Nā pilikia a me nā pilikia o Polycythemia Vera

Anter

• Nānā PV
• Nā pilikia
• Thrombosis
• Hoʻonui ākea a me ke ake
• Nā pae kiʻekiʻe o nā hunaola ʻulaʻula
• Myelofibrosis
• Leukemia
• Nā pilikia mai nā mālama ʻana

Hōʻike Overview

ʻO Polycythemia vera (PV) kahi ʻano mau a holomua o ka maʻi ʻaʻa koko. Hiki i ke kuhi mua ke kōkua i ka hoʻoliʻiliʻi o ka pilikia o ka hoʻoweliweli ola, e like me ke koko a me nā pilikia kahe.

Nānā PV

ʻO ka loaʻa ʻana o ka mutation JAK2 genetation, JAK2 V617F, ua kōkua i nā kauka e hōʻoia i ka poʻe me PV. Ma kahi o 95 pākēneka o ka poʻe i loaʻa iā PV kēia ʻano hoʻololi kūlohelohe.

Hāpai ka mutation JAK2 i nā hunaola ʻulaʻula e hoʻohua i kahi ʻano kipi ʻole. ʻO kēia ke kumu o ka momona o kou koko. Hoʻopili ke koko mānoanoa i kona kahe i kāu mau lālā a me nā ʻano. Hiki i kēia ke hoʻonele i ke kino o ka oxygen. Hiki iā ia ke kumu i ke kahe o ke koko.

Hiki i nā hoʻāʻo ʻana i ke koko ke hōʻike inā ʻaʻole maʻamau kāu mau hunaola a i ʻole inā kiʻekiʻe loa kāu helu helu koko. Hiki ke hoʻopili ʻia i ka helu o ke koko keʻokeʻo a me nā helu platelet e PV. Eia nō naʻe, ʻo ia ka helu o nā hunaola ʻulaʻula e hoʻoholo ai i ke kuhi. ʻO kahi hemoglobin ʻoi aku ma mua o 16.0 g / dL i nā wahine a ʻoi aku paha ma mua o 16.5 g / dL i nā kāne, a i ʻole he hematocrit i ʻoi aku ma mua o 48 pākēneka i nā wahine a ʻoi aku paha ma kahi o 49 pākēneka i nā kāne hiki ke hōʻike iā PV.

ʻO ke ʻike ʻana i nā ʻōuli he kumu paha e hoʻoholo ai a loaʻa kahi hōʻoia koko. Hiki i kēia mau ʻōuli ke komo pū me:

• ʻeha poʻo
• ʻūpā
• loli ka hihiʻo
• ʻūlū kino holoʻokoʻa
• Kaumaha emi
• luhi
• sweating nui loa

Inā manaʻo kāu kauka he PV kāu, e kuhikuhi lākou iā ʻoe i ka hematologist. E kōkua kēia loea i ke koko e hoʻoholo i kāu hoʻolālā lapaʻau. ʻO kēia maʻa mau o ka phlebotomy wā (ke kahakiʻi koko), me ka aspirin i kēlā me kēia lā a me nā lāʻau ʻē aʻe.

Nā pilikia

Hāʻawi ʻo PV iā ʻoe i ka makaʻu no nā ʻano pilikia like ʻole. Hiki i kēia mau mea ke:

Thrombosis

ʻO Thrombosis kekahi o nā mea hopohopo nui i PV. ʻO ka hoʻopili ʻia ʻana o ke koko i loko o kāu aʻa a i ʻole nā ​​uaua. ʻO ka nui o ke kōkō o ke koko e pili ana i kahi i hana ʻia ai ka ʻōpala. ʻO kahi lole i loko o kāu:

• hiki i ka lolo ke hana i ka maʻi hahau
• hopena ka puʻuwai i kahi puʻuwai puʻuwai a i ʻole ka hopena coronary
• ʻo ke akemāmā ka mea e hoʻoulu ai i ka pulmonary embolism
• ʻo nā veins hohonu kahi thrombosis hohonu (DVT) hohonu

Hoʻonui ākea a me ke ake

Aia kou palapū ma ka ʻaoʻao hema o kou ʻōpū. ʻO kekahi o kāna mau hana ka kānana ʻana i nā huna koko pau ʻole o ke kino. ʻO ka huhū a piha a piha paha i ʻelua mau hōʻailona o PV i hoʻoulu ʻia e kahi ākea hoʻonui.

E hoʻonui ʻia kou manamana ke hoʻāʻo ʻo ia e kānana i ka nui o nā hunaola o ke koko i hana ʻia e kou iwi iwi. Inā ʻaʻole hoʻi kāu lūlū i kona nui maʻamau me nā maʻamau maʻamau o PV, pono paha e hemo.

