Nā Biologics no AS: He aha kāu koho?

Anter

• He aha nā biologics no AS?
• 1. ʻO nā mea pale Tumros nekrosis factor (TNF)
• 2. Nā mea hoʻopukapuka Interleukin 17 (IL – 17)
• Pehea e hāʻawi ʻia ai nā biologics no AS?
• ʻO ke kumukūʻai o nā biologics no AS
• Nā hopena ʻaoʻao o nā biologics no AS
• Pehea e ʻike ai i ka biologic therapy kūpono no AS
• Lawe aku

ʻO Ankylosing spondylitis (AS) kahi maʻi maʻi autoimmune mau e hoʻopili nui i nā hono o ke kuamoʻo, akā ʻo nā hono nui, e like me nā pūhaka a me nā poʻohiwi, hiki ke pili pū kekahi.

ʻO ka hoʻowahāwahā, nā hopena o ka hana o ka ʻōnaehana pale, ke kumu o ka fusing ami ʻana i nā ʻāpana o ka iwi kuamoo, kahi e alakaʻi pinepine ai i ka ʻeha, ka pehu ʻana, a me ka ʻoʻoleʻa.

Hiki i kēia ke kaupalena i ka neʻe, paʻakikī i ka hoʻopau ʻana i nā hana o kēlā me kēia lā.

ʻAʻohe lāʻau lapaʻau no kēia maʻi, akā hiki i nā ʻano lāʻau lapaʻau like ʻole ke hoʻolohi i ka holomua a kōkua iā ʻoe e ola i kahi ola hana. E hoʻomohala kāu kauka olakino i kahi hoʻolālā lapaʻau ma hope o kāu ʻike ʻana.

Ma muli o ke ʻano o nā hōʻailona o AS mai ke akahai a i ʻole ke koʻikoʻi, hiki i kekahi poʻe ke hoʻokele i kā lākou mau hōʻailona me nā lāʻau anti-inflammatory nonsteroidal (NSAIDs), e like me ibuprofen (Motrin, Advil) a me naproxen sodium (Aleve).

Inā ʻaʻole pane kāu mau ʻōuli i kēlā mau lāʻau, ʻo nā lāʻau lapaʻau ka lālani pale hou.

Hoʻohui ʻia nā lāʻau i hoʻohana ʻia no AS me nā maʻi e hoʻololi nei i nā lāʻau anti-rheumatic (DMARDs) e hoʻoliʻiliʻi i nā hana immune immune.

ʻOiai ʻaʻole hiki iā lākou ke hoʻokau i ke kumu kikoʻī o ia, ua hoʻolālā ʻia nā NSAID a me nā DMARD ʻelua e hōʻoki i ka hoʻowahāwahā.

I kekahi manawa ʻaʻole e pane ka ʻeha a me ka ʻoʻoleʻa AS i kēia mau lāʻau i kuhikuhi ʻia. I mea e kōkua ai iā ʻoe e hoʻokele i nā ʻōuli, e ʻāpono paha kāu kauka i kahi ʻano lōkō like ʻole i kapa ʻia he biologics.

He aha nā biologics no AS?

Hoʻokumu ʻia nā biologics i nā protein i hana ʻia i nā genetically i hana ʻia mai nā meaola ola e hoʻohālike i nā hana olaola maʻamau.

Hoʻonohonoho ʻia lākou i nā hoʻoponopono i kuhikuhi ʻia i nā protein ponoʻī i loko o ka ʻōnaehana pale pale e hoʻoulu ai i ka momona, ʻo ia hoʻi:

• ʻiʻo tumo mikrosis (TNF)
• interleukin 17 (IL-17)

Ua ʻae ka Food and Drug Administration (FDA) i ka biologic mua ma 1988 e mālama i ka rheumatoid arthritis. Mai ia manawa, ua hoʻomohala ʻia kekahi mau biologics ʻē aʻe.

