā pilikia puʻuwai, me ka puʻuwai puʻuwai congestive, i ʻehiku mau kānaka
  • ʻeono mau hihia o ka maʻi ʻaʻai hou, me myeloma he nui i hoʻokahi kanaka a me ke kanulau kolone i kekahi kanaka ʻē aʻe

ʻO nā hopena maʻa mau ka mea maʻamau i ka makahiki mua o ka mālama ʻana me Gleevec. Akā ʻo ka lōʻihi o ka lawe ʻana o ka poʻe iā Gleevec, ʻo ka liʻiliʻi ka nui o kēia mau hopena ʻaoʻao. ʻO kahi laʻana, i ka makahiki mua o ke aʻo, ʻekolu mau kānaka i loaʻa i nā maʻi koko koʻikoʻi, akā ma hope o ka lima o ka makahiki, hoʻokahi wale nō kanaka i hana.

I loko o kahi makahiki he ʻelima mau makahiki o ka poʻe me nā ʻōpū stromal gastrointestinal (GIST), ua kū ka 16% o ka poʻe i ka lawe ʻana iā Gleevec ma muli o ka hopena. Ua like nā hopena ʻaoʻao me nā mea i wehewehe ʻia ma ka noiʻi CML ma luna. Ua kuhikuhi ʻia he kanaha pākēneka o ka poʻe i ke aʻo ʻana i nā lāʻau ma lalo o ka lāʻau e hoʻomāmā ai i nā hopena ʻaoʻao.

Inā ʻoe hopohopo e pili ana i nā hopena lōʻihi loa o Gleevec, e kamaʻilio me kāu kauka. Hiki iā lākou ke kuhikuhi i nā ala e hōʻemi ai i kāu mau pilikia no kekahi hopena ʻaoʻao.

Nā hopena pili pili i ka maka

I nā noiʻi hoʻokolohua o Gleevec, ua loaʻa i kekahi poʻe nā hopena pili e pili ana i ka maka e like me ka pehu ʻana a me ka hihi o ka hihi.

ʻO ka ʻōpala a me ka pehu ʻana a puni nā maka kekahi o nā hopena ʻaoʻao maʻamau. Hiki i ka 74.2% o ka poʻe i lawe iā Gleevec i loaʻa i ka edema periorbital (ʻōhū o ka maka o ka maka).

Inā loaʻa iā ʻoe kēia hopena ʻaoʻao, hiki i kāu kauka ke kuhikuhi i kahi diuretic (i kapa ʻia he pil wai). Kōkua nā diuretics i kou kino e kāpae i ka wai keu a me ka paʻakai ke mimi ʻoe. Māmā kēia i ka hana ʻana o ka wai. Hiki i kāu kauka ke hoʻohaʻahaʻa i kāu lāʻau o Gleevec, inā pono.

Hoʻohui ʻia, ua hōʻike ʻia nā noiʻi hoʻokolohua a hiki i ka 11.1% o ka poʻe i lawe iā Gleevec i ʻike hihi. Inā he ʻike maka ʻole ʻoe, mai hoʻokele a hoʻohana i nā mīkini kaumaha. A e ʻike pono e haʻi aku i kāu kauka ʻaʻole hiki iā ʻoe ke ʻike akāka.

ʻO nā hopena ʻē aʻe pili pili maka ʻole ʻia e pili pū me:

  • maka maloʻo
  • maka maka wai
  • hoʻonāukiuki maka
  • conjunctivitis (pinepine i kapa ʻia he maka poni)
  • moku koko naha i ka maka
  • pehu o ka retina (kahi papa o nā kiko i ka hope o kou maka)

Inā lawe ʻoe iā Gleevec a loaʻa nā hopena pili e pili ana i ka maka, e kamaʻilio me kāu kauka. Hiki iā lākou ke ʻōlelo i nā ala e hōʻoluʻolu ai i kāu mau ʻōuli.

Lilo ka lauoho

ʻO ka lilo o ka lauoho (alopecia) kahi hopena hopena o ka lawe ʻana iā Gleevec.

Ua hoʻāʻo kahi noiʻi i ka hana a Gleevec i ka poʻe me ka chromosome-positive (Ph +) maʻi myeloid leukemia (CML). ʻEhiku pākēneka o kēia poʻe i lilo ka lauoho ma hope o ka lawe ʻana i ka lāʻau.

I loko o kahi noi ʻē aʻe, lawe nā kānaka iā Gleevec e mālama i nā tumomoma stromal gastrointestinal (GIST). Ma waena o 11.9% a me 14.8% o kēia poʻe i lilo ka lauoho. Ua ʻike pinepine ʻia kēia hopena i nā poʻe i lawe i nā koina kiʻekiʻe o Gleevec.

ʻO ka lilo o ka lauoho ma muli o ka mālama ʻana i ka maʻi ʻaʻaʻa he manawa pōkole ia. Inā pili ʻoe i kēia hopena ʻaoʻao, e kamaʻilio me kāu kauka. Hiki iā lākou ke ʻōlelo i nā ʻōlelo aʻoaʻo e kōkua iā ʻoe e hōʻemi i ka nalo ʻana o ka lauoho i kou wā e mālama ai.

ʻO Rash a me nā hopena ʻē aʻe o ka ʻili

Hiki i ka Gleevec ke hana i nā hopena ʻoluʻolu a koʻikoʻi hoʻi i kou ʻili.

ʻO nā hopena ʻili hou aʻe

ʻO nā rashes a me nā ʻili ʻili ʻē aʻe e ʻike pinepine ʻia i ka poʻe e lawe iā Gleevec.

I nā noiʻi hoʻokolohua, ua lawe ka poʻe iā Gleevec e mālama iā Ph + maʻi myeloid leukemia (CML). Aia i 40.1% o kēia poʻe i pākī a i ʻole nā ​​ʻili ʻē aʻe ma hope o ka lawe ʻana i ka lāʻau.

I nā noiʻi hoʻokolohua ʻē aʻe, ua lawe ka poʻe iā Gleevec no nā ʻōpū stromal gastrointestinal (GIST). Ma hope o ka lawe ʻana i ka lāʻau, a hiki i ka 49.8% o kēia poʻe i loaʻa i nā rashes a i ʻole nā ​​ʻili ʻē aʻe. Pākuʻi ʻia kēia mau mea:

  • ʻili ʻana o ka ʻili
  • ʻili maloʻo
  • ʻiliʻili (kahi aniani bluish i ka ʻili)
  • nā maʻi o nā lauoho follicle (ʻeke ma lalo o kou ʻili e paʻa ana i nā aʻa o kou lauoho)
  • erythema (ʻulaʻula o ka ʻili)
  • purpura (poni-ʻula nā kiko ma ka ʻili)

Ua maʻa mau kēia mau hopena i nā poʻe i lawe i nā kaupaona kiʻekiʻe o Gleevec.

Inā ʻoe hopohopo e pili ana i nā huehue a i ʻole nā ​​ʻili ʻili ʻē aʻe e pili ana iā Gleevec, e kamaʻilio me kāu kauka. Hiki iā lākou ke ʻōlelo i nā ala e hōʻoluʻolu ai i kāu mau ʻōuli.

Nā hopena ʻili koʻikoʻi

I nā noiʻi hoʻokolohua, laha ʻole ka hopena o ka ʻili koʻikoʻi i ka poʻe i lawe iā Gleevec. Aia a 1% o ka poʻe i lawe i kēia lāʻau i loaʻa i ka ʻili koʻikoʻi. ʻO nā laʻana o nā hopena ʻili e pili ana i ka lāʻau.

  • ʻO Stevens-Johnson Syndrome (ke kuni; ʻeha ʻeha ma kou waha, ʻāʻī, maka, genitalia, a i ʻole ke kino holoʻokoʻa)
  • exfoliative dermatitis (kaʻiliʻili i nā ʻāpana nui o kou kino)
  • ʻūhū vesicular (nā palapū liʻiliʻi a me kahi hua nui)

Hiki i nā rashes a me nā palapū ke ʻeha loa. A inā ʻaʻole mālama ʻia lākou, hiki iā lākou ke hei i nā bacteria a alakaʻi i nā maʻi nui. No laila inā ʻoe e lawe nei iā Gleevec a loaʻa kahi hū a i ʻole nā ​​palapū me kahi kuni a maikaʻi ʻole ʻoe, e haʻi koke i kāu kauka E haʻi pū kekahi i nā ʻili ʻē aʻe i loaʻa iā ʻoe.

Nā hopena e pili ana i ka hoʻokele

I nā noiʻi hoʻokolohua, ua loaʻa i kekahi poʻe i lawe iā Gleevec nā hopena i hiki ke hoʻopili i ko lākou hiki ke hoʻokele. Pākuʻi ʻia kēia mau mea:

  • dizziness: a i ka 19.4% o ka poʻe
  • ʻike hihi: a hiki i 11.1% o ka poʻe
  • luhi: i ka 74.9% o ka poʻe

Hoʻopili paha kēia mau hopena i kou hiki ke hoʻokele a hoʻohana paha i nā mīkini kaumaha. Ua loaʻa nā hōʻike o nā ulia kaʻa kaʻa e nā poʻe i lawe iā Gleevec. No laila pono ʻoe e akahele i ka wā e hoʻokele a hoʻohana ʻana paha i nā mīkini i ka lawe ʻana iā Gleevec.

Hoʻoiho hōʻeha (ʻaʻole kahi hopena)

ʻAʻole i hōʻike ʻia ka hōʻeha hōʻeha lohi i nā noiʻi maʻi o Gleevec.

ʻO kekahi ʻano o ka mālama ʻana i ka maʻi ʻaʻai, e like me ka radiation a me ka chemotherapy, e hoʻonāwaliwali paha i kou ʻōnaehana pale. Hiki i kēia ke hōʻolo mālie i nā hōʻeha.

Inā ʻoe hopohopo e pili ana i ka hoʻōla hōʻeha ʻana, e nīnau i kāu kauka inā he ʻoi aku kou kiʻekiʻe i kēia pilikia ma muli o kāu ʻano olakino.

Kanesa maʻi ʻaʻai (ʻaʻole paha he ʻaoʻao)

ʻAʻole i hōʻike ʻia ka maʻi ʻaʻai o ke ake ma ke ʻano he hopena ʻaoʻao i ka noiʻi olakino o Gleevec. Eia nō naʻe, ua hōʻino ʻia ke akepaʻa i ka hoʻohana pōkole a me ka wā lōʻihi o Gleevec. ʻO kekahi mau hihia o ka hōʻino ʻana o ke ake a ua alakaʻi i ka maikaʻi ʻole o ke ake a me ka lawe ʻana o ke ake.

ʻIke pinepine ka hōʻino o ke ake i ka wā e nānā ai nā kauka i nā enzymes (nā protein ponoʻī) i hana ʻia i ke ake. ʻO nā pae enzyme i ʻoi aku ka kiʻekiʻe ma mua o ka maʻamau ke lilo i hōʻailona o ka hōʻino o ke ake.

