ʻO Fingolimod (Gilenya) Nā ʻaoʻao ʻaoʻao a me ka ʻike palekana

Anter

• Nā hopena ʻaoʻao mai ka lāʻau mua
• Nā hopena ʻaoʻao
• Nā ʻōlelo aʻoaʻo a FDA
• Nā kūlana o ka hopohopo
• Nā launa lāʻau
• E kamaʻilio me kāu kauka

Hoʻolauna

ʻO Fingolimod (Gilenya) kahi lāʻau i lawe ʻia e ka waha e mālama i nā ʻōuli o ka hoʻi hou ʻana i nā sclerosis (RRMS). Kōkua ia i ka hoʻoliʻiliʻi i nā hanana o RRMS. Hiki i kēia mau ʻōuli ke komo pū me:

• ʻūpē mākala
• nāwaliwali a me ka helu
• nā pilikia kaohi o ka ʻōpū
• nā pilikia me ka ʻōlelo a me ka hihiʻo

Hana pū ʻo Fingolimod e hoʻolohi i ke kīnā o ke kino i hiki ke kumu ʻia e RRMS.

E like me nā lāʻau āpau, hiki i ka fingolimod ke kumu i nā hopena ʻaoʻao. I nā hihia maʻamau, hiki iā lākou ke koʻikoʻi.

Nā hopena ʻaoʻao mai ka lāʻau mua

Lawe ʻoe i ka lāʻau mua o ka fingolimod ma ke keʻena o kāu kauka. Ma hope o kāu lawe ʻana, e nānā ʻia ʻoe no ʻeono a ʻoi paha mau hola. Hana ʻia kahi electrocardiogram ma mua a ma hope o kou lawe ʻana i ka lāʻau e nānā i ka helu o kou puʻuwai a me kāu mele.

Lawe nā ʻoihana mālama ola i kēia mau hana no ka mea hiki i kāu mahele mua o ka fingolimod ke kumu i kekahi mau hopena ʻaoʻao, e like me ke kahe o ke koko a me ka bradycardia, kahi puʻuwai puʻuwai e hiki ai ke weliweli Hiki i nā ʻōuli o ke kuemi puʻuwai lohi ke komo pū me:

• luhi hikiwawe
• ʻūpā
• ʻeha ka umauma

Hiki ke hopena i kēia mau hopena me kāu kau mua, akā ʻaʻole pono ia e kū i kēlā me kēia manawa ke lawe ʻoe i ka lāʻau. Inā loaʻa iā ʻoe kēia mau ʻōuli ma ka home ma hope o kāu kau lāʻau ʻelua, e kāhea koke aku i kāu kauka.

Nā hopena ʻaoʻao

Lawe ʻia ʻo Fingolimod i hoʻokahi manawa i kēlā me kēia lā. ʻO nā hopena ʻē aʻe maʻamau i hiki ke hana ma hope o ka lua a me nā hopena e hiki ke hoʻopili ʻia:

• pāhoehoe
• ʻūhā
• ʻeha poʻo
• poho lauoho
• kaumaha
• nāwaliwali o nā mākala
• ʻili maloʻo a ʻili hoʻi
• ʻeha ka ʻōpū
• ʻeha kua

Hiki i ka Fingolimod ke hana i nā hopena ʻē aʻe i ʻoi aʻe. E hele aku kēia mau mea inā kū ʻoe i ka lawe ʻana i ka lāʻau. Ma mua o nā pilikia o ke ake, i hiki ke maʻa mau, pili ʻole kēia mau hopena ʻaoʻao. Hiki i nā hopena ʻē aʻe ke hoʻopili i:

