Mea Kākau: William Ramirez
Lā O Ka Hana: 15 Kepakemapa 2021
HōʻAno Hou I Ka Lā: 14 Nowemapa 2024
Anonim
Public Meeting on Patient Focused Drug Development for Alpha 1 Antitrypsin Part 2
Wikiō: Public Meeting on Patient Focused Drug Development for Alpha 1 Antitrypsin Part 2

Anter

He aha ka hōʻike alpha-1 antitrypsin (AAT)?

Ana kēia hōʻike i ka nui o ka alpha-1 antitrypsin (AAT) i loko o ke koko. ʻO AAT kahi protein i hana ʻia i ke ake. Kōkua ia i ka pale ʻana i kou mau māmā mai nā pohō a me nā maʻi, e like me ka emfysema a me ka maʻi pulmonary maʻi mau (COPD).

Hana ʻia ʻo AAT e kekahi mau gen i kou kino. ʻO nā Genes nā ʻāpana maʻamau o ka hoʻoilina i hoʻoili ʻia mai kou mau mākua mai. Hāpai lākou i ka ʻike e hoʻoholo ai i kāu ʻano kū hoʻokahi, e like me ke kiʻekiʻe a me ke kala o ka maka. Loaʻa i kēlā me kēia mea i ʻelua kope o ka ʻāpana e hana iā AAT, hoʻokahi mai ko lākou makuakāne a hoʻokahi mai ko lākou makuahine. Inā loaʻa kahi hoʻololi (hoʻololi) i hoʻokahi a i ʻole ʻelua kope o kēia moʻokūʻauhau, e hōʻemi ana kou kino iā AAT a i ʻole AAT e holo pono ʻole e like me ka mea e pono ai.

  • Inā loaʻa iā ʻoe nā kope mutated ʻelua o ka ʻāpana, ʻo ia hoʻi he maʻi kāu i kapa ʻia ʻo ka hemahema AAT. ʻOi aku ka nui o ka makaʻu o ka poʻe me kēia maʻi i loaʻa i ka maʻi maʻi a i ʻole ka hōʻeha o ke ake ma mua o ka makahiki 45.
  • Inā loaʻa iā ʻoe kekahi gen AAT mutated, loaʻa paha iā ʻoe ka haʻahaʻa ma mua o ka nui maʻamau o AAT, akā akahai a ʻaʻohe hōʻailona o ka maʻi. ʻO ka poʻe me hoʻokahi gen mutated nā mea lawe i ka hemahema AAT. ʻO kēia ka manaʻo ʻaʻohe ou ʻano, akā hiki iā ʻoe ke hoʻoili i ka moʻo hoʻohuli i kāu poʻe keiki.

Hiki i kahi hōʻike AAT ke kōkua ke hōʻike inā loaʻa iā ʻoe kahi hoʻololi kūʻē e hoʻoweliweli iā ʻoe no ka maʻi.


Nā inoa ʻē aʻe: A1AT, AAT, alpha-1-antiprotease deficit, α1-antitrypsin

No ke aha ia e hoʻohana ai?

Hoʻohana pinepine ʻia kahi hōʻike AAT e kōkua i ke kuhi hewa ʻana i ka hemahema AAT i ka poʻe e hoʻomohala i nā maʻi o ka maʻi maʻi i ka wā ʻōpio (45 a ʻoi paha makahiki) a ʻaʻohe o lākou mau pilikia e like me ka puhipaka.

Hiki ke hoʻohana ʻia ke hoʻokolohua e hōʻoia ai i kahi ʻano laha ʻole o ka maʻi ate i nā pēpē.

No ke aha wau e pono ai i kahi hōʻike AAT?

Pono ʻoe i kahi hoʻokolohua AAT inā ʻoe ma lalo o ka makahiki 45, ʻaʻole ʻoe he puhipaka, a loaʻa nā ʻōuli o ka maʻi puʻupuʻu, e like me:

  • ʻUhihi
  • Pokole o ka hanu
  • Mū kau mau
  • ʻOi aku ka wikiwiki ma mua o ke kuʻi o ka puʻuwai maʻamau ke kū ʻoe i luna
  • Nā pilikia ʻike
  • Asthma e pane maikaʻi ʻole i ka lāʻau

Hiki paha iā ʻoe ke loaʻa i kēia hōʻike inā loaʻa iā ʻoe ka moʻolelo ʻohana o ka hemahema AAT.

Hoʻopili pinepine ka hemahema AAT i nā pēpē i ke ake. No laila makemake paha kāu pēpē i kahi hōʻike AAT inā loaʻa i kāna kauka olakino nā hōʻailona o ka maʻi ate. Pākuʻi ʻia kēia mau mea:


  • ʻO Jaundice, kahi melemele o ka ʻili a me nā maka e mau ana ma mua o hoʻokahi pule a ʻelua paha
  • ʻO kahi spleen hoʻonui ʻia
  • Māliʻi pinepine

He aha ka hana i ka wā o kahi hōʻike AAT?