ʻO kekahi mau hōʻailona kino o ka hōʻino o ke ake pū kekahi:

  • nausea
  • pāhoehoe
  • nalo ʻai ʻole
  • ʻili ʻili
  • jaundice (kala melemele o kou ʻili a me nā keʻokeʻo o nā maka)
  • edema (hāhā o kou mau wāwae, nā kuʻekuʻe wāwae, a me nā wāwae)
  • ascites (hoʻoulu wai i kou ʻōpū)
  • ʻāpā pinepine
  • kahe pinepine ʻana o ke kahe

I ka wā o nā noiʻi maʻi ʻana, a hiki i ka 5% o ka poʻe me ka leukemia myeloid maʻi (CML) i kiʻekiʻe loa nā pae o ka ʻenema ate i ka wā o Gleevec lapaʻau. Hiki i ka 6.8% o ka poʻe me nā ʻōpū stromal gastrointestinal (GIST) i loaʻa i nā kiʻekiʻe nā ʻenemene kiʻekiʻe kiʻekiʻe i ka wā o ka lapaʻau. A i ka 0,1% o ka poʻe i lawe iā Gleevec i loaʻa ʻole ke akepaʻa o ke ake.

ʻOiai ʻoe e lawe iā Gleevec, e nānā kāu kauka pehea e holo nei kou ake. Inā loaʻa iā ʻoe kahi hōʻailona o ka hōʻino o ke ake i ka wā e lawe ana iā Gleevec, hiki i kāu kauka ke hōʻemi i kāu lāʻau. Pale aku paha kēia i ka hōʻino e hiki ai i ke kō ʻole o ke ake.

Nā hopena ʻē aʻe i nā keiki

ʻO nā kamaliʻi i loko o nā noiʻi hoʻokolohua nāna i lawe iā Gleevec he mau ʻaoʻao ʻē aʻe i like loa me nā poʻe mākua. Akā ua loaʻa i nā mea noiʻi kēia mau hoʻokoe.

  • ʻoi aku ka liʻiliʻi o nā keiki i ka ʻeha a me ka ʻeha o ka iwi ma mua o ka ʻelemakule
  • ʻO ka edema (ka pehu o nā wāwae, nā kuʻekuʻe wāwae, nā wāwae, a me nā wahi a puni nā maka) ʻaʻole i hōʻike ʻia i nā keiki

ʻO nā hopena i hōʻike pinepine ʻia e hōʻike ʻia i nā keiki ʻo ka nausea a me ka luaʻi. ʻO nā hopena ʻino nui e like me nā haʻahaʻa haʻahaʻa o nā hunaola keokeo a me nā pā.

Inā loaʻa i kāu keiki kēia mau hopena ʻaoʻao, e kamaʻilio me kāu kauka o kāu keiki e pili ana i nā ala e mālama ai iā lākou.

Gleevec no CML

Ua ʻae ka Food and Drug Administration (FDA) iā Gleevec no kekahi poʻe me ka Philadelphia chromosome-positive (Ph +) leukemia myeloid mau (CML). ʻO ka chromosome Philadelphia he chromosome helu 22 me kahi kīnā. Loaʻa ka poʻe me Ph + CML i kahi loli kikoʻī i kā lākou DNA e hana ai i nā hunaola keokeo he nui e hana.

Māhele ʻia ʻo CML i ʻekolu mau hanana:

  • Pae kau. ʻO kēia ka pae mua o CML. Hoʻomaopopo ʻia ka hapanui o ka poʻe me CML i ka wā hoʻomau. Mālie nā ʻōuli, inā aia kekahi.
  • ʻĀina wikiwiki. I kēia pae ʻelua, piʻi ka nui o nā hunaola maʻi ʻaʻai i loko o kou koko. Loaʻa paha iā ʻoe nā hōʻailona hou aku, e like me ke kuni a me ka pohō kaumaha.
  • ʻAha pōpilikia pahū. I kēia pae holomua loa, ua pālahalaha ʻia nā hunaola maʻi ʻaʻai i loko o kou koko i nā ʻōpala a me nā ʻaʻa ʻē aʻe. ʻOi aku paha ke koʻikoʻi o kāu mau hōʻailona.

Ua ʻae ʻia ʻo Gleevec e mālama iā Ph + CML hou i hōʻike ʻia i ka manawa mau i nā poʻe o nā makahiki āpau.

Ua ʻae pū ʻia e mālama iā Ph + CML i ka wā pōkole, i hōʻeleu ʻia, a i ʻole ʻūlū pōpilikia pahū no ka poʻe i loaʻa ʻole ka lāʻau kūleʻa me ka interferon-alpha therapy. ʻO Interferon-alpha kahi lāʻau i hoʻohana pinepine ʻia i ka wā ma mua e mālama iā CML. Ua hoʻololi ʻia e nā lāʻau e like me Gleevec i hōʻike ʻia e ʻoi aku ka maikaʻi.

Ka hoʻokō ʻana

I loko o kahi makahiki he ʻehiku makahiki noiʻi maʻi, ʻo ka helu ola no nā mākua i lawe iā Gleevec no Ph + CML i hōʻike hou ʻia he 86.4%. ʻO ka manaʻo o kēia ua ola ka 86.4% o nā mākua no ʻehiku mau makahiki ma hope o ka hoʻomaka ʻana e lawe iā Gleevec. Ua hoʻohālikelike ʻia kēia me 83.3% o ka poʻe i lawe i nā lāʻau chemotherapy maʻamau.

I kahi hoʻokolohua hoʻokolohua, ʻo nā poʻe i hoʻāʻo mua i ka interferon-alpha no CML i lawe iā Gleevec. Ua pane piha kekahi o kēia poʻe i ka mālama ʻana iā Gleevec. ʻO kēia ka manaʻo ʻaʻole i loaʻa nā hunaola maʻi ʻino i loko o kā lākou koko, a ʻaʻohe o lākou ʻōuli o ke kanesa. Eia ka nui o ka poʻe me CML i pane piha i ka lawe ʻana iā Gleevec:

  • 95% o ka poʻe i ka pae mau
  • 38% o ka poʻe i ka pae wikiwiki
  • 7% o ka poʻe i ka wā pilikia pahū

Ua hoʻokomo pū ʻia ka noiʻi maʻi me nā keiki me Ph + CML i ka pae mau. I ka hui i lawe iā Gleevec, 78% o nā keiki i pane piha i ka lāʻau.

Nā hoʻohana ʻē aʻe no Gleevec

Hoʻohui ʻia me ka leukemia myeloid mau (ʻike ma luna), ua ʻae ka Food and Drug Administration (FDA) iā Gleevec e mālama i kekahi mau ʻano ʻē aʻe.

Gleevec no ka maʻi leukemia lymphocytic huehue (ALL)

Ua ʻae ʻia ʻo Gleevec e mālama iā:

  • ʻO ka chromosome-positive (Ph +) leukemia lymphocytic huikau (ALL) i hoʻi hou ʻia * * a i ʻole refractory * i nā mākua
  • ʻike hou ʻia ʻo Ph + ALL i nā keiki ke hoʻohana ʻia me chemotherapy

* Ua hoʻi mai ka maʻi ʻaʻai kope ma hope o ke kala ʻia ʻana, kahi hōʻemi o nā hōʻailona maʻi ʻaʻai a me nā ʻōuli. ʻAʻole i pane ka maʻi ʻaʻai Refractory i nā mālama maʻi ʻaʻai mua.

I loko o kahi noiʻi hoʻokolohua, 19% o nā mākua me ka hoʻi hou ʻana a i ʻole refactory ALL i lawe iā Gleevec i pane piha i ko lākou koko i ka lāʻau. ʻO kēia ka manaʻo ʻaʻohe o lākou hōʻailona o ka maʻi ʻaʻai.

Ua nānā pū kekahi kahi noiʻi hoʻokolohua i nā keiki me ALL ka poʻe i lawe iā Gleevec a ua loaʻa iā chemotherapy. No 70% o nā keiki, ʻaʻole iʻoi aku ka maikaʻi o ko lākou maʻi ʻaʻai no ʻehā mau makahiki.

Gleevec no nā ʻano maʻi ʻaʻai ʻē aʻe

Ua ʻae ʻia ʻo Gleevec e mālama i nā ʻano ʻē aʻe o nā maʻi maʻi koko, e like me:

  • Nā maʻi Myelodysplastic / myeloproliferative (nā maʻi ʻaʻa pū iwi) i nā mākua me nā receptor ulu ulu i loaʻa i ka platelet (PDGFR). I kahi noi hoʻokolohua liʻiliʻi, 45% o ka poʻe i mālama ʻia me Gleevec i pane piha i ko lākou koko i ka lāʻau. ʻO kēia ka manaʻo ʻaʻole i loaʻa i nā hunaola maʻi ʻaʻai i loko o kā lākou koko, a ʻaʻohe o lākou ʻōuli o ka maʻi ʻaʻai.
  • ʻO ka Hypereosinophilic Syndrome a me / a i ʻole leukemia eosinophilic mau i nā mākua, me nā poʻe me ka FIP1L1-PDGFRα fusion kinase. I nā noi olakino liʻiliʻi, 100% o ka poʻe me ka mutation gen PDGFR nāna i lawe iā Gleevec i pane piha i ko lākou koko i ka lāʻau. Ma waena o 21% a me 58% o ka poʻe me ka ʻole o ka mutation a i ʻole me kahi kūlana mutation ʻike ʻole ʻia i lawe iā Gleevec i pane piha i loko o kā lākou koko.
  • ʻO ka mastocytosis ʻōnaehana aggressive i nā mākua me ka ʻole o ka D816v c-Kit mutation. I kahi noi olakino liʻiliʻi, 100% o ka poʻe me ka FIP1L1-PDGFRα fusion kinase mutation i mālama ʻia me Gleevec i pane piha i ka lāʻau.

Gleevec no ka maʻi ʻaʻai ʻili

Ua ʻae ʻia ʻo Gleevec e mālama iā dermatofibrosarcoma protuberans, kahi ʻano maʻi ʻaʻai ʻili ʻole o ka ʻili, i nā mākua. Ua ʻae ʻia no ka poʻe i loaʻa i ka maʻi ʻaʻai.

  • ʻaʻole hiki ke hoʻohana ʻia
  • ua hoʻi mai ma hope o ka lapaʻau ʻana
  • metastatic (ua hoʻolaha ʻia i nā ʻāpana ʻē aʻe o ke kino)

Ua mālama ʻia kahi poʻe liʻiliʻi me Gleevec no kēia ʻano i nā noiʻi maʻi. ʻO kēlā poʻe i lawe iā Gleevec, he 39% ka pane i ka lapaʻau. ʻO kēia ke kumu o kahi biopsy o ka ʻili (wehe a hoʻāʻo ʻana i kahi hāpana ʻili o ka ʻili) i hōʻike ʻole i nā ʻōuli o ke kanesa.

