Mea Kākau: William Ramirez
Lā O Ka Hana: 19 Kepakemapa 2021
HōʻAno Hou I Ka Lā: 17 Nowemapa 2024
Anonim
Stewart Factor, MD: Long-Term Data on Apomorphine Sublingual Film in Parkinson
Wikiō: Stewart Factor, MD: Long-Term Data on Apomorphine Sublingual Film in Parkinson

Anter

Hoʻohana ʻia ka sublingual Apomorphine e mālama ai i nā ʻāpana "off" (mau manawa o ka paʻakikī e neʻe, hele wāwae, a ʻōlelo e hiki ke hana ʻia e like me ka pau ʻana o ka lāʻau lapaʻau a i ʻole me ke kaulike) i ka poʻe me ka maʻi maʻi Parkinson kiʻekiʻe (PD; kahi maʻi o ka ʻōnaehana ʻōnaehana i kumu nā pilikia me ka neʻe ʻana, ka mālama ʻana i nā mākala, a me ke kaulike). Aia ʻo Apomorphine i ka papa o nā lāʻau i kapa ʻia he agonists dopamine. Hana ia e ka hana ma kahi o ka dopamine, kahi mea kūlohelohe i hana ʻia i ka lolo e pono ai e kaohi i ka neʻe.

Hele mai ʻo Apomorphine ma ke ʻano he kiʻi sublingual e lawe ma lalo o ke alelo. Hoʻohana pinepine ʻia ʻo sublingual Apomorphine ke pono, e like me nā kuhikuhi a kāu kauka. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. E hoʻohana pono i ka sublingual apomorphine e like me ke kuhikuhi. Mai hoʻohana i ka ʻoi aku a i ʻole ka liʻiliʻi o ia mea a hoʻohana pinepine paha iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

Mai hoʻohana i ka mahele lāʻau ʻelua o ka sublingual apomorphine no ka mālama ʻana i ka ʻāpana "off" like. E kali ma ka liʻiliʻi he 2 mau hola ma waena o nā lāʻau a mai hoʻohana i nā mea ʻoi aku ma mua o 5 mau lā i ka lā.


E hāʻawi aku kāu kauka iā ʻoe i kekahi lāʻau ʻē aʻe i kapa ʻia ʻo trimethobenzamide (Tigan) e ʻai ke hoʻomaka ʻoe e hoʻohana i ka sublingual apomorphine. E kōkua kēia lāʻau i ka hoʻohaʻahaʻa ʻana i kou manawa o ka hoʻomālū a me ka luaʻi ʻoiai ʻoe e hoʻohana ana i ka apomorphine, keu hoʻi i ka hoʻomaka ʻana o ka lāʻau. E haʻi paha kāu kauka iā ʻoe e hoʻomaka i ka trimethobenzamide 3 mau lā ma mua o kou hoʻomaka ʻana e hoʻohana i ka apomorphine, a hoʻomau i ka lawe ʻana a hala i 2 mau mahina. Pono ʻoe e ʻike i ka lawe ʻana i ka trimethobenzamide me ka apomorphine e hoʻonui ai i kāu makaʻu o ka hiamoe, ʻūlū, a hāʻule. Eia naʻe, mai hooki i ka lawe ʻana i ka trimethobenzamide me ka ʻole o ke kamaʻilio mua ʻana me kāu kauka.

E loaʻa iā ʻoe kāu kau mua o ka apomorphine i kahi keʻena olakino kahi e hiki ai i kāu kauka ke nānā pono i kāu ʻano e hoʻoholo ai i kāu maʻi. Ma hope o kēlā, e haʻi aku kāu kauka iā ʻoe e hoʻohana i ka sublingual apomorphine ma ka home a e nānā no nā hopena maikaʻi ʻole.

E hoʻohana ai i ke kiʻi sublingual kiʻiʻoniʻoni apomorphine, e hāhai i kēia mau kaʻina hana:

