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ʻO nā maʻi Mitochondrial nā moʻokūʻauhau a me nā hoʻoilina hoʻoilina i hōʻike ʻia e ka hemahema a i ʻole hoʻemi ʻia ka hana o mitochondria, me ka lawa ʻole o ka ikehu i hana ʻia i ke keena, kahi e hopena ai i ka make ʻana o ka huna a, i ka wā lōʻihi, maikaʻi ʻole o nā meaola.

ʻO Mitochondria nā hale liʻiliʻi i kū i loko o nā pūnaewele i kuleana no ka hana ʻana ma mua o 90% o ka ikehu e pono ai no nā pūnaewele e hana i kā lākou hana. Hoʻohui ʻia, pili pū ka mitochondria i ke kaʻina hana o ka hana ʻana i ka hui heme o hemoglobins, i ka metabolism o ka cholesterol, neurotransmitters a me ka hana ʻana i nā radical manuahi. No laila, ʻo kekahi hoʻololi i ka hana o ka mitochondria hiki ke loaʻa i nā hopena olakino koʻikoʻi.

Nā hōʻailona nui

Hoʻololi nā ʻōuli o nā maʻi mitochondrial e like me ka hoʻololi ʻana, ka helu o nā mitochondria i hoʻopili ʻia i loko o kahi huna a me nā helu o nā hunaola i pili. Hoʻohui ʻia, hiki iā lākou ke loli ke kaukaʻi ʻia i kahi o nā hunaola a me mitochondria.


ʻO ka maʻamau, ʻo nā hōʻailona a me nā hōʻailona e hōʻike ana i ka maʻi mitochondrial ʻo:

  • ʻO ka nāwaliwali o ka mākala a me ka nalo ʻana o ka hoʻohui ʻana o nā mākala, ʻoiai nā mākala e pono ai ka ikaika nui;
  • Hoʻololi i ka ʻike a me ka hoʻohaʻahaʻa lolo.
  • Hoʻololi Gastrointestinal, ke loaʻa nā hoʻololi e pili ana i ka ʻōnaehana digestive;
  • Cardiac, ophthalmic, hakuʻala a me nā pilikia o ke ake.

Hiki ke ʻike ʻia nā maʻi Mitochondrial i kēlā me kēia manawa o ke ola, akā ʻo ka wikiwiki o ka hoʻololi ʻana, ʻoi aku ke koʻikoʻi o nā ʻōuli a ʻoi aku ke kiʻekiʻe o ka lethality.

Pehea e hana ʻia ai ke kuhi

He paʻakikī ka hōʻailona, ​​ʻoiai hōʻike nā hōʻailona o ka maʻi i nā kūlana ʻē aʻe. Hana pinepine ʻia ka mitochondrial diagnosis ke hōʻoia ʻole nā ​​hopena o nā hōʻike i noi pinepine ʻia.

ʻO ka hoʻomaopopo ʻana i ka maʻi mitochondrial e hana pinepine ʻia e nā kauka e loea ana i nā maʻi mitochondrial ma o nā hoʻokolohua a me nā molekole.


Nā kumu kūpono

ʻO nā maʻi Mitochondrial he moʻokūʻauhau, ʻo ia hoʻi, hōʻike ʻia lākou e like me ke alo a i ʻole ka ʻole o nā hoʻololi i ka DNA mitochondrial a e like me ka hopena o ka hoʻololi i loko o ka cell. He mau haneli mitochondria ko kēlā me kēia cell i loko o kāna cytoplasm, me kēlā me kēia me kāna pono pilikino.

Hiki ke ʻokoʻa ka mitochondria i loko o ka huna like i kēlā me kēia, e like me ka nui a me ke ʻano o ka DNA i ka mitochondria i ʻokoʻa mai kēlā me kēia hunaʻi i kahi huna. Hana ʻia ka maʻi Mitochondrial ke loaʻa i loko o ka cell hoʻokahi ka mitochondria nona ka waiwai a me kēia hopena maikaʻi ʻole i ka hana ʻana o ka mitochondria. No laila, ʻo ka mitochondria hemahema hou aʻe, hana ʻia ka liʻiliʻi o ka ikehu a ʻoi aku ka nui o ka make o ke kelepona, ka mea e hoʻopilikia ai i ka hana o ka meaola a ka hunaola.

Pehea e hana ai i ka lāʻau

Hoʻolālā ka mālama ʻana no ka maʻi mitochondrial e hoʻoikaika i ka pono o ke kanaka a hoʻolohi i ka holomua o ka maʻi, a me ka hoʻohana ʻana i nā wikamina, hydration a me ka papaʻai kaulike e ʻōlelo ʻia e ke kauka. Hoʻohui ʻia, aʻoaʻo ʻia e kūʻē i ka hana o nā hana hoʻoikaika kino ikaika i ʻole ai ka ikaika o ka ikehu e mālama i nā hana nui o ka meaola. No laila, he mea nui e mālama ke kanaka i ko lākou ikehu.


ʻOiai ʻaʻohe mālama pilikino no nā maʻi mitochondrial, hiki i ka hiki ke pale aku i ka hoʻomau mau ʻana o ka mitochondrial DNA mai ka hoʻoili ʻia i kēlā hanauna i kēia hanauna. E hana ʻia kēia ma ka hoʻohui ʻana i ka nucleus o ka pūnana hua manu, i kūlike i ka hua manu momona me ka sperm, me ka mitochondria olakino mai kekahi wahine ʻē aʻe, i kapa ʻia he mitochondria donor.

No laila, loaʻa i ka embryo nā ʻano moʻokūʻauhau o nā mākua a me ka mitochondrial o kekahi kanaka ʻē aʻe, a kapa ʻia ʻo "pēpē o ʻekolu mau mākua". ʻOiai ka maikaʻi e pili ana i ka kahamaha o ka hoʻoilina, pono e hoʻoponopono hou ʻia kēia ʻenehana a ʻae ʻia e nā komite loina.

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