I kēia manawa, ʻehiku mau ʻano biologics i ʻae ʻia no ka mālama ʻana iā AS. Pākuʻi ʻia kēia mau mea:

1. ʻO nā mea pale Tumros nekrosis factor (TNF)

• adalimumab (Humira)
• certolizumab pegol (Cimzia)
• etanercept (Enbrel)
• golimumab (Simponi, Simponi Aria)
• infliximab (Remicade)

2. Nā mea hoʻopukapuka Interleukin 17 (IL – 17)

• secukinumab (Cosentyx)
• ixekizumab (Taltz)

Pehea e hāʻawi ʻia ai nā biologics no AS?

Pono e hāʻawi i nā biologics i loko o nā mea ma lalo o ka ʻili a i ʻole i loko o ka mākala. ʻAʻole lākou i loaʻa i ka pila a i ʻole ke ʻano waha. Loaʻa iā lākou iā lākou ma o nā injection a infusions paha.

ʻO ke alapine o nā injection a i ʻole nā ​​infusions e pono ai e loli ma muli o ka biologic therapy.

Hiki paha iā ʻoe ke infusion i kēlā me kēia mahina. A i ʻole, koi paha ʻoe i nā injection he nui a laila kaomi ʻana i loko o ka makahiki.

ʻO kahi laʻana, koi ka Simponi biologic i ʻekolu mau inikua hoʻomaka:

• ʻelua injection i ka lā mua o ka mālama ʻana
• hoʻokahi injection 2 mau pule ma hope

Ma hope, hāʻawi ʻoe iā ʻoe iho i hoʻokahi injection i kēlā me kēia 4 pule.

Ma ka ʻaoʻao ʻē aʻe, inā ʻoe e lawe iā Humira, hāʻawi ʻoe iā ʻoe iho i hoʻokahi injection i kēlā me kēia pule ʻē aʻe ma hope o ʻehā mau doma hoʻomaka.

E haʻi aku kāu kauka iā ʻoe i ka manawa hea ʻoe e pono ai i ka biologic therapy, a hāʻawi lākou iā ʻoe i nā ʻōkuhi pehea e lawelawe ai i kāu inikua.

ʻAʻole hoʻomaikaʻi nā Biologics i nā ʻōuli o AS ma ka pō wale nō, akā pono ʻoe e hoʻomaka e ʻike maikaʻi ma kahi o 4 a 12 mau pule, i kekahi manawa ma mua koke.

ʻO ka pahuhopu o ka mālama ʻana e kaohi i kāu mau ʻōuli i ʻole e hoʻopilikia ke ʻano i kou ola. He mea nui e hoʻomaopopo ʻaʻole e hōʻola nā biologics iā AS.

ʻO ke kumukūʻai o nā biologics no AS

Kūleʻa pinepine ka Biologics, akā pipiʻi nui lākou i United States. Ma ka awelika, ke kumu kūʻai o nā biologics a i kekahi manawa ʻoi aku ka nui no nā mea ʻoi loa ke kumukūʻai.

E uhi paha ka ʻinikua i kekahi ʻāpana o nā kumukūʻai, akā e hilinaʻi ia i kāu uhi ʻana.

E kamaʻilio me kāu kauka e pili ana i nā koho no biosimilars (ʻano like me nā biologics) a me nā papahana kōkua hoʻomanawanui ma o nā mea hana lāʻau.

Nā hopena ʻaoʻao o nā biologics no AS

Aia ka makaʻu o nā hopena a i ʻole nā ​​hopena maʻi me nā ʻano o nā lāʻau, a ʻaʻohe ʻokoʻa nā biologics.

Hiki i nā hopena ʻaoʻao o ka biologic therapy ke hoʻopili pū me:

• ʻeha, ʻulaʻula, ʻāwīwī, a palapū paha i ka pūnaewele injection
• ʻeha poʻo
• hives a wīwī paha
• ʻeha ka ʻōpū
• ʻeha kua
• nausea
• ʻeha a ʻeha ʻeha paha
• ke kunu a i ʻole ke anuanu
• paʻakikī i ka hanu ʻana
• haʻahaʻa haʻahaʻa haʻahaʻa

Māmā mau kēia mau hopena a e maʻa mau a hele i hope.

