Hōʻike CPK: no ke aha ia a no ke aha i hoʻololi ʻia ai
Anter
ʻO Creatinophosphokinase, ka mea i ʻike ʻia e ka acronym CPK a i ʻole CK, kahi enzyme e hana nui i nā mākala, ka lolo a me ka puʻuwai, a noi ʻia nā mea e noi ai e hōʻino i kēia mau ʻino.
Hiki i ke kauka ke kauoha i kēia hoʻokolohua ke hōʻea ke kanaka i ka haukapila e namunamu ana i ka ʻeha o ka umauma a i ʻole e nānā i nā hōʻailona o ka hahau a i ʻole nā maʻi e hoʻopili i nā io, no ka laʻana.
Nā manaʻo kūmole
ʻO nā kumukūʻai kūmole no ka creatine phosphokinase (CPK) 32 a me 294 U / L no nā kāne a 33 a 211 U / L no nā wahine akā hiki iā lākou ke ʻokoʻa ma muli o ke keʻena hoʻokolohua kahi e hana ai ka hōʻike.
No ke aha ia
He mea maikaʻi ka hoʻāʻo creatinophosphokinase (CPK) e kōkua i ke kuhi ʻana i nā maʻi e like me ka puʻuwai puʻuwai, ka puʻuwai a me ka hakahaka ʻole, a me nā mea ʻē aʻe. Māhele ʻia kēia ʻākena i loko o ʻekolu ʻano e like me kona wahi.
- CPK 1 a BB paha: Hiki ke loaʻa ma nā akemāmā a me ka lolo, ʻo ka hapanui;
- CPK 2 a i ʻole MB: Loaʻa iā ia i ka puʻuwai puʻuwai a no laila hiki ke hoʻohana ʻia ma ke ʻano he marker of infarction, no ka laʻana;
- CPK 3 a i ʻole MM: Aia ia i loko o nāʻiʻo muscle a hōʻike i 95% o nā phinefininases creatine (BB a me MB).
Hana ʻia ke ana o kēlā me kēia ʻano o CK e nā ʻano hana ʻokoʻa e like me kāna waiwai a e like me ka hōʻailona olakino. Ke noi ʻia nā ana CPK e nānā i ka infarction, no ka laʻana, ana ʻia ka CK MB me ka hoʻohui ʻia me nā māka puʻuwai ʻē aʻe, e like me myoglobin a me troponin.
A CK MB waiwai e like ai a i ʻole ʻoi aku ma mua o 5 ng / mL i manaʻo ʻia he maʻamau a kiʻekiʻe ka piʻina o ka nui inā loaʻa ka puʻuwai puʻuwai. Hoʻonui mau nā pae o CK MB i 3 mau hola ma hope o ka infarction, a hōʻea i kahi piko a 24 mau hola a hoʻi ka waiwai i ka maʻamau ma waena o 48 a 72 mau hola ma hope o ka infarction. ʻOiai i manaʻo ʻia he māka naʻau maikaʻi, e ana pū ʻia ke ana o CK MB no ka hōʻailona o infarction me troponin, no ka mea hoʻi nā waiwai o ka troponin i 10 mau lā ma hope o ka infarction, no laila, ʻoi aku ka kikoʻī. E ʻike i ke ʻano o ka hōʻike troponin.
He aha ke kiʻekiʻe a me ka haʻahaʻa CPK
Hoʻomaopopo ka hoʻonui ʻana i ka nui o ka proteine proteinophosphokinase:
| CPK kiʻekiʻe | CPK haʻahaʻa | |
| ʻO CPK BB | Infarction, stroke, lolo tumo, ka hopu ʻana, hū ʻole | -- |
| CPK MB | ʻO ka maʻi Cardiac, ka hōʻeha o ka umauma, haʻalulu uila, i ka hihia o ka defibrillation o ka naʻau, ke kīʻaha puʻuwai | -- |
| MM CPK | ʻO ka hōʻeha ʻeha, hoʻoikaika kino ikaika, immobilization lōʻihi, hoʻohana ʻana i nā lāʻau i pāpā ʻole ʻia, hoʻāhu i ke kino, mustrular dystrophy, ma hope o ka electromyography | Ka nalowale o ka nui o nā mākala, cachexia a me nā pono ʻole |
| TOTAL CPK | ʻO ka lawe nui ʻana i nā mea inu ʻona, ma muli o ka hoʻohana ʻana i nā lāʻau e like me amphotericin B, clofibrate, ethanol, carbenoxolone, halothane a me succinylcholine i lawelawe pū ʻia, ʻona me nā barbiturates | -- |
No ka hana ʻana i ka hana CPK, ʻaʻole koi ʻia ka hoʻokē ʻai, a ʻaʻole paha e koi ʻia e ke kauka, akā naʻe he mea nui e hōʻalo i ka hana ʻana i nā hoʻoikaika kino ikaika ma kahi o 2 mau lā ma mua o ka hana ʻana i ka hoʻokolokolo, no ka mea hiki ke hoʻokiʻekiʻe ʻia kēia enzyme ma hope o ka hoʻoikaika pono ʻana. i kāna hana e nā mākala, i ka hoʻohui ʻana i ke kau ʻana o nā lāʻau, e like me Amphotericin B a me Clofibrate, no ka laʻana, no ka mea hiki iā lākou ke hoʻopilikia i ka hopena hōʻike.
Inā noi ʻia ka hoʻokolohua no ke kumu o ke kuhi ʻana i ka puʻuwai puʻuwai, koi ʻia e loiloi ʻia ka pilina ma waena o CPK MB a me CPK me ka hoʻohana ʻana i kēia ʻano hana: 100% x (CK MB / CK huina). Inā ʻoi aku ka hopena o kēia pilina ma mua o 6%, he hōʻailona ia o nā ʻeha i ka puʻuwai puʻuwai, akā inā ʻoi aku ka liʻiliʻi ma mua o 6%, he hōʻailona ia o nā hōʻeha i ka ʻiwi iwi, a pono ke kauka e nānā i ke kumu.
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