Gleevec no ka maʻi ʻaʻai gastrointestinal

Ua ʻae ʻia ʻo Gleevec e mālama iā Kit-positive gastrointestinal stromal tumors (GIST) i nā mākua i hiki ʻole ke hana a metastatic paha (ua hoʻolaha ʻia i nā ʻāpana ʻē aʻe o ke kino). ʻAe ʻia ʻo Gleevec e mālama iā GIST i nā mākua i loaʻa i ka ʻokiʻoki e wehe i nā tumors. Hoʻohana ʻia kēia ʻano lapaʻau (adjuvant treatment) e pale i ka maʻi ʻaʻai mai ka hoʻi ʻana ma hope o ke kaha ʻana.

I nā noiʻi maʻi, ʻo ka poʻe me GIST i hiki ʻole ke wehe ʻia i ka lāʻau i lawe iā 400 a i ʻole 800 mg o Gleevec. Ua ola lākou ma kahi o ʻehā mau makahiki.

ʻO nā kānaka ʻē aʻe me GIST i hana ʻoki ʻia. Ma waena o 14 a me 70 mau lā ma hope, ua hoʻomaka lākou e lawe iā Gleevec i ke aʻo ʻana. Loaʻa iā lākou ma kahi o 60% ka makaʻu haʻahaʻa o ka make ʻana a i ʻole ke hoʻi ʻana o ka maʻi ʻaʻai i loko o 12 mau mahina. Hoʻohālikelike ʻia kēia i ka poʻe i lawe i kahi placebo (lapaʻau me ka lāʻau hana ʻole).

Hoʻohana ʻia ka inoa lepili no Gleevec

Ma waho aʻe o nā hoʻohana i helu ʻia ma luna, hoʻohana ʻia ʻo Gleevec i ka lepili inoa no nā hoʻohana ʻē aʻe. ʻO ka hoʻohana ʻana i ka lāʻau lapaʻau ʻole ka wā hoʻohana ʻia kahi lāʻau i ʻae ʻia no ka hoʻohana hoʻokahi i kuhikuhi ʻia no kahi mea ʻē aʻe i ʻae ʻole ʻia.

Hiki ke hoʻohana ʻia ʻo Gleevec i ka lepili no nā maʻi ʻē aʻe, e like me:

  • maʻi ʻaʻai prostate, e like me kahi noiʻi 2015
  • melanoma, e like me ka National Comprehensive Cancer Network lapaʻau lapaʻau
  • ʻano 1 diabetes, e like me ka hoʻokolohua hoʻokolohua 2018

Eia nō naʻe, ʻaʻole nui ka noiʻi e pili ana i ka hana a Gleevec i loko o ke kanaka me kēia mau ʻano. Pono nā noi hou e hoʻoholo inā kōkua ʻo Gleevec i ka mālama ʻana i kēlā me kēia ʻano.

Gleevec no nā keiki

Ua ʻae ʻia ʻo Gleevec e lapaʻau ʻia no nā keiki me nā ʻano aʻe:

  • ʻike hou ʻia ʻo Philadelphia-positive (Ph +) leukemia myeloid mau loa (CML) i ka wā mau (ka pae mua o ka maʻi)
  • ʻike hou ʻia ʻo Ph + huehue lymphocytic leukemia (ALL) ke hoʻohana ʻia me chemotherapy

ʻAe ʻia ʻo Gleevec e hoʻohana i nā keiki o nā makahiki āpau. Eia nō naʻe, ʻaʻole i loaʻa nā noiʻi ʻana e pili ana i ke ʻano palekana a maikaʻi paha o Gleevec i nā keiki ma mua o ka makahiki 1.

Kālā Gleevec

E like me nā lāʻau āpau, hiki ke hoʻololi ke kumukūʻai o Gleevec.

ʻO ke kumukūʻai maoli āu e uku ai ma muli o kāu ʻinikua uhi a me ka hale kūʻai lāʻau lapaʻau āu e hoʻohana ai.

Kōkua kālā a me nā ʻinikua

Inā makemake ʻoe i kākoʻo kālā e uku no Gleevec, a inā ʻoe e kōkua i ka hoʻomaopopo ʻana i kāu ʻinikua uhi, loaʻa ke kōkua.

Hāʻawi ʻo Novartis Pharmaceutical Corporation, ka mea hana o Gleevec, i kahi papahana i kapa ʻia ʻo Novartis Oncology Universal Co-pay Program. No ka ʻike hou aku a e ʻike inā ua kūpono ʻoe no ke kākoʻo, kāhea iā 877-577-7756 a i ʻole kipa i ka pūnaewele pūnaewele.

Nā mea hana Gleevec

ʻO ka lāʻau Gleevec i kuhikuhi ʻia e kāu kauka e pili ana i nā kumu he nui. Pākuʻi ʻia kēia mau mea:

  • ke ʻano a me ke koʻikoʻi o ke ʻano āu e hoʻohana nei iā Gleevec e mālama ai
  • makahiki
  • ke kaupaona (no nā keiki)
  • alo o ka hoʻololi gen
  • nā kūlana olakino ʻē aʻe āu
  • nā lāʻau ʻē aʻe āu e ʻai ai
  • nā hopena ʻē aʻe i loaʻa iā ʻoe

ʻO ka mahele lāʻau e loaʻa iā ʻoe e pili ana i kāu maʻi ʻaʻai. No kekahi mau maʻi ʻino, hiki i kāu kauka ke hoʻomaka iā ʻoe ma kahi lāʻau haʻahaʻa. A laila e hoʻoponopono lākou iā ia ma ka manawa e hiki i ke ana i kūpono iā ʻoe.

Hōʻike ka ʻikepili aʻe i nā lāʻau i hoʻohana pinepine ʻia a koi ʻia paha. Eia nō naʻe, e mālama pono i nā lāʻau a ke kauka i kuhikuhi ai nāu. E hoʻoholo kāu kauka i ke ana ʻoi loa e kūpono i kāu mau pono.

Nā ʻano lāʻau a me nā ikaika

Hele mai ʻo Gleevec ma ke ʻano he papaha āu e lawe ai ma ka waha (ale ʻoe iā ia). Loaʻa ia i nā papa 100-mg a me nā papa 400-mg.

Hiki mai nā ʻōmole 100-mg a me 400-mg i nā ʻōmole. Hele mai nā papa 400-mg i loko o nā ʻeke pelele i paʻakikī e wehe nā keiki.

Nā dosage Gleevec

ʻO nā mahele aʻe nā ʻano dosages hoʻomaka no kēlā me kēia kūlana:

  • nā mākua me Philadelphia-positive (Ph +) myeloid leukemia (CML) i ka wā mau (ka pae mua o ka maʻi). 400 mg / lā
  • nā mākua me Ph + CML i ka manawa pōkole a i ʻole pohā pahū (ʻo ka ʻelua a me ke kolu o nā pae o ka maʻi): 600 mg / lā
  • nā mākua me ka Ph + huʻi lymphocytic leukemia (ALL): 600 mg / lā
  • nā mākua me ka myelodysplastic / myeloproliferative maʻi: 400 mg / lā
  • nā mākua me ka mastocytosis ʻōnaehana kolohe: 100 mg a i ʻole 400 mg / lā
  • nā mākua me ka maʻi hypereosinophilic a me / a i ʻole leukemia eosinophilic mau. 100 mg / lā a 400 mg / lā paha
  • nā mākua me nā dermatofibrosarcoma protuberans: 800 mg / lā
  • nā mākua me nā ʻōpū stromal gastrointestinal (GIST): 400 mg / lā

Kauoha paha kāu kauka i kahi lāʻau ʻokoʻa nāu. E hoʻokumu lākou ia ma ke ʻano o ka maikaʻi o ka pane ʻana o kou kino i ka lāʻau, pehea ke koʻikoʻi o kāu hopena a, a me nā kumu ʻē aʻe. Inā he mau nīnau kāu e pili ana i ke ana pono o Gleevec nāu, e kamaʻilio me kāu kauka.

ʻĀpana pēpē

Nā hana no nā keiki eia kēia:

  • nā keiki me Ph + CML i ka wā mau (ka pae mua o ka maʻi). 340 mg / m2 / lā
  • keiki me Ph + ALL: 340 mg / m2 / lā e lawe ʻia me chemotherapy

E hoʻokumu ke kauka o kāu keiki i ka mahele lāʻau i ke kiʻekiʻe a me ke kaumaha o kāu keiki. (No laila 340 mg / m2 340 mg no ka mika mika o ka ʻili o ke kino.) Eia kekahi laʻana, inā he 4 kapuaʻi ke kiʻekiʻe o kāu keiki a kaupaona ʻia he 49 lbs. No laila ʻo ka hana no Ph + CML he 300 mg.

He aha inā e haʻo wau i kahi lāʻau?

Inā ʻoe e nalo i kahi mahele o Gleevec, e lawe i kahi ke hoʻomanaʻo ʻoe. Inā kokoke i ka manawa no kāu kaukona aʻe, kali a lawe i ka lāʻau aʻe e like me ka mea i hoʻonohonoho ʻia. Mai lawe i ʻelua mau kaha e pani no ka mahele lāʻau i hala. Hiki i kēia ke hoʻonui i kou makaʻu no nā hopena ʻaoʻao koʻikoʻi.

Pono wau e hoʻohana i kēia lāʻau lōʻihi?

Hoʻohana ʻia ʻo Gleevec ma ke ʻano he lapaʻau lōʻihi. Inā hoʻoholo ʻoe a me kāu kauka he palekana a maikaʻi ʻo Gleevec nāu, lawe paha ʻoe i kahi wā lōʻihi.

Nā koho ʻē aʻe iā Gleevec

Loaʻa nā lāʻau ʻē aʻe i hiki ke mālama i kou ʻano. Kūpono paha kekahi iā ʻoe ma mua o nā poʻe ʻē aʻe. Inā hoihoi ʻoe i ka ʻimi ʻana i kahi ʻē aʻe iā Gleevec, e kamaʻilio me kāu kauka e aʻo hou e pili ana i nā lāʻau ʻē aʻe e holo pono paha iā ʻoe.

Kaha: Hoʻohana ʻia kekahi o nā lāʻau i helu ʻia ma aneʻi i ka lepili e mālama ai i kēia mau ʻano kikoʻī.

Nā koho ʻē aʻe no CML

Nā laʻana o nā lāʻau ʻē aʻe i hiki ke hoʻohana ʻia e mālama iā Philadelphia-positive (Ph +) leukemia myeloid mau (CML) ʻo:

  • dasatinib (Sprycel)
  • nilotinib (Tasigna)
  • bosutinib (Bosulif)
  • ponatinib (Iclusig)
  • omacetaxine (Synribo)
  • daunorubicin (Cerubidine)
  • cytarabine
  • interferon-alpha (Intron A)

Nā koho ʻē aʻe no GIST

ʻO nā laʻana o nā lāʻau ʻē aʻe i hiki ke hoʻohana ʻia e mālama i nā tumomoma stromal gastrointestinal (GIST):

  • sunitinib (Sutent)
  • regorafenib (Stivarga)
  • sorafenib (Nexavar)
  • nilotinib (Tasigna)
  • dasatinib (Sprycel)
  • pazopanib (Votrient)

Loaʻa nā koho ʻē aʻe no nā kūlana ʻē aʻe Gleevec. E kamaʻilio me kāu kauka e pili ana i nā lāʻau i hiki ke hoʻohana ʻia no kāu maʻi.