Eia nō naʻe, pono ʻoe e kāhea i kāu kauka inā loaʻa nā ʻōuli e like me ka hives, ka pehu ʻana, a i ʻole ka hanu paʻakikī. He hōʻailona paha kēia o ka hopena maʻi ʻaʻano.

Ma muli o ke kāohi ʻana o nā biologics i kāu ʻōnaehana pale, hiki iā lākou ke hoʻonui i kou makaʻu no nā maʻi a me ka maʻi ʻaʻai.

Hiki i kāu kauka ke kauoha i nā hoʻokolohua lab ma mua o kāu injection mua a infusion paha e nānā no:

• maʻi puʻu
• hepatitis B a me C
• nā maʻi ʻē aʻe

E ʻike i kāu kauka inā hoʻomohala ʻoe i nā hōʻailona o ka maʻi ma hope o ka hoʻomaka ʻana o ka lāʻau ʻana, e like me:

• fiva
• haʻalulu
• pokole o ka hanu
• ʻūhā

Eia kekahi, e hoʻomaopopo i kāu kauka inā ʻaʻole ʻoe i wehewehe.

• ʻāpala
• Kaumaha emi
• luhi laha ʻole

Hiki i nā biologics ke hoʻonui i ka makaʻu o ka hoʻomohala ʻana i nā maʻi ʻaʻa koko e like me lymphoma.

Pehea e ʻike ai i ka biologic therapy kūpono no AS

ʻOiai nā biologics āpau no AS i manaʻo e hoʻolohi i ka holomua o ka maʻi a hoʻōki i ka mumū, ʻaʻole hana like nā biologics no kēlā me kēia.

Inā ʻoe e hoʻomaka i ka lāʻau biologic, hiki i kāu kauka ke hoʻomaka iā ʻoe me hoʻokahi ʻano a nānā i kāu kūlana ma nā mahina 3 e hiki mai nei e ʻike inā he hoʻomaikaʻi hou aʻe.

Mai hoʻonāwaliwali inā ʻaʻole e hōʻemi kāu mau hōʻailona ma hope o kāu infusions mua a i ʻole nā ​​injection. Inā ʻaʻole hoʻomaikaʻi kāu AS, e ʻōlelo paha kāu kauka e hoʻololi i kahi biologic ʻē aʻe i ʻae ʻia no AS.

ʻAʻole wale ka biologic therapy wale nō ke koho.

ʻAʻole pono ʻoe e lawe i hoʻokahi biologic ma mua o ka hopena o ka maʻi, akā hiki iā ʻoe ke lawe i nā biologics me nā lāʻau ʻē aʻe no AS. ʻO ka loaʻa ʻana o ke kōkua mai AS kekahi manawa i ka hihia o ka hoʻokolokolo a me ka hewa.

E hoʻomanawanui. Lōʻihi paha ka manawa e ʻike i ka hui kūpono o nā lāʻau.

ʻO kahi laʻana, ʻoiai ʻaʻole i hoʻomaikaʻi kāu mau ʻōuli i ka lawe ʻana i nā NSAID a i ʻole nā ​​DMARD, e hoʻohui pono paha i kahi biologic me kēia mau lāʻau.

Lawe aku

Me ka ʻole o ka mālama pono ʻana, hiki i ka AS ke hele a holomua a hoʻonui i ka ʻeha, ʻoʻoleʻa, a me ka palena o ka neʻe ʻana.

E kamaʻilio me kāu kauka inā manaʻo ʻoe ʻaʻole e holo kāu lāʻau i kēia manawa. He moho paha ʻoe no nā meaolaola.

Akā ma mua o ka hoʻomaka ʻana i ka lāʻau biologic (e like me nā lapaʻau), e ʻike pono ʻike ʻoe i kāu koho a nīnau i nā nīnau.