Mea Kākau: Robert Simon
Lā O Ka Hana: 24 Iune 2021
HōʻAno Hou I Ka Lā: 16 Nowemapa 2024
Anonim
Cinqair (reslizumab)- Asthma- by Saro Arakelians, PharmD- Episode # 123
Wikiō: Cinqair (reslizumab)- Asthma- by Saro Arakelians, PharmD- Episode # 123

Anter

He aha ʻo Cinqair?

ʻO Cinqair kahi lāʻau lapaʻau inoa inoa inoa inoa inoa. Hoʻohana ʻia ia e mālama i ka hānō eosinophilic koʻikoʻi i ka poʻe mākua. Me kēia ʻano hānō koʻikoʻi, he kiʻekiʻe kāu o nā eosinophil (kahi ʻano o ke keʻokeʻo koko keʻokeʻo). Lawe ʻoe iā Cinqair me ka hoʻohui i kāu lāʻau asthma ʻē aʻe. ʻAʻole hoʻohana ʻia ʻo Cinqair e mālama i ka hānō o ka hānō.

Aia i loko o Cinqair reslizumab, kahi ʻano lāʻau i kapa ʻia he biologic. Hana ʻia nā meaolaola mai nā hunaola a ʻaʻole mai nā kemika.

ʻO Cinqair kahi ʻāpana o kahi papa lāʻau i kapa ʻia interleukin-5 antagonist monoclonal antibodies (IgG4 kappa). ʻO kahi papa lāʻau kahi hui o nā lāʻau e hana i kahi ala like.

E hāʻawi kahi mea mālama ola iā ʻoe iā Cinqair ma ke ʻano he infravenous (IV) infusion i ke keʻena o kāu kauka a i ʻole kahi keʻena lapaʻau. ʻO kēia kahi injection i loko o kou aa koko i kahe lohi i ka holo ʻana o ka manawa. Lawe pinepine nā infusions ʻo Cinqair i 20 a 50 mau minuke.

Ka hoʻokō ʻana

Ua ʻike ʻia ka maikaʻi o ka Cinqair no ka mālama ʻana i ka hānō eosinophilic koʻikoʻi.


I loko o ʻelua mau noiʻi hoʻokolohua, 62% a me 75% o ka poʻe i loaʻa iā Cinqair no ka hānō eosinophilic koʻikoʻi ʻaʻole i loaʻa i ka hānō hū. Akā ʻo 46% a me 55% wale nō o ka poʻe i lawe i kahi placebo (ʻaʻohe lapaʻau) ʻaʻole i loaʻa kahi mumū hānō. Ua mālama ʻia ka poʻe āpau me Cinqair a i ʻole placebo no 52 mau pule. Eia kekahi, ʻo ka hapanui o ka poʻe e lawe i nā corticosteroids inhal a me nā beta-agonists i ka wā o ke aʻo ʻana.

ʻO Cinqair generic a biosimilar paha

Loaʻa ʻo Cinqair ma ke ʻano he lāʻau inoa inoa inoa. Loaʻa iā ia ka reslizumab lāʻau lapaʻau hana.

ʻAʻole i loaʻa ʻo Cinqair i kēia manawa ma kahi ʻano biosimilar.

ʻO kahi biosimilar kahi lāʻau e like me ka lāʻau lapaʻau inoa. ʻO kahi lāʻau laulā, ma ka ʻaoʻao ʻē aʻe, he kope kikoʻī o kahi lāʻau lapaʻau inoa inoa. Hoʻokumu ʻia nā biosimilars i nā lāʻau biologic, i hana ʻia mai nā ʻāpana o nā meaola ola. Hoʻokumu ʻia nā generics i nā lāʻau lapaʻau maʻamau i hana ʻia mai nā kemikū.

ʻO nā biosimilars a me nā generics he mea palekana a maikaʻi hoʻi e like me ka lāʻau inoa inoa i hana ʻia e kope. Eia kekahi, mālama lākou i ke kumukūʻai ma mua o nā lāʻau lapaʻau inoa.


ʻO kā Cinqair kumukūʻai

E like me nā lāʻau āpau, hiki ke loli ke kumukūʻai o Cinqair. Hāʻawi kahi mea mālama ola iā ʻoe i ka lāʻau i infusion (IV) infravenous ma ke keʻena o kāu kauka a i ʻole kahi keʻena lapaʻau. ʻO ke kumukūʻai āu e uku ai no kāu infusion e hilinaʻi ia i kāu hoʻolālā ʻinikua a ma kahi e loaʻa ai iā ʻoe kāu lāʻau. ʻAʻole loaʻa ʻo Cinqair iā ʻoe e kūʻai ma kahi hale kūʻai lāʻau kūloko.

Kōkua kālā a me nā ʻinikua

Inā makemake ʻoe i kākoʻo kālā e uku no Cinqair, a inā ʻoe e kōkua i ka hoʻomaopopo ʻana i kāu ʻinikua uhi, loaʻa ke kōkua.

Hāʻawi ʻo Teva Respiratory, LLC, ka mea hana a Cinqair, i nā Teva Support Solutions. No ka ʻike hou aku a e ʻike inā he kūpono ʻoe no ke kākoʻo, kāhea iā 844-838-2211 a i ʻole kipa i ka pūnaewele pūnaewele.

Nā hopena ʻino Cinqair

Hiki i ke Cinqair ke hana i nā hopena ʻoluʻolu a koʻikoʻi paha. Loaʻa i nā papa inoa aʻe kekahi o nā hopena ʻaoʻao nui i hiki ke loaʻa iā Cinqair. ʻAʻole pili kēia mau papa inoa i nā hopena āpau āpau.

No ka ʻike hou aku e pili ana i nā hopena ʻē aʻe o Cinqair, e kamaʻilio me kāu kauka a kauka paha. Hiki iā lākou ke hāʻawi iā ʻoe i nā ʻōlelo aʻoaʻo e pili ana i ka hana me nā hopena ʻē aʻe e hoʻonāukiuki paha.


Nā hopena ʻaoʻao hou aʻe

ʻO ka hopena ʻaoʻao maʻamau o Cinqair ka ʻeha oropharyngeal. ʻO kēia ka ʻeha ma ka ʻāpana o kou ʻāʻī ma hope o kou waha. I nā noiʻi hoʻokolohua, 2.6% o ka poʻe i lawe iā Cinqair i loaʻa i ka ʻeha oropharyngeal. Hoʻohālikelike ʻia kēia me 2.2% o ka poʻe i lawe i kahi placebo (ʻaʻohe lapaʻau).

E hala paha ka ʻeha Oropharyngeal i loko o kekahi mau lā a i ʻole ʻelua mau pule. Inā kaumaha ka ʻeha a hele ʻole paha, e kamaʻilio me kāu kauka a kauka paha. Hiki iā lākou ke ʻōlelo i nā hōʻailona e kōkua iā ʻoe e hōʻoluʻolu maikaʻi.

Nā hopena hopena koʻikoʻi

ʻAʻole maʻamau nā hopena koʻikoʻi mai Cinqair, akā hiki iā lākou ke hana. Kāhea koke i kāu kauka inā loaʻa nā hopena koʻikoʻi. Kāhea iā 911 inā manaʻo kou mau hōʻailona i ka hoʻoweliweli ola a i ʻole inā manaʻo ʻoe e loaʻa ana kahi pilikia olakino.

Hiki i nā hopena ʻē aʻe a me kā lākou mau hōʻailona ke hoʻohui i kēia:

  • Anaphylaxis * (he ʻano ʻano maʻi ʻino nui). Hiki i nā ʻōuli ke hoʻohui pū:
    • pilikia i ka hanu ʻana, me ka ʻeha a me ka ʻūhā ʻana
    • pilikia i ka ale ʻana
    • pehu i kou alo, waha, a ʻāʻā paha
    • pulse mālie
    • haʻalulu anaphylactic (hāʻule koke i ke kahe o ke koko a me ka hanu pilikia)
    • hūwī
    • ʻili ʻili
    • haʻi waha
    • ʻeha o ka ʻōpū (ʻōpū)
    • nausea
    • huikau
    • hopohopo
  • Kanesa. Hiki i nā ʻōuli ke hoʻohui pū:
    • nā loli i kou kino (ʻokoʻa ke kala, nā lau, ka pehu, a i ʻole nā ​​puʻupuʻu i kou umauma, pūpū, ʻōpū, a i ʻole ʻili)
    • ʻeha poʻo
    • ka hopu ʻana
    • ʻike pilikia a lohe pilikia paha
    • heleleʻi ma kekahi ʻaoʻao o kou alo
    • kahe kahe a ʻeha paha
    • ʻūhā
    • loli i ka makemake
    • luhi (nele o ka ikaika)
    • fiva
    • pehu a puʻupuʻu paha
    • loaʻa kaupaona a hoʻemi kino paha

Nā kikoʻī hopena ʻaoʻao

Mahalo paha ʻoe i ka hopena o kekahi mau hopena ʻē aʻe me kēia lāʻau. Eia kekahi kikoʻī ma kekahi o nā hopena i hiki i kēia lāʻau ke kumu.