• Nā pilikia ate. E hana paha kāu kauka i nā hoʻokolohua koko maʻamau i kāu wā e mālama ai e nānā i nā pilikia o ke ake. Hiki i nā ʻōuli o nā pilikia o ke ake ke komo i loko o ka jaundice, a he kumu ia e melemele ai ka ʻili a me nā keʻokeʻo o nā maka.
• Hoʻonui i ka pilikia o nā maʻi. Hoʻemi ʻo Fingolimod i kāu helu o nā hunaola keʻokeʻo. Hoʻokumu kēia mau pūnaewele i kekahi o nā aʻa ʻino mai MS. Eia nō naʻe, kōkua lākou i kou kino e hakakā i nā maʻi.No laila, piʻi aʻe kou makaʻu o ka maʻi. Hiki i kēia ke hala i ʻelua mau mahina ma hope o kou hoʻōki ʻana i ka lawe ʻana i ka fingolimod.
• Edema makala. Me kēia kūlana, kūkulu ka wai i ka macula, kahi ʻāpana o ka retina o ka maka. Hiki i nā ʻōuli ke hoʻopili me ka hihi maka, kahi makapō a ʻike ʻana i nā kala ʻokoʻa. ʻOi aku kou makaʻu i kēia ʻano inā loaʻa ʻoe i ka maʻi kō.
• Hī pilikia. Hiki ke hana i ka hanu ke lawe ʻoe i ka fingolimod.
• Hoʻonui i ke kahe o ke koko. E nānā paha kāu kauka i kou kaomi koko i kou wā e mālama ai me ka fingolimod.
• Leukoencephalopathy. I nā hihia maʻamau, hiki i ka fingolimod ke kumu i nā pilikia o ka lolo. Hoʻopili kēia i ka leukoencephalopathy multifocal holomua a me ka maʻi hope encephalopathy. Hiki i nā ʻōuli ke hoʻohui i nā loli i ka noʻonoʻo ʻana, ka hōʻemi ʻana i ka ikaika, ka hoʻololi ʻana i kāu ʻike, ka hopu ʻana, a me ka ʻehaʻeha nui e hiki koke mai ana. E haʻi koke i kāu kauka inā loaʻa kēia mau ʻōuli iā ʻoe.
• Kanesa. Basal cell carcinoma a me melanoma, ʻelua ʻano o ka maʻi ʻaʻai ʻili, i hoʻopili ʻia me ka hoʻohana ʻana o ka fingolimod. ʻOiai e hoʻohana ana i kēia lāʻau, pono ʻoe a me kāu kauka e nānā no nā puʻupuʻu a ulu ʻole paha i kou ʻili.
• ʻAhaʻi ʻaʻano. E like me nā lāʻau lapaʻau, hiki i ka fingolimod ke kumu i kahi hopena maʻi. Hiki i nā ʻōuli ke hoʻopili i ka pehu, ka pehu, a me ka hives. ʻAʻole pono ʻoe e lawe i kēia lāʻau inā ʻike ʻoe he maʻi āpau ʻoe.

Nā ʻōlelo aʻoaʻo a FDA

Kākaʻikahi nā hopena koʻikoʻi i ka fingolimod. Ua hōʻike ka make i 2011 i pili i kahi hoʻohana mua o ka fingolimod. Ua hōʻike pū ʻia kekahi mau hanana ʻē aʻe o ka make ʻana mai nā pilikia puʻuwai mai. Eia naʻe, ʻaʻole i loaʻa i ka FDA kahi loulou pololei ma waena o kēia mau make ʻē aʻe a me ka hoʻohana ʻana o ka fingolimod.

Eia nō naʻe, ma muli o kēia mau pilikia, ua loli ka FDA i kāna mau kulekele no ka hoʻohana ʻana i ka fingolimod. Ke ʻōlelo nei i kēia manawa ʻaʻole pono nā poʻe e lawe i kekahi lāʻau antiarrhythmic a i ʻole he moʻolelo ko lākou no kekahi ʻano naʻau a i ʻole hahau paha i ka fingolimod.

Ua hōʻike pū kekahi i nā hihia kūpono o kahi maʻi lolo ʻole i kapa ʻia ʻo leukoencephalopathy multifocal holomua ma hope o ka hoʻohana ʻana o ka fingolimod.

Weliweli paha kēia mau hōʻike, akā e hoʻomanaʻo i ka nui ʻole o nā pilikia koʻikoʻi me ka fingolimod. Inā he hopohopo kāu e pili ana i ka hoʻohana ʻana i kēia lāʻau, e noʻonoʻo e kūkākūkā me lākou me kāu kauka. Inā ua kau ʻia ʻoe i kēia lāʻau, mai hōʻoki i ka lawe ʻana inā ʻaʻole haʻi ʻia e kāu kauka.

