Mea Kākau: Roger Morrison
Lā O Ka Hana: 17 Kepakemapa 2021
HōʻAno Hou I Ka Lā: 1 Iulai 2024
Anonim
What You Need to Know About Aubagio®
Wikiō: What You Need to Know About Aubagio®

Anter

He aha ka Aubagio?

ʻO Aubagio kahi lāʻau lapaʻau inoa inoa inoa inoa inoa inoa. Hoʻohana ʻia ia e mālama i nā ʻano relapsing o nā sclerosis (MS) he nui i nā mākua. He maʻi ʻo MS kahi e hoʻouka ai kāu ʻōnaehana pale maʻi i kāu ʻōnaehana pūnana.

Aia i loko o Aubagio ka lāʻau teriflunomide, kahi mea hoʻopuka synthetic pyrimidine. Kōkua nā lāʻau i loko o kēia papa i ka pale ʻana i nā hunaola pale mai ka hoʻonui ʻana i ka wikiwiki. Kōkua kēia hana i ka hoʻohaʻahaʻa ʻana i ka pehu.

Hele mai ʻo Aubagio ma ke ʻano he papa āu e moni ai. Loaʻa ka lāʻau i loko o ʻelua mau ikaika: 7 mg a me 14 mg.

Hoʻohālikelike ʻia ʻo Aubagio i kahi placebo (ʻaʻohe lapaʻau) i ʻehā mau hoʻokolohua hoʻokolohua. ʻO ka poʻe i lawe iā Aubagio iā:

  • emi iki nā hoʻi (ahi-i)
  • ka lohi o ka holomua o ke kīnā (ʻaʻole i ʻoi aku ka ʻino o ko lākou kino kīnā)
  • kahi hoʻoweliweli haʻahaʻa no nā liona hou (nāʻiʻo scar) i ka lolo

No ka ʻike kikoʻī mai kēia mau aʻo ʻana, e ʻike i ka ʻāpana ʻo “Aubagio e hoʻohana”.

Aubagio generic

Loaʻa ʻo ʻAubagio i kēia manawa ma ke ʻano he lāʻau lapaʻau inoa wale nō.


Aia i loko o Aubagio ka teriflunomide e pono ai. I ka 2018, ua ʻae ka Food and Drug Administration (FDA) i kahi mana generic o teriflunomide, akā ʻaʻole naʻe loaʻa.

Nā hopena ʻaoʻao Aubagio

Hiki i ka Aubagio ke hana i nā hopena ʻoluʻolu a koʻikoʻi paha. Loaʻa i ka papa inoa aʻe kekahi o nā hopena ʻē aʻe i hiki ke hana ʻia ke lawe iā Aubagio. ʻAʻole pili kēia papa inoa i nā hopena ʻē aʻe āpau.

No ka ʻike hou aku e pili ana i nā hopena ʻē aʻe o Aubagio, e kamaʻilio me kāu kauka a kauka paha. Hiki iā lākou ke hāʻawi iā ʻoe i nā ʻōlelo aʻoaʻo e pili ana i ka hana me nā hopena ʻaoʻao pōpilikia.

Nā hopena ʻaoʻao hou aʻe

Hiki i nā hopena ʻaoʻao maʻamau o Aubagio ke hoʻopili pū me:

  • ʻeha poʻo
  • alopecia (lauoho lahilahi a lauoho lauoho)
  • hoʻemi i nā pae phosphate
  • hoʻemi i nā pae o nā hunaola keokeo
  • nausea
  • pāhoehoe
  • hoʻonui i nā pae o nā akepona akepau (hiki i hōʻailona o ka hōʻino o ke ake)
  • hoʻonui i ke kahe o ke koko
  • numbness a i ʻole ke kani ʻana i kou mau lima a me kou mau wāwae
  • ʻeha pū

E hala paha ka hapa nui o kēia mau hopena i loko o kekahi mau lā a i ʻole ʻelua mau pule. Inā ʻoi aku ke koʻikoʻi a i ʻole hele aku, e kamaʻilio me kāu kauka a kauka paha.


Nā hopena hopena koʻikoʻi

Kāhea koke i kāu kauka inā loaʻa nā hopena koʻikoʻi. Kāhea iā 911 inā manaʻo kou mau hōʻailona i ka hoʻoweliweli ola a i ʻole inā manaʻo ʻoe e loaʻa ana kahi pilikia olakino.

Hiki i nā hopena ʻē aʻe a me kā lākou mau hōʻailona ke hoʻohui i kēia:

  • Nā hopena āpau. Hiki i nā ʻōuli ke hoʻohui pū:
    • pehu i kou alo a i ʻole nā ​​lima
    • ʻalalā a i nā hives
    • ka pehu ʻana a i ʻole ke kani ʻana i kou waha a i ʻole ka puʻu
    • paʻa paʻa o ka umauma
    • pilikia hanu
  • Poino ke akepaa, me ke kō ʻole o ke ake. Hiki i nā ʻōuli o nā pilikia o ke ake ke komo pū:
    • nausea
    • ka luaʻi
    • ʻeha ma kou ʻōpū
    • nalo ʻai ʻole
    • luhi
    • mimi ʻeleʻele
    • melemele o kou ʻili a i ʻole nā ​​keʻokeʻo o kou mau maka
  • Nā pae haʻahaʻa o nā hunaola keokeo. Hiki i nā ʻōuli ke hoʻohui pū:
    • fiva
    • luhi
    • ʻeha ke kino
    • haʻalulu
    • nausea
    • ka luaʻi
  • Nā hopena ʻili koʻikoʻi. Hiki i nā ʻōuli ke hoʻohui pū:
    • Stevens-Johnson syndrome (ʻehaʻeha ma kou waha, ʻāʻī, maka, a i ʻole nā ​​genital)
    • ʻehaʻeha ʻole a hoʻokahe koko paha
    • pehu
    • ʻili a ʻili paha
    • ʻeha i kou waha, maka, ihu, a ʻāʻī paha
  • Piʻi koko kiʻekiʻe. Hiki i nā ʻōuli ke hoʻohui pū:
    • ʻeha poʻo
    • luhi a huikau paha
    • loli ka hihiʻo
    • kuʻi naʻau kaulike ʻole
  • Nā pilikia hanu, e like me ka maʻi lele ma waena. Hiki i nā ʻōuli ke hoʻohui pū:
    • pokole o ka hanu
    • ka puʻu ʻana me ka ʻole o ke kuni

Nā kikoʻī hopena ʻaoʻao

E noʻonoʻo paha ʻoe i ka pinepine o kekahi mau hopena i hopena ʻia me kēia lāʻau, a i ʻole pili kekahi mau ʻaoʻao iā ia. Eia kekahi mau kikoʻī e pili ana i kekahi o nā hopena i hiki ʻole ai i kēia lāʻau.


Ka hopena hoʻowali

E like me ka nui o nā lāʻau, hiki i kekahi poʻe ke loaʻa i kahi hopena maʻi ma hope o ka lawe ʻana iā Aubagio. Hiki i nā ʻōuli o ke ʻano ʻāpiki mālie ke hoʻopili pū i:

  • ʻāwīwī o ka ʻili
  • ʻumeʻume

Kākaʻikahi ka hopena maʻi ʻino ʻoi aku ka paʻakikī akā hiki. Hiki i nā ʻōuli o ke ʻano ʻāpiki koʻikoʻi ke komo pū me:

  • angioedema (hāhā ma lalo o kou ʻili, maʻamau i kou mau lihilihi, nā lehelehe, nā lima, a me nā wāwae)
  • pehu o kou alelo, waha, a ʻāʻī paha
  • pilikia hanu
  • ʻili ʻulaʻula a ʻili paha

Kāhea koke i kāu kauka inā loaʻa iā ʻoe kahi maʻi maʻi ʻino iā ʻAubagio. Kāhea iā 911 inā manaʻo kou mau hōʻailona i ka hoʻoweliweli ola a i ʻole inā manaʻo ʻoe e loaʻa ana kahi pilikia olakino.

Nā pilikia o ka ʻili / ʻehu

Hiki iā Aubagio ke hana i nā hopena o ka ʻili koʻikoʻi. Hoʻopili kēia i ka maʻi ʻo Stevens-Johnson, kahi maʻi olakino. Mālama ia i nā ʻeha ʻeha ma kou waha, ʻāʻī, maka, a i ʻole nā ​​genital.