Ka hopena hoʻowali

E like me ka nui o nā lāʻau, hiki i kekahi poʻe ke loaʻa i kahi hopena maʻi ma hope o ka loaʻa ʻana iā Cinqair. Hiki i nā ʻōuli o ke ʻano ʻāpiki mālie ke hoʻopili pū i:

  • ʻāwīwī o ka ʻili
  • ʻumeʻume
  • flushing (hoʻomehana a ʻulaʻula i kou ʻili)

ʻAʻole maopopo i ka nui o ka poʻe i hoʻomohala i kahi hopena maʻi ahulau ma hope o ka loaʻa ʻana iā Cinqair.

Kākaʻikahi ka hopena maʻi ʻino ʻoi aku ka paʻakikī akā hiki. Kapa ʻia ia he anaphylaxis (ʻike ma lalo).

Anaphylaxis

ʻOiai e loaʻa ana iā Cinqair, hiki i kekahi poʻe ke hoʻomohala i kahi ʻano maʻi ʻaʻano loa loa i kapa ʻia he anaphylaxis. He koʻikoʻi kēia hopena a hiki ke hoʻoweliweli i ke ola. I nā noiʻi hoʻokolohua, 0.3% o ka poʻe i loaʻa iā Cinqair i hoʻomohala i ka anaphylaxis.

Kōkua kāu ʻōnaehana pale i ka pale ʻana i kou kino i nā lāʻau e hiki ai i ka maʻi. Akā i kekahi manawa e huikau kou kino a hakakā i nā mea i kumu ʻole i nā maʻi. No kekahi poʻe, hōʻeha kā lākou ʻōnaehana pale i nā mea hana ma Cinqair. Hiki i kēia ke alakaʻi i ka anaphylaxis.

Hiki i nā ʻōuli o ka anaphylaxis ke hoʻopili pū me:

  • ʻōhū ma lalo o kou ʻili, maʻamau i kou lihilihi, lehelehe, lima, a mau wāwae paha
  • pehu o kou alelo, waha, a ʻāʻī paha
  • pilikia hanu

Hiki ke hana ʻo Anaphylaxis ma hope pono o kāu mahele lāʻau ʻelua o Cinqair, no laila he mea nui e kaohi ʻia ka hopena i ka manawa hoʻokahi.

ʻO kēia ke kumu e nānā ai kāu kauka olakino iā ʻoe no kekahi mau hola ma hope o kou loaʻa ʻana iā Cinqair. Inā hoʻomohala ʻoe i nā ʻōuli o anaphylaxis, e mālama koke kāu kauka iā ʻoe. E hoʻomaopopo lākou i kāu kauka.

Inā makemake kāu kauka iā ʻoe e haʻalele i ka hoʻohana ʻana iā Cinqair, e ʻōlelo paha lākou i kahi lāʻau ʻokoʻa.

Hiki i nā hopena anaphylactic ke kumu i nā anaphylaxis biphasic. He hoʻouka kaua lua kēia o ka anaphylaxis. Hiki i nā anaphylaxis Biphasic ke hana i mau hola i kekahi mau lā ma hope o ka hoʻouka mua. Inā loaʻa iā ʻoe kahi hopena anaphylactic, makemake paha kāu mea mālama ola e nānā hou iā ʻoe. Makemake lākou e hōʻoia ʻaʻole hoʻomohala i nā anaphylaxis biphasic.

Hiki i nā ʻōuli o ka anaphylaxis biphasic ke hoʻopili pū:

  • ʻili ka ʻili, ʻulaʻula, a i ʻole nā ​​hives (weliweli welts)
  • pehu ke alo a me ke elelo
  • pilikia hanu
  • ʻeha o ka ʻōpū (ʻōpū)
  • ka luaʻi
  • pāhoehoe
  • haʻahaʻa haʻahaʻa haʻahaʻa
  • lilo o ka ʻike (maule)
  • haʻalulu anaphylactic (hāʻule koke i ke kahe o ke koko a me ka hanu pilikia)

Inā ʻaʻole ʻoe ma kahi keʻena olakino a manaʻo ʻoe ke loaʻa nei kahi anaphylactic a i ʻole biphasic react iā Cinqair, e kāhea koke iā 911. Ma hope o ka mālama ʻia ʻana o ka hopena, e hōʻike i kāu kauka. Paipai paha lākou i kahi lāʻau ʻauhau ʻokoʻa.

Kanesa

Hiki i kekahi mau lāʻau lapaʻau ke hoʻoulu i ka nui a i ka helu a lilo i maʻi ʻaʻai. I kekahi manawa neʻe kēia mau hunaola maʻi maʻi i nā kiko i nā wahi like ʻole o kou kino. Kapa ʻia kēia mau pūnaewele lehulehu i nā tumors.

I nā noiʻi hoʻokolohua, 0.6% o ka poʻe i loaʻa iā Cinqair i hoʻomohala i nā tumors i hana ʻia i nā ʻāpana like ʻole o ke kino. ʻO ka hapa nui o ka poʻe i ʻike ʻia me nā tumors i loko o ʻeono mau mahina o kā lākou lāʻau mua o Cinqair. Hoʻohālikelike ʻia kēia me 0.3% o ka poʻe i lawe i kahi placebo (ʻaʻohe lapaʻau).

Inā ʻoe e ʻike i kekahi ʻōuli o nā tumors ʻaʻole e hele, e haʻi i kāu kauka. (E ʻike i ka ʻāpana "Nā ʻaoʻao ʻino" ma luna no ka papa inoa o nā ʻōuli.) Pono ʻoe i nā hoʻokolohua e kōkua i kāu kauka e ʻike hou aʻe e pili ana i nā tumors. E ʻōlelo paha kāu kauka i kahi lāʻau lapaʻau hānō ʻokoʻa.

ʻĀpana cinqair

ʻO ka lāʻau Cinqair i kau ʻia e kāu kauka e kaukaʻi ai i kou kaupaona.

Hōʻike ka ʻikepili aʻe i nā lāʻau i hoʻohana pinepine ʻia a koi ʻia paha. Eia nō naʻe, hāʻawi paha kāu kauka iā ʻoe i kahi ʻokoʻa ʻē aʻe inā kuhikuhi ʻia e kāu kauka e hana pēlā. E hoʻoholo kāu kauka i ke ana ʻoi loa e kūpono i kāu mau pono.

Nā ʻano lāʻau a me nā ikaika

Hele mai ʻo Cinqair i kahi hue 10-mL. Loaʻa i kēlā me kēia kīʻaha 100 mg o reslizumab. E hāʻawi aku kāu mea mālama ola iā ʻoe i kēia hopena ma ke ʻano he infusion intravenous (IV). ʻO kēia kahi injection i loko o kou aa koko i kahe lohi i ka holo ʻana o ka manawa. Lawe pinepine nā infusions ʻo Cinqair i 20 a 50 mau minuke.

Nā hana no ka hānō

Hoʻonohonoho pinepine ʻia ʻo Cinqair i nā dosages o 3 mg / kg, hoʻokahi manawa i kēlā me kēia ʻehā pule.

ʻO ka nui o Cinqair e loaʻa iā ʻoe e kaukaʻi i ka nui o kou kaupaona. ʻO kahi laʻana, 150-lb. kaupaona ke kanaka ma kahi o 68 kg. Inā kēnā kauka i 3 mg / kg o Cinqair i hoʻokahi manawa i kēlā me kēia ʻehā pule, ʻo ka nui o Cinqair he 204 mg i kēlā me kēia infusion (68 x 3 = 204).

He aha inā e haʻo wau i kahi lāʻau?

Inā haʻalele ʻoe i kahi manawa e loaʻa ai iā Cinqair, e kāhea koke aku i kāu kauka. Hiki iā lākou ke hoʻonohonoho i kahi manawa hou a hoʻomaʻa i ka manawa o nā kipa ʻē aʻe inā pono.