  1. E inu i ka wai e māʻona i kou waha.
  2. E wehe i ka ʻeke me ka hoʻohana ʻana i nā kapu ʻēheu. E kau pono i kou mau manamana lima ma nā kiko i hāpai ʻia ma kēlā me kēia ʻaoʻao ʻēheu. E huki mālie i nā ʻaoʻao ʻeheu e wehe i ka ʻeke. Mai wehe i ka pūʻolo pepa a makaukau ʻoe e hoʻohana i ka lāʻau. Mai ʻoki a haehae paha i ke kiʻi ʻoniʻoni.
  3. Paʻa i ke kiʻi ʻoniʻoni apomorphine ma waena o kou mau manamana lima e nā kihi o waho a hemo i ke kiʻi ʻoniʻoni āpau mai ka ʻeke. E hoʻohana i ka ʻoniʻoni sublingual ʻo apomorphine āpau. Inā haki, hoʻolei iā ia a hoʻohana i kahi lāʻau hou.
  4. E hoʻonoho i kahi kiʻi ʻoniʻoni sublingual holoʻokoʻa ma lalo o kou alelo a hoʻi i lalo o kou alelo i hiki iā ʻoe. Pani i kou waha.
  5. E waiho i ke kiʻi ʻoniʻoni a hiki i ka wā e pau ai. He 3 minuke paha e hemo ai ke kiʻi ʻoniʻoni. Mai nau wale a ale i ke kiʻi ʻoniʻoni. Mai ale i kou kuha a kamaʻilio paha ke hoʻoheheʻe ʻia ke kiʻi ʻoniʻoni.
  6. E wehe i kou waha e ʻike inā ua pau loa ke kiʻi ʻoniʻoni.
  7. Ma hope o ka pau ʻana o ke kiʻi ʻoniʻoni sublingual, hiki iā ʻoe ke ale hou.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.


Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka hoʻohana ʻana i ka apomorphine,