Ua hōʻike ʻia hoʻokahi kanaka nāna i lawe iā Aubagio i hoʻomohala i ka lāʻau hemermisis epidermal (TEN), he mea make ia. ʻO TEN ka maʻi maʻi ʻo Stevens-Johnson e pili ana ma mua o 30% o kou kino. Hoʻomaka ia ma ke ʻano he ʻehaʻeha me nā ʻōuli e like me ka flu, a laila hoʻomohala nā palapū.

Inā ʻili kouʻili a i ʻulaʻula, pehu, a hū paha, e haʻi koke i kāu kauka. Inā loaʻa iā ʻoe ʻo Stevens-Johnson Syndrome a TEN paha, pono ʻoe e hōʻeha ʻia i ka haukapila.

Poino ke ake

I nā hoʻokolohua hoʻokolohua, ma kahi o 6% o ka poʻe i lawe iā Aubagio i hoʻonui i ka nui o nā ʻenema ate. Ma kahi o 4% o ka poʻe i loaʻa kahi placebo (ʻaʻohe lapaʻau) i hoʻonui i nā pae enzyme ate.

Hiki i ka Aubagio ke hoʻonui i nā pae o nā ʻenema ate, a lilo ia i hōʻailona no nā pilikia nui o ke ake. E haʻi i kāu kauka inā loaʻa iā ʻoe kekahi o kēia mau ʻōuli.

  • nausea
  • ka luaʻi
  • ʻeha ma kou ʻōpū
  • nalo ʻai ʻole
  • luhi
  • mimi ʻeleʻele
  • melemele o kou ʻili a i ʻole nā ​​keʻokeʻo o kou mau maka

Ma mua o kou hoʻomaka ʻana e lawe iā ʻAubagio, e hāʻawi ke kauka iā ʻoe i kahi hōʻoia koko e nānā i kāu hana ate. Hāʻawi pū lākou iā ʻoe i nā hoʻokolohua ma kēlā me kēia mahina ʻoiai ʻoe e lawe iā Aubagio e ʻike i ke ʻano o ka hana o kou ake.

Lilo ka lauoho

ʻO kekahi o nā hopena maʻa mau o Aubagio ka alopecia (lauoho lauoho a i ʻole ka lauoho lauoho).

I nā hoʻokolohua hoʻokolohua, ma kahi o 13% o ka poʻe i lawe iā Aubagio he alopecia. ʻO ka hapa nui o ka poʻe i loaʻa nā ʻōuli o ka alopecia i loko o ʻekolu mau mahina o ka lawe ʻana i ka lāʻau. Ua emi ʻo Alopecia ma mua o ʻeono mau mahina ma ka awelika. He manawa pōkole kēia hopena, a hoʻomaikaʻi ka hapa nui o nā hihia i ka hoʻomau ʻana o ka poʻe iā Aubagio.

Inā lawe ʻoe iā Aubagio a hopohopo e pili ana i ka nalo ʻana o ka lauoho, e kamaʻilio me kāu kauka.

Pohā

ʻO ka diarrhea kahi hopena ʻaoʻao maʻamau o Aubagio.

I nā hoʻokolohua hoʻokolohua, ma kahi o 14% o ka poʻe i lawe iā ʻAubagio i ka maʻi pākī. Hoʻohālikelike ʻia kēia me 8% o ka poʻe i loaʻa kahi placebo (ʻaʻohe lapaʻau). ʻO ka hapa nui o nā maʻi diarrhea he akahai a haʻahaʻa a hele aku i kā lākou iho.

No ka mālama ʻana i ka maʻi diarrhea mehana, inu i ka wai a i ʻole nā ​​haʻina electrolyte e kōkua i kou kino e pani i nā wai i nalowale. Inā kū lōʻihi kou ʻōpū, e kāhea i kāu kauka. Hiki iā lākou ke ʻōlelo i nā ala e hōʻoluʻolu ai i kāu mau ʻōuli.

PML (ʻaʻole kahi hopena)

ʻO ka leukoencephalopathy multifocal holomua (PML) ʻaʻole ia he hopena ʻaoʻao o Aubagio. ʻO PLM kahi maʻi e hōʻeha i kāu ʻōnaehana waena.

I kahi hōʻike hihia, ua hoʻomohala kekahi kanaka i ka PML ma hope o ka hoʻololi ʻana iā Aubagio mai natalizumab, kahi lāʻau i hoʻohana ʻia e mālama ai i nā sclerosis he nui (MS). ʻO ka lāʻau natalizumab kahi ʻōlelo hoʻolaha mai ka Food and Drug Administration (FDA) e pili ana i ka hoʻonui ʻana i ka makaʻu o ka hoʻomohala PML. ʻO kahi ʻōlelo aʻoaʻo i pahu ʻia ka ʻōlelo aʻoaʻo koʻikoʻi loa mai ka FDA. Hoʻomaopopo ia i nā kauka a me nā mea maʻi e pili ana i nā hopena lāʻau e weliweli paha.

He mea hiki ʻole paha iā Aubagio ke kumu i ke kanaka e hoʻomohala iā PML. He mea hiki i ka natalizumab ke kumu o ia.

Inā ʻoe e hoʻololi iā Aubagio ma hope o ka lawe ʻana i natalizumab, e nānā ke kauka iā ʻoe no PML.

Ka luhi (ʻaʻole kahi hopena)

ʻO ka luhi (nele i ka ikaika) ʻaʻole ia he hopena ʻaoʻao maʻamau o Aubagio. Eia nō naʻe, ʻo ka luhi ka hōʻailona maʻamau o nā sclerosis (MS) he nui. ʻO ka luhi paha kahi hōʻailona o ka hōʻino o ke ake.

Inā ʻoe e hopohopo e pili ana i ka luhi ke lawe nei iā Aubagio, e kamaʻilio me kāu kauka. Hiki iā lākou ke nānā i nā kumu kūpono a hōʻike i nā ala e hoʻonui ai i kou ikehu.

Ka hōʻemi kaumaha a i ʻole loaʻa waiwai (ʻaʻole kahi hopena)

ʻAʻole ka hopena o ke kaupaona a me ke kaupaona ʻana i nā hopena maikaʻi o Aubagio i nā noiʻi maʻi. ʻAʻole paha ʻoe e lilo a loaʻa ke kaupaona ke lawe iā Aubagio.

Eia nō naʻe, ʻo kekahi o nā ʻōuli maʻamau o ka sclerosis (MS) he luhi (ka nele o ka ikaika). Ke haʻahaʻa kou pae ikehu, ʻaʻole paha ʻoe e eleu. Hiki i kēia ke alakaʻi iā ʻoe e loaʻa ka kaumaha. Inā loaʻa iā ʻoe ke kaumaha, hiki paha iā ʻoe ke ʻai i nā mea nui a liʻiliʻi paha, i hiki ai i ke kaupaona ʻana a me ka pohō kaumaha.

Inā hopohopo ʻoe e pili ana i nā loli i kou kaupaona, e kamaʻilio me kāu kauka. Hiki iā lākou ke ʻōlelo i nā ʻōlelo aʻoaʻo kōkua maikaʻi a ʻōlelo paha i kahi kaukaʻai e kōkua e ʻike pono i ka loaʻa ʻana o ka meaʻai kūpono.

Kanesa (ʻaʻole kahi hopena)

ʻO ka lawe ʻana i nā lāʻau e hoʻopili i kāu ʻōnaehana pale, e like me Aubagio, hiki ke hoʻonui i kou makaʻi no ka maʻi ʻaʻai. Eia naʻe, ʻaʻole hōʻike nā hoʻokolohua hoʻokolohua no Aubagio i ka piʻi ʻana o ka nui o ka poʻe i ulu i ka maʻi ʻaʻai.

Inā ʻoe hopohopo e pili ana i ka hoʻomohala ʻana i ka maʻi ʻaʻai, e kamaʻilio me kāu kauka.

Kaumaha (ʻaʻole kahi hopena)

ʻAʻole ka hopena kaumaha o Aubagio. Eia nō naʻe, ʻo ke kaumaha kahi hōʻailona maʻamau o MS.

Inā loaʻa iā ʻoe nā ʻōuli o ke kaumaha, e hoʻomaopopo i kāu kauka. Loaʻa nā lāʻau lapaʻau antidepressant i hiki ke kōkua i ka hōʻoluʻolu i kāu mau ʻōuli.