He manaʻo noʻeau e kākau i kāu papa hana hoʻomaʻamaʻa ma ka kalena. Hiki iā ʻoe ke hoʻonohonoho i kahi hoʻomanaʻo ma kāu kelepona i ʻole ʻoe e haʻalele i kahi manawa.

Pono wau e hoʻohana i kēia lāʻau lōʻihi?

Hoʻohana ʻia ʻo Cinqair e like me ka lapaʻau lōʻihi no ka hānō eosinophilic koʻikoʻi. Inā ʻoe a me kāu kauka e hoʻoholo i ka palekana a me ka maikaʻi o Cinqair nou, e hoʻohana paha ʻoe ia no kekahi manawa lōʻihi.

ʻO Cinqair no ka hānō

Ua ʻae ka Food and Drug Administration (FDA) i nā lāʻau i kuhikuhi ʻia e like me Cinqair e mālama i kekahi mau ʻano. ʻAe ʻia ʻo Cinqair e mālama i ka hānō eosinophilic koʻikoʻi i nā mākua. ʻAʻole ʻae ʻia ka lāʻau e mālama i nā ʻano hānō ʻē aʻe. Eia kekahi, ʻaʻole ʻae ʻia ʻo Cinqair e mālama i ka hānō o ka hānō.

Lawe ʻoe iā Cinqair me ka hoʻohui i kāu lapaʻau hānō i kēia manawa.

I kahi noi hoʻokolohua, hāʻawi ʻia ʻo Cinqair i ka poʻe 245 me ka hānō eosinophilic koʻikoʻi no 52 mau pule. I kēia hui, 62% o ka poʻe ʻaʻole i loaʻa kahi hānō hila i kēlā manawa. Hoʻohālikelike ʻia kēia me 46% o ka poʻe i loaʻa kahi placebo (ʻaʻohe lapaʻau). ʻO nā mea i loaʻa i ka hānō hila-i:

  • ʻO ka poʻe i loaʻa iā Cinqair he 50% ka nui o ka nui o nā uila i hoʻokahi makahiki ma mua o ka poʻe i loaʻa kahi placebo.
  • Loaʻa i ka poʻe i loaʻa iā Cinqair kahi 55% haʻahaʻa o ka lapalapa e koi ana i ka hoʻohana ʻana i nā corticosteroids ma mua o ka poʻe i loaʻa kahi placebo.
  • ʻO ka poʻe i loaʻa iā Cinqair he 34% ka nui o ka nui o nā uila i alakaʻi ʻia i kahi noho haukapila ma mua o ka poʻe i loaʻa kahi placebo.

I kahi noi hoʻokolohua ʻē aʻe, hāʻawi ʻia ʻo Cinqair i ka poʻe 232 me ka hānō eosinophilic koʻikoʻi no 52 mau pule. I kēia hui, 75% o ka poʻe ʻaʻole i loaʻa kahi hānō hila i kēlā manawa. Hoʻohālikelike ʻia kēia i 55% o ka poʻe i loaʻa kahi placebo (ʻaʻohe lapaʻau). ʻO nā mea i loaʻa i ka hānō hila-i:

  • ʻO ka poʻe i loaʻa iā Cinqair he 59% ka nui o ka nui o nā lapalapa ma mua o ka poʻe i loaʻa kahi placebo.
  • ʻO ka poʻe i loaʻa iā Cinqair he 61% ka helu haʻahaʻa o ka lapalapa e koi ana i nā corticosteroids ma mua o ka poʻe i loaʻa kahi placebo.
  • ʻO ka poʻe i loaʻa iā Cinqair he 31% ka nui o ka nui o nā uila i alakaʻi ʻia i kahi noho haukapila ma mua o ka poʻe i loaʻa kahi placebo.

Hoʻohana ʻo Cinqair me nā lāʻau ʻē aʻe

Pono ʻoe e hoʻohana iā Cinqair me kāu lāʻau lapaʻau hānō o kēia manawa. ʻO nā laʻana o nā lāʻau e hiki ke hoʻohana ʻia me Cinqair e mālama i ka hānō eosinophilic koʻikoʻi e komo pū me:

  • Hoʻokomo ʻia a me nā huaʻai Corticosteroids. ʻO ka mea i hoʻohana pinepine ʻia no ka hānō ʻoi loa:
    • beclomethasone dipropionate (Qvar Redihaler)
    • budesonide (Pulmicort Flexhaler)
    • cicleonide (Alvesco)
    • fluticasone propionate (ArmonAir RespiClick, Arnuity Ellipta, Flovent Diskus, Flovent HFA)
    • mometasone furoate (Asmanex HFA, Asmanex Twisthaler)
    • prednisone (Rayos)
  • Nā bronchodilator beta-adrenergic. ʻO ka mea i hoʻohana pinepine ʻia no ka hānō ʻoi loa:
    • salmeterol (Serevent)
    • formoterol (Foradil)
    • albuterol (ProAir HFA, ProAir RespiClick, Proventil HFA, Ventolin HFA)
    • levalbuterol (Xopenex, Xopenex HFA)
  • Hoʻololi nā ala hele leukotriene. ʻO ka mea i hoʻohana pinepine ʻia no ka hānō ʻoi loa:
    • montelukast (Singulair)
    • zafirlukast (Hoʻohui)
    • zileuton (Zyflo)
  • Muscarinic blockers, kahi ʻano anticholinergic. ʻO ka mea i hoʻohana pinepine ʻia no ka hānō ʻoi loa:
    • tiotropium bromide (Spiriva Respimat)
    • ipratropium
  • ʻO Theophylline

Hele mai ka hapa nui o kēia mau lāʻau e like me nā huahana hoʻohui. ʻO kahi laʻana, Symbicort (budesonide a formoterol) a me Advair Diskus (fluticasone a me salmeterol).

ʻO kekahi ʻano lāʻau lapaʻau āu e pono ai e hoʻomau me ka hoʻohana ʻana me Cinqair kahi mea hoʻopakele hoʻopakele. ʻOiai ʻo Cinqair e hana e kōkua i ka pale ʻana i ka hānō o ka hānō, loaʻa paha iā ʻoe kahi hoʻouka hānō. Ke kū kēia, pono ʻoe e hoʻohana i kahi inhaler hoʻopakele e kaohi koke i kāu hānō. No laila e halihali pū i kāu mea hoʻopakele hoʻopakele me ʻoe i nā manawa āpau.

Inā ʻoe e hoʻohana ana iā Cinqair, mai hoʻōki i ka lawe ʻana i kāu lāʻau lapaʻau hānō ʻē aʻe ke ʻōlelo ʻole kāu kauka iā ʻoe. A inā he nīnau kāu e pili ana i ka helu o nā lāʻau āu e lawe ai, e nīnau i kāu kauka.

Nā koho ʻē aʻe iā Cinqair

Loaʻa nā lāʻau ʻē aʻe i hiki ke mālama i ka hānō eosinophilic koʻikoʻi. Kūpono paha kekahi iā ʻoe ma mua o nā poʻe ʻē aʻe. Inā hoihoi ʻoe i ka ʻimi ʻana i kahi ʻē aʻe iā Cinqair, e kamaʻilio me kāu kauka. Hiki iā lākou ke haʻi iā ʻoe e pili ana i nā lāʻau ʻē aʻe i hana maikaʻi iā ʻoe.

Nā laʻana o nā lāʻau ʻē aʻe i hiki ke hoʻohana ʻia e mālama i ka hānō eosinophilic koʻikoʻi e komo pū me:

  • mepolizumab (Nucala)
  • benralizumab (Fasenra)
  • omalizumab (Xolair)
  • dupilumab (Dupixent)

ʻO Cinqair vs. Nucala

Mahalo paha ʻoe pehea e hoʻohālikelike ai ʻo Cinqair i nā lāʻau ʻē aʻe i kuhikuhi ʻia no nā hoʻohana like. Maanei mākou e nānā ai pehea e like ai a ʻokoʻa ai hoʻi ʻo Cinqair a me Nucala.

Hoʻohana

Ua ʻae ka Food and Drug Administration (FDA) iā Cinqair a me Nucala e mālama i ka hānō eosinophilic koʻikoʻi i nā mākua. Ua ʻae ʻia ʻo Nucala e mālama i ka hānō eosinophilic koʻikoʻi i nā keiki mai ka makahiki 12 a 18. Hoʻohana ʻia nā lāʻau ʻelua me nā lāʻau hānō ʻē aʻe āu e lawe nei.