ʻO Gleevec vs. Tasigna

Mahalo paha ʻoe pehea e hoʻohālikelike ai ʻo Gleevec i nā lāʻau ʻē aʻe i kuhikuhi ʻia no nā hoʻohana like. Maanei mākou e nānā ai i ka like a like ʻole o Gleevec a me Tasigna.

Hoʻohana

Ua ʻae ka Food and Drug Administration (FDA) iā Gleevec a me Tasigna e mālama i kekahi ʻano maʻi maʻi koko.

Ua ʻae ʻia nā lāʻau ʻelua e kauka e hoʻomaʻamaʻa hou ʻia ʻo Philadelphia-positive (Ph +) leukemia myeloid mau loa (CML) i ka manawa mau o nā mākua a me nā keiki.

Māhele ʻia ka leukemia myeloid maʻi (CML) i ʻekolu mau hanana:

  • Pae kau. ʻO kēia ka pae mua o CML. Hoʻomaopopo ʻia ka hapanui o ka poʻe me CML i ka wā hoʻomau. Mālie nā ʻōuli, inā aia kekahi.
  • ʻĀina wikiwiki. I kēia pae ʻelua, piʻi ka nui o nā hunaola maʻi ʻaʻai i loko o kou koko. Loaʻa paha iā ʻoe nā hōʻailona hou aku, e like me ke kuni a me ka pohō kaumaha.
  • ʻAha pōpilikia pahū. I kēia pae holomua loa, ua pālahalaha ʻia nā hunaola maʻi ʻaʻai i loko o kou koko i nā ʻōpala a me nā ʻaʻa ʻē aʻe. ʻOi aku paha ke koʻikoʻi o kāu mau hōʻailona.

Ua ʻae ʻia ʻo Gleevec e mālama iā Philadelphia-positive (Ph +) CML i nā mākua i ka wā mau, holo wikiwiki, a i ʻole wā pōkole inā ʻaʻole i holo ka interferon-alpha therapy.

ʻO Interferon-alpha kahi lāʻau i hoʻohana mau ʻia e mālama iā CML i ka wā i hala. He lāʻau hana ia na ke kanaka e hana e like me kekahi protein immune system a pale i ka ulu ʻana o nā hunaola maʻi ʻaʻai.

Ua ʻae ʻia ʻo Tasigna e mālama iā Ph + CML i nā manawa hoʻomau a i hōʻeleu ʻia paha i nā mākua inā ʻaʻole i hana nā ʻano lapaʻau ʻē aʻe, e like me ka lapaʻau ʻana me Gleevec. ʻAʻole ʻae ʻia ʻo Tasigna no ka wā pilikia pahū.

Ua ʻae ʻia ʻo Tasigna e mālama iā Ph + CML i nā keiki mai 1 mau makahiki a ʻoi paha inā ʻaʻole i hana nā ʻano lāʻau ʻē aʻe. ʻAe ʻia ʻo Gleevec e mālama iā Ph + CML hou i hōʻike ʻia i nā keiki.

ʻAe ʻia ʻo Gleevec e mālama i nā ʻano ʻē aʻe. E ʻike i ka mahele “Nā hoʻohana ʻē aʻe no Gleevec” e aʻo hou ai.

Nā ʻano lāʻau a me ka hoʻoponopono ʻana

Loaʻa i ka Gleevec ka imatinib lāʻau. Aia i loko o Tasigna ka lāʻau nilotinib.

Hele mai ʻo Gleevec ma ke ʻano he papa. Hele mai ʻo Tasigna ma ke ʻano he capsule. Lawe ʻia nā lāʻau ʻelua e ka waha.

Lawe ʻia ʻo Gleevec hoʻokahi a ʻelua mau manawa paha i ka lā, ke kaukaʻi ʻia i kāu lāʻau. Lawe ʻia ʻo Tasigna i ʻelua mau manawa i ka lā.

Hele mai ʻo Gleevec ma ke ʻano he 100-mg a me 400-mg mau papa. Hele mai ʻo Tasigna ma ke ʻano he 50-mg, 150-mg, a me 200-mg capsule.

Nā hopena a me nā pilikia

Loaʻa iā Gleevec a me Tasigna nā lāʻau like. No laila, hiki i nā lāʻau ʻelua ke hana i nā hopena ʻaoʻao like loa. Ma lalo nā hiʻohiʻona o kēia mau hopena ʻaoʻao.

Nā hopena ʻaoʻao hou aʻe

Aia i loko o kēia mau papa inoa nā laʻana o nā hopena ʻē aʻe i hiki ke hana ʻia me Gleevec, me Tasigna, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me Gleevec:
    • edema (ʻōhū o kou mau wāwae, nā kuʻekuʻe wāwae, a me nā wāwae, a puni kou mau maka)
    • ʻūpē mākala
    • ʻeha ʻeha
    • ʻeha iwi
    • ʻeha ka ʻōpū
  • Hiki ke hana me Tasigna:
    • ʻeha poʻo
    • ʻili ʻili
    • ʻūhā
    • kōpaʻa
    • ʻeha pū
    • nasopharyngitis (maʻamau anu)
    • fiva
    • puhū pō
  • Hiki ke hana me nā Gleevec a me Tasigna:
    • nausea
    • ka luaʻi
    • pāhoehoe
    • hūwī
    • luhi (nele o ka ikaika)

Nā hopena hopena koʻikoʻi

Aia i loko o kēia mau papa inoa nā laʻana o nā hopena ʻino e hiki ke hana me Gleevec, me Tasigna, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me Gleevec:
    • kūleʻa puʻuwai congestive a i ʻole nā ​​pilikia puʻuwai e like me ka maikaʻi ʻole o ka puʻuwai hema
    • gastrointestinal perforations (puka i loko o kou ʻōpū a me kou ʻōpū)
    • nā hopena ʻili koʻikoʻi, e like me ka maʻi maʻi ʻo Stevens-Johnson (fiva; ʻehaʻeha ma kou waha, ʻāʻī, maka, genitalia, a i ʻole ke kino holoʻokoʻa)
    • hōʻino kīhāpai
    • hypothyroidism (pae haʻahaʻa thyroid) i ka poʻe i hemo kā lākou thyroid
  • Hiki ke hana me Tasigna:
    • wā lōʻihi QT (ka hana uila uila i loko o kou puʻuwai), he mea laha ʻole akā hiki ke hopena i ka make koke
    • ālai ʻia nā kīʻaha koko i ka puʻuwai
    • pancreatitis
    • electrbalte imbalances (kiʻekiʻe a i ʻole pae haʻahaʻa o kekahi mau minelala)
  • Hiki ke hana me nā Gleevec a me Tasigna:
    • nā maʻi koko, me ka anemia (nā pae haʻahaʻa o nā hunaola ʻulaʻula), neutropenia (nā pae haʻahaʻa o nā hunaola keokeo), a me ka thrombositopenia (nā pae haʻahaʻa o nā platelet)
    • hōʻino ka ate
    • tumo lysis maʻi pale (maʻi koʻohune ke kala i nā Nine Inch weliweli i loko o kou koko)
    • hemorrhage (kahe ʻole ke koko)
    • paʻa kahe paʻa (ʻoi loa ka wai a wai paha)
    • lohi ka ulu ʻana o nā keiki

Ka hoʻokō ʻana

Loaʻa iā Gleevec a me Tasigna nā ʻano ʻokoʻa i ʻae ʻia e ka FDA. Akā mālama lāua ʻelua iā Ph + CML i nā manawa hoʻomau a me ka wikiwiki inā ʻaʻole i holo kekahi mau ʻano lāʻau ʻē aʻe. ʻEkolu mau ʻāpana o ka CML: ka lōʻihi (pae 1), ka wikiwiki (pae 2), a me ka ulia pōpilikia (pae 3).

Hoʻohālikelike ka hoʻohana ʻana o Gleevec a me Tasigna i ka mālama ʻana iā Ph + CML hou i nā mākua i kahi noiʻi hoʻokolohua. Hoʻohālikelike nā kānaka noiʻi i ka poʻe i lawe i 400 mg o Gleevec i hoʻokahi manawa i ka lā a i ʻole 300 mg o Tasigna i ʻelua mau lā i ka lā.

Ma hope o 12 mau mahina o ka mālama ʻana, 65% o ka poʻe i lawe iā Gleevec ʻaʻohe o lākou mau hunaola Ph + i ko lākou iwi iwi (kahi e ulu ai nā hunaola CML maʻi ʻaʻai). ʻO nā poʻe i lawe iā Tasigna, 80% ʻaʻohe o lākou mau Ph + cell i ko lākou iwi iwi.

Ma hope o ʻelima mau makahiki o ka mālama ʻana, 60% o ka poʻe i lawe iā Gleevec ua hōʻemi loa i nā helu maʻi ʻaʻai i loko o kā lākou koko. Ua hoʻohālikelike ʻia kēia me 77% o ka poʻe i lawe iā Tasigna.

Ma hope o ʻelima mau makahiki o ka mālama ʻana, 91.7% o ka poʻe i lawe iā Gleevec e ola nei. Hoʻohālikelike ʻia me 93.7% o ka poʻe i lawe iā Tasigna.

Hōʻike nā hopena o kēia noi ʻana e ʻoi aku ka maikaʻi o Tasigna ma mua o Gleevec i ka mālama ʻana iā Ph + CML hou i ka wā maʻi.

Nā kumukūʻai

ʻO Gleevec lāua ʻo Tasigna nā lāʻau lapaʻau inoa ʻelua. ʻAʻohe o generic form ʻo Tasigna, akā he ʻano generic kā Gleevec i kapa ʻia imatinib. ʻOi aku ke kumu kūʻai o nā lāʻau lapaʻau inoa inoa ma mua o nā generics.

Wahi a nā koho ma GoodRx.com, ʻoi aku ka uku o ka inoa inoa Gleevec ma mua o Tasigna. ʻO ke ʻano generic o Gleevec (imatinib) he kumukūʻai hoʻi ma mua o Tasigna. ʻO ke kumukūʻai maoli āu e uku ai no nā lāʻau ʻelua e pili ana i kāu lāʻau, hoʻolālā inikua, kou wahi, a me ka lāʻau kūʻai āu e hoʻohana ai.

Gleevec vs. Sprycel

Mahalo paha ʻoe pehea e hoʻohālikelike ai ʻo Gleevec i nā lāʻau ʻē aʻe i kuhikuhi ʻia no nā hoʻohana like. Maanei mākou e nānā ai pehea e like ai a ʻokoʻa ai ʻo Gleevec a me Sprycel.

Hoʻohana

Ua ʻae ka Food and Drug Administration (FDA) iā Gleevec a me Sprycel e mālama i kekahi ʻano maʻi maʻi koko.

Ua ʻae ʻia nā lāʻau ʻelua i ka FDA e mālama i kahi mea hou i hōʻike ʻia ʻo Philadelphia-positive (Ph +) leukemia myeloid mau loa (CML) i ka manawa mau o nā mākua a me nā keiki.