Kumukūʻai Aubagio

E like me nā lāʻau āpau, hiki ke hoʻololi ke kumukūʻai o Aubagio.

ʻO ke kumukūʻai maoli āu e uku ai e pili ana i kāu ʻinikua uhi, kou wahi, a me ka hale kūʻai lāʻau lapaʻau āu e hoʻohana ai.

Kōkua kālā

Inā makemake ʻoe i kākoʻo kālā e uku no Aubagio, loaʻa ke kōkua. Hāʻawi ʻo Genzyme Corporation, ka mea hana a Aubagio, i ka Polokalamu Aubagio Co-Pay. No ka ʻike hou aku a e ʻike inā he kūpono ʻoe no ke kākoʻo, kāhea iā 855-676-6326 a i ʻole kipa i ka pūnaewele pūnaewele.

Hoʻohana ʻo Aubagio

Ua ʻae ka Food and Drug Administration (FDA) i nā lāʻau i kuhikuhi ʻia e like me Aubagio e mālama i kekahi mau ʻano.

Aubagio no MS

Ua ʻae ʻia ʻo Aubagio e mālama i nā mākua me nā ʻano hou o nā sclerosis (MS). ʻO MS kahi maʻi maʻi lōʻihi (lōʻihi) e hoʻouka i kāu ʻōnaehana pale maʻi e hoʻouka i ka myelin (ka papa waho) ma nā aʻalolo i kou mau maka, lolo, a me ka iwi kuamoo. Hana kēia i nāʻiʻo makaʻu, kahi mea paʻakikī i kou lolo e hoʻouna i nā hōʻailona i nā ʻāpana ʻē aʻe o kou kino.

I kahi hoʻokolohua hoʻokolohua, ʻoi aku ka nui o ka poʻe i loaʻa iā MS relapses (flare-up) i lawe iā Aubagio a i kahi placebo (ʻaʻohe lapaʻau). I ka hui Aubagio, 57% o lākou i noho hou me ka hoʻohana ʻole ʻana i ka lāʻau. Ua hoʻohālikelike ʻia kēia i 46% o ka hui placebo. ʻO ka poʻe i lawe iā Aubagio he 31% ka liʻiliʻi o ka hoʻi hou ʻana ma mua o ka poʻe i lawe i kahi placebo.

Ua hōʻike ʻia ka hoʻokolohua hoʻokolohua like, ke hoʻohālikelike ʻia me ka hui placebo, ʻo ka poʻe i lawe iā Aubagio:

  • hoʻokahi wale nō hoʻi hou i kēlā me kēia ʻeono mau makahiki ʻoiai e lawe ana i ka lāʻau
  • ka lohi o ka holomua o ke kīnā (ʻaʻole i ʻoi aku ka ʻino o ko lākou kino kīnā)
  • ʻoi aku ka liʻiliʻi o nā liona hou (kaʻiʻo maka) i ka lolo

Ua nānā kekahi mau noiʻi ʻē aʻe i ka maikaʻi o Aubagio:

  • I hoʻokahi hoʻokolohua hoʻokolohua, ma kahi o 72% o ka poʻe i lawe iā Aubagio e noho manuahi ana i ka wā o ke aʻo ʻana. Ua hoʻohālikelike ʻia kēia i 62% o ka poʻe i lawe i kahi placebo.
  • Nānā ʻelua mau noiʻi hoʻokolohua i ka poʻe me MS i hoʻi hou. I hoʻokahi noiʻi, ʻo ka poʻe i lawe iā Aubagio he 31% ka liʻiliʻi o ka hoʻi hou ʻana ma mua o ka poʻe i lawe i kahi placebo. I ke aʻo ʻē aʻe, he 36% kēlā helu.
  • I nā hoʻokolohua hoʻokolohua, ma ka liʻiliʻi 80% o ka poʻe i lawe iā Aubagio ʻaʻohe holomua i ko lākou kīnā ʻole. ʻO kēia ka manaʻo ʻaʻole i hōʻino koke ko lākou kino kīnā. No ka hapa nui o kēia mau poʻe, ua lōʻihi kēia hopena i nā makahiki 7.5.

I loko o kahi noiʻi hoʻokolohua ʻē aʻe, lawe nā kānaka iā Aubagio i nā koina 14-mg a i ʻole 7-mg. Ua ʻike nā mea noiʻi ua hoʻohālikelike ʻia i ka poʻe i lawe i kahi placebo:

  • 80% o ka poʻe i ka hui 14-mg i loaʻa i nā liona hou
  • 57% o ka poʻe i ka hui mahele lāʻau 7-mg i loaʻa nā liona hou

ʻAubagio a me ka waiʻona

ʻAʻohe pilina i ʻike ʻia ma waena o Aubagio a me ka waiʻona. Eia nō naʻe, ʻo ka inu ʻona ʻana ʻoiai e lawe ana iā Aubagio e hoʻonui paha i kou makaʻi no kekahi mau hopena ʻaoʻao, e like me:

  • nausea
  • pāhoehoe
  • ʻeha poʻo

ʻO ka inu nui ʻana i ka waiʻona i ka wā e lawe ana iā Aubagio e hoʻonui paha i kou makaʻi no ka hōʻino o ke ake.

Inā lawe ʻoe iā Aubagio, e kamaʻilio me kāu kauka e pili ana inā palekana ka inu ʻana i ka ʻalekohola.

Nā pilina ʻo Aubagio

Hiki iā Aubagio ke launa pū me nā lāʻau ʻē aʻe. Hiki iā ia ke launa pū me kekahi mau mea hoʻopihapiha a me nā meaʻai.

Hiki i nā launa like ʻole ke kumu i nā hopena like ʻole. ʻO kahi laʻana, hiki i kekahi mau pilina ke hoʻopilikia me ka maikaʻi o ka hana ʻana o ka lāʻau. Hiki i nā pilina ʻē aʻe ke hoʻonui i ka helu o nā hopena a i ʻole e hoʻonui i ke koʻikoʻi.

Aubagio a me nā lāʻau ʻē aʻe

Ma lalo ka papa inoa o nā lāʻau i hiki ke launa pū me Aubagio. ʻAʻohe i loko o kēia papa inoa nā lāʻau i hiki ke launa pū me Aubagio.

Ma mua o ka lawe ʻana iā Aubagio, e kamaʻilio me kāu kauka a me kāu kauka lāʻau. E haʻi iā lākou e pili ana i nā kuhikuhi āpau, nā mea kūʻai aku, a me nā lāʻau ʻē aʻe āu e lawe ai. E haʻi pū iā lākou e pili ana i nā wikamina, nā mea kanu, a me nā mea hoʻopiha āu e hoʻohana ai. Hiki ke kōkua i ka hāʻawi ʻana i kēia ʻike iā ʻoe e hōʻalo i nā launa ʻole.

Inā he mau nīnau kāu e pili ana i nā launa lāʻau e hoʻopili iā ʻoe, e nīnau i kāu kauka a kauka paha.

ʻAubagio a me ka lāʻau kō

He palekana ke kiʻi ʻana i kahi pū palahū ʻoiai ʻoe e lawe iā Aubagio. ʻAʻohe hana ka lāʻau lapaʻau flu, ʻo ia hoʻi ua hana ʻia ia mai kahi germ i pepehi ʻia.

ʻO kahi lāʻau ola, ma ka ʻaoʻao ʻē aʻe, kahi i loaʻa kahi ʻano nāwaliwali o kahi germ. Inā loaʻa iā ʻoe kahi ʻōnaehana pale nāwaliwali, aʻoaʻo pinepine ʻia ʻoe e pili ana i ka loaʻa ʻole o nā lāʻau ola. ʻO kēia no ka mea ma nā manawa liʻiliʻi loa, hiki i nā lāʻau āpau ke hoʻololi i ka germ ikaika piha i kumu i kahi maʻi. Inā kū kēia, ʻoi aku ka nui o ka makaʻu o nā poʻe me nā ʻōnaehana pale nawaliwali no ka hoʻomohala ʻana i ka maʻi e pale ʻia ai ka lāʻau lapaʻau.

Inā lawe ʻoe iā Aubagio, ʻaʻole pono ʻoe e loaʻa nā lāʻau ola. E hoʻonāwaliwali paha ʻo Aubagio i kāu ʻōnaehana pale, no laila ke kiʻi ʻana i kahi lāʻau lapaʻau ola e hoʻokau iā ʻoe i ka makaʻu no ka maʻi e pale ai ka lāʻau iā ʻoe mai.

