Gigantism

Anter

• He aha ke kumu o ka gigantism?
• Ke ʻike nei i nā ʻōuli o ka gigantism
• Pehea e ʻike ʻia ai ka gigantism?
• Pehea e mālama ʻia ai ka gigantism?
• ʻOki kino
• Laau Lapaʻau
• ʻO ka leki uila Gamma
• ʻO ka nānā wā lōʻihi no nā keiki me ka gigantism

He aha ka Gigantism?

ʻO Gigantism kahi kūlana maʻamau i kumu e ulu i nā keiki maʻamau. Kaulana kēia loli ma ke ʻano o ke kiʻekiʻe, akā pili ka girth kekahi. Kū i ka wā e hana ai ka pituitary gland o kāu keiki i ka nui o ka ulu o ka hormone, a ʻo ia hoʻi ʻo somatotropin.

He mea nui ka ʻike mua ʻana. Hiki i ka mālama koke ʻana ke hoʻokū a hoʻolohi i nā loli i hiki i kāu keiki e ulu nui aʻe ma mua o ka maʻamau. Eia nō naʻe, paʻakikī ke ʻano no ka ʻike ʻana o nā mākua. ʻO nā ʻōuli o ka gigantism e like paha me ka ulu ʻana o ka ulu ʻana o ka wā kamaliʻi i ka wā mua.

He aha ke kumu o ka gigantism?

ʻO kahi tumo pituitary gland ka mea kokoke i ke kumu o ka gigantism. Aia ka pituitary gland pea i ka nui o kou lolo. Hana ia i nā hormones e kaohi i nā hana i loko o kou kino. ʻO kekahi mau hana e mālama ʻia e ka gland.

• kaohi wela
• ulu kolohe
• ulu ana
• kinikini
• hana mimi

Ke ulu ka tumo ma ka pituitary gland, ʻoi aku ka nui o ka hormone ulu ma mua o ka pono o ke kino.

Aia kekahi mau kumu liʻiliʻi ʻē aʻe o ka gigantism:

• ʻO ke kumu ʻo McCune-Albright ke kumu o ka ulu pono ʻole ʻana o nā iwi iwi, nā pā o ka ʻili ʻōmaʻomaʻo ʻeleʻele, a me nā mea kūpono ʻole o ka momona.
• ʻO ka Carney complex kahi ʻano hoʻoilina e hoʻokumu i nā tumors noncancerous ma nā mea hoʻopili, nā tumo endocrine cancer a i ʻole noncancerous, a me nā wahi o ka ʻili ʻeleʻele.
• ʻO ka neoplasia endocrine Multiple type 1 (MEN1) kahi maʻi hoʻoilina e hoʻoulu ʻia i nā tumors i ka pituitary gland, pancreas, a i ʻole nā ​​parathyroid glands.
• ʻO Neurofibromatosis kahi maʻi i hoʻoili ʻia e kumu ai i nā hikoko i loko o ka ʻōnaehana nūhou.

Ke ʻike nei i nā ʻōuli o ka gigantism

Inā he gigantism kāu keiki, ʻike paha ʻoe i ka nui o lākou ma mua o nā keiki ʻē aʻe o ka makahiki like. Eia kekahi, ʻoi aku ka nui o kekahi mau ʻāpana o ko lākou kino i ka likelika i nā ʻāpana ʻē aʻe. ʻO nā ʻōuli maʻamau ka:

• nui loa nā lima a me nā wāwae
• manamana wāwae mānoanoa a me nā manamana lima
• kahi iwi ā koʻikoʻi a me ka lae
• hiʻohiʻona helehelena

ʻO nā keiki me ka gigantism paha he ihu pālahalaha a me nā poʻo nui, nā lehelehe, a me nā alelo.

Pili paha nā ʻōuli o kāu keiki i ka nui o ka hikoko pituitary gland. Ke ulu nei ka tumo, kaomi paha ia i nā ʻalolo i ka lolo. ʻIke ka hapa nui o ka poʻe i nā poʻo poʻo, nā pilikia ʻike, a i ʻole ka nausea mai nā tumors i kēia wahi. ʻO nā ʻōuli ʻē aʻe o gigantism e hoʻopili pū paha:

• sweating nui loa
• ʻeha poʻo poʻo hou a hoʻi hou paha
• nāwaliwali
• hiamoe a me nā maʻi hiamoe ʻē aʻe
• lohi ka wā ʻōpio i ke keikikāne a me nā kaikamahine
• i nā wā maʻamau o nā kaikamahine
• kuli

Pehea e ʻike ʻia ai ka gigantism?

Inā kānalua ke kauka o kāu keiki i ka gigantism, hiki iā lākou ke koi i kahi hoʻokolohua koko e ana i nā pae o ka ulu ʻana o nā homone a me ka ulu ʻana o ka like me ka insulin 1 (IGF-1), ʻo ia kahi hōmona i hana ʻia e ke ake. E paipai paha ke kauka i kahi hōʻike tolerance kō glucose waha.

I ka wā o ka hoʻāʻo ʻana o ka glucose tolerance waha, e inu kāu keiki i kahi mea inu kūikawā me ka glucose, kahi ʻano kō. Lawe ʻia nā laʻana koko ma mua a ma hope o ka inu ʻana o kāu keiki i ka mea inu.