Māhele ʻia ʻo CML i ʻekolu mau hanana:

  • Pae kau. ʻO kēia ka pae mua o CML. Hoʻomaopopo ʻia ka hapanui o ka poʻe me CML i ka wā hoʻomau. Mālie nā ʻōuli, inā aia kekahi.
  • ʻĀina wikiwiki. I kēia pae ʻelua, piʻi ka nui o nā hunaola maʻi ʻaʻai i loko o kou koko. Loaʻa paha iā ʻoe nā hōʻailona hou aku, e like me ke kuni a me ka pohō kaumaha.
  • ʻAha pōpilikia pahū. I kēia pae holomua loa, ua pālahalaha ʻia nā hunaola maʻi ʻaʻai i loko o kou koko i nā ʻōpala a me nā ʻaʻa ʻē aʻe. ʻOi aku paha ke koʻikoʻi o kāu mau hōʻailona.

Hoʻohana ʻia ʻo Gleevec a me Sprycel e mālama iā Ph + CML i nā mākua i ka wā mau.

Hoʻohana ʻia ʻo Gleevec e mālama iā Ph + CML i nā mākua i nā manawa mau, wikiwiki, a me nā pōpilikia inā ʻaʻole i holo ka interferon-alpha therapy. ʻO Interferon-alpha kahi lāʻau i hoʻohana mau ʻia e mālama iā CML i ka wā i hala. He lāʻau hana ia na ke kanaka e hana e like me kekahi protein immune system a pale i ka ulu ʻana o nā hunaola maʻi ʻaʻai.

Hoʻohana ʻia ʻo Sprycel e mālama iā Ph + CML i nā mākua i nā manawa mau, wikiwiki, a me nā pōpilikia inā ʻaʻole i holo ʻo Gleevec.

Ua ʻae ʻia ʻo Gleevec a me Sprycel e mālama iā Ph + CML i ka manawa mau o nā keiki. Ua ʻae ʻia lāua ʻelua e mālama iā Ph + huakō lymphocytic leukemia (ALL) i nā keiki me chemotherapy.

ʻAe ʻia ʻo Gleevec e mālama i nā ʻano ʻē aʻe. E ʻike i ka mahele “Nā hoʻohana ʻē aʻe no Gleevec” e aʻo hou ai.

Nā ʻano lāʻau a me ka hoʻoponopono ʻana

Loaʻa i ka Gleevec ka imatinib lāʻau. Loaʻa i ka Sprycel ka lāʻau dasatinib.

Hele mai ʻo Gleevec lāua ʻo Sprycel ma ke ʻano he mau papa e lawe ai ʻoe ma ka waha (ale ʻoe iā lākou).

Hele mai nā papa Gleevec i nā ikaika ʻelua: 100 mg a 400 mg. Lawe ʻia hoʻokahi a ʻelua mau manawa paha i ka lā, ke kaukaʻi ʻia i kāu lāʻau.

Hele mai nā papa Sprycel i nā ikaika e hiki mai ana: 20 mg, 50 mg, 70 mg, 80 mg, 100 mg, a me 140 mg. Lawe ʻia ʻo Sprycel i hoʻokahi manawa i ka lā.

Nā hopena a me nā pilikia

Kūlike ʻo Gleevec a me Sprycel akā loaʻa nā lāʻau ʻokoʻa. No laila, hiki i nā lāʻau ʻelua ke hana i nā hopena ʻaoʻao like loa. Ma lalo nā hiʻohiʻona o kēia mau hopena ʻaoʻao.

Nā hopena ʻaoʻao hou aʻe

Aia i loko o kēia mau papa inoa nā laʻana o nā hopena ʻē aʻe i hiki ke hana ʻia me Gleevec, me Sprycel, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me Gleevec:
    • ka luaʻi
    • ʻūpē mākala
    • ʻeha ka ʻōpū
    • edema maka-ʻā (ʻōhū a puni nā maka)
  • Hiki ke hana me Sprycel:
    • pilikia hanu
    • ʻeha poʻo
    • kahe ana ke koko
    • hoʻonāwaliwali ʻōnaehana pale (ʻaʻole hiki i kou kino ke hakakā i nā maʻi pū kekahi)
  • Hiki ke hana me Gleevec a me Sprycel:
    • edema (hāhā o kou mau wāwae, nā kuʻekuʻe wāwae, a me nā wāwae)
    • nausea
    • ʻeha ʻeha
    • ʻeha iwi
    • pāhoehoe
    • hūwī
    • luhi (nele o ka ikaika)

Nā hopena hopena koʻikoʻi

Aia i loko o kēia mau papa inoa nā laʻana o nā hopena ʻino e hiki ke hana me Gleevec, me Sprycel, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me Gleevec:
    • nā pilikia puʻuwai, e like me ka puʻuwai puʻuwai congestive
    • hōʻino ka ate
    • gastrointestinal perforations (puka i loko o kou ʻōpū a me kou ʻōpū)
    • hōʻino kīhāpai
    • hypothyroidism (pae haʻahaʻa thyroid) i ka poʻe i hemo kā lākou thyroid
  • Hiki ke hana me Sprycel:
    • pulmonary arterial hypertension (ke koko kiʻekiʻe i nā kīʻaha koko i kou mau māmā)
    • ka wā QT lōʻihi (kahi ʻano o ka hana uila uila ʻole i loko o kou puʻuwai)
    • hoʻouka puʻuwai ischemic (nele o ka oxygen i nā mākala puʻuwai)
  • Hiki ke hana me Gleevec a me Sprycel:
    • paʻa kahe nui (ka nui o ka wai a wai paha) a puni kou mau māmā, puʻuwai, a me kou ʻōpū
    • nā maʻi koko koʻikoʻi (nā pae haʻahaʻa o nā hunaola ʻulaʻula, platelet, a i ʻole nā ​​ʻula koko keʻokeʻo)
    • hemorrhage nui (kahe ʻole ke koko)
    • nā hopena ʻili koʻikoʻi, e like me ka maʻi maʻi ʻo Stevens-Johnson (fiva; ʻehaʻeha ma kou waha, ʻāʻī, maka, genitalia, a i ʻole ke kino holoʻokoʻa)
    • tumo lysis maʻi pale (maʻi koʻohune ke kala i nā Nine Inch weliweli i loko o kou koko)
    • ka helu o ka puʻuwai a i ʻole ka ritim (kuʻi ka puʻuwai i wikiwiki loa, lohi, a i ʻole kaulike)
    • ulu ulu o nā keiki

Ka hoʻokō ʻana

ʻO Gleevec lāua ʻo Sprycel he mau hoʻohana ʻokoʻa i ʻae ʻia e ka FDA. Akā mālama lāua ʻelua i ka Ph + CML hou ʻia i ka pae mau (ka pae mua o CML) i nā mākua a me nā keiki. Mālama pū ʻo Gleevec lāua ʻo Sprycel iā Ph + ALL i nā keiki ke hoʻohana ʻia me ka chemotherapy.

Hoʻohui ʻia, mālama ʻo Gleevec lāua ʻo Sprycel iā Ph + CML i nā pae holomua a hāhā i nā mākua, a i ʻole Ph + ALL, inā ʻaʻole i holo pono nā lāʻau ʻē aʻe na lāua.

Hoʻohālikelike ʻia ka hoʻohana ʻana o Gleevec a me Sprycel i ka mālama ʻana iā Ph + CML hou i ka poʻe mākua i kahi noiʻi hoʻokolohua. Hoʻohālikelike nā kānaka noiʻi i ka poʻe i lawe i 400 mg o Gleevec i kahi lā a i ʻole 100 mg o Sprycel i ka lā.

Ma waena o 12 mau mahina, 66.2% o ka poʻe i lawe iā Gleevec ʻaʻohe o lākou mau huna Ph + i ko lākou iwi iwi (kahi e ulu ai nā hunaola CML maʻi ʻaʻai). I ka hui i lawe iā Sprycel, 76.8% o ka poʻe ʻaʻohe o lākou keena Ph + i ko lākou iwi iwi.

Ma hope o ʻelima mau makahiki o ka mālama ʻana, ua ola he 89.6% o ka poʻe i lawe iā Gleevec. Hoʻohālikelike ʻia i kahi 90.9% i koho ʻia o ka poʻe i lawe iā Sprycel.

Hōʻike nā hopena o kēia hoʻopaʻa ʻana e ʻoi aku paha ka maikaʻi o Sprycel ma mua o Gleevec i ka mālama ʻana iā Ph + CML hou i ka wā mau.

Nā kumukūʻai

ʻO Gleevec lāua ʻo Sprycel nā lāʻau lapaʻau inoa ʻelua. ʻAʻohe o generic form a Sprycel, akā he ʻano generic kā Gleevec i kapa ʻia imatinib. ʻOi aku ke kumu kūʻai o nā lāʻau lapaʻau inoa inoa ma mua o nā generics.

Wahi a nā koho ma GoodRx.com, ʻoi aku ka uku o ka inoa inoa Gleevec ma mua o Sprycel. ʻO ke ʻano generic o Gleevec (imatinib) kahi mea kūʻai aku paha ma mua o Sprycel. ʻO ke kumukūʻai maoli āu e uku ai no nā lāʻau ʻelua e pili ana i kāu lāʻau, kāu hoʻolālā ʻinikua, kou wahi, a me ka hale kūʻai āu e hoʻohana ai.

Gleevec a me ka waiʻona

ʻAʻole maopopo inā pili paha ʻo Gleevec a me ka waiʻona i kekahi.

Eia nō naʻe, metabolises (haki i kou ake) nā Gleevec a me nā waiʻona. No laila ke inu nei i ka waiʻona nui ke lawe nei ʻoe iā Gleevec e pale paha i kou ake mai ka wāwahi ʻana i ka lāʻau. Hiki i kēia ke hāpai i nā kiʻekiʻe o Gleevec i kou kino a hoʻonui i kou makaʻu no nā hopena ʻino, a me nā hōʻino o ke ake.

Hiki i nā Gleevec a me ka waiʻona ke hana i nā hopena ʻē aʻe e like me:

  • nausea
  • pāhoehoe
  • ʻeha poʻo
  • luhi (nele o ka ikaika)

ʻO ka inu ʻana i ka waiʻona i kou wā Gleevec lapaʻau hiki ke hoʻonui i kou makaʻu i ka loaʻa ʻana o kēia mau hopena ʻaoʻao.

Inā inu ʻoe i ka waiʻona, e kamaʻilio me kāu kauka e pili ana i ka nui o ka palekana iā ʻoe i kāu wā Gleevec.

Nā pilina Gleevec

Hiki iā Gleevec ke launa pū me nā lāʻau ʻē aʻe. Hiki iā ia ke launa pū me kekahi mau mea hoʻopihapiha a me kekahi mau meaʻai.

Hiki i nā launa like ʻole ke kumu i nā hopena like ʻole. ʻO kahi laʻana, hiki i kekahi ke hoʻopilikia i ka maikaʻi o ka hana ʻana o ka lāʻau, ʻoiai ʻo kekahi e hoʻonui i nā hopena ʻaoʻao.

