Hiki iā Migraine i kāu Genes?

Anter

• Hiki i ka migraine ke genetic?
• He aha ka ʻōlelo a ka noiʻi?
• Hoʻopili ʻia nā hoʻololi ʻana o Gene me ka migraine
• ʻO nā ʻano ʻē aʻe e pili ana i ka migraine
• Loaʻa i kekahi ʻano o migraine ka loulou o ka pilina ma mua o nā mea ʻē aʻe?
• Pehea e hiki ai i ka loaʻa ʻana o kahi loulou i ka migraine ke kōkua iā ʻoe?
• Ka wā e ʻike ai i ke kauka
• He aha nā koho lapaʻau maʻamau?
• Nā lāʻau no ka ʻōpū migraine koʻikoʻi
• Nā lāʻau e pale ai i ka hōʻeha migraine
• Nā hoʻoponopono hoʻohui
• Ke laina lalo

ʻO Migraine kahi maʻi neurological e pili kokoke i 40 miliona mau kānaka i ka United States.

Kū pinepine nā hoʻouka kaua ma ka ʻaoʻao o ke poʻo. Hiki i mua o lākou i kekahi manawa a hele pū paha me nā haunaele ʻike a ʻike paha i ʻike ʻia ma ke ʻano he aura.

ʻO nā ʻōuli ʻē aʻe, e like me ka nausea, ka luaʻi, a me ka ʻike māmā, hiki ke loaʻa pū i ka wā o ka neʻe ʻana o ka migraine.

ʻOiai ʻaʻole ʻike ʻia ke kumu kikoʻī o migraine, ua manaʻo ʻia he mea nui nā ʻano o ka nohona a me nā genetics i kēia kūlana. Ma lalo, e nānā pono mākou i ka pilina ma waena o migraine a me nā genetics.

Hiki i ka migraine ke genetic?

Kuhi ʻia kāu DNA, i loaʻa i kāu mau ʻāpana, i loko o 23 mau chromosome. Loaʻa iā ʻoe kahi ʻāpana chromosome mai kou makuahine a ʻo kekahi mai kou makuakāne mai.

ʻO kahi ʻāpana kahi ʻāpana o DNA e hāʻawi i ka ʻike e pili ana i ka hana ʻana i nā protein i loko o kou kino.

I kekahi manawa hiki i nā genes ke hoʻololi i nā loli, a ʻo kēia mau hoʻololi ke kumu a predispose paha i kekahi kanaka i kekahi ʻano olakino. Hiki ke hoʻoili ʻia kēia mau hoʻololi kūʻē mai ka makua a ke keiki.

Hoʻohui ʻia nā hoʻololi genetic a i ʻole nā ​​ʻokoʻa i ka migraine. I ka ʻoiaʻiʻo, ua koho ʻia he ʻoi aku ma mua o ka hapalua o ka poʻe i loaʻa ka migraine ma kahi o hoʻokahi ʻohana ʻē aʻe i loaʻa pū ka maʻi.

He aha ka ʻōlelo a ka noiʻi?

E luʻu hohonu kākou i loko o ka mea e aʻo nei nā mea noiʻi e pili ana i nā genetics a me migraine.

Hoʻopili ʻia nā hoʻololi ʻana o Gene me ka migraine

Ua lohe paha ʻoe e pili ana i kekahi noiʻi i loko o ka nūhou e pili ana i ka hoʻololi ʻana o nā ʻaoʻao ʻē aʻe i pili me ka migraine. Aia kekahi mau laʻana:

• KCNK18. Hoʻopili kēia gen i kahi protein i kapa ʻia TRESK, e pili ana me nā ala ʻeha a loaʻa i nā wahi nerve pili i ka migraine. Kahi hoʻololi kikoʻī ma KCNK18 ua pili ʻia me migraine me ka aura.
• CKIdelta. Hoʻopili kēia gen i kahi enzyme i loaʻa nā hana he nui i loko o ke kino, pili kekahi o ia me kāu pōpō hiamoe. Wahi a kahi noi ma 2013, ua hoʻololi ʻia kekahi ʻano kikoʻī ma CKIdelta ua pili me ka migraine.