E lawe kahi ʻoihana mālama ola i kahi laʻana koko mai kahi aa i kou lima, e hoʻohana ana i kahi nila kuʻikuʻi. Ma hope o ka hoʻokomo ʻia ʻana o ka nila, e hōʻiliʻili ʻia kahi koko liʻiliʻi i loko o kahi pahu hoʻāʻo a ipu paha. Hiki paha iā ʻoe ke ʻoni iki i ka wā e hele ai a kuʻi paha ka nila. Lōʻihi kēia ma mua o ʻelima mau minuke.

Pono wau e hana i kekahi mea e hoʻomākaukau ai no ka hoʻāʻo?

ʻAʻole pono ʻoe i kahi hoʻomākaukau kūikawā no kahi hōʻike AAT.

Aia kekahi mau pilikia i ka hoʻāʻo?

Aia ka liʻiliʻi o ka makaʻu kino i ka hoʻāʻo ʻana i ke koko. Loaʻa paha iā ʻoe ka ʻeha a ʻeha paha ma kahi o ka nila i hoʻokomo ʻia ai, akā ʻo ka hapa nui o nā ʻōuli e hele wikiwiki aku.

He aha ke ʻano o nā hopena?

Inā hōʻike kāu mau hopena i kahi haʻahaʻa ma mua o ka nui maʻamau o AAT, manaʻo paha ia he hoʻokahi a ʻelua paha mau genes AAT i hoʻohuli ʻia. ʻO ka haʻahaʻa o ka pae, ʻoi aku paha ka nui o kāu mau genes mutate ʻelua a me ka hemahema AAT.


Inā ʻike ʻia ʻoe me ka hemahema AAT, hiki iā ʻoe ke hana i nā hana e hōʻemi ai i kou makaʻi o ka maʻi. Pākuʻi ʻia kēia mau mea:

  • ʻAʻole puhipaka. Inā ʻoe he puhipaka, haʻalele i ka puhipaka. Inā ʻaʻole ʻoe puhipaka, mai hoʻomaka. ʻO ka puhihihi ka mea nui e hiki ai ke hōʻeha i ka maʻi maʻi i loko o ka poʻe me ka hemahema AAT.
  • Ma hope o ka papaʻai olakino
  • Ke kiʻi i ka hoʻoikaika kino maʻamau
  • Ke ʻike pinepine nei i kāu kahu mālama ola
  • Lawe i nā lāʻau e like me ka mea i kauoha ʻia e kāu mea hāʻawi

Inā he mau nīnau kāu e pili ana i kāu hopena, e kamaʻilio me kāu kauka olakino.

E aʻo hou aʻe e pili ana i nā hoʻokolohua hoʻokolohua, nā pae kuhikuhi, a me ka hoʻomaopopo ʻana i nā hopena.

Aia kekahi mea ʻē aʻe e pono iaʻu e ʻike e pili ana i kahi hōʻike AAT?

Ma mua o kaʻae ʻana e hoʻāʻo ʻia, kōkua paha ia e kamaʻilio me ke kākāʻōlelo. He loea aʻoaʻo aʻo loea kūikawā i ka genetics a me ka hoʻāʻo genetic. Hiki i ke kākā'ōlelo ke kōkua iā ʻoe e hoʻomaopopo i nā pilikia a me nā pono o ka hoʻāʻo ʻana. Inā hoʻāʻo ʻia ʻoe, hiki i ke kākāʻōlelo ke kōkua iā ʻoe e hoʻomaopopo i nā hopena a hāʻawi i ka ʻike e pili ana i ke ʻano, me kāu makaʻu e hoʻoili i ka maʻi i kāu mau keiki.

