Hōʻoiaʻiʻo BRCA Genetic Test

Anter

• He aha ka hoʻokolohua kūlohelohe BRCA?
• No ke aha ia e hoʻohana ai?
• No ke aha e pono ai iaʻu kahi hoʻokolohua kūlohelohe BRCA?
• He aha ka hana i ka wā o ka hoʻāʻo genetic BRCA?
• Pono wau e hana i kekahi mea e hoʻomākaukau ai no ka hoʻāʻo?
• Aia kekahi mau pilikia i ka hoʻāʻo?
• He aha ke ʻano o nā hopena?
• Aia paha kekahi mea ʻē aʻe e pono iaʻu e ʻike e pili ana i ka hoʻokolohua kūlohelohe BRCA?
• Nā kūmole

He aha ka hoʻokolohua kūlohelohe BRCA?

Nānā kahi hoʻāʻo genic BRCA no nā loli, ʻike ʻia ʻo mutation, i nā genes i kapa ʻia ʻo BRCA1 a me BRCA2. ʻO nā ʻāpana nā ʻāpana o ka DNA i hoʻoili ʻia mai kou makuahine a me kou makuakāne. Hāpai lākou i ka ʻike e hoʻoholo ai i kāu ʻano kū hoʻokahi, e like me ke kiʻekiʻe a me ke kala o ka maka. He kuleana pū kekahi ʻo Genes no kekahi ʻano olakino. ʻO BRCA1 a me BRCA2 nā ʻāpana e pale ai i nā hunaola e ka hana ʻana i nā protein e kōkua i ka pale ʻana i nā tumors mai ka hana ʻana.

Hiki i kahi hoʻololi i kahi moʻokūʻauhau BRCA1 a i ʻole BRCA2 ke hoʻopōʻino i ka cell i hiki ke alakaʻi ʻia i ka maʻi ʻaʻai. ʻOi aku ka nui o ka makaʻu o nā wahine me ka genc BRCA mutated o ka loaʻa ʻana o ka umauma a i ʻole ka maʻi ʻaʻai ovarian. ʻO nā kāne me kahi gen BRCA mutated i ka nui o ka makaʻu no ka loaʻa ʻana o ka umauma a i ʻole ka maʻi ʻaʻai prostate. ʻAʻole nā ​​kānaka i hoʻoilina i ka hoʻololi BRCA1 a i ʻole BRCA2 e loaʻa i ka maʻi ʻaʻai. ʻO nā kumu ʻē aʻe, e like me kou nohona a me kou ʻano, hiki ke hoʻopili i kāu maʻi ʻaʻai.

Inā ʻike ʻoe he hoʻololi BRCA kāu, hiki paha iā ʻoe ke hana i nā hana e pale ai i kou olakino.

Nā inoa ʻē aʻe: BRCA gene test, BRCA gene 1, BRCA gene 2, gene cancer susceptibility gene1, umauma maʻi palapū maʻi genes 2

No ke aha ia e hoʻohana ai?

Hoʻohana ʻia kēia hōʻike e ʻike inā loaʻa iā ʻoe kahi BRCA1 a i ʻole BRCA2 hoʻololi mutation. Hiki i kahi mutation gene BRCA ke hoʻonui i kou makaʻu i ka loaʻa ʻana i ka maʻi ʻaʻai.

No ke aha e pono ai iaʻu kahi hoʻokolohua kūlohelohe BRCA?

ʻAʻole hōʻike ʻia ka hoʻāʻo BRCA no ka hapa nui o ka poʻe. Kākaʻikahi ka hoʻololi ʻana o ka ʻenekia BRCA, e pili ana ma kahi o ka 0.2 pakeneka wale nō o ka U.S. Akā makemake paha ʻoe i kēia hoʻokolohua inā manaʻo ʻoe aia ʻoe i kahi makaʻu kiʻekiʻe loa i ka hoʻololi ʻana. Loaʻa paha iā ʻoe kahi hoʻololi BRCA inā ʻoe:

• Ua loaʻa a loaʻa paha iā ʻoe ka maʻi ʻaʻai umauma i ʻike ʻia ma mua o ka makahiki 50
• Loaʻa a i ʻole loaʻa i ka maʻi ʻaʻai umauma i nā umauma ʻelua
• Loaʻa a i ʻole loaʻa i ka umauma a me ka maʻi ʻaʻai ovarian
• Loaʻa i hoʻokahi a ʻoi aku paha nā lālā o ka ʻohana me ka maʻi ʻaʻai umauma
• Loaʻa kahi kāne pili i ka maʻi ʻaʻai
• Ua ʻike mua ʻia kahi hoahānau me kahi hoʻololi BRCA
• No Ashkenazi (Hikina ʻEulopa) kūpuna Iudaio. ʻOi aku ka maʻamau o nā hoʻololi BRCA i kēia hui ke hoʻohālikelike ʻia i ka heluna lehulehu. ʻOi aku ka maʻamau o nā hoʻololi BRCA i nā poʻe mai nā wahi ʻē aʻe o ʻEulopa, e like me, ʻIlia, Nolewai, a me Denmark.

