Mea Kākau: Marcus Baldwin
Lā O Ka Hana: 15 Iune 2021
HōʻAno Hou I Ka Lā: 15 Nowemapa 2024
Anonim
Azacitidine and decitabine in treatment naive AML patients
Wikiō: Azacitidine and decitabine in treatment naive AML patients

Anter

Hoʻohana ʻia ʻo Azacitidine e mālama i ka leukemia myeloid koʻikoʻi (AML; ka maʻi ʻaʻai o nā hunaola keʻokeʻo) i nā mākua i hoʻomaikaʻi ma hope o ka chemotherapy, akā ʻaʻole hiki iā lākou ke hoʻopau i ka hoʻōla curative ikaika. Aia ʻo Azacitidine i kahi papa o nā lāʻau i kapa ʻia nā mea hana demethylation. Hana ia ma ke kōkua ʻana i ka iwi iwi e hana i nā hunaola kūlohelohe a me ka luku ʻana i nā hunaola ʻino.

Hele mai ʻo Azacitidine ma ke ʻano he papa e lawe ma ka waha. Lawe pinepine ʻia me a me ka ʻole o ka meaʻai i kēlā me kēia lā no nā lā 14 mua o kahi pōʻaiapuni 28 mau lā. E hoʻoholo kāu kauka i nā manawa āu e hana hou ai i kēia pōʻaiapili e pili ana i kāu pane i kēia lāʻau a me nā hopena ʻē aʻe āu e ʻike ai. Lawe iā azacitidine ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pololei iā azacitidine e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā papa holoʻokoʻa; mai hoʻokaʻawale, a nau aku, a hoka ʻole iā lākou.


Inā pili kou ʻili i ka pauka mai loko o nā papa, holoi koke i kahi i hōʻike ʻia me ke kopa a me ka wai. Inā pili kou maka a waha paha i ka pauka mai loko o nā papa, e ninini koke i ka wahi me ka wai.

E hāʻawi aku kāu kauka iā ʻoe i ka lāʻau e pale ai i ka nausea a me ka luaʻi ʻana he 30 mau minuke ma mua o kou loaʻa ʻana i kēlā me kēia kau o ka azacitidine no nā pōʻaiapili ʻelua. E hoʻomau paha kāu kauka i ka hāʻawi ʻana iā ʻoe i kēia lāʻau no ke kaʻa hope, inā pono.

Inā luaʻi ʻoe ma hope o ka lawe ʻana i ka azacitidine, mai lawe i kahi lāʻau ʻē aʻe. E hoʻomau i kāu papa hana maʻamau.

Hiki i kāu kauka ke hōʻemi i kāu lāʻau a i ʻole manawa kūmau a paʻa mau paha i kāu lāʻau inā ʻike ʻoe i kekahi mau hopena ʻaoʻao. E pono e haʻi aku i kāu kauka i kou ʻano i kou wā e mālama ai me ka azacitidine.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.


Ma mua o ka lawe ʻana i ka azacitidine,

  • e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka azacitidine, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā papa azacitidine. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
  • e haʻi i kāu kauka inā loaʻa a loaʻa paha ʻoe i ka maʻi ate a me nā puʻupaʻa.
  • E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a inā ʻoe e hoʻolālā i kahi keiki i kahi keiki. ʻAʻole ʻoe a i ʻole kāu pakanā e hāpai i ka wā e lawe ana ʻoe i ka azacitidine. Inā he wahine ʻoe, pono ʻoe e lawe i kahi hōʻike hāpai keiki ma mua o kou hoʻomaka ʻana i ka lāʻau lapaʻau a hoʻohana i ka kaohi hānau e pale ai i ka hāpai ʻana i kāu wā lapaʻau a no 6 mau mahina ma hope o kāu hopena hope loa. Inā he kāne ʻoe a hiki i kāu pakanā ke hāpai, pono ʻoe e hoʻohana i ka kaohi hānau pono i kou wā e mālama ai a no 3 mau mahina ma hope o kāu hopena hope loa. Inā hāpai ʻoe a ʻo kāu hoa paha i ka lawe ʻana iā azacitidine, e kāhea i kāu kauka. Hiki paha iā Azacitidine ke hōʻeha i ka fetus.
  • mai hānai i ka wā e lawe ana ʻoe i ka azacitidine a no 1 mau pule ma hope o kāu hopena hope loa.
  • pono ʻoe e ʻike i kēia lāʻau i hoʻemi ai i ka momona i nā kāne a me nā wahine. E kamaʻilio me kāu kauka e pili ana i nā pilikia o ka lawe ʻana iā azacitidine.
  • pono ʻoe e ʻike ʻo ka azacitidine ke kumu pinepine i ka maʻi diarrhea, a hiki ke koʻikoʻi. E haʻi paha kāu kauka iā ʻoe e lawe i kahi lāʻau anti-diarrhea e pale ai i ka make wai (ka nalowale o ka wai he nui mai kou kino) i kou wā e mālama ai me ka azacitidine.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.


Inā haʻo ʻoe i kahi lāʻau a inā ʻaʻole ʻoe e lawe i kāu lāʻau i ka manawa maʻamau, e lawe ia me ka hikiwawe loa i kēlā lā. E lawe i kāu kau ma hope aʻe i ka manawa maʻamau i ka lā aʻe. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu paha ʻo Azacitidine i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • nausea
  • ka luaʻi
  • pāhoehoe
  • kōpaʻa
  • nalo ʻai ʻole
  • luhi
  • ʻeha ka ʻōpū
  • ʻeha pū
  • ʻeha mākala
  • ʻūpā
  • ʻeha ma nā lima a me nā wāwae

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

  • ʻeha ka ʻāʻī, ke kuni, ka haʻalulu, ka ʻeha o ke kino, a i ʻole nā ​​hōʻailona ʻē aʻe o ka maʻi
  • ka pōkole o ka hanu a me ka ʻili haikea
  • ʻehaʻeha a hoʻokahe paha, ka luaʻi koko, ka luaʻi e like me nā papa kope, a ʻeleʻele paha, hoʻolohi, a i ʻole nā ​​noho koko.

Hoʻokumu paha ʻo Azacitidine i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua. E mālama i nā disiccant ʻelua (mea hoʻomaloʻo) i nā ʻōpala i loko o ka hue o ka lāʻau e hoʻomau i nā papa maloʻo. Mai ʻai i nā kēpau desiccant.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua lab a ma mua a i kāu wā e mālama ai e nānā i ka pane o kou kino iā azacitidine.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

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Nānā Hou - 11/15/2020

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