Inā he mau nīnau kāu e pili ana i ka loaʻa ʻana o nā lāʻau āpau i ka lawe ʻana iā Aubagio, e kamaʻilio me kāu kauka.

ʻAubagio a me leflunomide

ʻO Arava (leflunomide) kahi lāʻau i hoʻohana ʻia e mālama ai i ka rheumatoid arthritis (RA). ʻO ka lawe ʻana iā Aubagio me ka leflunomide e hoʻonui paha i ka nui o Aubagio i kou kino. Hiki i kēia ke hōʻeha i kou ake. Mai lawe pū iā Aubagio a me leflunomide.

Inā lawe ʻoe iā Arava a pono e lawe iā Aubagio, e kamaʻilio me kāu kauka. Hōʻike paha lākou i kahi lāʻau RA ʻokoʻa.

ʻAubagio a me warfarin

Lawe ʻo Aubagio me warfarin i mea e hōʻemi ai ka warfarin (ʻaʻole maikaʻi e hana ʻia i kou kino). A ʻo kahi hopena, ʻoi aku paha ke kō ʻana o kou koko.

Inā lawe ʻoe i warfarin, e kamaʻilio me kāu kauka. E hoʻāʻo lākou i kou koko ma mua a i ka wā o kāu mālama ʻana me ʻAubagio.

Aubagio a me nā immunosuppressants

ʻO kekahi mau lāʻau, e like me nā lāʻau ʻaʻai, hiki ke hoʻonāwaliwali i kāu ʻōnaehana pale. Kapa ʻia lākou he mau pale pale maʻi. E hoʻonāwaliwali paha ʻo Aubagio i kāu ʻōnaehana pale. Inā ʻoe e inu i kahi lāʻau ʻaʻai me ʻAubagio, ʻaʻole lawa paha ka ikaika o kāu ʻōnaehana pale pale i nā mikamina. Hiki i kēia ke hoʻonui i kou makaʻi no nā maʻi.

ʻO nā laʻana o kēia mau lāʻau:

  • bendamustine (Bendeka, Treanda, Belrapzo)
  • cladribine (Mavenclad)
  • erlotinib (Tarceva)

Inā ʻoe e lawe i kahi lāʻau kanesa a i ʻole lāʻau ʻē aʻe e kāohi i kou ʻōnaehana pale maʻi, e kamaʻilio me kāu kauka. E noʻonoʻo paha lākou e hoʻololi i kāu hoʻolālā lapaʻau.

Aubagio a me nā mea pale i ka waha

ʻO nā kauka waha (nā lāʻau kaohi hānau) he lāʻau lapaʻau e kōkua i ka pale ʻana i ka hāpai keiki. ʻO ka lawe ʻana iā Aubagio me kekahi mau lāʻau kaohi hānau e hoʻonui ai i kou mau kino i nā pae i loko o nā kaola kaohi hānau. Hiki i kēia ke kumu i kahi kaulike ʻole i kāu pae hormonone.

ʻO nā laʻana o kēia mau lāʻau:

  • ethinyl estradiol
  • levonorgestrel (Plan B One-Step, Mirena, Skyla)
  • ethinyl estradiol / levonogestrel (Lutera, Vienva)

Inā ʻoe e inu i nā lāʻau kaohi hānau, e kamaʻilio me kāu kauka. Hiki iā lākou ke paipai i kahi ʻano e hana ʻole e like me ka ikaika me Aubagio.

Aubagio a me nā lāʻau hoʻohaʻahaʻa kolesterol

ʻO ka lawe ʻana iā Aubagio me kekahi mau lāʻau hoʻohaʻahaʻa kolesterol e hoʻonui ai i nā pae o kēia mau lāʻau i kou kino. Hiki i kēia ke hoʻonui i nā hopena ʻē aʻe mai ka lāʻau kolesterol.

ʻO nā laʻana o kēia mau lāʻau:

  • atorvastatin (Lipitor)
  • pravastatin (Pravachol)
  • simvastatin (Zocor, FloLipid)
  • rosuvastatin

Inā ʻoe e lawe i kahi lāʻau e hoʻohaʻahaʻa ai i kāu kolamu, e kamaʻilio me kāu kauka. E nānā paha lākou i kāu lāʻau o kēlā me kēia lāʻau a hōʻoia i ka palekana o lākou e lawe pū.

ʻAubagio a me nā lāʻau ʻē aʻe

Hiki iā Aubagio ke launa pū me nā lāʻau like ʻole. A hiki i kekahi o kēia mau lāʻau ke hoʻololi i ka hana a Aubagio. ʻO kēia no ka mea metabolises kou kino (haki) Aubagio a me nā lāʻau ʻē aʻe he nui i kahi ala like. Ke wāwahi pū ʻia nā lāʻau, hiki i kekahi manawa ke launa pū kekahi me kekahi.

Hiki iā Aubagio ke hana i kou kino e wāwahi i kekahi mau lāʻau i ka wikiwiki a lohi paha.Hiki i kēia ke hoʻonui a hōʻemi paha i nā pae o kēlā mau lāʻau i kou kino. Inā hoʻonui ia i nā pae, hiki iā ia ke hāpai i kāu makaʻi i nā hopena ʻaoʻao. Inā hoʻemi ia i nā pae, ʻaʻole e holo pū paha ka lāʻau.

ʻO nā laʻana o kēia mau lāʻau:

  • amodiaquine
  • asunaprevir
  • ʻO Bacillus Calmette-Guerin (BCG)
  • elagolix (Orilissa)
  • grazoprevir
  • natalizumab (Tysabri)
  • pazopanib (Votrient)
  • pimecrolimus (Elidel)
  • Kahaia (Yupelri)
  • kālailai topical
  • topotecan (Hycamtin)
  • voxilaprevir

Inā lawe ʻoe i kekahi o kēia mau lāʻau, e kamaʻilio me kāu kauka. E nānā lākou i nā pae o kēia mau lāʻau i kou kino ʻoiai ʻoe e lawe iā Aubagio.

ʻUbaglelo Aubagio

ʻO ka lāʻau Aubagio i kuhikuhi ʻia e kāu kauka e pili ana i nā kumu he nui. Pākuʻi ʻia kēia mau mea:

  • ke ʻano a me ke koʻikoʻi o ke ʻano āu e lawe nei iā Aubagio
  • kou mau makahiki
  • ke ʻano o ʻAubagio āu e lawe nei
  • nā kūlana olakino ʻē aʻe āu

ʻO ka maʻamau, e hoʻomaka kāu kauka iā ʻoe ma kahi lāʻau haʻahaʻa. A laila e hoʻoponopono lākou iā ia ma ka manawa e hiki i ke ana i kūpono iā ʻoe. Na lākou e kuhikuhi i ka mea liʻiliʻi loa e hāʻawi i ka hopena i makemake ʻia.

Hōʻike ka ʻikepili aʻe i nā lāʻau i hoʻohana pinepine ʻia a koi ʻia paha. Eia nō naʻe, e mālama pono i nā lāʻau a ke kauka i kuhikuhi ai nāu. E hoʻoholo kāu kauka i ke ana ʻoi loa e kūpono i kāu mau pono.

Nā ʻano lāʻau a me nā ikaika

Hele mai ʻo Aubagio ma ke ʻano he papa āu e moni ai. Loaʻa ia i nā ikaika ʻelua: 7 mg a me 14 mg.

Nā hana no ka hoʻi hou ʻana i nā ʻano MS

E hoʻomaka paha kāu kauka iā ʻoe ma 7 mg, hoʻokahi manawa i ka lā. Inā ʻaʻole holo pono kēia mahele lāʻau hoʻomaka iā ʻoe, hoʻonui paha lākou i nā kaha i 14 mg, hoʻokahi manawa i ka lā.

He aha inā e haʻo wau i kahi lāʻau?

Inā haʻalele ʻoe i kahi lāʻau, lawe i kāu lāʻau i hala i kou wā e hoʻomanaʻo ai. Inā kokoke ʻoe i ka manawa no kāu kaukona aʻe, lele i ka lāʻau i hala a hoʻi i kāu manawa maʻamau. Mai lawe i ʻelua mau lāʻau i ka manawa like a i ʻole nā ​​kaukana keu.