Gleevec a me nā lāʻau ʻē aʻe

Ma lalo ka papa inoa o nā lāʻau i hiki ke launa pū me Gleevec. ʻAʻohe i loko o kēia papa inoa nā lāʻau āpau e launa pū me Gleevec.

Ma mua o ka lawe ʻana iā Gleevec, e kamaʻilio me kāu kauka a me kāu kauka lāʻau. E haʻi iā lākou e pili ana i nā kuhikuhi āpau, nā mea kūʻai aku, a me nā lāʻau ʻē aʻe āu e lawe ai. E haʻi pū iā lākou e pili ana i nā wikamina, nā mea kanu, a me nā mea hoʻopiha āu e hoʻohana ai. Hiki ke kōkua i ka hāʻawi ʻana i kēia ʻike iā ʻoe e hōʻalo i nā launa ʻole.

Inā he mau nīnau kāu e pili ana i nā launa lāʻau e hoʻopili iā ʻoe, e nīnau i kāu kauka a kauka paha.

ʻO Gleevec lāua ʻo Tylenol

Lawe iā Gleevec me Tylenol (acetaminophen) hiki ke hoʻonui i kou makaʻu no nā hopena ʻino, e like me ka hōʻino o ke ake.

ʻO nā Enzymes (nā protein kūikawā) i kou ake e wāwahi i nā Gleevec a me Tylenol. Hiki pū, hiki i nā lāʻau ʻelua ke hoʻokahuli i nā enzyme a hōʻino i nā hunaola i kou ake.

E nīnau i kāu kauka inā palekana iā ʻoe e lawe iā Tylenol i ka wā o kāu mālama iā Gleevec.

Gleevec a me kekahi mau lāʻau hopu

Lawe iā Gleevec me kekahi mau lāʻau i hopu ʻia hiki ke hoʻēmi i nā pae Gleevec i kou kino. Hiki i kēia ke hana iā Gleevec i mea liʻiliʻi (hana maikaʻi ʻole).

ʻO nā laʻana o nā lāʻau i hopu ʻia e hiki ke hoʻemi i nā pae Gleevec e komo pū ana:

  • phenytoin (Dilantin, Phenytek)
  • carbamazepine (Carbatrol, Tegretol)
  • phenobarbital

Inā ʻoe e lawe iā Gleevec a me kekahi mau lāʻau hopu, hiki i kāu kauka ke kuhikuhi i kahi lāʻau ʻālau ʻokoʻa a i ʻole hoʻoponopono i ke ana o Gleevec.

Gleevec a me kekahi mau antibiotic

Lawe iā Gleevec me kekahi mau lāʻau antibiotic (nā lāʻau e mālama i nā maʻi bacteria) hiki ke hoʻonui i nā pae Gleevec i kou kino. Pale aku nā Antibiotics iā Gleevec mai ka haki ʻana i kou kino. Hoʻonui kēia i kou makaʻi no nā hopena ʻaoʻao koʻikoʻi.

ʻO kahi laʻana o kahi antibiotic i hiki ke hoʻonui i nā pae Gleevec ʻo clarithromycin (Biaxin XL).

Inā lawe ʻoe iā Gleevec a makemake i kahi antibiotic, hiki i kāu kauka ke nānā iā ʻoe no nā hopena ʻaoʻao. Hiki iā lākou ke hōʻemi i kāu hana Gleevec no kekahi manawa.

Gleevec a me kekahi mau antifungals

Lawe iā Gleevec me kekahi mau antifungals (nā lāʻau e mālama i nā maʻi fungal) hiki ke pale i ka haki o Gleevec i kou kino. Hiki i kēia ke hāpai i nā pae Gleevec i loko o kou koko a hoʻonui i kou makaʻi no nā hopena ʻino.

Nā laʻana o nā antifungals i hiki ke hoʻonui i nā pae Gleevec:

  • itraconazole (Onmel, Sporanox, Tolsura)
  • ketoconazole (Extina, Ketozole, Xolegel)
  • voriconazole (Vfend)

Inā ʻoe e lawe iā Gleevec a pono i ka lāʻau antifungal, e nānā ke kauka iā ʻoe no nā hopena ʻaoʻao. Hiki iā lākou ke hōʻemi i kāu hana Gleevec no kekahi manawa.

Gleevec a me nā opioids

Lawe iā Gleevec me kekahi mau lāʻau lapaʻau ʻeha e hiki ke hoʻonui i nā pae o ka mea hōʻoluʻolu ʻeha i kou kino. ʻO kēia ka mea e loaʻa iā ʻoe i nā hopena ʻē aʻe e like me ka sedation (hiamoe a emi iki ka makaʻala) a me ke kaumaha o ka hanu (hanu mālie).

ʻO nā laʻana o nā lāʻau ʻeha opioid i hiki ke hoʻonui i nā pae Gleevec me:

  • ʻoxycodone (Oxycontin, Roxicodone, Xtampza ER)
  • tramadol (ConZip, Ultram)
  • methadone (Dolophine, Methadose)

E kamaʻilio me kāu kauka e pili ana inā palekana ka lawe ʻana i nā lāʻau ʻeha i ka wā o kāu mālama iā Gleevec. Hōʻike paha lākou i nā ala ʻē aʻe e hōʻoluʻolu ai i kou ʻeha.

Gleevec a me kekahi mau lāʻau HIV

Lawe iā Gleevec me kekahi mau lāʻau lapaʻau HIV hiki ke hoʻonui i kou makaʻu no nā hopena ʻino. Hiki i kekahi mau lāʻau HIV ke pale aku iā Gleevec mai ka wāwahi ʻana, e alakaʻi ana i nā kiʻekiʻe kiʻekiʻe o Gleevec i kou kino.

Nā laʻana o nā lāʻau lapaʻau HIV e hiki ai ke hoʻonui i nā pae Gleevec i loko:

  • atazanavir (Reyataz)
  • nevirapine (Viramune)
  • saquinavir (Hoʻokele)

ʻO kekahi lāʻau HIV, efavirenz (Sustiva), hiki ke hoʻemi i nā kiʻekiʻe o Gleevec i kou kino. Hiki i kēia ke kumu o ka maikaʻi o ka Gleevec.

Hele mai nā lāʻau lapaʻau he nui i nā papa hoʻohui, ʻo ia hoʻi hoʻokomo lākou ma mua o hoʻokahi lāʻau. No laila e kamaʻilio pū me kāu kauka e pili ana i nā lāʻau HIV āpau āu e lawe ai.

Inā pono ʻoe e lawe iā Gleevec me kekahi mau lāʻau HIV, hiki i kāu kauka ke hoʻololi i kāu hana Gleevec.

ʻO Gleevec a me kekahi mau lāʻau kahe koko

Lawe iā Gleevec me kekahi mau lāʻau kaomi koko hiki ke hoʻonui a hōʻemi paha i nā kiʻekiʻe o nā lāʻau i loko o kou kino. Hiki iā ʻoe ke loaʻa i nā ʻaoʻao a hōʻemi paha i ka maikaʻi o ka hana ʻana o nā lāʻau.

ʻO kahi laʻana o kēia mau lāʻau e pili ana iā verapamil (Calan, Tarka).

Inā pono ʻoe e lawe iā Gleevec me kekahi o kēia mau lāʻau, e nānā pono kāu kauka iā ʻoe no nā hopena ʻaoʻao. Hoʻololi paha lākou i ke ana o nā lāʻau a koi paha i kahi lāʻau ʻokoʻa.

ʻO Gleevec a me warfarin

Lawe iā Gleevec me warfarin (Coumadin, Jantoven) hiki ke hoʻonui i kou makaʻu no ke kahe ʻana o ke kahe. Pale ʻo Gleevec i ka warfarin mai ka wāwahi ʻana i kou kino. Hoʻonui kēia i nā pae o warfarin a hiki ke alakaʻi i ke kahe e paʻakikī e kaohi.

Inā makemake ʻoe i kahi anticoagulant (wīwī o ke koko) ʻoiai ke lawe nei iā Gleevec, e kuhikuhi paha kāu kauka i kahi lāʻau ʻē aʻe ma mua o warfarin.

ʻO Gleevec lāua ʻo St.

Lawe iā Gleevec me ka wort o St. John hiki ke hoʻemi i nā kiʻekiʻe o Gleevec i kou kino. Hiki i kēia ke hoʻolilo iā Gleevec i mea liʻiliʻi (ʻaʻole pono e hana).

E noi i kāu kauka inā palekana ʻo Wort John wort nāu e lawe i ka wā o kāu mālama Gleevec. Hiki paha iā lākou ke ʻōlelo i kahi koho ʻē aʻe i St. John's Wort a hoʻonui paha i kāu lāʻau Gleevec.

ʻO Gleevec a me ka hua waina

ʻO ka ʻai ʻana i ka huaʻulu a me ka inu ʻana i ka wai momona i ka wā o kāu hoʻoponopono Gleevec hiki ke hoʻonui i kou makaʻu no nā hopena ʻino. Loaʻa ka huaola i ka huaola i pale i ka haʻihaʻi ʻia o Gleevec i kou kino. ʻO kēia ke kumu o ka hoʻonui ʻia o nā kiʻekiʻe o Gleevec, i hiki ke alakaʻi i nā hopena ʻē aʻe i ʻoi loa.

E hōʻalo pono i ka ʻai ʻana i ka huaʻulu a me ka inu ʻana i ka wai huaʻakeʻake i kou wā Gleevec.

Pehea e lawe ai iā Gleevec

E mālama pono iā Gleevec e like me kāu kauka a i ʻole nā ​​ʻōkuhi mālama ola.

I ka manawa hea e lawe ai

No nā kaha Gleevec o 600 mg a ʻoi aku paha, pono e lawe i ka lāʻau i hoʻokahi manawa i ka lā. Hiki iā ʻoe ke lawe ia i kēlā me kēia manawa.

Inā kau kauka i 800 mg o Gleevec i ka lā, lawe ʻoe iā ia i ʻelua mau kaha: 400 mg i ke kakahiaka a me 400 mg i ke ahiahi.

E hāʻawi aku kāu kauka iā ʻoe i nā ʻōkuhi ke lawe ʻoe i kāu lāʻau.

Lawe iā Gleevec me ka meaʻai

E lawe iā Gleevec me kahi pāʻina a me kahi aniani wai nui. Hiki i kēia ke pale i ka ʻōpū huhū.

Hiki iā Gleevec ke haki, wāwahi ʻia, a nau ʻia paha.

ʻAʻole pono ʻoe e wāwahi, wāwahi, a nau i nā papa Gleevec. Hiki i nā papa ʻoki a hoʻokaʻawale ke hōʻeha i kekahi ʻili a i ʻole nā ​​ʻāpana kino ʻē aʻe i pili pū me lākou.

Inā pilikia ʻoe i ka ale ʻana i nā papa Gleevec, kau i ka papa i loko o ke kīʻaha wai nui a i ʻole ka wai ʻāpala. E hoʻoulu i ka wai me kahi puna e kōkua ai i ka papa e hoʻoheheʻe. A laila inu koke i ka hui.