Hoʻohui ʻia, ʻae ʻia ʻo Nucala e mālama i kahi maʻi laha i kapa ʻia ʻo eosinophilic granulomatosis me polyangiitis (EGPA). Ua ʻike ʻia ka maʻi ʻo Churg-Strauss Syndrome, a he kumu ia e wela ai kou mau kīʻaha koko.

ʻO Cinqair lāua ʻo Nucala no kekahi papa o nā lāʻau i kapa ʻia interleukin-5 antagonist monoclonal antibodies. ʻO kahi papa lāʻau kahi hui o nā lāʻau e hana i kahi ala like.

Nā ʻano lāʻau a me ka hoʻoponopono ʻana

Aia i loko o Cinqair ka reslizumab lāʻau lapaʻau hana. Loaʻa iā Nucala ka lāʻau lapaʻau mepolizumab.

Hele mai ʻo Cinqair i loko o nā hue. E hāʻawi aku kāu mea mālama ola iā ʻoe i ka hopena ma ke ʻano he injection i loko o kou aa (infravenous infusion). Lawe pinepine nā infusions ʻo Cinqair i 20 a 50 mau minuke.

Hele mai ʻo Nucala i nā ʻano ʻekolu:

  • ʻO kahi kīʻaha kū hoʻokahi o ka pauka. E hoʻopili kā kāu kauka olakino i ka pauka me ka wai sterile. A laila e hāʻawi lākou iā ʻoe i ka hopena ma ke ʻano he injection ma lalo o kou ʻili (subcutaneous injection).
  • Kahi peni piha preinfill autoinjector. E aʻo mua kāu kauka iā ʻoe e hoʻohana i ka peni. A laila hiki iā ʻoe ke hāʻawi iā ʻoe iho i nā injection i lalo o kou ʻili.
  • ʻO kahi syringe prefilled hoʻokahi-mahele lāʻau. E aʻo mua kāu kauka iā ʻoe pehea e hoʻohana ai i ka syringe. A laila hiki iā ʻoe ke hāʻawi iā ʻoe iho i nā injection i lalo o kou ʻili.

Hoʻonohonoho pinepine ʻia ʻo Cinqair i nā dosages o 3 mg / kg, hoʻokahi manawa i kēlā me kēia ʻehā pule. ʻO ka nui o nā lāʻau i loaʻa iā ʻoe e kaukaʻi ʻia i kou kaupaona.

ʻO ka mahele i koi ʻia o Nucala no ka hānō he 100 mg, hoʻokahi manawa i kēlā me kēia ʻehā pule.

Nā hopena a me nā pilikia

ʻO Cinqair lāua ʻo Nucala no ka papa like o nā lāʻau, no laila hana like lāua. Hiki i nā lāʻau ʻelua ke hana i nā hopena ʻokoʻa a like ʻole paha. Ma lalo nā hiʻohiʻona o kēia mau hopena ʻaoʻao.

Nā hopena ʻaoʻao hou aʻe

Aia i loko o kēia mau papa inoa nā laʻana o nā hopena ʻē aʻe i hiki ke hana ʻia me Cinqair a i ʻole me Nucala.

  • Hiki ke hana me Cinqair:
    • ʻeha oropharyngeal (ʻeha ma ka ʻāpana o kou ʻāʻī ma hope o kou waha)
  • Hiki iā Nucala ke hana.
    • ʻeha poʻo
    • ʻeha kua
    • luhi (nele o ka ikaika)
    • nā hopena o ka ʻili ma ke kahua o ka pahu kui, e like me ka ʻeha, ʻulaʻula, pehu, ʻume, a me ka naʻau wela

Nā hopena hopena koʻikoʻi

Aia i loko o kēia mau papa inoa nā laʻana o nā hopena ʻino e hiki ke hana ʻia me Cinqair, me Nucala, a i ʻole me nā lāʻau ʻelua (ke hāʻawi pākahi ʻia).

  • Hiki ke hana me Cinqair:
    • ʻōiwi
  • Hiki iā Nucala ke hana.
    • herpes zoster maʻiʻaʻai (shingles)
  • Hiki ke hana ʻia me Cinqair a me Nucala:
    • nā hopena koʻikoʻi, e like me ka anaphylaxis *

Ka hoʻokō ʻana

Hoʻohana ʻia ʻo Cinqair a me Nucala e mālama i ka hānō eosinophilic koʻikoʻi.

ʻAʻole i hoʻohālikelike pololei ʻia kēia mau lāʻau i loko o nā noiʻi haukapila, akā he loiloi i nā noiʻi i loaʻa iā Cinqair a me Nucala e maikaʻi i ka hōʻemi ʻana i ka nui o nā hānā o ka hānō.

Nā kumukūʻai

ʻO Cinqair lāua ʻo Nucala nā lāʻau lapaʻau inoa ʻelua. ʻAʻohe ʻano biosimilar o kēia lā lāʻau ʻelua.

ʻO kahi biosimilar kahi lāʻau e like me ka lāʻau lapaʻau inoa. ʻO kahi lāʻau laulā, ma ka ʻaoʻao ʻē aʻe, he kope kikoʻī o kahi lāʻau lapaʻau inoa inoa. Hoʻokumu ʻia nā biosimilars i nā lāʻau biologic, i hana ʻia mai nā ʻāpana o nā meaola ola. Hoʻokumu ʻia nā generics i nā lāʻau lapaʻau maʻamau i hana ʻia mai nā kemikū. ʻO nā biosimilars a me nā generics he mea palekana a maikaʻi hoʻi e like me ka lāʻau inoa inoa e hoʻāʻo nei lākou e kope. Eia kekahi, mālama lākou i ke kumukūʻai ma mua o nā lāʻau lapaʻau inoa.

Wahi a nā kuhi ma WellRx.com, ʻoi aku ka uku o Cinqair ma mua o Nucala. ʻO ke kumukūʻai maoli āu e uku ai no kēlā me kēia lāʻau e pili ana i kāu hoʻolālā ʻinikua a me kāu wahi.

ʻO Cinqair vs. Fasenra

Ma waho o Nucala (ma luna), ʻo Fasenra kekahi lāʻau i hoʻohana e like me kā Cinqair. Maanei mākou e nānā ai pehea e like ai a ʻokoʻa ai hoʻi ʻo Cinqair a me Fasenra.

Hoʻohana

Ua ʻae ka Food and Drug Administration (FDA) iā Cinqair a me Fasenra e mālama i ka hānō eosinophilic koʻikoʻi i nā mākua. ʻAe ʻia ʻo Fasenra e mālama i ka hānō eosinophilic koʻikoʻi i nā keiki mai ka makahiki 12 a 18. Hoʻohana ʻia nā lāʻau ʻelua me nā lāʻau lapaʻau hānō ʻē aʻe āu e lawe nei.

ʻO Cinqair lāua ʻo Fasenra no kahi papa o nā lāʻau i kapa ʻia interleukin-5 antagonist monoclonal antibodies. ʻO kahi papa lāʻau kahi hui o nā lāʻau e hana i kahi ala like.

Nā ʻano lāʻau a me ka hoʻoponopono ʻana

Aia i loko o Cinqair ka reslizumab lāʻau lapaʻau hana. Aia ʻo Fasenra i ka lāʻau lapaʻau benralizumab.

Hele mai ʻo Cinqair i kahi hue. E hāʻawi aku kāu mea mālama ola iā ʻoe i ka hopena ma ke ʻano he injection i loko o kou aa (infravenous infusion). Lawe pinepine nā infusions ʻo Cinqair i 20 a 50 mau minuke.

Hele mai ʻo Fasenra i kahi syringe i hoʻomākaukau ʻia. Hāʻawi kahi mea mālama ola iā ʻoe i ka lāʻau e like me ka injection i lalo o kou ʻili (subcutaneous injection).

Hoʻonohonoho pinepine ʻia ʻo Cinqair i nā dosages o 3 mg / kg, hoʻokahi manawa i kēlā me kēia ʻehā pule. ʻO ka nui o nā lāʻau i loaʻa iā ʻoe e kaukaʻi ʻia i kou kaupaona.

No kāu kau mua ʻekolu o Fasenra, loaʻa iā ʻoe he 30 mg i hoʻokahi manawa i kēlā me kēia pule ʻehā. Ma hope o kēlā, loaʻa iā ʻoe he 30 mg o Fasenra hoʻokahi i kēlā me kēia pule ʻewalu.

Nā hopena a me nā pilikia

ʻO Cinqair lāua ʻo Fasenra no ka papa like o nā lāʻau, no laila hana like lāua. Hiki i nā lāʻau ʻelua ke hana i nā hopena ʻokoʻa a like ʻole paha. Ma lalo nā hiʻohiʻona o kēia mau hopena ʻaoʻao.