Pono wau e hoʻohana i kēia lāʻau lōʻihi?

Hoʻohana ʻia ʻo Aubagio ma ke ʻano he lapaʻau lōʻihi no ka hoʻi hou ʻana i nā ʻano sclerosis he nui. Inā ʻoe a me kāu kauka e hoʻoholo i ka palekana a me ka maikaʻi o Aubagio iā ʻoe, e lawe paha ʻoe i kahi wā lōʻihi. E mālama pono i ka lāʻau e like me ka ʻōlelo a kāu kauka iā ʻoe.

Nā koho ʻē aʻe iā Aubagio

Loaʻa nā lāʻau ʻē aʻe i hiki ke mālama i nā ʻano relapsing o nā sclerosis (MS) he nui. Kūpono paha kekahi iā ʻoe ma mua o nā poʻe ʻē aʻe. Inā makemake ʻoe i ka ʻimi ʻana i kahi ʻē aʻe iā Aubagio, e kamaʻilio me kāu kauka e aʻo hou e pili ana i nā lāʻau ʻē aʻe e holo pono paha iā ʻoe.

ʻO nā laʻana o nā lāʻau ʻē aʻe i hiki ke hoʻohana ʻia e mālama i nā ʻano relapsing o MS me:

  • beta interferons (Rebif, Avonex)
  • ocrelizumab (Ocrevus)
  • dimethyl fumarate (Tecfidera)
  • glatiramer acetate (Copaxone)
  • fingolimod (Gilenya)
  • natalizumab (Tysabri)
  • alemtuzumab (Lemtrada)
  • mitoxantrone

Aubagio vs. Tecfidera

Mahalo paha ʻoe pehea e hoʻohālikelike ai ʻo Aubagio i nā lāʻau ʻē aʻe i kuhikuhi ʻia no nā hoʻohana like. Maanei mākou e nānā ai i ke ʻano like a like ʻole hoʻi o Aubagio a me Tecfidera.

Nā Pono

Aia i loko o Aubagio ka teriflunomide e pono ai. No ka papa pyrimidine synthesis mea hōʻoki papa papa lāʻau.

Loaʻa iā Tecfidera kahi mea hana ʻokoʻa, dimethyl fumarate. Pili ia i ka papa lāʻau lapaʻau hoʻoliʻiliʻi maʻi.

Hoʻohana

Ua ʻae ka Food and Drug Administration (FDA) iā Aubagio lāua ʻo Tecfidera e mālama i nā ʻano relapsing o nā sclerosis (MS) ʻelua.

Nā ʻano lāʻau a me ka hoʻoponopono ʻana

Hele mai ʻo Aubagio ma ke ʻano he papa. Lawe ʻoe ma ka waha (ʻai ʻoe iā ia) hoʻokahi manawa i ka lā.

Hele mai ʻo Tecfidera ma ke ʻano he capsule. Lawe ʻoe ma ka waha (ʻānai ʻoe) i ʻelua mau manawa i ka lā.

Nā hopena a me nā pilikia

Hana ʻo Aubagio lāua ʻo Tecfidera i nā ʻano ʻano like ʻole akā loaʻa kekahi mau hopena ʻaoʻao like. ʻO nā hiʻohiʻona o nā hopena āpau a koʻikoʻi hoʻi no kēlā me kēia lāʻau i helu ʻia ma lalo.

Nā hopena ʻaoʻao hou aʻe

Aia i loko o kēia mau papa inoa nā laʻana o nā hopena ʻē aʻe i hiki ke hana ʻia me Aubagio, me Tecfidera, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me ʻAubagio:
    • alopecia (lauoho lahilahi a lauoho lauoho)
    • hoʻonui i nā pae o nā akepona akepau (hiki i hōʻailona o ka hōʻino o ke ake)
    • ʻeha poʻo
    • hoʻemi i nā pae phosphate
    • numbness a i ʻole ke kani ʻana i kou mau lima a me kou mau wāwae
    • ʻeha pū
  • Hiki ke hana me Tecfidera:
    • flushing (hoʻomehana a ʻulaʻula i kou ʻili)
    • ʻāwīwī o ka ʻili
    • ʻeha ma kou ʻōpū
  • Hiki ke hana me nā Aubagio a me Tecfidera:
    • nausea
    • pāhoehoe

Nā hopena hopena koʻikoʻi

Loaʻa i kēia mau papa inoa nā laʻana o nā hopena ʻino e hiki ke hana ʻia me Aubagio, me Tecfidera, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me ʻAubagio:
    • nā hopena ʻili koʻikoʻi ʻē aʻe, e like me ka maʻi maʻi ʻo Stevens-Johnson (ʻehaʻeha ma kou waha, ʻāʻī, maka, a me nā genital)
    • hoʻonui i ke kahe o ke koko
  • Hiki ke hana me Tecfidera:
    • ka leukoencephalopathy multifocal holomua (PML), kahi maʻi viral o ka ʻōnaehana waena
  • Hiki ke hana me nā Aubagio a me Tecfidera:
    • hōʻino ka ate
    • hoka ʻole o ke ake
    • haʻahaʻa pae o ke keʻokeʻo keena
    • hopena hopena maʻi ʻino

Ka hoʻokō ʻana

Multiple sclerosis (MS) ʻo ia wale nō ke kūlana e hoʻohana ʻia ai ʻo Aubagio a me Tecfidera e mālama ai.

Hoʻohālikelike kahi noiʻi hoʻokolohua i ka maikaʻi o Aubagio a me Tecfidera i ka mālama ʻana iā MS. Nānā nā kānaka noiʻi i ka nānā ʻana o ka magnetic resonance imaging (MRI) i ka poʻe i lawe i nā lāʻau ʻelua. No ka poʻe i lawe iā Aubagio, 30% he mau liona hou a i ʻole ʻoi aku ka nui. Ua hoʻohālikelike ʻia kēia i 40% o ka poʻe i lawe iā Tecfidera.

Ua like ka maikaʻi o nā lāʻau ʻelua. Eia nō naʻe, ke nānā nei i ka hopena o nā lāʻau i ka lolo ma ka hopena, ʻoi aku ka maikaʻi o nā hopena a Aubagio ma mua o Tecfidera.

ʻLelo ia, no ka mea he 50 wale nō ka poʻe i loko o ke aʻo ʻana, pono hou ʻia kahi noiʻi e hana i kahi hoʻohālikelike kūlike i waena o nā lāʻau ʻelua.

Nā kumukūʻai

ʻO Aubagio lāua ʻo Tecfidera nā lāʻau lapaʻau inoa ʻelua. ʻAʻohe o lākou ʻano generic. ʻOi aku ke kumu kūʻai o nā lāʻau lapaʻau inoa inoa ma mua o nā generics.

Wahi a nā koho ma GoodRx.com, ʻoi aku ke kumukūʻai ʻo Tecfidera ma mua o Aubagio. ʻO ke kumukūʻai maoli āu e uku ai no nā lāʻau ʻelua e pili ana i kāu hoʻolālā ʻinikua, kou wahi, a me ka lāʻau kūʻai āu e hoʻohana ai.

Aubagio vs. Gilenya

Ma waho o Tecfidera (ma luna), hoʻohana pū ʻia ʻo Gilenya e mālama i nā sclerosis he nui. Maanei mākou e nānā ai i ke ʻano like a like ʻole hoʻi o Aubagio a me Gilenya.

Hoʻohana

Ua ʻae ka Food and Drug Administration (FDA) iā Aubagio lāua ʻo Gilenya e mālama i nā mākua me nā ʻano relapsing o nā sclerosis (MS) ʻelua. Akā ua ʻae ʻia ʻo Gilenya e mālama iā MS i nā keiki ma mua o 10 mau makahiki.

Aia i loko o Aubagio ka teriflunomide e pono ai. Loaʻa iā Gilenya kahi mea hana ʻokoʻa, fingolimod hydrochloride. ʻAʻole kēia mau lāʻau i ka papa lāʻau like, no laila hana lākou i nā ʻano like ʻole e mālama ai iā MS.

Nā ʻano lāʻau a me ka hoʻoponopono ʻana

Hele mai ʻo Aubagio ma ke ʻano he papa āu e moni ai. Lawe ʻoe i ka lāʻau i hoʻokahi manawa i ka lā. Hele mai ʻo Gilenya ma ke ʻano he capsule āu e ale ai. Lawe ʻoe i ka lāʻau i hoʻokahi manawa i ka lā.

