ʻO Enbrel vs. Humira no ka Rheumatoid Arthritis: Hoʻohālikelike ʻaoʻao a ʻaoʻao

Anter

• Hōʻike Overview
• Nā kumuhana ma Enbrel a me Humira
• ʻO nā hiʻohiʻona lāʻau ma ka ʻaoʻao
• Ka mālama lāʻau
• Kālā, loaʻa, a me ka ʻinikua
• Nā hopena ʻaoʻao
• Nā launa lāʻau
• Hoʻohana me nā kūlana olakino ʻē aʻe
• E kamaʻilio me kāu kauka

Hōʻike Overview

Inā loaʻa iā ʻoe ka rheumatoid arthritis (RA), kamaʻāina loa ʻoe me ke ʻano o ka ʻeha a me ka ʻāʻī o ka ami i hiki ke hana i ke ala ʻana i waho o kahi moe i ke kakahiaka i kahi hakakā.

ʻO Enbrel lāua ʻo Humira nā lāʻau ʻelua i kōkua. E nānā i ka hana a kēia mau lāʻau a pehea lākou e kūʻē ai i kekahi.

Nā kumuhana ma Enbrel a me Humira

ʻO Enbrel lāua ʻo Humira nā lāʻau lapaʻau i hoʻohana ʻia e mālama ai iā RA.

ʻO kēia mau lāʻau ʻelua he tumzeris factor (TNF) alpha inhibitors. ʻO ka TNF alpha kahi protein i hana ʻia e kāu ʻōnaehana pale. Hāʻawi ia i ka mumū a me ka hōʻino pū.

Pākuʻi ʻo Enbrel lāua ʻo Humira i ka hana a ka TNF alpha e alakaʻi ai i ka hōʻino ʻana mai ka hoʻowahāwahā maʻamau.

ʻAʻole hōʻike nā alakaʻi i kēia manawa i nā mea kāohi TNF ma ke ʻano he laina mua no RA. Akā, paipai lākou i ka mālama ʻana me kahi DMARD (e like me methotrexate).

Ma waho o RA, mālama pū ʻo Enbrel lāua ʻo Humira:

• ʻōpio ʻōiwi idiopathic (JIA)
• arthritis psoriatic (PsA)
• spondylitis ankylosing
• pākuʻi psoriasis

Eia hou, mālama pū ʻo Humira:

• Maʻi ʻo Crohn
• ulcerative colitis (UC)
• hidradenitis suppurativa, kahi ʻano ʻili
• uveitis, pehu i ka maka

ʻO nā hiʻohiʻona lāʻau ma ka ʻaoʻao

Hana like ʻo Enbrel lāua ʻo Humira i ka hana like e mālama ai iā RA, a like ka nui o kā lāua hiʻohiʻona.

ʻAʻole hōʻike nā kuhikuhi i ka makemake no kekahi mea kāohi iā TNF ma luna o ka mea ʻē aʻe, ma muli o ka nele o nā hōʻike hōʻoiaʻiʻo e ʻoi aku ka maikaʻi o kekahi ma mua o kekahi.

Pōmaikaʻi kekahi poʻe i ka hoʻololi ʻana i kahi mea kāohi TNF ʻokoʻa inā ʻaʻole holo ka mea mua, akā makemake ka hapanui o ke kauka e hoʻololi i kahi lāʻau RA ʻokoʻa.

Hōʻike ka papa aʻe i nā hiʻohiʻona o kēia mau lāʻau ʻelua.

Hiki paha iā ʻoe ke ʻike he maʻalahi a maʻalahi hoʻi ka hoʻohana ʻana o nā peni prefilled ʻo Enbrel SureClick Autoinjector a me Humira ma mua o nā syringes i hoʻopihapiha ʻia. Koi lākou i nā ʻanuʻu liʻiliʻi.

E ʻike mau ka poʻe i kekahi mau pono o nā lāʻau āpau ma hope o 2 a 3 pika, akā ʻo ka hoʻāʻo kūpono o ka lāʻau ma kahi o 3 mau mahina e ʻike i ko lākou pono piha.