Pehea e hana ai ʻo Gleevec

Loaʻa ʻo Gleevec i ka lāʻau imatinib, i pili i ka papa o nā lāʻau i kapa ʻia he tyrosine kinase inhibitors (TKI). Hoʻohālikelike nā lāʻau i ka papa hana lāʻau TKI. Hoʻopili lākou i nā protein kikoʻī loa i nā hunaola maʻi ʻaʻai.

ʻAe ʻia ʻo Gleevec e mālama i nā ʻano ʻano like ʻole. Ma aneʻi mākou e ʻimi ai i ka hana a Gleevec e mālama ai i ʻelua o lākou.

No Ph + CML

Ma Philadelphia-maikaʻi (Ph +) leukemia myeloid mau (CML), he hewa nā kele e hana i nā hunaola keokeo i kā lākou hanauna kūlohelohe. ʻIke ʻia kēia kuhi hewa ma kahi pae DNA i kapa ʻia ʻo chromosome Philadelphia.

Aia i loko o ka chromosome Philadelphia kahi ʻāpana ʻokoʻa (BCR-ABL1) i kumu e hoʻokumu ʻia nā hunaola keokeo he nui. ʻAʻole oʻo kēia mau keʻokeʻo koko a oʻo a make e like me kā lākou e manaʻo ai. ʻO nā hunaola keʻokeʻo ʻole i kapa ʻia ʻo "blasts" e hōʻuluʻulu i nā ʻano ʻē aʻe o ke koko e pono e hana pono kāu koko.

Hana ʻo Gleevec i ka hoʻopili ʻana i kahi protein, i kapa ʻia ʻo tyrosine kinase, i loko o nā pūnaewele i hana ʻia e BCR-ABL1. Ke hoʻopaʻa ʻo Gleevec i kēia protein, pale ka lāʻau i ke kele mai ka hoʻouna ʻana i nā hōʻailona e haʻi i ka ulu o ka cell. Me ka ʻole o kēia mau hōʻailona ulu, make nā aʻa koko maʻi maʻi. Kōkua kēia i ka hoʻihoʻi hou ʻana i ka helu o nā huna huna i kahi helu olakino.

No GIST

Kōkua pū ʻo Gleevec i ka mālama ʻana i nā ʻōpū stromal gastrointestinal (GIST). I loko o nā pūnaewele tuma GIST he nui aʻe o kekahi mau protein, i kapa ʻia ʻo Kit a me nā mea ulu i loaʻa i ka platelet (PDGF), ma mua o nā hunaola maʻamau. Kōkua kēia mau proteins i nā hunaola maʻi ʻaʻai e ulu a hoʻokaʻawale.

Kuhi ʻo Gleevec i kēia mau protein a pale iā lākou mai ka hana ʻana. Hoʻohiohi kēia i ka ulu ʻana o ka maʻi ʻaʻai. ʻO ia pū kekahi e make ai nā hunaola maʻi ʻaʻai.

Pehea ka lōʻihi o ka hana?

Pili ia. ʻO ka manawa ke hoʻomaka ʻo Gleevec e hana i ʻokoʻa no kēlā me kēia kanaka.

Nānā nā noiʻi maʻi i ka poʻe me CML i lawe iā Gleevec. I hoʻokahi mahina, ua hoʻemi ʻia ka helu o nā hunaola maʻi ʻaʻai i loko o ke koko ma kahi o ka hapalua o ka poʻe i ka wā o ka pilikia pahū (pae kiʻekiʻe o CML). I ke aʻo ʻana o ka poʻe me GIST nāna i lawe ʻo Gleevec, kū nā tumors i ka ulu ʻana a i ʻole emi iho i loko o ʻekolu mau mahina.

E nānā mau kāu kauka i kou koko e ʻike inā e hana ana ʻo Gleevec iā ʻoe.

Gleevec a hāpai

Pono ʻoe e hōʻalo iā Gleevec inā hāpai ʻoe. Ua hōʻike ʻia no ka hānau ʻole ʻana a me ka hōʻeha ʻana i ka ʻōpū i nā wahine i lawe iā Gleevec i ka wā hāpai. A i loko o nā noiʻi holoholona, ​​nā wahine hāpai hāpai i hāʻawi ʻia iā Gleevec i ka nui o ka makaʻu no ka hānau hānau.

Inā hāpai ʻoe, hiki i kāu kauka ke aʻoaʻo iā ʻoe e kali a hiki i ka manawa o kou hānau ʻana e hoʻomaka i ka lawe ʻana iā Gleevec. A i ʻole e ʻōlelo lākou i kahi lāʻau ʻokoʻa.

Inā lawe ʻoe iā Gleevec, he mea nui e hoʻohana i ka kaohi hānau kūpono i ʻole ʻoe e hāpai. Ma hope o kou lawe ʻana i kāu lā hope loa o Gleevec, e hoʻomau i ka hoʻohana ʻana i ka kaohi hānau no 14 mau lā.

Gleevec a me ka waiū hānai

Hōʻike nā noiʻi e hele ʻo Gleevec i ka waiū umauma kanaka. Hiki i kēia ke kumu i ka hōʻeha koʻikoʻi i kahi pēpē pēpē.

Inā hānai ʻoe a noʻonoʻo i ka lawe ʻana iā Gleevec, hiki i kāu kauka ke ʻōlelo iā ʻoe e haʻalele i ka hānai ʻana iā ʻoe ke hoʻomaka i ka lāʻau.

Ma hope o kou lawe ʻana i kāu lā hope loa o Gleevec, e kali ma ka liʻiliʻi o hoʻokahi mahina ma mua o kou hoʻomaka ʻana i ka hānai ʻana.

ʻO overlee dosis o Gleevec

Lawe i ka nui loa o ka Gleevec hiki ke hoʻonui i kou makaʻi no nā hopena ʻino.

Nā hōʻailona overdose

Hiki i nā ʻōuli o ka overdose ke komo pū me:

  • nausea
  • ka luaʻi
  • pāhoehoe
  • ʻeha ka ʻōpū
  • ʻāwīwī koʻikoʻi
  • Muscle spasms (twitches)
  • ʻeha poʻo
  • nele i ka makemake ʻole
  • nāwaliwali o nā mākala
  • luhi (nele o ka ikaika)
  • pehu
  • nā maʻi o ke koko, e like me nā pae haʻahaʻa o nā platelet, nā ʻulaʻula o ke koko, a i ʻole nā ​​aʻa koko keʻokeʻo
  • fiva

He aha e hana ai inā he overdose

Inā manaʻo ʻoe ua lawe nui ʻoe i kēia lāʻau, e kāhea i kāu kauka. Hiki iā ʻoe ke kāhea i ka ʻAmelika Hui Pū ʻIa o nā Poison Control ma 800-222-1222 a i ʻole hoʻohana i kā lākou mea hana pūnaewele. Akā inā koʻikoʻi kāu mau ʻōuli, e kāhea iā 911 a i ʻole e hele koke i kahi lumi pilikia kokoke.

Nā nīnau e pili ana iā Gleevec

Eia nā pane i kekahi o nā nīnau e nīnau pinepine ʻia e pili ana iā Gleevec.

ʻO Gleevec kahi ʻano chemotherapy?

ʻAʻole ʻenehana ʻo Gleevec kahi ʻano chemotherapy. ʻO Gleevec kahi lāʻau i hoʻomākaukau ʻia e hoʻopili i nā mole kikoʻī i nā hunaola maʻi ʻaʻai.

Ma ke koho ʻana i nā mole kikoʻī, nā therapies i hoʻolālā ʻia e like me Gleevec kōkua i ka hoʻolohi i ka ulu a hoʻolaha ʻana o nā hunaola maʻi ʻaʻai. E kauoha maʻamau kāu kauka i kahi lāʻau hoʻomākaukau ʻia no ʻoe e pili ana i ke ʻano o ka maʻi ʻaʻai āu.

ʻOkoʻa nā lāʻau Chemotherapy mai nā lāʻau hoʻomōkō pahuhopu. Hana nā lāʻau Chemotherapy ma nā hunaola āpau i ke kino e ulu wikiwiki nei, ʻaʻole wale i nā hunaola maʻi ʻaʻai. Pepehi pinepine nā lāʻau Chemotherapy i nā hunaola ulu a hoʻopili i nā hunaola i loko o ke kino ma mua o ka hana ʻana i ka hoʻomōhala.

ʻO ke ʻano laulā o Gleevec e like me ka laikini inoa inoa?

Koi ʻia ka Food and Drug Administration (FDA) i nā mea hana i nā lāʻau laulaha e hōʻoia i kā lākou huahana:

  • ka mea hana like e like me ka lāʻau lapaʻau inoa-inoa
  • ʻo ka ikaika a me ke ʻano hana like e like me ka laikini inoa inoa
  • ke ala like o ka hoʻokele (pehea ʻoe e lawe ai i ka lāʻau)

Koi ʻia ka lāʻau laulaha e hana i ke ala like a like me ka huahana inoa inoa.

Wahi a ka FDA, hoʻokō ke ʻano laulā o Gleevec i kēia mau koi. ʻO kēia ke kumu o ka hōʻoia ʻana o ka FDA i ka mana o ka generic form e like me ka lāʻau lapaʻau inoa.

Hiki iaʻu ke hoʻomohala i ke kūpaʻa ʻana me Gleevec?

Ae. Hiki iā ʻoe ke hoʻomohala i ke kūʻē iā Gleevec. ʻO ke kūpaʻa ke kumu o ka pau ʻana o ka lāʻau i ka manawa. Manaʻo ʻia ʻo kēia ke kumu o ka hoʻololi ʻana i nā genes o nā hunaola maʻi ʻaʻai.

Inā hoʻomohala ʻoe i ke kūʻē iā Gleevec, hiki i kāu kauka ke kuhikuhi i kahi lāʻau kiʻekiʻe. E ʻike lākou inā e pane hou nā hunaola maʻi ʻaʻai i ka lāʻau. E kuhikuhi paha kāu kauka i kahi lāʻau ʻokoʻa ʻē aʻe i ʻole ʻoe e kūʻē.

Aia kekahi mau papaʻai meaʻai aʻu e ukali ai i ka lawe ʻana iā Gleevec?

ʻAʻole nā ​​kapu papaʻai maʻamau e pono ai ʻoe e hāliʻi i ka lawe ʻana iā Gleevec. Eia nō naʻe, pono ʻoe e hōʻalo i ka ʻai ʻana i ka huaʻikuʻi a me ka inu ʻana i ka wai momona. Loaʻa i ka hua waina kahi kemika e hiki ke pale i kou kino mai ka metabolizing (wāwahi ʻana) Gleevec. Hiki i kēia ke alakaʻi i nā kiʻekiʻe kiʻekiʻe o ka lāʻau i kou koko. ʻO nā pae o Gleevec i ʻoi aku ka kiʻekiʻe ma mua o ka maʻamau e hoʻonui i kāu makaʻikaʻi no nā hopena ʻino.