Nā kūlana o ka hopohopo

Hiki i ka Fingolimod ke hana i nā pilikia inā loaʻa iā ʻoe kekahi ʻano olakino. Ma mua o ka lawe ʻana i ka fingolimod, e ʻike pono e haʻi i kāu kauka inā loaʻa iā ʻoe:

• arrhythmia, a i ʻole helu kaulike ʻole a i ʻole maʻamau
• ka mōʻaukala o ka hahau a i ʻole ka pāhuna liʻiliʻi, i kapa ʻia hoʻi he hoʻouka ischemic kuewa
• nā pilikia puʻuwai, me ka puʻuwai a i ʻole ka ʻeha o ka umauma
• moʻolelo o ka maʻule pinepine
• fiva a maʻi paha
• kahi kūlana e hoʻopilikia ai i kāu ʻōnaehana pale, e like me HIV a i ʻole leukemia
• ka mōʻaukala o ka pīpī a i ʻole ka maʻi koʻohuna moa
• nā pilikia o ka maka, me kahi kūlana i kapa ʻia ʻo uveitis
• diabetes
• nā pilikia hanu, me ka hiamoe
• nā pilikia ate
• kahe koko kiʻekiʻe
• ʻano o ka maʻi ʻaʻai ʻili, ʻo ia hoʻi ka carcinoma basal cell a i ʻole melanoma
• maʻi thyroid
• nā pae haʻahaʻa o ka calcium, sodium, a pāhare potassium paha
• hoʻolālā e hāpai, hāpai, a inā hānai ʻoe

Nā launa lāʻau

Hiki i ka Fingolimod ke launa pū me nā lāʻau like ʻole. Hiki i kahi pilina ke hana i nā pilikia olakino a i ʻole e hoʻemi pono i ka lāʻau.

E haʻi i kāu kauka e pili ana i nā lāʻau āpau, nā wikamina, a me nā mea hoʻopihapiha āu e lawe ai, keu hoʻi i ʻike ʻia e launa pū me ka fingolimod. ʻO kekahi mau laʻana o kēia mau lāʻau lapaʻau:

• nā lāʻau e hoʻopōʻino ai i ka ʻōnaehana pale, e like me nā corticosteroids
• nā lāʻau āpau ola
• nā lāʻau e hoʻolohi ai i kāu helu puʻuwai, e like me beta-blockers a i ʻole nā ​​blockers calcium

E kamaʻilio me kāu kauka

ʻAʻole i loaʻa kahi lāʻau no MS. No laila, ʻo nā lāʻau e like me ka fingolimod kahi ala nui e hoʻomaikaʻi ai i ka maikaʻi o ke ola a hoʻolohi i ke kīnā ʻole no ka poʻe me RRMS.

Hiki iā ʻoe a me kāu kauka ke kaupaona i nā pono kūpono a me nā pilikia o ka lawe ʻana i kēia lāʻau. Nā nīnau āu e makemake ai e nīnau i kāu kauka.

• Aia wau i kahi makaʻu nui i nā hopena ʻaoʻao mai ka fingolimod?
• Lawe paha wau i nā lāʻau e hiki ke launa me kēia lāʻau?
• Aia kekahi mau lāʻau MS ʻē aʻe e hōʻemi i nā hopena ʻē aʻe noʻu?
• He aha nā hopena ʻē aʻe e hōʻike koke aku ai iā ʻoe inā loaʻa iaʻu?

Aia ʻo Fingolimod ma ka mākeke mai ka makahiki 2010. ʻO ia ka lāʻau mua waha no MS i ʻae ʻia e ka FDA. Mai ia manawa, ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ae ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ʻ ’ʻ’ ʻ ’ʻ’ ’’ ’ʻ’ ʻ ’ʻ’ ’a’ a ’a e hōʻike ai: teriflunomide (Aubagio) a me dimethyl fumarate (Tecfidera)