ʻO nā ʻano ʻē aʻe e pili ana i ka migraine

He mea nui e kuhikuhi i ka nui o nā migraine hōʻeha i manaʻo ʻia he polygenic. Kuhi kēia i ke hāʻawi ʻana o nā gen he nui i ke ʻano. Kuhi ʻia kēia ma muli o nā loli liʻiliʻi i kapa ʻia hoʻokahi-nucleotide polymorphism (SNPs).

Ua ʻike ʻia nā noiʻi genetic ma mua o 40 mau wahi genetics me nā lauwili e pili ana me nā ʻano maʻamau o ka migraine. Hoʻohui pinepine ʻia kēia mau wahi me nā mea e like me ke kelepona a me ka hōʻailona nerve a i ʻole ka vascular (moku koko) ka hana.

ʻO ʻoe wale, he hopena liʻiliʻi paha kēia mau ʻano ʻokoʻa. Eia nō naʻe, ke hōʻiliʻili ka hapa nui o lākou, hiki ke kōkua i ka ulu ʻana o ka migraine.

Ua ʻike ʻia kahi noiʻi ma 2018 o 1,589 mau ʻohana me ka migraine i hoʻonui ʻia ka "hoʻoili" o kēia mau ʻano kūʻē ke hoʻohālikelike ʻia i ka heluna lehulehu.

Hōʻike pū kekahi nā ʻano genetika e hoʻoholo i nā hiʻohiʻona nui o ka migraine. ʻO ka loaʻa ʻana o ka mōʻaukala ʻohana ikaika o migraine hiki ke hoʻonui i kou makaʻala no ka loaʻa ʻana:

• migraine me ka aura
• ʻoi aku ka pinepine o ka hōʻeha migraine
• kahi makahiki ma mua o ka hoʻomaka ʻana o ka migraine
• i nā lā hou inā pono ʻoe e hoʻohana i ka lāʻau migraine

Loaʻa i kekahi ʻano o migraine ka loulou o ka pilina ma mua o nā mea ʻē aʻe?

Loaʻa i kekahi ʻano o ka migraine kahi hui kūpuna kaulana. ʻO kahi laʻana o kēia ka ʻohana hemiplegic migraine (FHM). Ma muli o kēia hui ʻike ʻia, ua aʻo nui ʻia ʻo FHM e pili ana i nā genetics o ka migraine.

ʻO FHM kahi ʻano o ka migraine me ka aura i loaʻa i ka makahiki mua o ka hoʻomaka ma mua o nā ʻano migraine ʻē aʻe. Me nā ʻōuli aura like ʻole, loaʻa ka helu a me ka nāwaliwali o ka poʻe me FHM ma kekahi ʻaoʻao o ke kino.

ʻEkolu mau ʻokoʻa ʻokoʻa i ʻike ʻia e pili pū ana me FHM. O lākou:

• CACNA1A
• ATP1A2
• SCN1A

Hiki i kahi mutation i kekahi o kēia mau gen ke hoʻopili i ka neʻe ʻana o ke aʻa nerve, kahi e hoʻonāukiuki ai i ka neʻe ʻana o ka migraine.

Ua hoʻoili ʻia ʻo FHM i ke ʻano autosomal domant. ʻO kēia ke kumu hoʻokahi wale nō kope o ka gen mutated e loaʻa ai ke ʻano.

Pehea e hiki ai i ka loaʻa ʻana o kahi loulou i ka migraine ke kōkua iā ʻoe?

Kūleʻa paha ia, akā ʻo ka loaʻa ʻana o kahi loulou i migraine hiki ke lilo i mea maikaʻi. ʻO ia no ka mea hiki iā ʻoe ke loaʻa i ka ʻike koʻikoʻi a me ke kākoʻo mai nā lālā o kou ʻohana i maopopo i ke ʻano.