Eia hou, hiki i kāu kauka ke hāʻawi iā ʻoe i ka ʻōlelo aʻoaʻo ākea e pili ana i kāu papaʻai e kōkua ai i ka hōʻoluʻolu ʻana i kekahi mau hopena ʻaoʻao. ʻO kahi laʻana, hana ʻo Gleevec i ka nausea a me ka luaʻi i nā poʻe he nui. I mea e pale aku ai i kēia, hiki i kāu kauka ke koi aku iā ʻoe e hōʻalo i nā meaʻai e hiki ai ke hōʻeha i ka nausea. Hoʻopili kēia i nā meaʻai kaumaha, momona, a momona paha, a me nā meaʻai nīoi a ʻākika paha. ʻO nā laʻana he nui nā mea ʻulaʻula, nā mea ʻai palai, a me nā mea ʻai wikiwiki.

ʻO ka mea hope loa, inā ʻoe e lawe iā Gleevec no kahi maʻi ʻaʻai gastrointestinal, e like me nā ʻōpū stromal gastrointestinal (GIST), hiki i kāu kauka ke koi aku i nā kapu papaʻai maʻamau. ʻO ka pahuhopu ka pale ʻana i nā pilikia i kou ʻōpū a i ʻole nā ​​ʻōpū. E kamaʻilio me kāu kauka e pili ana i nā meaʻai e pono ai nāu.

E loaʻa paha iaʻu nā ʻōuli haʻalele inā kū wau i ka hoʻohana ʻana iā Gleevec?

Hiki paha iā ʻoe. Ua loaʻa i kekahi poʻe nā ʻōuli o ka haʻalele ʻana ma hope o ka pau ʻana o kā lākou lapaʻau Gleevec. I hoʻokahi o nā noi hoʻokolohua liʻiliʻi, 30% o ka poʻe i ʻeha a i ʻole ʻeha iwi ma hope o ke kū ʻana iā Gleevec. ʻO kaʻeha ka mea pinepine i ko lākou poʻohiwi, ka pūhaka, nā wāwae, a me nā lima. Ua hana ʻia kēia hōʻailona haʻalele i loko o hoʻokahi a ʻeono pule o ka hoʻōki ʻana i ka lāʻau.

Ma kahi o ka hapalua o ka poʻe i mālama i ko lākou ʻeha me nā mea hōʻemi ʻeha o ka counter. ʻO ka hapalua e pono ai ka lāʻau lapaʻau. I ka hapanui o ka poʻe i loaʻa i kēia mau hōʻailona haʻalele, hele ka ʻeha a me ka ʻeha o ka iwi i loko o ʻekolu mau mahina i hoʻokahi makahiki a ʻoi paha.

Pono wau e hoʻohana i nā lāʻau ʻē aʻe me Gleevec no ka mālama ʻana?

Aia ia i ka holomua o kou maʻi ʻaʻai. No nā pae holomua o ka maʻi ʻaʻai a i ʻole nā ​​maʻi ʻino i hoʻolaha i ka lolo a i ʻole ka iwi kuamoʻo, hiki i kāu kauka ke hoʻohui i ka chemotherapy i kāu lapaʻau Gleevec. Hoʻohui ʻia, ʻo nā keiki me Philadelphia-positive (Ph +) leukemia lymphocytic koʻikoʻi (ALL) e loaʻa iā Gleevec me chemotherapy.

No kekahi ʻano ʻano maʻi ʻaʻai, hiki i kāu kauka ke kuhikuhi i kahi steroid. A pono paha ʻoe e hoʻohana i nā lāʻau e hoʻokele ai i nā hopena, e like me nā mea ʻeha no ka ʻehaʻeha o nā mākala.

Pau ka Gleevec, mālama, a hoʻolei

Ke kiʻi ʻoe iā Gleevec mai ka hale kūʻai lāʻau, e hoʻohui ka kauka i kahi lā palena pau i ka lepili ma ka ʻōmole. ʻO kēia lā maʻamau hoʻokahi makahiki mai ka lā a lākou i hāʻawi ai i ka lāʻau.

Kōkua ka lā palena i ka hōʻoia ʻana i ka maikaʻi o nā lāʻau i kēia manawa. ʻO ke kūlana o ka Food and Drug Administration (FDA) i kēia manawa e hōʻalo i ka hoʻohana ʻana i nā lāʻau i make. Inā loaʻa iā ʻoe kahi lāʻau i hoʻohana ʻole ʻia i hala i ka lā palena pau, e kamaʻilio me kāu kauka lāʻau. Hiki iā lākou ke haʻi iā ʻoe inā paha hiki iā ʻoe ke hoʻohana.

Waihona

Pehea ka lōʻihi o ka maikaʻi o ka lāʻau e hiki ai ke hilinaʻi i nā kumu he nui, e like me pehea a ma hea ʻoe e mālama ai i ka lāʻau.

E mālama i kāu mau pila Gleevec ma ke ana wela o ka lumi i loko o kahi pahu paʻa paʻa. E pale pono iā lākou mai ka pulu.

Hoʻolei

Inā ʻaʻole pono ʻoe e lawe hou iā Gleevec a loaʻa nā lāʻau i koe, he mea nui ia e hoʻolei aku me ka palekana.

Kōkua kēia i ka pale aku i nā poʻe ʻē aʻe, e like me nā keiki a me nā holoholona, ​​mai ka lawe lāʻau ʻana ʻole. Mālama pū kekahi ia i ka lāʻau mai hōʻino i ke kaiapuni.

Hāʻawi ka pūnaewele FDA i nā ʻōlelo aʻoaʻo e pili ana i ka hoʻolāʻau lāʻau. Hiki iā ʻoe ke nīnau i kāu kauka lāʻau no ka ʻike e pili ana i ka hoʻolilo ʻana i kāu lāʻau.

ʻO ka ʻike ʻoihana no Gleevec

Hāʻawi ʻia ka ʻike aʻe no nā kauka lapaʻau a me nā ʻoihana ola.

Nā Hōʻike

Ua ʻae ʻia ʻo Gleevec (imatinib) e mālama i kēia mau mea:

  • nā mākua a me nā keiki me ka ʻike hou ʻia ʻo Philadelphia-positive (Ph +) leukemia myeloid mau (CML) i ka wā mau
  • nā mākua me Ph + CML i kēlā me kēia pae, ma hope o ka holo pono ʻole o interferon-alpha therapy
  • makua me ka relapsed a refactory Ph + huehue lymphocytic leukemia (ALL)
  • nā keiki me Ph + ALL hou i ʻike ʻia me ka chemotherapy
  • makua me ka myelodysplastic / myeloproliferative maʻi e pili ana me ka platelet-ulu ulu receptor gen hoʻoponopono hou
  • makua me ka mastocytosis ʻōnaehana kolohe me ka ʻole o ka mutation D816V c-Kit a i ʻole me ke kūlana mutation c-Kit i ʻike ʻole ʻia.
  • nā mākua me ka hypereosinophilic syndrome a me / a i ʻole leukemia eosinophilic mau me FIP1L1-PDGFRα fusion kinase, maikaʻi ʻole no ka FIP1L1-PDGFRα kinase fusion, a i ʻole kūlana ʻike ʻole ʻia.
  • makua me ka unresectable, recurrent, a metastatic dermatofibrosarcoma protuberans (DFSP)
  • mākua me ka unresectable a metastatic malignant kini puʻe wale + gastrointestinal stromal hikoko (GIST)
  • adjuvant therapy no nā mākua me Kit + GIST e ukali nei i ka hoʻopau piha loa

Mekanism o ka hana

Hoʻopili ʻo Gleevec i ka BCR-ABL tyrosine kinase, ʻo ia ka tyrosine kinase maʻamau i loaʻa ma Ph + CML. Ke kāohi nei i ka BCR-ABL tyrosine kinase e pale i ka hoʻonui ʻana o ka cellular a hoʻokomo i ka apoptosis i nā laina pūnaewele BCR-ABL a i nā laina leukemikō. Pākuʻi ʻo Gleevec i nā kinases tyrosine no ka mea ulu ulu i loaʻa i ka platelet (PDGF) a me ka pūnaehana cell stem (SCF) a me c-Kit, ka mea e kāohi i ka hoʻonui a hoʻokomo i ka apoptosis i nā pūnaewele GIST.

Pharmacokinetics a me ka metabolism

ʻO ke kumu ʻo bioavailability paʻa he 98% ma hope o ka hoʻoponopono waha. Ma kahi o 95% o ka hopena i hoʻopaʻa ʻia i nā protein plasma (ʻo ka hapa nui albumin a me α1-acid glycoprotein).

Kū ka Metabolism ma o CYP3A4 i kahi metabolite hana, me ka metabolism liʻiliʻi e loaʻa ana ma o CYP1A2, CYP2D6, CYP2C9, a me CYP2C19. Hoʻokumu mua ʻia ka metabolite hana e kaʻapuni nei e CYP3A4. Ma kahi o 68% hoʻopau ʻia i nā feces, me 13% i ka mimi. ʻO ka hapalua o ka hoʻopau ʻana o ka lāʻau i hoʻololi ʻole ʻia he 18 mau hola a me ka hoʻopau ʻana i ka hapalua o ke ola o ka metabolite hana nui he 40 mau hola.

Nā Kūʻai Kūʻai

ʻAʻohe contraindications loa i ka hoʻohana ʻana o Gleevec.

Ka mālama a me ka lawelawe ʻana

Pono e mālama ʻia nā papa Gleevec i ka mahana wela (77 ° F / 25 ° C) i loko o kahi pahu paʻa paʻa. Palekana papa mai ka ona.

Manaʻo ʻia ʻo nā papa ʻo Gleevec he mea weliweli ia, e like me nā kūlana palekana o ka Health and Health Administration (OSHA). ʻAʻole pono e haki i nā papa. Hōʻalo i ka hoʻopili ʻana i nā papa i wāwahi ʻia. Inā pili ka ʻili a me nā membrane mucus i nā papa i wāwahi ʻia, holoi i kahi i hoʻopili ʻia e like me ke alakaʻi ʻana a OSHA.

Hoʻolaha: Ua hana ʻo Nūhou Lapaʻau i kēia mau lā e hōʻoia i ka pololei, ka laulā, a me ka lā hou o nā ʻike āpau. Eia nō naʻe, ʻaʻole pono e hoʻohana i kēia ʻatikala i pani no ka ʻike a me ka mākaukau o kahi loea mālama ola laikini. E nīnau mau ʻoe i kāu kauka a i ʻole ʻoihana olakino ʻē aʻe ma mua o ka lawe ʻana i nā lāʻau. Hiki ke loli i ka ʻike o ka lāʻau i loko a ʻaʻole i manaʻo ʻia e uhi i nā hoʻohana a pau, nā kuhikuhi, ka mālama ʻana, nā ʻōlelo aʻoaʻo, nā launa lāʻau, nā hopena maʻi ʻaʻai, a me nā hopena maikaʻi ʻole. ʻO ka loaʻa ʻole o nā ʻōlelo aʻoaʻo a i ʻole nā ​​ʻike ʻē aʻe no kahi lāʻau i hāʻawi ʻia ʻaʻole ia e hōʻike i ka palekana o ka lāʻau a lāʻau paha i kūpono no nā mea maʻi āpau a i ʻole nā ​​hoʻohana kikoʻī āpau.

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