Nā hopena a me nā pilikia

Hana ʻo Aubagio lāua ʻo Gilenya i nā ʻano ʻano like ʻole akā loaʻa nā hopena ʻaoʻao like. ʻO nā hiʻohiʻona o nā hopena āpau a koʻikoʻi hoʻi no kēlā me kēia lāʻau i helu ʻia ma lalo.

Nā hopena ʻaoʻao hou aʻe

Aia i loko o kēia mau papa inoa nā laʻana o nā hopena ʻē aʻe i hiki ke hana ʻia me Aubagio, me Gilenya, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me ʻAubagio:
    • alopecia (lauoho lahilahi a lauoho lauoho)
    • nausea
    • numbness a i ʻole ke kani ʻana i kou mau lima a me kou mau wāwae
    • ʻeha pū
    • hoʻemi i nā pae phosphate
  • Hiki iā Gilenya:
    • ʻeha ma kou ʻōpū
    • flu
    • ʻeha kua
    • ʻūhā
  • Hiki ke hana me nā Aubagio a me Gilenya:
    • pāhoehoe
    • hoʻonui i nā pae o nā enzymes ate (hiki i hōʻailona o ka hōʻino o ke ake)
    • ʻeha poʻo

Nā hopena hopena koʻikoʻi

Loaʻa i loko o kēia mau papa inoa nā laʻana o nā hopena ʻino e hiki ke hana ʻia me Aubagio, me Gilenya, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me ʻAubagio:
    • nā hopena ʻili koʻikoʻi, e like me ka maʻi maʻi ʻo Stevens-Johnson (ʻeha ʻeha ma kou waha, ʻāʻī, maka, a me nā genital)
    • hānau kīnā ʻole
    • haʻahaʻa pae o ke keʻokeʻo keena
    • hopena maʻi ʻaʻai
  • Hiki iā Gilenya:
    • maʻi ʻaʻai ʻili
    • pilikia pilikia ʻike
    • huikau koke
  • Hiki ke hana me nā Aubagio a me Gilenya:
    • hoʻonui i ke kahe o ke koko
    • nā pilikia hanu
    • hōʻino ka ate
    • hoka ʻole o ke ake

Ka hoʻokō ʻana

I kahi noiʻi hoʻokolohua, ua hoʻohālikelike pololei ʻia ʻo Aubagio iā Gilenya i ka poʻe me nā sclerosis (MS) he nui. ʻO ka poʻe i lawe iā Gilenya he 0.18 MS relapses i kēlā me kēia makahiki, ʻo ka poʻe i lawe iā Aubagio he 0.24 MS relapses i kēlā me kēia makahiki. Akā ua like ka hopena o nā lāʻau ʻelua i ka lohi ʻana i ka holomua o nā kīnā. ʻO kēia ka manaʻo ʻaʻole i hōʻino koke ke kino kīnā o kānaka.

Nā kumukūʻai

ʻO Aubagio lāua ʻo Gilenya nā lāʻau lapaʻau inoa ʻelua. ʻAʻohe o lākou ʻano generic. ʻOi aku ke kumu kūʻai o nā lāʻau lapaʻau inoa inoa ma mua o nā generics.

Wahi a nā koho ma GoodRx.com, ʻoi aku ka uku o Gilenya ma mua o Aubagio. ʻO ke kumukūʻai maoli āu e uku ai no nā lāʻau ʻelua e pili ana i kāu hoʻolālā ʻinikua, kou wahi, a me ka lāʻau kūʻai āu e hoʻohana ai.

Pehea e lawe ai iā Aubagio

E lawe ʻoe iā Aubagio e like me ke kauka a kauka paha e haʻi aku ai iā ʻoe.

Manawa

Lawe iā Aubagio i hoʻokahi manawa i ka lā ma kahi o ka manawa like i kēlā me kēia lā.

Lawe iā ʻAubagio me ka meaʻai

Hiki iā ʻoe ke lawe iā Aubagio me ka ʻole o ka meaʻai. ʻAʻole e hoʻopili ka lawe ʻana i kēia lāʻau me ka meaʻai i ka hana o ka lāʻau i kou kino.

Hiki iā Aubagio ke haki, ke kuʻi ʻia a ʻoki ʻia paha?

ʻAʻole koi ʻia e haki, wāwahi ʻia, a nau ʻia paha ʻo Aubagio. ʻAʻole i hana ʻia kekahi mau noiʻi e hoʻoholo inā hana kēia mau mea e loli pehea e hana ai ʻo Aubagio i ke kino.

ʻO ka lāʻau hana ma Aubagio, teriflunomide, ʻike ʻia e hāpai i kahi ʻono ʻawaʻawa, no laila ke paipai nui ʻia e lawe piha iā Aubagio.

He aha nā hoʻokolohua e pono ai wau ma mua o ka hoʻomaka ʻana i ka lāʻau?

Ma mua o kou lawe ʻana iā Aubagio, e holo ana kāu kauka i nā hoʻokolohua e hōʻoia i ka palekana o ka lāʻau iā ʻoe. Pākuʻi ʻia kēia mau mea:

  • Nā hōʻoia koko e ʻike inā lawa ke olakino o kou ake.
  • Hōʻike ʻili tuberculosis (TB) ʻili a i ʻole hoʻāʻo koko e nānā ai no ka TB.
  • Heluhelu piha ke koko e nānā i ka maʻi, e like me ka leukoencephalopathy multifocal holomua (PML). (E ʻike i ka ʻaoʻao "ʻaoʻao kikoʻī hopena" ʻaoʻao ma luna e aʻo hou aʻe e pili ana i ka PML.)
  • He hōʻike hāpai keiki. ʻAʻole pono ʻoe e lawe iā Aubagio inā hāpai ʻoe.
  • Kaha kaomi koko. ʻO ka lawe ʻana iā Aubagio e hoʻonui ai i kou kahe koko, no laila e ʻike ai kāu kauka inā loaʻa ke koko kiʻekiʻe i mua.
  • Mākēneki resonance kiʻi (MRI) ma mua a ʻoiai ʻoe e lawe iā Aubagio. E nānā kāu kauka i kou lolo no nā loli i nā liona (nāʻiʻo scar).

ʻOiai ʻoe e lawe iā Aubagio, e hāʻawi ana kāu kauka iā ʻoe i nā hōʻike koko i kēlā me kēia mahina e nānā i kou ake. E mālama lākou i kāu kaomi koko.

Pehea e hana ai ʻo Aubagio

ʻO ka sclerosis maha (MS) kahi maʻi mau (lōʻihi). Kuhi ia i kāu ʻōnaehana pale pale e hoʻouka i ka myelin (ʻāpana waho) ma nā aʻalolo i kou mau maka, lolo, a me ka iwi kuamoo. Hana kēia i nāʻiʻo makaʻu, kahi mea paʻakikī i kou lolo e hoʻouna i nā hōʻailona i kēia mau ʻāpana o kou kino.

Hana ʻokoʻa ʻo Aubagio mai nā lāʻau ʻē aʻe no MS. ʻO ia wale nō ka mea kāohi synthesist pyrimidine no ka mālama ʻana iā MS.

Pehea ka hana pololei ʻole ʻana o Aubagio. Manaʻo ʻia ʻo teriflunomide, ka lāʻau i hana ʻia ma Aubagio, ālai i kekahi enzyme. Pono nā hunaola palekana i kēia enzyme e hoʻonui koke. Ke ālai ʻia ka enzyme, ʻaʻole hiki i nā hunaola pale ke hoʻolaha a hoʻouka i ka myelin.

Pehea ka lōʻihi o ka hana?

Hoʻomaka koke ʻo Aubagio e hana ma hope koke o kou lawe ʻana. Eia nō naʻe, ʻaʻole ʻoe e ʻike i kahi ʻokoʻa i kāu mau ʻōuli ma hope o ka hoʻomaka ʻana o ka lāʻau. ʻO ia no ka mea e hana ia e kōkua i ka pale ʻana i nā hoʻi hou a me nā liona hou, nā hana i ʻike ʻole ʻia paha.

ʻAubagio a hāpai

ʻO ka lawe ʻana iā Aubagio ke hāpai ʻoe ke kumu o nā kīnā hānau nui. Mai lawe i kēia lāʻau inā hāpai ʻoe. Inā hāpai ʻoe a hoʻohana ʻole i ka kaohi hānau pono, ʻaʻole pono ʻoe e lawe iā Aubagio.