Nā hopena ʻaoʻao hou aʻe

Aia i loko o kēia mau papa inoa nā laʻana o nā hopena ʻē aʻe i hiki ke hana ʻia me Cinqair a i ʻole me Fasenra.

  • Hiki ke hana me Cinqair:
    • ʻeha oropharyngeal (ʻeha ma ka ʻāpana o kou ʻāʻī ma hope o kou waha)
  • Hiki iā Fasenra ke hana.
    • ʻeha poʻo
    • eha ka 'ā'ī

Nā hopena hopena koʻikoʻi

Loaʻa i kēia mau papa inoa nā laʻana o nā hopena ʻino e hiki ke hana ʻia me Cinqair, me Fasenra, a i ʻole me nā lāʻau ʻelua (ke hāʻawi pākahi ʻia).

  • Hiki ke hana me Cinqair:
    • ʻōiwi
  • Hiki iā Fasenra ke hana.
    • kekahi mau hopena ʻaoʻao maʻamau
  • Hiki ke hana ʻia me Cinqair a me Fasenra:
    • nā hopena koʻikoʻi, e like me ka anaphylaxis *

Ka hoʻokō ʻana

Hoʻohana ʻia ʻo Cinqair a me Fasenra e mālama i ka hānō eosinophilic koʻikoʻi.

ʻAʻole i hoʻohālikelike pololei ʻia kēia mau lāʻau i nā noiʻi maʻi. Akā kahi loiloi o nā noiʻi i ʻike ʻia ʻo Cinqair e ʻoi aku ka maikaʻi i ka pale ʻana i nā mumū hānō ma mua o Fasenra.

Nā kumukūʻai

ʻO Cinqair lāua ʻo Fasenra nā lāʻau lapaʻau inoa inoa ʻelua. ʻAʻohe ʻano biosimilar o kēia lā lāʻau ʻelua.

ʻO kahi biosimilar kahi lāʻau e like me ka lāʻau lapaʻau inoa. ʻO kahi lāʻau laulā, ma ka ʻaoʻao ʻē aʻe, he kope kikoʻī o kahi lāʻau lapaʻau inoa inoa. Hoʻokumu ʻia nā biosimilars i nā lāʻau biologic, i hana ʻia mai nā ʻāpana o nā meaola ola. Hoʻokumu ʻia nā generics i nā lāʻau lapaʻau maʻamau i hana ʻia mai nā kemikū. ʻO nā biosimilars a me nā generics he mea palekana a maikaʻi hoʻi e like me ka lāʻau inoa inoa e hoʻāʻo nei lākou e kope. Eia kekahi, mālama lākou i ke kumukūʻai ma mua o nā lāʻau lapaʻau inoa.

Wahi a nā koho ma WellRx.com, ʻoi aku ka uku o Cinqair ma mua o Fasenra. ʻO ke kumukūʻai maoli āu e uku ai no kēlā me kēia lāʻau e pili ana i kāu hoʻolālā ʻinikua a me kāu wahi.

ʻO Cinqair a me ka waiʻona

ʻAʻohe mea i ʻike ʻia ma waena o Cinqair a me ka waiʻona i kēia manawa. Akā hiki i kekahi poʻe me ka hānō ke hoʻomohala i nā ahi i ka wā e inu ana i ka ʻalekiko a i ʻole ma hope o kā lākou inu rama. ʻO ka waina, cider, a me ka pia ka mea e ʻoi aku ai kēia mau lapalapa ʻana ma mua o nā mea inu ʻona ʻē aʻe.

Inā loaʻa iā ʻoe kahi hānō i ka inu ʻana i ka ʻalekohola, e hoʻōki koke i ka inu ʻana i ka waiʻona. E hoʻomaopopo i kāu kauka e pili ana i ka lapalapa i kāu kipa hou aʻe.

Eia kekahi, e kamaʻilio me kāu kauka e pili ana i ka nui a me ke ʻano o ka waiʻona āu e inu ai. Hiki iā lākou ke haʻi iā ʻoe i ka nui o ka palekana iā ʻoe e inu ai i kāu wā e mālama ai.

Nā pilina ʻo Cinqair

ʻAʻohe mea i ʻike ʻia ma waena o Cinqair a me nā lāʻau ʻē aʻe, nā mea kanu, nā mea hoʻohui, a me nā meaʻai. Akā ʻo kekahi o kēia mau mea e hoʻonui i kou manawa o ka loaʻa ʻana o ka hānō hū. ʻO kahi laʻana, hiki i kekahi mau mea ʻaʻai a lāʻau paha ke kumu i ka hake ʻana o ka hānō.

Inā he meaʻai kāu a i ʻole nā ​​lāʻau āpau, e haʻi i kāu kauka. E ʻōlelo pū kekahi i nā lāʻau, nā mea kanu, a i ʻole nā ​​mea hoʻopihapiha āu e lawe ai. Koi paha kāu kauka i nā hoʻoponopono i kāu papaʻai, ka lāʻau, a i ʻole ke ʻano o ka nohona inā pono.

Pehea e hāʻawi ʻia ai ʻo Cinqair

E hāʻawi kahi mea mālama ola iā ʻoe iā Cinqair ma ke ʻano he infravenous (IV) infusion i ke keʻena o kāu kauka a i ʻole kahi keʻena lapaʻau. ʻO kēia kahi injection i loko o kou aa koko i kahe lohi i ka holo ʻana o ka manawa.

ʻO ka mea mua, e hoʻokau kāu mea mālama ola i kahi nila i loko o kekahi o kou mau uaua. A laila e hoʻopili lākou i kahi ʻeke i piha iā Cinqair i ka nila. E kahe ka lāʻau mai ka ʻeke i kou kino. Lawe kēia ma kahi o 20 a 50 mau minuke.

Ma hope o ka loaʻa ʻana o kāu lāʻau, hiki i kāu kauka olakino ke kiaʻi iā ʻoe e ʻike inā hoʻomohala ʻoe i ka anaphylaxis. * He ʻano ʻano maʻi ʻino kēia. (No nā hōʻailona kūpono, e ʻike i ka ʻāpana "Cinqair effects" ma luna). Hana ʻia ʻo Anaphylaxis ma hope o nā lāʻau o Cinqair. No laila hiki i kāu kauka olakino ke kiaʻi iā ʻoe inā ua loaʻa iā ʻoe ʻo Cinqair ma mua.

I ka manawa e loaʻa iā Cinqair

Hāʻawi pinepine ʻia ʻo Cinqair i kēlā me kēia pule ʻehā. Hiki iā ʻoe a me kāu kauka ke kūkākūkā i ka manawa ʻoi loa o ka lā na ʻoe e hoʻokomo ai.

He manaʻo noʻeau e kākau i kāu papa hana hoʻomaʻamaʻa ma ka kalena. Hiki iā ʻoe ke hoʻonohonoho i kahi hoʻomanaʻo ma kāu kelepona i ʻole ʻoe e haʻalele i kahi manawa.

Pehea e hana ai ʻo Cinqair

ʻO Asthma kahi ʻano e wela ai ke ala o ke kahawai i hiki i kou mau māmā. Hoʻopili ʻia nā mākala e hoʻopuni ana i nā alaloa, kahi e pale ai i ka ea mai ka neʻe ʻana ma waena o lākou. ʻO ka hopena, ʻaʻole hiki i ka oxygen i kou koko.

Me ka hānō nui loa, ʻoi aku paha ka maikaʻi o nā ʻōuli ma mua o ka hānō maʻamau. A i kekahi manawa hana ʻole nā ​​lāʻau e kōkua i ka mālama ʻana i ka hānō no ka hānō nui. No laila inā loaʻa ʻoe i ka hānō nui, pono ʻoe i kahi lāʻau hou aʻe.

ʻO kekahi ʻano hānō koʻikoʻi ka hānō eosinophilic nui. Me kēia ʻano hānō, he kiʻekiʻe kāu o nā eosinophil i kou koko. ʻO Eosinophils kahi ʻano kikoʻī o ke keʻokeʻo koko keʻokeʻo. (ʻO nā hunaola keokeo nā hunaola mai kāu ʻōnaehana pale, e kōkua ai iā ʻoe e pale aku i ka maʻi.) ʻO ka hoʻonui ʻia ʻana o nā eosinophil e lawe mai i ka pehu i loko o kou mau ala ea a me nā ake māmā. ʻO kēia ke kumu o kāu mau hōʻailona hānō.