Pehea e pane ai kēlā me kēia kanaka i kēlā me kēia lāʻau.

Ka mālama lāʻau

Mālama ʻia ʻo Enbrel lāua ʻo Humira i ke ala like.

Pono e mālama ʻia nā mea ʻelua i ka carton kumu e pale ai i ka pōʻino o ke kino a i ʻole ke kino. ʻIke ʻia nā ʻōlelo aʻoaʻo ʻē aʻe ma lalo:

• E mālama i ka lāʻau i loko o ka pahu hau ma kahi mahana ma waena o 36 ° F a me 46 ° F (2 ° C a me 8 ° C).
• Inā hele, e mālama i ka lāʻau i ka mahana wela (68-77 ° F a i ʻole 20-25 ° C) a 14 mau lā.
  • Palekana i ka lāʻau mai ka mālam a me ka momona.
  • Ma hope o 14 mau lā i ka mahana wela, hoʻolei i ka lāʻau. Mai hoʻihoʻi i loko o ka pahu hau.
  • Mai hoʻopili i ka lāʻau a hoʻohana paha inā ua paʻahau a laila hoʻoheheʻe.

Kālā, loaʻa, a me ka ʻinikua

Loaʻa wale ʻo Enbrel lāua ʻo Humira ma ke ʻano he lāʻau laikini inoa, ʻaʻole he generics, a ua like ke kumu kūʻai o lāua.

Hiki i ka pūnaewele GoodRx ke hāʻawi iā ʻoe i kahi manaʻo kikoʻī e pili ana i kā lākou uku i kēia manawa.

Pono nā mea hoʻolako ʻinikua he ʻae ma mua o kāu kauka ma mua o ka uhi ʻana a uku no kekahi o kēia mau lāʻau. E hōʻoia me kāu ʻoihana inikua a i ʻole ka hale kūʻai lāʻau e ʻike inā pono ʻoe i kahi ʻae mua no Enbrel a i ʻole Humira.

Hiki i kāu lāʻau lapaʻau ke kōkua iā ʻoe me ka pepa inā pono ka ʻae.

Hāpai ka hapa nui o nā hale kūʻai i nā Enbrel a me Humira. Eia nō naʻe, he mea maikaʻi e kāhea i kāu kauka lāʻau i mua e hōʻoia i ka loaʻa ʻana o kāu lāʻau.

Loaʻa nā biosimilars no nā lāʻau ʻelua. Ke loaʻa a loaʻa, hiki i nā biosimilars ke kumu kūʻai aku ma mua o ka lāʻau inoa inoa inoa mua.

ʻO ka biosimilar o Enbrel ʻo Erelzi.

Ua ʻae ʻia ʻelua biosimilars o Humira, Amjevita lāua ʻo Cyltezo e ka U.S. Food and Drug Administration (FDA). Eia naʻe, ʻaʻole i loaʻa i kēia manawa no ke kūʻai ʻana ma ʻAmelika Hui Pū ʻIa.

Ua loaʻa ʻo Amjevita ma ʻEulopa i ka makahiki 2018, akā ʻaʻole ia e manaʻo ʻia e pā i nā mākeke ʻo U.S. a hiki i ka makahiki 2023.

Nā hopena ʻaoʻao

ʻO Enbrel lāua ʻo Humira no ka papa lāʻau like. ʻO ka hopena, loaʻa iā lākou nā hopena ʻaoʻao like.

ʻO kekahi o nā hopena ʻē aʻe e like me:

• hopena ma ka pūnaewele injection
• maʻi lele
• ʻeha poʻo
• hūwī

Hiki i nā hopena ʻē aʻe koʻikoʻi ke hoʻopili pū i:

• hoʻonui i ka makaʻu o ka maʻi ʻaʻai
• pilikia ʻōnaehana
• nā pilikia o ke koko
• hou a hōʻino ʻole paha ka puʻuwai
• psoriasis hou a ʻinoʻino paha
• hopena maʻi ʻaʻai
• nā hopena autoimmune
• nā maʻi kūpilikiʻi
• kaohi ʻana i ka ʻōnaehana pale pale

Ua ʻike kekahi o ka 177 poʻe i adalimumab, a i ʻole Humira, ʻoi aku ma mua o ʻekolu mau manawa o ka poʻe hoʻohana e hōʻike ai i ka puhi ʻana o ka pūnaewele injection a infing-site ma hope o ʻeono mau mahina o ka mālama ʻana.