He aha ka hana i ka wā o ka hoʻāʻo genetic BRCA?

E lawe kahi ʻoihana mālama ola i kahi laʻana koko mai kahi aa i kou lima, e hoʻohana ana i kahi nila kuʻikuʻi. Ma hope o ka hoʻokomo ʻia ʻana o ka nila, e hōʻiliʻili ʻia kahi koko liʻiliʻi i loko o kahi pahu hoʻāʻo a ipu paha. Hiki paha iā ʻoe ke ʻoni iki i ka wā e hele ai a kuʻi paha ka nila. Lōʻihi kēia ma mua o ʻelima mau minuke.

Pono wau e hana i kekahi mea e hoʻomākaukau ai no ka hoʻāʻo?

ʻAʻole pono ʻoe i kahi hoʻomākaukau kūikawā no ka hoʻāʻo BRCA. Akā makemake paha ʻoe e hui mua me ke kākāʻōlelo genetic e ʻike inā pono ka hōʻike iā ʻoe. E kamaʻilio pū paha kāu kākāʻōlelo me ʻoe e pili ana i nā pilikia a me nā pōmaikaʻi o ka hoʻāʻo genetic a me nā hopena ʻokoʻa e hiki ke manaʻo.

Pono ʻoe e noʻonoʻo e pili ana i ka loaʻa ʻana o ka ʻōlelo aʻo kūpuna ma hope o kāu hoʻāʻo. Hiki i kāu ʻōlelo aʻoaʻo ke kūkākūkā i ka hopena o kāu hopena iā ʻoe a me kou ʻohana, ma ka lāʻau olakino a me ka naʻau.

Aia kekahi mau pilikia i ka hoʻāʻo?

ʻAʻohe liʻiliʻi loa i ka hōʻoia ʻana o ke koko. Loaʻa paha iā ʻoe ka ʻeha a ʻeha paha ma kahi o ka nila i hoʻokomo ʻia ai, akā ʻo ka hapa nui o nā ʻōuli e hele wikiwiki aku.

He aha ke ʻano o nā hopena?

Hōʻike ʻia ka hapa nui o nā hopena he maikaʻi ʻole, maopopo ʻole, a maikaʻi paha, a ʻo ka manaʻo maʻamau ka mea aʻe:

• ʻO kahi hopena maikaʻi ʻole ʻo ia hoʻi ʻaʻohe BRCA hoʻololi mutation i loaʻa, akā ʻaʻole ia manaʻo ʻaʻole ʻoe e loaʻa i ka maʻi ʻaʻai.
• ʻO kahi hopena maopopo ʻole ʻo ia hoʻi kekahi ʻano BRCA gen mutation i loaʻa, akā pili a pili ʻole paha me ka hoʻonui ʻia o ka maʻi ʻaʻai. Pono paha ʻoe i nā hoʻokolohua hou a / a i ʻole ka nānā ʻana inā maopopo ʻole kāu hopena.
• ʻO kahi hopena maikaʻi mea i loaʻa i kahi hoʻololi i BRCA1 a i ʻole BRCA2 i loaʻa. Hoʻonohonoho kēia mau hoʻololi iā ʻoe i kahi makaʻu kiʻekiʻe loa o ka loaʻa ʻana i ka maʻi ʻaʻai. Akā ʻaʻole kēlā me kēia kanaka me ka mutation ka maʻi ʻaʻai.

He mau pule paha ka lōʻihi e loaʻa ai kāu mau hopena. Inā he mau nīnau kāu e pili ana i kāu mau hopena, e kamaʻilio me kāu kauka olakino a / a i ʻole i kou kākāʻōlelo kūlohelohe.

E aʻo hou aʻe e pili ana i nā hoʻokolohua hoʻokolohua, nā pae kuhikuhi, a me ka hoʻomaopopo ʻana i nā hopena.

Aia paha kekahi mea ʻē aʻe e pono iaʻu e ʻike e pili ana i ka hoʻokolohua kūlohelohe BRCA?