Aia kou akepa i ka ʻaoʻao ʻākau i luna o kou ʻōpū. E like me ka spleen, hiki ke hoʻonui ʻia i PV. Hiki i kēia ke hoʻololi i ke kahe o ke koko i ke ake a i ʻole ka hana keu a ke akepaʻa e hana ai i PV. Hiki i ke ake nui ke hōʻeha i ka ʻeha o ka ʻōpū a i ʻole ka wai keu e kūkulu i loko o ka

Nā pae kiʻekiʻe o nā hunaola ʻulaʻula

Hiki i ka hoʻonui ʻia ʻana o nā hunaola ʻulaʻula ke kumu i ka pehu o ka hui, me ka noʻonoʻo, nā poʻo poʻo, nā pilikia o ka hihi, a me ka helu a me ke kani ʻana i kou mau lima a me kou mau wāwae. E hōʻike ana kāu hematologist i nā ala e mālama ai i kēia mau ʻōuli.

Hiki i nā transfusions ke koko ke kōkua i ka mālama ʻana i nā hunaola ʻulaʻula i kahi pae ʻae ʻia. Ke holo ʻole kēia koho a kōkua ʻole paha nā lāʻau lapaʻau, e ʻōlelo paha kāu kauka i kahi transplant cell stem e mālama i ka maʻi.

Myelofibrosis

ʻO Myelofibrosis, i kapa ʻia ʻo ka "wā pau" o PV, e pili ana ma kahi o 15 pākēneka o ka poʻe i ʻike ʻia me ka PV. Hana ʻia kēia inā ʻaʻole hana hou kāu iwi iwi i nā hunaola e olakino a hana pono paha. Ma kahi o kou iwi iwi kuapo me ka maka maka. ʻAʻole pili wale ʻo Myelofibrosis i ka helu o nā hunaola ʻulaʻula, akā ʻo kou mau keʻokeʻo koko keʻokeʻo a me nā pā.

Leukemia

Hiki i ka PV lōʻihi ke alakaʻi i ka leukemia koʻikoʻi, a i ʻole ke kanesa o ke koko a me ka iwi iwi. ʻOi aku ka maʻamau o kēia pilikia ma mua o myelofibrosis, akā hoʻonui ʻia kona makaʻi me ka manawa. ʻO ka lōʻihi o ke kanaka he PV, ʻo ka kiʻekiʻe o ka makaʻu o ka hoʻomohala ʻana i ka leukemia.

Nā pilikia mai nā mālama ʻana

Hiki i ka lawelawe ʻana me ka PV ke hana i nā pilikia a me nā hopena ʻaoʻao.

Hoʻomaka paha ʻoe e luhi a luhi paha ma hope o ka phlebotomy, keu hoʻi inā loaʻa pinepine ʻoe i kēia kaʻina hana. E hōʻino ʻia paha kou mau uaua mai ka hana hou ʻana i kēia kaʻina hana.

I kekahi mau hihia, hiki i kahi regimen aspirin haʻahaʻa haʻahaʻa ke alakaʻi i ke kahe ʻana o ke kahe.

ʻO Hydroxyurea, kahi ʻano chemotherapy, hiki ke hoʻohaʻahaʻa i kou helu ʻulaʻula a me keʻokeʻo a me nā platelet. ʻO Hydroxyurea kahi lāʻau lapaʻau i waho o ka lepili no PV. ʻO kēia ka mea ʻaʻole i ʻae ʻia ka lāʻau no ka mālama ʻana iā PV, akā ua hōʻike ʻia he mea maikaʻi i nā poʻe he nui. ʻO nā hopena ʻē aʻe o ka mālama ʻana i ka hydroxyurea i ka PV hiki ke hoʻopili i ka ʻeha o ka ʻōpū, ka ʻeha o ka iwi, a me ka poni.

ʻO Ruxolitinib (Jakafi), ʻo ka FDA wale nō i ʻae ʻia ka lapaʻau ʻana no myelofibrosis a me PV, hiki iā ia ke kāohi i ka nui o kāu helu ʻana i ke koko. Hiki i nā hopena ʻē aʻe ke komo i ka pualu, ka maʻi poʻo, ka luhi, ka ʻeha o ka ʻū, ka ʻeha o ka ʻōpū, ka hanu paʻakikī, a.

Inā ʻoe e ʻike i nā hopena koʻikoʻi mai kekahi o kāu lapaʻau ʻana a i ʻole nā ​​lāʻau, e kamaʻilio me kāu hui kauka. Hiki iā ʻoe a me kāu hematologist ke loaʻa i nā koho lapaʻau e kūpono loa iā ʻoe.