Mea Kākau: Janice Evans
Lā O Ka Hana: 25 Iulai 2021
HōʻAno Hou I Ka Lā: 15 Nowemapa 2024
Anonim
Pharmacology of opicapone used for treatment of on-off phenomena seen with levodopa (New Drug 2020)
Wikiō: Pharmacology of opicapone used for treatment of on-off phenomena seen with levodopa (New Drug 2020)

Anter

Hoʻohana ʻia ʻo Opicapone me ka levodopa a me ka carbidopa (Sinemet, Rytary) e mālama ai i nā hōʻailona o ka hopena o ka hopena o ka maʻi Parkinson. ʻO Opicapone kahi mea kāohi o catechol-O-methyltransferase (COMT). Kōkua ʻo Opicapone i ka levodopa a me ka carbidopa e hana ʻoi aku ka maikaʻi ma ka ʻae ʻana i nā mea hou aʻe e kiʻi i ka lolo, kahi e loaʻa ai nā hopena.

Hele mai ʻo Opicapone ma ke ʻano he capsule e lawe ma ka waha. Lawe ʻia ia i hoʻokahi manawa i ka lā i ka manawa moe a pono e lawe ma kahi o 1 mau hola ma mua a i ʻole 1 mau hola ma hope o ka ʻai ʻana. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. E lawe i ka opicapone e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

Mālama ʻo Opicapone i ka maʻi o Parkinson akā ʻaʻole ia e hoʻōla iā ia. E hoʻomau i ka lawe ʻana i ka opicapone ʻoiai inā maikaʻi ʻoe. Mai hōʻoki i ka lawe ʻana i ka opicapone me ka walaʻau ʻole ʻana me kāu kauka. Inā kū koke ʻoe i ka lawe ʻana i ka opicapone, hiki iā ʻoe ke hoʻomohala i kahi maʻi kūpilikiʻi e kumu ai ke kuni, nā mākala ʻoʻoleʻa, ka neʻe ʻana o ke kino ʻē a me ka huikau. Pono paha kāu kauka e hōʻemi i kāu lāʻau o ka opicapone me ka lohi a hoʻololi i nā kaha o kāu mau lāʻau ʻē aʻe no ka maʻi ʻo Parkinson.