Inā hāpai ʻoe i ka hoʻohana ʻana iā Aubagio, e hoʻōki i ka lawe ʻana i ka lāʻau a haʻi koke i kāu kauka. E haʻi pū i kāu kauka inā makemake ʻoe e hāpai i loko o ʻelua mau makahiki. I kēia hihia, hiki iā lākou ke hoʻomaka iā ʻoe ma ka therapy e hoʻoneʻe koke iā Aubagio mai kāu ʻōnaehana (ʻike iā "Nā nīnau maʻamau e pili ana iā Aubagio" ma lalo).

Hiki iā ʻAubagio ke noho i loko o kou koko no ka manawa lōʻihi, a ʻoi paha i ʻelua mau makahiki ma hope o kou hōʻoki ʻana i ka lāʻau. ʻO ke ala wale nō e ʻike inā aia nō ʻo Aubagio i kāu ʻōnaehana e hana i kahi hōʻoia koko. Hana pū me kāu kauka e hoʻāʻo i kāu pae e hōʻoia i ka palekana o ka hāpai ʻana. A hiki i kou ʻike ʻaʻohe o Aubagio i waho o kāu ʻōnaehana, he mea nui e hoʻomau i ka hoʻohana ʻana i ka kaohi hānau.

Hiki iā ʻoe ke kau inoa no kahi papa inoa e kōkua ai e hōʻiliʻili i ka ʻike e pili ana i kāu ʻike. Kōkua nā mea kākau hoʻopuka i nā kauka i ke aʻo hou ʻana e pili ana i ka hopena o kekahi mau lāʻau i nā wahine a me kā lākou hāpai keiki. No ke kau inoa, e kāhea iā 800-745-4447 a kaomi i ke koho 2.

Inā ʻoe hopohopo e pili ana i ka hāpai ʻana i ka wā e lawe ana iā Aubagio, e kamaʻilio me kāu kauka. Hiki iā lākou ke kuhikuhi i nā hana kūpono o ka kaohi hānau.

No nā kāne: Pono nā kāne e lawe iā Aubagio e hoʻohana pono i ka pale pale. E hoʻomaopopo lākou i kā lākou kauka inā hoʻolālā kā lākou hoa i ka hāpai ʻana.

ʻAubagio a me ka waiū hānai

ʻAʻole maopopo inā hele ʻo Aubagio i ka waiū umauma.

Ma mua o ka lawe ʻana iā Aubagio, e haʻi i kāu kauka inā e hānai ʻoe i kāu keiki a i ʻole e hoʻolālā e hānai. Hiki iā lākou ke kūkākūkā me ʻoe i nā pilikia a me nā pōmaikaʻi o ka lawe ʻana i ka lāʻau i ka wā e hānai ana.

ʻO nā nīnau maʻamau e pili ana iā Aubagio

Eia nā pane i kekahi mau nīnau e nīnau pinepine ʻia e pili ana iā Aubagio.

ʻO Aubagio kahi pale pale pale?

ʻAʻole hoʻolaha ʻia ʻo Aubagio ma ke ʻano he immunosuppressant, akā e hoʻonāwaliwali paha ia i kāu ʻōnaehana pale. Inā ʻaʻole lawa ka ikaika o kāu ʻōnaehana pale pale e hakakā ai i nā germat, loaʻa paha ʻoe i kahi maʻi.

Inā ʻoe e hopohopo e pili ana i nā maʻi hiki ke lawe ʻia ʻo Aubagio, e kamaʻilio me kāu kauka.

Pehea wau e hana ai i kahi "holoi holoʻokoʻa" o Aubagio?

Inā lawe ʻoe iā Aubagio a hāpai a makemake paha e hāpai, e haʻi koke i kāu kauka. Hiki iā lākou ke hana e wehe koke iā Aubagio mai kou kino.

Hiki iā Aubagio ke noho i kāu ʻōnaehana a i ʻelua mau makahiki ma hope o kou hoʻōki ʻana i ka lawe ʻana. I ʻike ai inā loaʻa iā ʻoe ʻo Aubagio i kāu ʻōnaehana, pono ʻoe e hōʻoia i ke koko.

No kahi "washout," a i ʻole ka hoʻopau wikiwiki ʻana o Aubagio, e hāʻawi aku kāu kauka iā ʻoe i chol cholineramine a i ʻole ka pauka lanahu i hoʻāla ʻia.

E hoʻohana paha wau i ka kaohi hānau ʻoiai e lawe ana iā Aubagio?

ʻAe, pono ʻoe e hoʻohana i ka pale keiki (kaohi hānau) ʻoiai ke lawe nei iā Aubagio.

Inā he wahine ʻoe i hiki ke hāpai, hāʻawi ke kauka iā ʻoe i kahi hōʻike hāpai ma mua o kou hoʻomaka ʻana i ka hoʻomaʻamaʻa Aubagio. He mea nui ʻaʻole ʻoe e hāpai i ka lawe ʻana iā Aubagio no ka mea hiki i ka lāʻau ke kumu i nā kīnā hānau.

Pono nā kāne e lawe iā Aubagio e hoʻohana pono i ka pale pale. E hoʻomaopopo lākou i kā lākou kauka inā hoʻolālā kā lākou hoa i ka hāpai ʻana.

Hana ʻo Aubagio i ka flush?

ʻAʻole hōʻike ʻo Studies o Aubagio i ka hoʻopiʻi ʻana (hoʻomehana a me ka ʻulaʻula i kou ʻili) ma ke ʻano he hopena o ka lawe ʻana i ka lāʻau.

Eia nō naʻe, he hopena ʻaoʻao ka flushing o nā lāʻau ʻē aʻe e mālama i nā sclerosis he nui (MS), e like me Tecfidera.

E loaʻa paha iaʻu nā hopena hope inā kū wau i ka lawe ʻana iā Aubagio?

ʻAʻole i hōʻike ʻia nā hopena me ke aʻo ʻana iā Aubagio. No laila ʻaʻole paha e loaʻa iā ʻoe nā hōʻailona haʻalele ke kū ʻoe i ka lāʻau Aubagio.

Eia nō naʻe, eʻoi aʻe ka maikaʻi o kāu mau maʻi sclerosis (MS) ke pau kou lawe ʻana iā Aubagio. Me he mea lā he pane huki paha kēlā, akā ʻaʻole ia ka mea like.

Mai hōʻoki i ka lawe ʻana iā Aubagio me ka ʻole e kamaʻilio mua me kāu kauka. Hiki iā lākou ke kōkua iā ʻoe e hoʻokele i nā maʻi MS.

Hiki iā Aubagio ke kumu i ka maʻi ʻaʻai? Ua pili ʻia me kekahi make?

I nā noiʻi hoʻokolohua o Aubagio, ʻaʻole ka maʻi ʻaʻai i ka hopena i kū. Eia nō naʻe, i loko o kahi hōʻike hihia, ua hoʻomohala kahi wahine me ka sclerosis maha follicular lymphoma ma hope o ka lawe ʻana iā Aubagio no ʻewalu mau mahina. ʻAʻole i koi ka hōʻike ʻo Aubagio ke kumu o ka maʻi ʻaʻai, akā ʻaʻole ia i hōʻole i ka hiki.

I ke aʻo olakino Aubagio, ʻehā mau kānaka i make i nā pilikia puʻuwai. ʻO kēia ma kahi o 2,600 poʻe e lawe ana i ka lāʻau. Akā ʻaʻole i hōʻike ʻia ka lawe ʻana iā Aubagio i kumu o kēia make.

ʻUbaglelo Aubagio

Hele mai kēia lāʻau lapaʻau me nā ʻōlelo aʻoaʻo.

Nā ʻōlelo aʻoaʻo a FDA

Ua kau ʻia nā lāʻau lapaʻau i kēia lāʻau ʻO kahi ʻōlelo aʻoaʻo i pahu ʻia ka ʻōlelo aʻoaʻo nui loa mai ka Food and Drug Administration (FDA). Hoʻomaopopo ia i nā kauka a me nā mea maʻi e pili ana i nā hopena lāʻau e weliweli paha.