Nā launa lāʻau

E hoʻomaopopo mau i kāu kauka e pili ana i nā lāʻau āpau, nā wikamina, a me nā mea kanu āu e lawe nei. Hiki i kēia ke kōkua i kāu kauka e pale aku i nā launa lāʻau hiki, hiki ke hoʻololi i ke ʻano o kāu hana lāʻau.

Hiki i nā pilina ke hōʻeha a pale paha i nā lāʻau mai ka hana maikaʻi.

Hana pū ʻo Enbrel lāua ʻo Humira me kekahi o nā lāʻau like. Ke hoʻohana nei iā Enbrel a i ʻole Humira me nā lāʻau āpau aʻe a me nā lāʻau e hoʻonui i kou makaʻi o ka maʻi.

• Nā lāʻau āpau e like me:
  • varicella a me varicella zoster (ka moa moa) nā lāʻau āpau
  • herpes zoster (shingles) lāʻau āpau
  • ʻO FluMist, kahi spray intranasal no ka maʻi flu
  • measles, mumps, and rubella (MMR) vaccine
  • nā lāʻau i hoʻohana ʻia e kāohi i kou ʻōnaehana pale pale e like me anakinra (Kineret) a i ʻole abatacept (Orencia)
• ʻO kekahi mau lāʻau lapaʻau maʻi ʻaʻai, e like me cyclophosphamide a me methotrexate
• ʻO kekahi lāʻau RA e like me sulfasalazine
• ʻO kekahi mau lāʻau e hoʻoponopono ʻia e kahi protein i kapa ʻia ʻo cytochrome p450, me:
  • Warfarin (Coumadin)
  • cyclosporine (Neoral, Sandimmune)
  • theophylline

Hoʻohana me nā kūlana olakino ʻē aʻe

Inā loaʻa ʻoe i ka maʻi virus hepatitis B, lawe iā Enbrel a i ʻole Humira hiki ke hoʻoulu i kāu maʻi. ʻO ia hoʻi hiki iā ʻoe ke hoʻomaka e ʻike i nā hōʻailona hepatitis B, e like me:

• luhi
• nele i ka makemake ʻole
• melemele o kou ʻili a i ʻole nā ​​keʻokeʻo o kou mau maka
• ʻeha ma ka ʻaoʻao ʻākau o kou ʻōpū

Hiki i ka maʻi hōʻino ke alakaʻi i ka make ʻole o ka ate a me ka make. E hoʻāʻo kāu kauka i kou koko e ʻike pono ʻaʻohe ou hepatitis B ma mua o kou loaʻa ʻana i kekahi o kēia mau lāʻau.

E kamaʻilio me kāu kauka

ʻO Enbrel lāua ʻo Humira nā lāʻau like loa. Kūpono like lākou i ka hoʻomaha ʻana i nā ʻōuli o RA.

Eia nō naʻe, aia kekahi mau ʻokoʻa iki, ʻo kekahi o ia mau mea e ʻoi aku kahi maʻalahi no kāu e hoʻohana ai.

ʻO kahi laʻana, hiki ke lawe ʻia ʻo Humira i kēlā me kēia pule ʻē aʻe a i ʻole kēlā me kēia pule, ʻoiai ʻo Enbrel hiki ke lawe ʻia i kēlā me kēia pule.ʻIke paha ʻoe makemake ʻoe i kekahi mea hoʻopili, e like me nā peni a me nā autoinjectors. E hoʻoholo paha kēlā makemake i nā lāʻau āu e koho ai.

ʻO ka ʻike iki ʻana e pili ana i kēia mau lāʻau ʻelua hiki ke kōkua iā ʻoe e kamaʻilio me kāu kauka e ʻike inā he koho paha kekahi o lākou iā ʻoe.