He aha ka hana a Cinqair?

Aia ka helu o nā eosinophil i kou koko i nā kumu he nui. Pili kekahi mea nui me kahi protein i kapa ʻia interleukin-5 (IL-5). ʻAe ʻo IL-5 i nā eosinophil e ulu a hele i kou koko.

Hoʻopili ʻo Cinqair iā IL-5. Ma ka hoʻopili ʻana iā ia, hoʻopau ʻo Cinqair iā IL-5 mai ka hana ʻana. Kōkua ʻo Cinqair i ka pale ʻana iā IL-5 mai ka waiho ʻana i nā eosinophil e ulu a neʻe i kou koko. Inā hiki ʻole i nā eosinophil ke piʻi i kou koko, ʻaʻole hiki iā lākou ke kiʻi i kou mau akemāmā. No laila ʻaʻole hiki i nā eosinophil ke kumu i ka pehu ʻana i kāu mau alaloa a me nā māmā.

Pehea ka lōʻihi o ka hana?

Ma hope o kāu mahele lāʻau mua o Cinqair, lawe paha ia i ʻehā mau pule no ka haʻalele ʻana o kāu ʻōuli hānō.

Ua hōʻea ʻo Cinqair i kou koko i ka manawa hāʻawi ʻia iā ʻoe. Hele ka lāʻau i loko o kou koko i kou mau pūnaewele. Ke hiki aku ʻo Cinqair i kāu mau pūnaewele, hoʻopili aku ia iā IL-5 a hooki iā ia mai ka hana koke ʻana.

Akā ke hoʻopau ʻo IL-5 i ka hana, aia nō i laila nā pae kiʻekiʻe o nā eosinophil i kou koko. E kōkua ʻo Cinqair i ka pale ʻana i kēia nui mai ka hoʻonui ʻana. E kōkua pū ka lāʻau i ka hōʻemi ʻana i ka nui o nā eosinophil, akā ʻaʻole hiki koke kēia.

E ʻehā paha pule ka lōʻihi e hoʻohaʻahaʻa i ka nui o nā eosinophil i loko o kou koko. No laila hiki i kāu mau hōʻailona hānō ke lilo i ʻehā mau pule e nalo ai ma hope o kāu kau mua o Cinqair. Ke hala aku kāu mau hōʻailona, ​​ʻaʻole paha lākou e hoʻi mai inā lōʻihi ʻoe e loaʻa iā Cinqair.

ʻO Cinqair a me ka hāpai keiki

ʻAʻole lawa nā noiʻi lapaʻau i hana ʻia i loko o nā kānaka e hōʻoia ai inā palekana ʻo Cinqair e hoʻohana i ka wā hāpai. Akā ʻike ʻia hele ʻo Cinqair i ka placenta a hiki i ka pēpē. ʻO ka placenta kahi mea ulu i loko o kou ʻōpū ʻoiai ʻoe hāpai.

Hōʻike nā noiʻi i nā holoholona ʻaʻole e loaʻa nā hopena ʻino i ka pēpē. Akā ʻaʻole hōʻike mau ka noiʻi holoholona i nā mea e hana ʻia i nā kānaka.

Inā lawe ʻoe iā Cinqair a hāpai a makemake paha e hāpai, e kamaʻilio me kāu kauka. Hiki iā lākou ke kōkua iā ʻoe e hoʻoholo inā ʻo Cinqair a i ʻole kekahi lāʻau lapaʻau hānō ka mea maikaʻi loa nāu.

ʻO Cinqair a me ka waiū hānai

ʻAʻohe haʻawina hoʻokolohua i loko o nā kānaka e hōʻoia inā palekana i ka hānai ʻana i ka wā e lawe ana iā Cinqair. Akā hōʻike nā kānaka noiʻi i nā proteins e like me nā mea ma Cinqair i loko o ka waiū umauma kanaka. Eia kekahi, i loko o nā noiʻi holoholona, ​​loaʻa ʻo Cinqair i ka waiū umauma makuahine. No laila manaʻo ʻia e loaʻa ʻia ʻo Cinqair i ka waiū umauma kanaka pū kekahi. ʻAʻole maopopo pehea ka hopena o kēia i ke keiki.

Inā makemake ʻoe e hānai i ka wā e loaʻa ana iā Cinqair, e haʻi i kāu kauka. Hiki iā lākou ke kūkākūkā pū me ʻoe i nā mea maikaʻi a maikaʻi ʻole.

Nā nīnau e pili ana iā Cinqair

Eia nā pane i kekahi o nā nīnau e nīnau pinepine ʻia e pili ana iā Cinqair.

He lāʻau biologic ʻo Cinqair?

Ae. ʻO Cinqair kahi ʻano lāʻau i kapa ʻia he biologic, i hana ʻia mai nā meaola ola. ʻO nā lāʻau lapaʻau maʻamau, ma ka ʻaoʻao ʻē aʻe, hana ʻia mai nā kemika.

ʻO Cinqair kekahi he antibody monoclonal. ʻO kēia kahi ʻano biologic e launa pū me kāu ʻōnaehana pale. (ʻO kou ʻōnaehana pale ka mea e kōkua ai e pale aku i kou kino mai ka maʻi.) Monoclonal antibodies like Cinqair hoʻopili i nā protein i loko o kāu pale pale. Ke hoʻopili aku ʻo Cinqair i kēia mau protein, hoʻōki ia iā lākou mai ka hoʻomāmā ʻana (pehu) a me nā ʻōuli hānō ʻē aʻe.

No ke aha e hele ʻole mai ai ʻo Cinqair ma ke ʻano he inhaler a i ʻole ka ʻāpana?

ʻAʻole hiki i kou kino ke hana iā Cinqair i ka inhaler a i ʻole ka pila pila, no laila ʻaʻole hiki i ka lāʻau ke kōkua i ka mālama hānō.

ʻO Cinqair kahi ʻano o ka lāʻau biologic i ʻike ʻia ma ke ʻano he antibody monoclonal. (No ka mea hou aku e pili ana i nā biologics, e ʻike iā "ʻO Cinqair kahi lāʻau biologic?" Ma luna.) ʻO nā monoclonal antibodies he mau protein nui. Inā ʻoe e lawe i kēia mau lāʻau i nā pila, hele pololei lākou i kou ʻōpū a me kou ʻōpū. Ma laila, nā ʻākika a me nā protein ʻē aʻe e wāwahi i nā meaola monoclonal. Ma muli o ka wāwahi ʻia ʻana o nā antibodies monoclonal i nā ʻāpana liʻiliʻi, ʻaʻole pono lākou no ka mālama ʻana i ka hānō. No laila i ka pila pila, ʻaʻole holo pono kēia ʻano lāʻau.

ʻAʻole hiki iā ʻoe ke inhale i nā antibodies monoclonal kekahi. Inā ʻoe i hana, e wāwahi koke nā proteins i kou mau māmā i ka lāʻau i ʻona. ʻO ka liʻiliʻi loa o ka lāʻau e lilo ia i kou koko a me nā hunaola. E hōʻemi kēia i ka maikaʻi o ka hana ʻana o ka lāʻau i kou kino.

ʻO ke ala ʻoi loa āu e lawe ai i nā antibodies monoclonal, me Cinqair, ma o ka hoʻokomo ʻana i loko (IV). (He iniki kēia i loko o kou aa i ninini lohi ʻia i ka manawa.) I kēia palapala, hele pololei ka lāʻau i loko o kou koko. ʻAʻohe acid a protein paha e wāwahi i ka lāʻau i lalo no ʻelua mau pule. No laila hiki i ka lāʻau lapaʻau ke hele i kou koko a hana i nā ʻāpana o kou kino e pono ai.

No ke aha e hiki ʻole ai iaʻu ke kiʻi iā Cinqair mai kahi kauka lāʻau?

ʻO ke ala wale nō e kiʻi ai iā Cinqair ma o kāu kauka. E hāʻawi kahi mea mālama ola iā ʻoe iā Cinqair ma ke ʻano he infravenous (IV) infusion i ke keʻena o kāu kauka a i ʻole kahi keʻena lapaʻau. ʻO kēia kahi injection i loko o kou aa koko i kahe lohi i ka holo ʻana o ka manawa. No laila ʻaʻole hiki iā ʻoe ke kūʻai iā Cinqair i kahi hale kūʻai lāʻau a lawe iā ʻoe iho.

Hiki i nā keiki ke hoʻohana iā Cinqair?