I loko o kahi kino maʻamau, e hāʻule nā ​​pae o ka hormone ulu ma hope o ka ʻai ʻana a inu paha i ka glucose. Inā kū mau nā pae o kāu keiki, ʻo ia hoʻi ke hana nei ko lākou kino i ka nui o ka ulu ulu.

Inā hōʻike nā hōʻoia o ke koko i ka gigantism, pono i kāu keiki i kahi scan MRI o ka pituitary gland. Hoʻohana nā kauka i kēia scan e ʻike i ka tumo a ʻike i ka nui a me ke kūlana.

Pehea e mālama ʻia ai ka gigantism?

Hoʻopaʻa nā mālama ʻana no ka gigantism e hōʻoki a hoʻolohi paha i ka hana ʻana o kāu mau homone ulu.

ʻOki kino

ʻO ka wehe ʻana i ka tumo ka hoʻomaʻamaʻa makemake ʻia no ka gigantism inā ʻo ia ke kumu kumu.

E hōʻea ke kaukipoki i ka tumo ma ka hoʻopaʻa ʻana i ka ihu o kāu keiki. Hiki paha ke hoʻohana ʻia nā mikilope a i ʻole nā ​​kiʻi paʻi liʻiliʻi e kōkua i ka mea lōkō e ʻike i ka tumo i ke gland. I ka hapanui o nā hihia, pono i kāu keiki e hoʻi i ka home mai ka haukapila i ka lā ma hope o ke kaha ʻana.

Laau Lapaʻau

I kekahi mau hihia, ʻaʻole paha ke ʻoki he koho. ʻO kahi laʻana, inā nui ka pilikia o ka hōʻeha i kahi kīʻaha koko koʻikoʻi a nerve paha.

E paipai paha ke kauka o kāu keiki i ka lāʻau inā ʻaʻole ke koho ke koho. Pono kēia hana e hōʻemi i ka tumelo a i ʻole hoʻokū i ka hana ʻana o ka nui o ka ulu ʻana o ka hormone.

Hiki i kāu kauka ke hoʻohana i nā lāʻau octreotide a i ʻole lanreotide e pale ai i ka hoʻokuʻu ʻana o ka hormone ulu. Hoʻohālikelike kēia mau lāʻau i kekahi hormone e hoʻōki i ka hana ʻana o ka hormone ulu. Hāʻawi pinepine ʻia lākou ma ke ʻano he injection i hoʻokahi manawa i ka mahina.

ʻO Bromocriptine a me cabergoline nā lāʻau i hiki ke hoʻohana ʻia e hoʻohaʻahaʻa i nā pae o ka hormone ulu. Hāʻawi pinepine ʻia kēia mau mea i ka pila pila. Hiki ke hoʻohana ʻia lākou me ka octreotide. ʻO Octreotide kahi hormone synthetic ia, ke injected, hiki ke hoʻohaʻahaʻa i nā pae o ka ulu ʻana o nā homone a me ka IGF-1.

I nā kūlana i kōkua ʻole ai kēia mau lāʻau, hoʻohana ʻia paha nā pana o ka pegvisomant i kēlā me kēia lā. He lāʻau lapaʻau ʻo Pegvisomant i ālai i nā hopena o nā homone ulu. Hoʻoiho kēia i nā pae o ka IGF-1 i ke kino o kāu keiki.

ʻO ka leki uila Gamma

ʻO kahi radiosurgery pahi ʻo Gamma kahi koho inā manaʻo ke kauka o kāu keiki ʻaʻole hiki i kahi ʻoki kuʻuna.

ʻO ka "pahi gamma" kahi hōʻuluʻulu o nā kaola kukuna e kia nui ana. ʻAʻole hōʻino kēia mau kaola i kaʻiʻo a puni, akā hiki iā lākou ke hāʻawi i kahi lāʻau ikaika o ka radiation i ka manawa a lākou e hui ai a pā i ka tumelo. Ua lawa kēia mahele lāʻau e hoʻopau i ka tumo.

Hoʻomaʻamaʻa ka lāʻau pahi Gamma i mau mahina i mau makahiki e pono ai a hoʻihoʻi i nā pae o ka hormone ulu i ka maʻamau. Hana ʻia ia ma ke kumu o ka outpatient ma lalo o ka anesthetic ākea.

Eia naʻe, mai ka hoʻopili ʻana o ka pāhawewe i kēia ʻano ʻoki i ka momona, ke aʻo ʻana i ke kino kīnā, a me nā pilikia o ka naʻau i nā keiki, hoʻohana wale ʻia ia inā ʻaʻole holo nā koho lapaʻau ʻē aʻe.

ʻO ka nānā wā lōʻihi no nā keiki me ka gigantism

Wahi a ka haukapila ʻo St. Joseph a me Medical Center, 80 pākēneka o nā hihia gigantism i hoʻokumu ʻia e ka maʻi pituitary tumors i hoʻōla ʻia me ke ʻoki kino. Inā hoʻi ka tumo a i ʻole inā ʻaʻole hiki ke hoʻāʻo palekana, hiki ke hoʻohana ʻia i nā lāʻau e hōʻemi i nā hōʻailona o kāu keiki a ʻae iā lākou e ola i kahi ola lōʻihi a hoʻokō.