Inā hōʻike kāu hopena ua loaʻa iā ʻoe kahi hoʻololi hoʻololi BRCA, hiki iā ʻoe ke hana i nā ʻanuʻu e hoʻohaʻahaʻa ai i kou makaʻi o ka umauma maʻi ʻaʻai. Pākuʻi ʻia kēia mau mea:

• ʻO nā hoʻokolohua loiloi pinepine ʻana i ka maʻi ʻaʻai, e like me mammograms a me ultrasounds. ʻOi aku ka maʻalahi o ka mālama ʻana i ka maʻi ʻaʻai ke loaʻa i ka wā mua.
• Ka lawe ʻana i nā lāʻau kaohi hānau no kahi manawa palena. ʻO ka lawe ʻana i nā lāʻau kaohi hānau no ka palena ʻoi aku o ʻelima mau makahiki i hōʻike ʻia e hōʻemi i ka makaʻu o ka maʻi ʻaʻai ovarian i kekahi mau wahine me ka BRCA gen mutations. Lawe ʻia nā paila no ʻelima mau makahiki a ʻoi aku e hōʻemi i ka maʻi ʻaʻai ʻaʻole koi ʻia. Inā ʻoe e lawe i nā lāʻau hoʻomalu hānau ma mua o kou lawe ʻana i ka hōʻike BRCA, e haʻi i kāu mea mālama ola i kou mau makahiki i kou hoʻomaka ʻana e lawe i nā huaale a no ka lōʻihi. E paipai ʻo ia iā ʻoe inā ʻoe e hoʻomau i ka lawe ʻana iā lākou.
• Lawe i nā lāʻau hakakā kaua Ua hōʻike ʻia kekahi mau lāʻau, e like me hoʻokahi i kapa ʻia ʻo tamoxifen, e hōʻemi i ka pilikia o nā wahine me ka nui o ka maʻi ʻaʻai.
• Ke loaʻa ʻana i kahi ʻoki, i ʻike ʻia ma ke ʻano he mastectomy pale, e hoʻoneʻe i nā kiko o ka umauma olakino. Ua hōʻike ʻia ka mastectomy Preventive e hōʻemi i ka pilikia o ka maʻi ʻaʻai o ka umauma ma kahi o 90 pākēneka i nā wahine me ka BRCA gene mutation. Akā he hana nui kēia, koi wale ʻia no nā wahine i ka makaʻu nui loa no ka loaʻa ʻana i ka maʻi ʻaʻai.

Pono ʻoe e kamaʻilio me kāu mea mālama ola e ʻike i nā kaupae e pono ai nāu.