ʻO ka ʻikepili mai nā lālā o kou ʻohana i mea kōkua paha i kāu iho migraine ʻike:

• he aha ka mea a kā lākou migraine e hoʻokumu ai
• nā ʻōuli kikoʻī a lākou e ʻike ai
• nā mālama a lāʻau paha e kōkua i ka mālama pono ʻana i nā ʻōuli o ka migraine
• inā ua loli ko lākou migraine hōʻeha i ka pinepine, ka ikaika, a i ʻole nā ​​ala ʻē aʻe i ko lākou ola
• ka makahiki a lākou i ʻike ai i ka migraine

Ka wā e ʻike ai i ke kauka

Inā loaʻa iā ʻoe nā ʻōuli e kūlike me ka migraine, e hoʻopaʻa i kāu manawa me kāu kauka. ʻO nā ʻōuli hoʻouka Migraine me:

• kahi ʻeha a me ka ʻeha ʻana o ka ʻeha, pinepine ma kekahi ʻaoʻao o kou poʻo
• nausea a me ka luaʻi
• ʻālohilohi kukui
• lohe leo
• hōʻailona aura, kahi e hiki ai i mua o ka lele ʻana o ka migraine a komo pū paha me:
  • ke ʻike aku i nā ʻōlinolino o ke kukui
  • paʻakikī e ʻōlelo
  • nā manaʻo o ka nāwaliwali a i ʻole numbness ma kekahi ʻaoʻao o kou alo a i ʻole i kahi lālā

I kekahi manawa hiki i ka ʻeha poʻo ke hōʻailona o kahi pilikia olakino. E loaʻa koke i ka lāʻau lapaʻau no ka ʻeha poʻo e:

• hiki koke mai a kaumaha loa
• hana ma hope o kahi ʻeha i kou poʻo
• kū me nā ʻōuli e like me ka ʻāʻī ʻoʻoleʻa, huikau, a me ka helu
• ʻoi aku ka lōʻihi a ʻoi aku ka maikaʻi ma hope o ka hoʻoikaika ʻana iā ʻoe iho

He aha nā koho lapaʻau maʻamau?

Mālama pinepine ʻia ʻo Migraine me nā lāʻau. ʻElua ʻano o ka lāʻau migraine:

• kēlā mau mea e hōʻoluʻolu ai i nā ʻōuli nui loa
• ʻo kēlā mau mea kōkua i ka pale ʻana i ka lele ʻana o ka migraine

Aia kekahi mau hana hoʻohui e hiki ke kūpono. E ʻimi mākou i kēlā me kēia ʻano lapaʻau i nā kikoʻī ma lalo.

Nā lāʻau no ka ʻōpū migraine koʻikoʻi

Lawe pinepine ʻoe i kēia mau lāʻau i ka wā e hoʻomaka ai ʻoe e ʻike i nā hōʻailona o ka aura a me ka migraine. ʻO nā laʻana me:

• Nā lāʻau ʻeha ma over-the-counter. Hoʻopili kēia i nā NSAID e like me ibuprofen (Advil, Motrin), naproxen (Aleve), a me aspirin. Acetaminophen (Tylenol) hiki ke hoʻohana pū kekahi.
• Nā Triptans. Nui a hewahewa nā ʻano triptans. Kōkua kēia mau lāʻau i ka pale ʻana i ka mumū a hoʻopaʻa i nā kīʻaha koko, e hoʻomaha ai i ka ʻeha. ʻO kekahi mau laʻana e laʻa me sumatriptan (Imitrex), eletriptan (Relpax), a me rizatriptan (Maxalt).
• Nā alkaloid Ergot. Hana like kēia mau lāʻau i ka triptans. Hāʻawi ʻia paha lākou inā ʻaʻohe hopena ka mālama ʻana me nā triptans. ʻO kahi laʻana he dihydroergotamine (Migranal).
• ʻO Gepants. ʻO kēia nalu hou o ka migraine lapaʻau e ālai i kahi peptide e hoʻopili i ka mumū.
• ʻO Ditans. ʻO kahi ʻohana novel o nā lāʻau hoʻopakele, like ka ditans me nā triptans akā hiki ke hoʻohana ʻia i ka poʻe me ka mōʻaukala o ka puʻuwai puʻuwai a me ka hahau ʻana, no ka mea e hoʻonui ka triptans i ka pilikia o nā pilikia puʻuwai.