No. Ua ʻae wale ka Food and Drug Administration (FDA) iā Cinqair e mālama i nā mākua. Ua loiloi nā noiʻi lapaʻau i ka hoʻohana ʻana o Cinqair i nā keiki mai ka makahiki 12 a 18. Akā, ʻaʻole i hōʻike nā hopena i ka holo pono ʻana o ka lāʻau a palekana i hiki ke hoʻohana i nā keiki.

Inā loaʻa i kāu keiki ka hānō eosinophilic koʻikoʻi, e kamaʻilio me kā lākou kauka. Hiki iā lākou ke paipai i nā lāʻau ʻē aʻe ma mua o Cinqair i hiki ke kōkua i ka mālama ʻana i kāu keiki.

E pono anei wau e lawe i ka corticosteroid me Cinqair?

Maliʻa paha. ʻAʻole pono ʻoe e lawe iā Cinqair iā ia iho. Pono ʻoe e hoʻohana i ka lāʻau lapaʻau me kāu mau lāʻau hānō o kēia manawa, i hiki ke hoʻopili ʻia i kahi corticosteroid.

Kōkua wale ʻo Cinqair i ka maʻalahi i ka hānō eosinophilic koʻikoʻi. ʻO kēia kahi ʻano hānō e hoʻokumu ʻia e nā kiʻekiʻe o nā eosinophil (kahi ʻano o ke koko keʻokeʻo) i loko o kou koko.

E like me Cinqair, hana nā corticosteroids i ka hoʻemi ʻana i ka mumū (pehu) i loko o kou mau māmā. Eia nō naʻe, hōʻemi nā corticosteroids i ka mumū ma nā ʻano ʻokoʻa iki. Nui nā poʻe me ka hānō nui e pono iā Cinqair a me ka corticosteroid e kōkua i ka mālama ʻana i kā lākou hānō. No laila, hiki i kāu kauka ke kuhikuhi i nā lāʻau ʻelua nāu. Mai hōʻoki i ka lawe ʻana i ka corticosteroid ke ʻōlelo ʻole kāu kauka iā ʻoe.

Pono anei wau e loaʻa me kahi inhaler hoʻopakele me aʻu?

Ae.Pono nō ʻoe e hāpai i kahi inhaler hoʻopakele inā loaʻa iā ʻoe ʻo Cinqair.

ʻOiai ʻo Cinqair kōkua i ka mālama ʻana i ka hānō eosinophilic koʻikoʻi i kahi wā lōʻihi, hiki nō paha iā ʻoe ke lele i luna. A ʻaʻole hana wikiwiki ʻo Cinqair e mālama i nā hōʻailona hānō hikiwawe.

Inā ʻaʻole ʻoe e hoʻokele i nā ʻōuli o ka hānō i ka manawa koke, hiki lākou i ka ʻino. No laila ke ala ʻoi loa e loaʻa ai kahi lima iā lākou e hoʻohana i kahi inhaler hoʻopakele. E kōkua kēia mea i ka maʻalahi o kāu mau hōʻailona hānō.

E hoʻomanaʻo e pono nō ʻoe e lawe i kāu mau lāʻau hānō ʻē aʻe, e like me Cinqair.

Nā hana aka Cinqair

Hele mai kēia lāʻau lapaʻau me nā ʻōlelo aʻoaʻo.

Ka hoʻolaha ʻana a FDA: Anaphylaxis

Aia kēia lāʻau i ka ʻōlelo aʻoaʻo a ka pahu. ʻO kēia ka ʻōlelo aʻo koʻikoʻi loa mai ka Food and Drug Administration (FDA). ʻO ka leka hoʻomaopopo e hōʻike i nā kauka a me nā poʻe e pili ana i nā hopena lāʻau e weliweli paha.

Hiki ke hana i kahi hopena maʻi kūpilikiʻi i kapa ʻia ka anaphylaxis ma hope o ka loaʻa ʻana iā Cinqair. Hāʻawi ʻia ka lāʻau e ka mea mālama ola, no laila e nānā lākou i ka hopena o kou kino iā Cinqair. Hiki iā lākou ke mālama koke i nā anaphylaxis inā hoʻomohala ʻoe iā ia.

Nā ʻōlelo aʻoaʻo ʻē aʻe

Ma mua o ka lawe ʻana iā Cinqair, e kamaʻilio me kāu kauka e pili ana i kāu mōʻaukala olakino. ʻAʻole kūpono paha ʻo Cinqair iā ʻoe inā loaʻa iā ʻoe kekahi ʻano olakino. Pākuʻi ʻia kēia mau mea:

Maʻi maʻi Helminth

ʻAʻole kūpono paha ʻo Cinqair iā ʻoe inā loaʻa iā ʻoe kahi maʻi helminth (kahi maʻi parasite i hoʻokumu ʻia e nā ilo). Pono kāu kauka e mālama i ka maʻi ma mua o ka hiki iā ʻoe ke hoʻomaka e hoʻohana iā Cinqair.

Inā loaʻa ʻoe i kahi maʻi helminth i ka hoʻohana ʻana iā Cinqair, hoʻomaha paha kāu kauka i kāu lāʻau. Kau inoa paha lākou i ka lāʻau e hoʻomaʻemaʻe i ka maʻi. Ke hala aku ka maʻi, hoʻomaka paha kāu kauka e loaʻa hou iā Cinqair.

E hoʻomanaʻo i nā ʻōuli o kahi maʻi helminth i ʻike ʻoe i ka mea e nānā ai. Pākuʻi ʻia paha nā ʻōuli me ka maʻi diarrhea, ka ʻeha o kou ʻōpū, kaʻai pono ʻole, a me nā nāwaliwali.

Hapai keiki

ʻAʻole lawa nā noiʻi lapaʻau i hana ʻia i loko o nā kānaka e hōʻoia ai inā palekana ʻo Cinqair e hoʻohana i ka wā hāpai. E aʻo hou ai, e ʻike i ka ʻāpana ʻo "Cinqair and hāpai" ma luna.

Kaha: No ka ʻike hou aku e pili ana i nā hopena maikaʻi ʻole o Cinqair, e ʻike i ka ʻāpana ʻaoʻao ʻo Cinqair "ma luna.

ʻO ka ʻike ʻoihana no Cinqair

Hāʻawi ʻia ka ʻike aʻe no nā kauka lapaʻau a me nā ʻoihana ola.

Nā Hōʻike

Hōʻike ʻia ʻo Cinqair no ka mālama ʻana i ka hānō nui. Hoʻonohonoho ʻia ka ʻae ʻana o ka lāʻau i kona hoʻohana ʻia ma ke ʻano he mālama mālama mālama no ka hānō nui. ʻAʻole pono ʻo Cinqair e pani i ke ʻano o ka mālama ʻana i kēia manawa i wehewehe ʻia no nā mea maʻi, me ka hoʻohana pū ʻana i nā corticosteroids.

ʻO ka ʻae ʻo Cinqair no ka mālama ʻana i nā poʻe me kahi phenotype eosinophilic. ʻAʻole pono e mālama ʻia ka lāʻau i ka poʻe me nā phenotypes ʻokoʻa. ʻAʻole hoʻi ia e lawelawe ʻia no ka mālama ʻana i nā maʻi ʻē aʻe e pili ana i ka eosinophilic.

Eia kekahi, ʻaʻole hōʻike ʻia ʻo Cinqair e mālama i nā bronchospasms huikau a i ʻole kūlana asthmaticus. ʻAʻole i kālailai ʻia ka hoʻohana ʻana i ka lāʻau e hoʻopakele i nā ʻōuli i ka wā o nā noiʻi maʻi.

Pono e mālama ʻia ka hoʻohana ʻana iā Cinqair no ka poʻe i ʻoi aku i ka makahiki 18. ʻAʻohe ona ʻĀina a me nā lāʻau lapaʻau (FDA) ʻae ʻia no ka poʻe ʻōpio ma mua o kēlā makahiki.

Mekanism o ka hana

ʻAʻole i wehewehe pono ʻia ke ʻano hana o ka hana a Cinqair. Akā manaʻoʻiʻo ʻia ke hana nei ia ma o ke ala interleukin-5 (IL-5).

ʻO Cinqair kahi kanaka IgG4-kappa monoclonal antibody e hoʻopili iā IL-5. Loaʻa ka paʻa o ka paʻa o 81 picomolar (pM). Ma ka hoʻopaʻa ʻana iā IL-5, antagonize ʻo Cinqair i ka IL-5 a pāpā i kāna hana olaola. Kūpono kēia ma muli o ka pale ʻana o Cinqair iā IL-5 mai ka hoʻopaʻa ʻana i ka mea loaʻa i ka IL-5 i loaʻa i ka ʻili pūnaewele o eosinophils.