Nā kūmole

  1. Nā Hoʻokolohua Lab ma ka Pūnaewele [Pūnaewele]. Wakinekona D.C .: ʻAmelika Hui Pū ʻIa no ka Chemical Clinical; c2001–2019. Alpha-1 Antitrypsin; [hōʻano hou ʻia 2019 Jun 7; i helu ʻia ʻo 2019 ʻOkakopa 1]; [ma kahi o 2 pale]. Loaʻa mai: https://labtestsonline.org/tests/alpha-1-antitrypsin
  2. Nā Hoʻokolohua Lab ma ka Pūnaewele [Pūnaewele]. Wakinekona D.C .: ʻAmelika Hui Pū ʻIa no ka Chemical Clinical; c2001–2019. ʻO Jaundice; [hōʻano hou ʻia 2018 Feb 2; i helu ʻia ʻo 2019 ʻOkakopa 1]; [ma kahi o 3 pale]. Loaʻa mai: https://labtestsonline.org/conditions/jaundice
  3. Merck Manual Mea Kūʻai Manuahi [Pūnaewele]. Kenilworth (NJ): Merck & Co. Inc.; c2019. Ka hemahema o Alpha-1 Antitrypsin; [hōʻano hou ʻia 2018 Nov; i helu ʻia ʻo 2019 ʻOkakopa 1]; [ma kahi o 2 pale]. Loaʻa mai: https://www.merckmanuals.com/home/lung-and-airway-disorder/chronic-obstructive-pulmonary-disease-copd/alpha-1-antitrypsin-deficiency?query=alpha-1%20antitrypsin
  4. National Heart, Lung, and Blood Institute [Pūnaewele]. Bethesda (MD): Ke Keʻena ʻOihana Ola a me nā lawelawe kanaka; Ka hemahema o Alpha-1 Antitrypsin; [i helu ʻia ʻo 2019 ʻOkakopa 1]; [ma kahi o 2 pale]. Loaʻa mai: https://www.nhlbi.nih.gov/health-topics/alpha-1-antitrypsin-deficiency
  5. National Heart, Lung, and Blood Institute [Pūnaewele]. Bethesda (MD): Ke Keʻena ʻOihana Ola a me nā lawelawe kanaka; Nā ho'āʻo koko; [i helu ʻia ʻo 2019 ʻOkakopa 1]; [ma kahi o 3 pale]. Loaʻa mai: https://www.nhlbi.nih.gov/health-topics/blood-tests
  6. NIH U.S. National Library of Medicine: Genetics Home Reference [Pūnaewele]. Bethesda (MD): Ke Keʻena ʻOihana Ola a me nā lawelawe kanaka; He aha ka ʻāpana ?; 2019 ʻOkakopa 1 [helu ʻia 2019 ʻOkakopa 1]; [ma kahi o 3 pale]. Loaʻa mai: https://ghr.nlm.nih.gov/primer/basics/gene
  7. UF Health: Ke Kulanui o Florida Health [Pūnaewele]. Gainesville (FL): Ke Kula Nui o Florida; c2019. Hōʻike koko Alpha-1 antitrypsin: hōʻike ākea; [hōʻano hou ʻia 2019 ʻOkakopa 1; i helu ʻia ʻo 2019 ʻOkakopa 1]; [ma kahi o 2 pale]. Loaʻa mai: https://ufhealth.org/alpha-1-antitrypsin-blood-test
  8. Kulanui o Rochester Medical Center [Pūnaewele]. Rochester (NY): Kulanui o Rochester Medical Center; c2019. ʻO Encyclopedia Health: Alpha-1 Antitrypsin; [i helu ʻia ʻo 2019 ʻOkakopa 1]; [ma kahi o 2 pale]. Loaʻa mai: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=alpha_1_antitrypsin
  9. UW Ola [Pūnaewele]. Madison (WI): Ke Kulanui o Wisconsin Nā Haukapila a me nā Mana Haukino; c2019. Hōʻikeʻike Alpha-1 Antitrypsin Genetic Testing: He aha ka hemahema o Alpha-1 Antitrypsin ?; [hōʻano hou ʻia 2018 Sep 5; i helu ʻia ʻo 2019 ʻOkakopa 1]; [ma kahi o 2 pale]. Loaʻa mai: https://www.uwhealth.org/health/topic/special/alpha-1-antitrypsin-deficiency-genetic-testing/uf6753.html
  10. UW Ola [Pūnaewele]. Madison (WI): Ke Kulanui o Wisconsin Nā Haukapila a me nā Mana Haukino; c2019. Hōʻoiaʻiʻo ʻo Alpha-1 Antitrypsin Genetic Testing: he aha ka ʻōlelo aʻoaʻo ʻiʻo? [hōʻano hou ʻia 2018 Sep 5; i helu ʻia ʻo 2019 ʻOkakopa 1]; [ma kahi o 7 pale]. Loaʻa mai: https://www.uwhealth.org/health/topic/special/alpha-1-antitrypsin-deficiency-genetic-testing/uf6753.html#tv8548
  11. UW Ola [Pūnaewele]. Madison (WI): Ke Kulanui o Wisconsin Nā Haukapila a me nā Mana Haukino; c2019. Hōʻikeʻike Alpha-1 Antitrypsin Genetic: No ke aha ʻaʻole wau e hoʻāʻo ʻia ?; [hōʻano hou ʻia 2018 Sep 5; i helu ʻia ʻo 2019 ʻOkakopa 1]; [ma kahi o 6 pale]. Loaʻa mai: https://www.uwhealth.org/health/topic/special/alpha-1-antitrypsin-deficiency-genetic-testing/uf6753.html#uf6790

ʻAʻole pono e hoʻohana i ka ʻike ma kēia pūnaewele i pani no ka mālama olakino ʻoihana a ʻōlelo aʻoaʻo paha. Kāhea aku i ka mea mālama ola inā he nīnau kāu e pili ana i kou olakino.

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