Nā lāʻau e pale ai i ka hōʻeha migraine

Hiki i kāu kauka ke kauoha i kekahi o kēia mau lāʻau inā loaʻa pinepine iā ʻoe a hōʻeha nui paha i ka migraine. ʻO kekahi mau laʻana:

• Nā Anticonvulsants. Ua hoʻomohala mua ʻia kēia mau lāʻau e kōkua i ka mālama ʻana i ka hopu ʻana. ʻO nā laʻana me topiramate (Topamax) a me valproate.
• ʻO nā lāʻau kaomi koko. Hiki i kēia ke komo pū me nā beta-blockers a i ʻole nā ​​blockers channel calcium.
• Nā lāʻau Antidepressant. Hiki ke hoʻohana ʻia ʻo Amitriptyline, kahi antidepressant tricyclic.
• Nā mea kāohi CGRP. ʻO kēia kahi ʻano lāʻau hou i hāʻawi ʻia e ka injection. He mau mea pale umauma lākou e nakinaki i kahi mea loaʻa i ka lolo e paipai i ka vasodilation (hoʻonui ʻia o nā kīʻaha koko).
• Nā hoʻopili Botox. Ke loaʻa nei i kahi injection Botox i kēlā me kēia 12 mau pule e kōkua i ka pale ʻana i ka migraine i kekahi mau mākua.

Nā hoʻoponopono hoʻohui

Aia kekahi mau ʻano hoʻohui ʻē aʻe i kūpono no ka migraine, e like me:

• Nā loina hoʻomaha. ʻO ke koʻikoʻi ka mea ulu pinepine o ka migraine. Hiki i nā ʻano hoʻomaha ke kōkua iā ʻoe e mālama i nā pae koʻikoʻi i ka nānā ʻana. ʻO nā laʻana e laʻa me yoga, ka noʻonoʻo ʻana, nā hana hanu, a me ka hoʻomaha ʻana i nā mākala.
• Acupuncture. Hoʻopili ka Acupuncture i ka hoʻokomo ʻana i nā nila kui lahilahi i nā kiko kaomi o ka ʻili. Manaʻo ʻia he kōkua kēia e hoʻihoʻi i ke kahe o ka ikehu i ke kino. Kōkua paha ia me ka hoʻomaha ʻana i ka ʻeha migraine.
• Nā mea kanu, nā wikamina, a me nā minelala. Hiki ke kōkua i kekahi mau mea kanu a me nā mea hoʻopili me nā ʻōuli o ka migraine. ʻO kekahi mau laʻana e pili ana i ka butterbur, magnesium, a me ka wikamina B-2.

Ke laina lalo

ʻOiai ua ʻike nā kānaka noiʻi i nā kumu kūpono o ka migraine, aia nō i ka mea i ʻike ʻole ʻia.

Eia nō naʻe, mai ka noiʻi i hana ʻia, me he mea lā he huikau ka huikau o nā kaiapuni a me nā genetics i kumu i kēia ʻano.

Hoʻopili ʻia nā hoʻololi ʻana i nā ʻiʻo kikoʻī me kekahi ʻano o ka migraine, e like me ke ʻano o ka migraine hemiplegic ʻohana. Eia nō naʻe, ʻo ka hapa nui o ka migraine he polygenic paha ia, ʻo ia hoʻi ka hoʻololi ʻana i nā ʻano genes.

ʻO ka loaʻa ʻana o ka mōʻaukala ʻohana o ka migraine hiki ke lilo i waiwai i hiki iā ʻoe ke kiʻi i ka ʻike koʻikoʻi mai nā lālā o ka ʻohana i ʻike i ke ʻano like. Hiki paha iā ʻoe ke pane i nā ʻano lāʻau like.

Inā loaʻa iā ʻoe nā ʻōuli o ka migraine e paʻakikī e hele ma waena o ka lā, e ʻike i kāu kauka e kūkākūkā i kāu koho lapaʻau.