  • Poino ʻino nui. Hiki i ka Aubagio ke hoʻopilikia i nā pilikia o ke ake, e like me ka holo pono ʻole o ke ake. ʻO ka lawe ʻana iā Aubagio me nā lāʻau ʻē aʻe i hiki ke hoʻopili i kou ake ke hoʻonui i ka nui o Aubagio i kou kino. Hiki i kēia ke hōʻino i kou ake. ʻO kekahi o kēia mau lāʻau ʻo Arava (leflunomide), ka mea i kuhikuhi ʻia e mālama i ka rheumatoid arthritis. E hāʻawi aku kāu kauka iā ʻoe i nā hoʻokolohua koko ma mua a ʻoiai ʻoe e lawe iā Aubagio e nānā i kou ake.
  • Pilikia o nā hānau kīnā. Inā hāpai ʻoe, ʻaʻole pono ʻoe e lawe iā Aubagio no ka mea he kumu ia no nā kīnā hānau nui. Inā hāpai ʻoe a hoʻohana ʻole i ka kaohi hānau hilinaʻi, ʻaʻole pono ʻoe e lawe iā Aubagio. Inā hāpai ʻoe i ka lawe ʻana iā Aubagio, kāohi i ka lawe ʻana a haʻi koke i kāu kauka.

Nā ʻōlelo aʻoaʻo ʻē aʻe

Ma mua o ka lawe ʻana iā Aubagio, e kamaʻilio me kāu kauka e pili ana i kāu mōʻaukala olakino. ʻAʻole kūpono paha ʻo Aubagio iā ʻoe inā loaʻa iā ʻoe kekahi ʻano olakino. Pākuʻi ʻia kēia mau mea:

  • Maʻi maʻi ate. Hiki i ka Aubagio ke hōʻeha i ka ate. Inā loaʻa ʻoe i ka maʻi akepaʻa, e hoʻonui paha ʻo Aubagio iā ia.
  • Nā hopena hopena ma mua. Hōʻalo i ka lawe ʻana iā Aubagio inā ua loaʻa iā ʻoe kahi maʻi maʻi i:
    • teriflunomide
    • leflunomide
    • nā mea hoʻohui ʻē aʻe ma Aubagio

Aubagio overdose

Loaʻa ka palena o ka ʻike e pili ana i ka hoʻohana ʻana ma mua o ke ana i koi ʻia o Aubagio.

He aha e hana ai inā he overdose

Inā manaʻo ʻoe ua lawe nui ʻoe iā Aubagio, e kāhea i kāu kauka. Hiki iā ʻoe ke kāhea i ka ʻAmelika Hui Pū ʻIa o nā Poison Control ma 800-222-1222 a i ʻole hoʻohana i kā lākou mea hana pūnaewele. Akā inā ʻoe e manaʻo he pilikia olakino kou, e kāhea iā 911 a i ʻole e hele koke i kahi lumi pilikia kokoke.

Pau ʻo Aubagio, mālama, a hoʻolei

Ke kiʻi ʻoe iā Aubagio mai ka hale kūʻai lāʻau, e hoʻohui ka kauka i kahi lā palena pau i ka lepili ma ka ʻōmole. ʻO kēia lā maʻamau hoʻokahi makahiki mai ka lā a lākou i hāʻawi ai i ka lāʻau.

Kōkua ka lā palena i ka hōʻoia ʻana i ka maikaʻi o nā lāʻau i kēia manawa. ʻO ke kūlana o ka Food and Drug Administration (FDA) i kēia manawa e hōʻalo i ka hoʻohana ʻana i nā lāʻau i make. Inā loaʻa iā ʻoe kahi lāʻau i hoʻohana ʻole ʻia i hala i ka lā palena pau, e kamaʻilio me kāu kauka lāʻau e pili ana inā hiki paha iā ʻoe ke hoʻohana.

Waihona

Pehea ka lōʻihi o ka maikaʻi o ka lāʻau e hiki ai ke hilinaʻi i nā kumu he nui, e like me pehea a ma hea ʻoe e mālama ai i ka lāʻau.

E mālama i nā papa Aubagio ma ke ana wela ma waena o 68 ° F a me 77 ° F (20 ° C a me 25 ° C).

Hoʻolei

Inā ʻaʻole pono ʻoe e lawe hou iā Aubagio a loaʻa nā lāʻau i koe, he mea nui ia e hoʻolei aku me ka palekana. Kōkua kēia i ka pale aku i nā poʻe ʻē aʻe, e like me nā keiki a me nā holoholona, ​​mai ka lawe lāʻau ʻana ʻole. Mālama pū kekahi ia i ka lāʻau mai hōʻino i ke kaiapuni.

Hāʻawi ka pūnaewele FDA i nā ʻōlelo aʻoaʻo e pili ana i ka hoʻolāʻau lāʻau. Hiki iā ʻoe ke nīnau i kāu kauka lāʻau no ka ʻike e pili ana i ka hoʻolilo ʻana i kāu lāʻau.

ʻO ka ʻike ʻoihana no Aubagio

Hāʻawi ʻia ka ʻike aʻe no nā kauka lapaʻau a me nā ʻoihana ola.

Hōʻike

Hōʻike ʻia ʻo Aubagio e mālama i kēlā me kēia kanaka me nā ʻano relapsing o nā sclerosis (MS) he nui.

Mekanism o ka hana

Aia i loko o Aubagio ka teriflunomide e pono ai. Hoʻokipa ka Teriflunomide i kahi enzyme mitochondrial i kapa ʻia dihydroorotate dehydrogenase, i pili i ka de novo pyrimidine synthes. E hana pū paha ʻo Aubagio ma o ka hōʻemi ʻana i ka helu o nā lymphocytes i hoʻoulu ʻia i ka ʻōnaehana pūnana waena.

Pharmacokinetics a me ka metabolism

Ma hope o ka hoʻoponopono waha, ʻoi aku ka nui o ka noʻonoʻo ma loko o ʻehā mau hola. Hoʻokomo mua ʻia ʻo Aubagio i ka hydrolysis a hoʻopili ʻia i nā metabolites liʻiliʻi. ʻO nā ala ʻelua o ka metabolism me ka conjugation, oxidation, a me N-acetylation.

ʻO Aubagio kahi mea hoʻouluulu CYP1A2 a kāohi iā CYP2C8, transluver efflux transporter breast cancer resist protein (BCRP), OATP1B1, a me OAT3.

He hapalua ko Aubagio mau makahiki he 18 a 19 mau lā a hemo nui ʻia ma o nā feces (ma kahi o 38%) a me ka mimi (ma kahi o 23%).

Nā Kūʻai Kūʻai

Hoʻopiʻi ʻia ʻo Aubagio i nā maʻi i loaʻa:

  • hōʻino kino ʻino
  • kahi moʻolelo o ka hypersensitivity i teriflunomide, leflunomide, a i ʻole nā ​​mea ʻē aʻe o ka lāʻau.
  • hoʻohana pū ʻia me leflunomide
  • ka hiki no ka hāpai keiki me ka hoʻohana ʻole o nā mea pale a i ʻole hāpai

Waihona

Pono e mālama ʻia ʻo Aubagio i ka mahana ma waena o 68 ° F a me 77 ° F (20 ° C a me 25 ° C).

Hoʻolaha: Nūhou Nūhou i kēia lā i hana i nā hana āpau e hōʻoia i ka pololei, ka laulā, a me ka lā hou o nā ʻike āpau. Eia nō naʻe, ʻaʻole pono e hoʻohana i kēia ʻatikala i pani no ka ʻike a me ka mākaukau o kahi loea mālama ola laikini. E nīnau mau ʻoe i kāu kauka a i ʻole ʻoihana olakino ʻē aʻe ma mua o ka lawe ʻana i nā lāʻau. Hiki ke loli i ka ʻike o ka lāʻau i loko a ʻaʻole i manaʻo ʻia e uhi i nā hoʻohana a pau, nā kuhikuhi, ka mālama ʻana, nā ʻōlelo aʻoaʻo, nā launa lāʻau, nā hopena maʻi ʻaʻai, a me nā hopena maikaʻi ʻole. ʻO ka loaʻa ʻole o nā ʻōlelo aʻoaʻo a i ʻole nā ​​ʻike ʻē aʻe no kahi lāʻau i hāʻawi ʻia ʻaʻole ia e hōʻike i ka palekana o ka lāʻau a lāʻau paha i kūpono no nā mea maʻi āpau a i ʻole nā ​​hoʻohana kikoʻī āpau.

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