ʻO IL-5 ka cytokine nui nui loa no ka ulu ʻana, ka hoʻokaʻawale ʻana, ka hoʻoulu ʻana, ka hoʻoulu ʻana, a me ke ola ʻana o nā eosinophil. ʻO ka nele o ka pilina ma waena o IL-5 a me nā eosinophil e pale aku iā IL-5 mai ka loaʻa ʻana o kēia mau hana pūnaewele i nā eosinophil. No laila e hoʻopili ʻia ka pōʻaiapili eosinophil a me nā hana olaola. Hoʻopau ka hana ʻana ʻo Eosinophils i ka hana kūpono a make.

I ka poʻe me kahi prototype eosinophil o ka hānō nui, he kumu nui nā eosinophil o ka maʻi. Hoʻokumu ʻo Eosinophils i ka mumū mau i nā akemāmā, kahi e alakaʻi ai i ka hānō mau. Ma ka hoʻemi ʻana i ka helu a me ka hana o eosinophil, hoʻemi ʻo Cinqair i ka mumū i ka hāhā. No ka manawa pōkole e hoʻomalu ʻia ka hānō.

Hiki i nā hunaola mast, macrophages, neutrophil, a me nā lymphocytes ke hoʻā i nā māmā. Eia kekahi, ʻo nā eicosanoids, histamine, cytokines, a me nā leukotrienes ke kumu o kēia pehu. ʻAʻole maopopo inā hana ʻo Cinqair i kēia mau pūnaewele a me nā mea uwao e kaohi i ka mumū i nā akemāmā.

Pharmacokinetics a me ka metabolism

Loaʻa ʻo Cinqair i kāna kiʻekiʻe kiʻekiʻe ma ka hopena o ke kau infusion. ʻO nā alakaʻi he nui o Cinqair ke alakaʻi i kahi hōʻuluʻulu o ia mea i ke serum o 1.5- a 1.9-pā. Ua hoʻoliʻiliʻi nā kūmomo serum i ka piʻo biphasic. ʻAʻole loli kēia mau noʻonoʻo me ke kū ʻana o nā anti-Cinqair antibodies.

I ka manawa e hoʻomalu ai, he nui ka hāʻawi o Cinqair o 5 liters. ʻO ke kumu o kēia ʻaʻole hiki i nā nui o Cinqair i nā kino keu.

E like me ka nui o nā monodiesl monoclonal, pilikia ʻo Cinqair i ka hoʻohaʻahaʻa enzymatic. Hoʻololi nā enzyme Proteolytic iā ia i peptides liʻiliʻi a me nā amino acid. Hoʻopau ka proteolysis o Cinqair i ka manawa. ʻO kona hapalua ola ma kahi o 24 mau lā. Eia kekahi, ʻo ka helu o ka hoʻomaʻemaʻe aia ma kahi o 7 milliliter i kēlā me kēia hola (mL / hr). ʻAʻole hiki ke hele i ka ʻae-mediated clearance no Cinqair. ʻO kēia no ka mea e nakinaki ia i interleukin-5 (IL-5), kahi cytokine hiki ke hoʻoheheʻe ʻia.

ʻO nā haʻawina Pharmacokinetics o Cinqair he like loa i waena o nā poʻe o nā makahiki, ke kāne, a me ka lāhui. ʻO ka loli ma waena o kēlā me kēia kanaka ma waena o 20% a 30% no ka piʻi kiʻekiʻe a me ka hōʻike ākea.

Hōʻike nā noiʻi Pharmacokinetics i ka ʻokoʻa nui ma waena o ka poʻe me nā hoʻokolohua hana ate a hoʻonui ʻia me ka haʻahaʻa. ʻO kahi hana maʻamau e pili ana i nā pae o ka bilirubin a me ka aspirate aminotransferase ma lalo o a i ʻole ka mea like me ka palena kiʻekiʻe maʻamau (ULN). ʻO kahi hoʻokolohua hana hoʻonui hoʻonui haʻahaʻa ʻia e pili ana i nā pae o bilirubin ma luna o ka ULN a ʻoi aku ka liʻiliʻi ma mua a i ʻole 1.5 i ka ULN. Pili pū paha ia i nā pae o ka aspartate aminotransferase kiʻekiʻe ma mua o ka ULN.

Eia kekahi, ʻaʻole hōʻike nā noiʻi lāʻau lapaʻau ma waena o nā kānaka me ka hana renal maʻamau a maikaʻi ʻole paha. Hōʻike ka hana renal maʻamau i kahi helu filtration glomerular estimated (eGFR) ʻoi aku ma mua a i ʻole 90 mL no kēlā me kēia minuke no 1.73-mika pahu. (mL / min / 1.73 m2). ʻO nā hana ʻino a me ke kaulike e hōʻike i kahi eGFR i koho ʻia ma waena o 60 a 89 mL / min / 1.73 ka m2 a 30 i ka 59 mL / min / 1.73 ka m2, pakahi.

Nā Kūʻai Kūʻai

Hoʻopiʻi ʻia ʻo Cinqair i ka poʻe i hoʻomohala mua i ka hypersensitivity i kekahi mea hana a hana ʻole paha o Cinqair.

Hiki ke hana i ka hypersensitivity ma hope pono o ka hoʻoponopono ʻana o Cinqair. Akā i kekahi mau hihia, hiki paha i loko o kekahi mau hola ma hope o ka hoʻoponopono ʻana o ka lāʻau. ʻO ka nānā ʻana i nā mea maʻi ma hope o ka lawelawe ʻana o Cinqair he mea nui e nānā i ka ulu ʻana o nā hopena hypersensitivity.

ʻO ka hypersensitivity kahi maʻi maha-organ i hiki ke kumu i ka anaphylaxis a me ka make e ka haʻalulu anaphylactic. ʻO nā mea maʻi āpau me ka hypersensitivity i Cinqair e hoʻopau koke i ka mālama ʻana. I kēia hihia, pono e mālama ʻia nā ʻōuli o ka hypersensitivity. ʻAʻole pono kēia mau maʻi i ka lāʻau Cinqair.

E kamaʻilio me kāu poʻe maʻi e pili ana i nā ʻōuli o ka hypersensitivity a me ka anaphylaxis. E haʻi iā lākou e kāhea koke iā 911 inā manaʻo lākou ke loaʻa nei kēia mau ʻano iā lākou. Eia kekahi, e haʻi iā lākou e hoʻomaopopo i kā lākou poʻe lawelawe i ke olakino inā ʻike lākou i ka hypersensitivity a i ʻole anaphylaxis e hōʻano hou i ke ala lapaʻau.

Waihona

Pono e hoʻomaʻalili ʻo Cinqair ma waena o 36 ° F a 46 ° F (2 ° C a 8 ° C). He mea nui ʻaʻole e paʻa a haʻalulu paha ka lāʻau. He mea nui nō hoʻi e mālama iā Cinqair i kāna pūʻulu kumu a hiki i kona hoʻohana ʻana. Pale kēia i ka lāʻau mai ka hoʻohaʻahaʻa malamalama.

Hoʻolaha: Ua hana ʻo Nūhou Lapaʻau i kēia mau lā e hōʻoia i ka pololei, ka laulā, a me ka lā hou o nā ʻike āpau. Eia nō naʻe, ʻaʻole pono e hoʻohana i kēia ʻatikala i pani no ka ʻike a me ka mākaukau o kahi loea mālama ola laikini. E nīnau mau ʻoe i kāu kauka a i ʻole ʻoihana olakino ʻē aʻe ma mua o ka lawe ʻana i nā lāʻau. Hiki ke loli i ka ʻike o ka lāʻau i loko a ʻaʻole i manaʻo ʻia e uhi i nā hoʻohana a pau, nā kuhikuhi, ka mālama ʻana, nā ʻōlelo aʻoaʻo, nā launa lāʻau, nā hopena maʻi ʻaʻai, a me nā hopena maikaʻi ʻole. ʻO ka loaʻa ʻole o nā ʻōlelo aʻoaʻo a i ʻole nā ​​ʻike ʻē aʻe no kahi lāʻau i hāʻawi ʻia ʻaʻole ia e hōʻike i ka palekana o ka lāʻau a lāʻau paha i kūpono no nā mea maʻi āpau a i ʻole nā ​​hoʻohana kikoʻī āpau.

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