E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka opicapone,

  • e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka opicapone, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā capicules opicapone. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
  • e haʻi i kāu kauka inā lawe ʻoe i ka isocarboxazid (Marplan), phenelzine (Nardil) a i ʻole tranylcypromine (Parnate) a i ʻole inā ua oki ʻoe i ka lawe ʻana iā lākou i nā pule he 2 i hala. E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe i ka opicapone.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe.E mālama pono i kekahi o kēia mau mea: nā lāʻau no ke koko kiʻekiʻe, nā lāʻau e hōʻū ai ka hiamoe, dobutamine, epinephrine (Epipen, Primatine Mist, a me nā mea ʻē aʻe), nā mea hoʻohiamoe, nā lāʻau moe, a me nā tranquilizers. Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Nui paha nā lāʻau ʻē aʻe e launa pū paha me ka opicapone, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
  • e haʻi i kāu kauka inā loaʻa iā ʻoe ka pheochromocytoma a i ʻole paraganglioma (nā tumors a i ʻole a puni kahi gland liʻiliʻi kokoke i nā puʻupaʻa). E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe i ka opicapone.
  • e haʻi i kāu kauka inā loaʻa paha iā ʻoe kahi hiamoe o ke ao i manaʻo ʻole ʻia a i ʻole kahi maʻi hiamoe, dyskinesia (neʻe ʻole o ka neʻe ʻana o ka neʻe ʻana), kahi maʻi psychotic (nā maʻi noʻonoʻo e hiki ai i ka noʻonoʻo ʻana a i ʻole nā ​​ʻike), a i ʻole ka maʻi ate a me nā puʻupaʻa
  • E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā hāpai ʻoe i ka lawe ʻana i ka opicapone, e kāhea i kāu kauka.
  • inā ke ʻoki nei ʻoe, e like me ke kaha ʻana o nā niho, e haʻi i ke kauka a i ʻole kauka niho paha e lawe ana ʻoe i ka opicapone.
  • pono ʻoe e ʻike i ka opicapone e hiamoe ai ʻoe a e hiamoe ai paha ʻoe i kāu hana maʻamau o kēlā me kēia lā. ʻAʻole paha ʻoe e hiamoe a i ʻole he hōʻailona hōʻailona ʻē aʻe ma mua o kou hiamoe ʻana. Mai hoʻokele i kahi kaʻa, hana i nā mīkini, hana ma kahi kiʻekiʻe, a i ʻole e komo i nā hana weliweli i ka hoʻomaka ʻana o kāu lapaʻau a ʻike ʻoe i ka hopena o ka lāʻau iā ʻoe. Inā hiamoe ʻoe i ka wā e hana ana ʻoe i kahi mea e like me ka nānā ʻana i ke kīwī, kamaʻilio ʻana, ʻai ʻana, a i ʻole ke kaʻa ʻana i ke kaʻa, a inā hiamoe nui ʻoe, keu hoʻi i ke ao, e kāhea i kāu kauka. Mai kalaiwa, hana ma nā wahi kiʻekiʻe, a hana i nā mīkini a hiki i kou wā e kamaʻilio ai me kāu kauka.
  • E hoʻomanaʻo hiki i ka waiʻona ke hoʻohui i ka hiamoe i hoʻokumu ʻia e kēia lāʻau. E haʻi i kāu kauka inā inu pinepine ʻoe i nā mea inu ʻona.
  • pono ʻoe e ʻike i kekahi poʻe i lawe i nā lāʻau e like me ka opicapone i hoʻomohala i nā pilikia piliwaiwai hou a hoʻonui ʻia paha a i ʻole nā ​​ʻūlū ikaika a i ʻole nā ​​ʻano koʻikoʻi a koʻikoʻi paha no lākou, e like me ka hoʻonui ʻana i nā makemake moekolohe a i ʻole nā ​​lawena. ʻAʻole lawa ka ʻike e haʻi inā ua hoʻomohala ka poʻe i kēia mau pilikia no ka mea lawe lākou i ka lāʻau a i ʻole no nā kumu ʻē aʻe. Kāhea i kāu kauka inā makemake ʻoe e pāʻani i ka paʻakikī e kaohi, loaʻa iā ʻoe nā koi ikaika, a i ʻole hiki ʻole iā ʻoe ke kaohi i kāu hana. E haʻi aku i nā lālā o kou ʻohana e pili ana i kēia pilikia i hiki iā lākou ke kāhea i ke kauka inā ʻaʻole ʻoe e ʻike he pili pilikia kāu piliwaiwai a i ʻole nā ​​ʻano hoʻoikaika ʻē aʻe a i ʻole nā ​​ʻano hana ʻano ʻē.
  • pono ʻoe e ʻike he hiki i ka opicapone ke hoʻoluhi, ka māmā, a me ka maʻule ke ala koke ʻoe mai kahi kūlana wahaheʻe. ʻOi aku ka maʻamau o kēia ke hoʻomaka mua ʻoe i ka lawe ʻana i ka opicapone. I mea e hōʻalo ai i kēia pilikia, e hele mālie i waho o kahi moe, e hoʻomaha ana i kou mau wāwae i ka papahele no kekahi mau minuke ma mua o ke kū ʻana i luna.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.


Pono ʻoe e lele i ka lāʻau i hala. Lawe i kāu mahele lāʻau maʻamau i kou hiamoe hou. Mai pāpālua i ka mahele hope aʻe e pani no ka mahele lāʻau i hala.

Hiki i ka Opicapone ke kumu i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • kōpaʻa
  • waha maloo
  • paʻakikī e hiamoe a hiamoe paha
  • ʻūpā
  • Kaumaha emi
  • nā neʻe o ke kino ʻokoʻa a i ʻole kaohi ʻole ʻia

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli e kāhea koke i kāu kauka a i ʻole e loaʻa i ka lāʻau lapaʻau olakino.

  • hallucination (ke ʻike nei i nā mea a i ʻole ka lohe ʻana i nā leo i ʻole ola)
  • kuhi hewa (he mau manaʻo ʻano ʻē a manaʻoʻiʻo paha i kumu ʻole i ka ʻoiaʻiʻo)
  • hana hoʻomāinoino
  • maule ana

Hiki i ka Opicapone ke kumu i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).


E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a mamao aku mai ka mālamalama, ka wela a me ka momona o ka wela (ʻaʻole i loko o ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Mālama i nā manawa āpau me kāu kauka.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

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