Nā kūmole

1. American Society of Clinical Oncology [Pūnaewele]. ʻAmelika Hui Pū ʻIa o Oncology Lapaʻau; 2005-2018. Hereditary Breast a me ka ʻOvarian Cancer; [i helu ʻia 2018 Mar 19]; [ma kahi o 3 pale]. Loaʻa mai: https://www.cancer.net/cancer-types/hereditary-breast-and-ovarian-cancer
2. ʻO Hinkle J, Cheever K. Brunner & Suddarth's Handbook of Laboratory and Diagnostic Tests. ʻO Ed Ed, Kindle. Piladelapia: Wolters Kluwer Health, Lippincott Williams & Wilkins; c2014. BRCA hōʻike; 108 p.
3. Nā Hoʻokolohua Lab ma ka Pūnaewele [Pūnaewele]. Wakinekona D.C .: ʻAmelika Hui Pū ʻIa no ka Chemical Clinical; c2001–2018. ʻO BRCA Gene Mutation Testing [hōʻano hou ʻia Jan Jan 15; i helu ʻia 2018 Pep 23]; [ma kahi o 2 pale]. Loaʻa mai: https://labtestsonline.org/tests/brca-gene-mutation-testing
4. Mayo Clinic [Pūnaewele]. Mayo Foundation no ka Hoʻomaʻamaʻa Lapaʻau a me ka noiʻi; c1998–2018. ʻO ka hoʻāʻo ʻana o BRCA no ka makaʻu umauma a me ka maʻi ʻaʻai ovarian; 2017 Dec 30 [helu ʻia 2018 Pep 23]; [ma kahi o 3 pale]. Loaʻa mai: https://www.mayoclinic.org/tests-procedures/brca-gene-test/about/pac-20384815
5. Kahi hoʻomanaʻo ʻo Sloan Kettering Cancer Center [Pūnaewele]. Nu Ioka: Hale Hoʻomanaʻo ʻo Sloan Kettering Cancer Center; c2018. BRCA1 a me BRCA2 Genes: Pilikia no ka umauma a me ka maʻi ʻaʻai ʻōpani [cited 2018 Feb 23]; [ma kahi o 5 pale]. Loaʻa mai: https://www.mskcc.org/cancer-care/risk-assessment-screening/hereditary-genetics/genetic-counseling/brca1-brca2-genes-risk-breast-ovarian
6. Ka Papa ʻInikena Kanaka Makahiki [Pūnaewele]. Bethesda (MD): Ke Keʻena ʻOihana Ola a me nā lawelawe kanaka; Hoʻololi ʻo BRCA: ʻIke Pilikino a me nā Hōʻaʻike Genetic [i ʻōlelo ʻia 2018 Feb 23]; [ma kahi o 3 pale]. Loaʻa mai: https://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet#q1
7. Ka Papa ʻInikena Kanaka Makahiki [Pūnaewele]. Bethesda (MD): Ke Keʻena ʻOihana Ola a me nā lawelawe kanaka; Ka Papa Kuhikuhi NCI o nā ʻōlelo maʻi ʻaʻai: hoʻololi [i helu ʻia 2018 Pep 23]; [ma kahi o 3 pale]. Loaʻa mai: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q;=mutation
8. National Heart, Lung, and Blood Institute [Pūnaewele]. Bethesda (MD): Ke Keʻena ʻOihana Ola a me nā lawelawe kanaka; Nā ho'āʻo koko (cited 2018 Feb 23]; [ma kahi o 3 pale]. Loaʻa mai: https://www.nhlbi.nih.gov/health-topics/blood-tests
9. NIH U.S. National Library of Medicine: Genetics Home Reference [Pūnaewele]. Bethesda (MD): Ke Keʻena ʻOihana Ola a me nā lawelawe kanaka; ʻĀpana BRCA1; 2018 Mar 13 [i helu ʻia 2018 Mar 18]; [ma kahi o 3 pale]. Loaʻa mai: https://ghr.nlm.nih.gov/gene/BRCA1#conditions
10. NIH U.S. National Library of Medicine: Genetics Home Reference [Pūnaewele]. Bethesda (MD): Ke Keʻena ʻOihana Ola a me nā lawelawe kanaka; ʻĀpana BRCA2; 2018 Mar 13 [i helu ʻia 2018 Mar 18]; [ma kahi o 3 pale]. Loaʻa mai: https://ghr.nlm.nih.gov/gene/BRCA2#conditions
11. NIH U.S. National Library of Medicine: Genetics Home Reference [Pūnaewele]. Bethesda (MD): Ke Keʻena ʻOihana Ola a me nā lawelawe kanaka; He aha ka ʻāpana ?; 2018 Feb 20 [helu ʻia 2018 Pep 23]; [ma kahi o 3 pale]. Loaʻa mai: https://ghr.nlm.nih.gov/primer/basics/gene
12. Kulanui o Rochester Medical Center [Pūnaewele]. Rochester (NY): Kulanui o Rochester Medical Center; c2018. Encyclopedia Health: BRCA [helu ʻia 2018 Pep 23]; [ma kahi o 2 pale]. Loaʻa mai: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid;=brca
13. UW Ola [Pūnaewele]. Madison (WI): Ke Kulanui o Wisconsin Nā Haukapila a me nā Mana Haukino; c2018. Breast Cancer (BRCA) Gene Test: Pehea e hoʻomākaukau ai [hōʻano hou 2017 Jun 8; i helu ʻia 2018 Pep 23]; [ma kahi o 5 pale]. Loaʻa mai: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html#tu6465
14. UW Ola [Pūnaewele]. Madison (WI): Ke Kulanui o Wisconsin Nā Haukapila a me nā Mana Haukino; c2018. Hōʻikeʻike Gene (BRCA) Gene Test: Nā hopena [hoʻohou ʻia 2017 Jun 8; i helu ʻia 2018 Pep 23]; [ma kahi o 9 pale]. Loaʻa mai: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html#tu6469
15. UW Ola [Pūnaewele]. Madison (WI): Ke Kulanui o Wisconsin Nā Haukapila a me nā Mana Haukino; c2018. Breast Cancer (BRCA) Gene Test: Nānā Nānā Hōʻike [hoʻohou ʻia 2017 Jun 8; i helu ʻia 2018 Pep 23]; [ma kahi o 2 pale]. Loaʻa mai: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html
16. UW Ola [Pūnaewele]. Madison (WI): Ke Kulanui o Wisconsin Nā Haukapila a me nā Mana Haukino; c2018. Breast Cancer (BRCA) Gene Test: No ke aha e hana ʻia ai [hoʻohou ʻia 2017 Jun 8; i helu ʻia 2018 Pep 23]; [ma kahi o 4 pale]. Loaʻa mai: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html#tu646

ʻAʻole pono e hoʻohana i ka ʻike ma kēia pūnaewele i pani no ka mālama olakino ʻoihana a ʻōlelo aʻoaʻo paha. Kāhea aku i ka mea mālama ola inā he nīnau kāu e pili ana i kou olakino.