  • e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka apomorphine, nā lāʻau ʻē aʻe, nā sulfites, a i ʻole nā ​​mea hoʻohui ʻē aʻe i ka sublingual apomorphine. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
  • e haʻi i kāu kauka inā lawe ʻoe i ka alosetron (Lotronex), dolasetron (Anzemet), granisetron (Sancuso), ondansetron (Zofran), a i ʻole palonosetron (Aloxi). E haʻi paha kāu kauka iā ʻoe ʻaʻole e hoʻohana i ka apomorphine inā ʻoe e lawe i kekahi o kēia mau lāʻau.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E haʻi pono i kekahi o kēia mau mea: azithromycin (Zithromax), chlorpromazine, chloroquine, ciprofloxacin (Cipro), haloperidol (Haldol); nā lāʻau e mālama ai i ke koko kiʻekiʻe; methadone (Dolophine); metoclopramide (Reglan); prochlorperazine (Compro); promethazine; paina moe; thiothixene; a i ʻole nā ​​tranquilizers. E haʻi pū aku i kāu kauka a kauka paha inā e lawe ʻoe i nā nitrates e like me isosorbide dinitrate (Isordil, i Bidil), isosorbide mononitrate (Monoket), a i ʻole nitroglycerin (Nitro-Dur, Nitrostat, nā mea ʻē aʻe) i hele mai e like me nā papa, sublingual (ma lalo o ke alelo) nā papa, nā ʻōpala, nā pākuʻi, nā pāpaʻi, a me nā hamo.E noi i kāu kauka a kauka paha inā ʻaʻole ʻoe maopopo inā loaʻa i kekahi o kāu mau lāʻau i nā nitrates. Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
  • pono ʻoe e ʻike inā ʻoe e hoʻohana i ka nitroglycerin ma lalo o kou alelo i ka hoʻohana ʻana i ka sublingual apomorphine, e hoʻemi paha kou kaomi koko a hoʻolilo i ka lōlō. Ma hope o ka hoʻohana ʻana i ka sublingual apomorphine, pono ʻoe e moe i mua a me / a ma hope paha o ka hoʻohana ʻana i nitroglycerin.
  • e haʻi i kāu kauka inā inu ʻoe i ka waiʻona a i ʻole inā loaʻa paha iā ʻoe kahi wā QT hoʻolōʻihi (kahi pilikia puʻuwai laha ʻole e hoʻonāukiuki ai i ka puʻuwai ʻole, maʻule paha, a make koke paha), nā pelu wali, nā pae haʻahaʻa o ka potassium a me ka magnesium i loko o ke koko. kahi puʻuwai lohi a kaulike ʻole paha, ke koko haʻahaʻa, kahi maʻi hiamoe, kahi hahau, mini-stroke, a i ʻole nā ​​pilikia lolo ʻē aʻe, hānō, neʻe ʻole i ka hopena a hāʻule, maʻi noʻonoʻo, a puʻuwai, puʻuwai, a i ʻole nā ​​maʻi ate.
  • E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā hāpai ʻoe i ka hoʻohana ʻana i ka sublingual apomorphine, e kāhea i kāu kauka.
  • inā ke ʻoki ʻia ʻoe, e like me ke kaha ʻana o ka niho, e haʻi i ke kauka a i ʻole kauka niho paha e hoʻohana nei ʻoe i ka sublingual apomorhine.
  • pono ʻoe e ʻike i ka apomorphine e hiamoe ai ʻoe. Mai hoʻokele kaʻa, hana i nā mīkini, a hana i kekahi mea e hoʻokau iā ʻoe i ka ʻeha a ʻike ʻoe i ka hopena o kēia lāʻau iā ʻoe.
  • ʻaʻole pono ʻoe e inu i ka waiʻona i ka wā e hoʻohana ana ʻoe i ka apomorphine. Hiki i ka waiʻona ke hana i nā hopena ʻino mai ka apomorphine.
  • pono ʻoe e ʻike ʻo ka apomorphine ke kumu o ka hoʻoluhi, hoʻomālamalama, hoʻoluhi, sweating, a maʻule hoʻi ke ala koke ʻoe mai kahi wahaheʻe a noho paha. ʻOi aku ka maʻamau o kēia ke hoʻomaka mua ʻoe i ka hoʻohana ʻana i ka apomorphine a i ʻole ka hahai ʻana i ka hoʻonui ʻana o ka lāʻau. I mea e hōʻalo ai i kēia pilikia, e hele i waho o kahi moe a e ala aʻe mai kahi noho e lohi, e hoʻomaha ana i kou mau wāwae i ka papahele no kekahi mau minuke ma mua o ke kū ʻana i luna.
  • pono ʻoe e ʻike i kekahi poʻe i lawe i nā lāʻau e like me ka apomorphine i hoʻomohala i nā pilikia piliwaiwai a i ʻole nā ​​ʻūlū ikaika a i ʻole nā ​​ʻaoʻao koʻikoʻi a koʻikoʻi paha iā lākou, e like me ka hoʻonui ʻana i nā makemake moekolohe a i ʻole nā ​​lawena. ʻAʻole lawa ka ʻike e haʻi inā ua hoʻomohala ka poʻe i kēia mau pilikia no ka mea lawe lākou i ka lāʻau a i ʻole no nā kumu ʻē aʻe. Kāhea i kāu kauka inā makemake ʻoe e pāʻani i ka paʻakikī e kaohi, loaʻa iā ʻoe nā koi ikaika, a i ʻole hiki ʻole iā ʻoe ke kaohi i kāu hana. E haʻi aku i nā lālā o kou ʻohana e pili ana i kēia pilikia i hiki iā lākou ke kāhea i ke kauka inā ʻaʻole ʻoe e ʻike he pili pilikia kāu piliwaiwai a i ʻole nā ​​ʻano hoʻoikaika ʻē aʻe a i ʻole nā ​​ʻano hana ʻano ʻē.
  • pono ʻoe e ʻike he hiamoe paha ʻoe i kāu hana maʻamau i kēlā me kēia lā ʻoiai ʻoe e hoʻohana nei i ka sublingual apomorphine. ʻAʻole paha ʻoe e hiamoe ma mua o kou hiamoe ʻana. Inā hiamoe ʻoe i ka wā e hana ana ʻoe i kahi hana i kēlā me kēia lā e like me ka ʻai ʻana, kamaʻilio ʻana, a i ʻole ke nānā ʻana i ke kīwī, e kāhea aku i kāu kauka. Mai hoʻokele i kahi kaʻa a hana i nā mīkini a hiki i kou wā e kamaʻilio ai me kāu kauka.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.


Hoʻohana maʻamau kēia lāʻau i ka wā e pono ai.

Hoʻokumu paha ka sublingual ʻo Apomorphine i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • ka luaʻi
  • waha maloo
  • ʻeha poʻo
  • ihu ihope
  • luhi
  • ʻulaʻula waha, ʻeha, maloʻo, pehu, a ʻeha paha
  • ʻeha me ka ale ʻana

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i PRECAUTIONS SPECIAL, e kelepona koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

  • ʻehu; hives; ʻumeʻume; pehu o ka maka, ʻāʻī, elelo, a mau lehelehe paha; pāheʻe; ʻāʻī puʻupuʻu; a i ʻole paʻakikī i ka hanu ʻana a i ʻole ka ale ʻana
  • hāʻule ʻana i lalo
  • hallucination (ke ʻike nei i nā mea a i ʻole ka lohe ʻana i nā leo i ʻole), ka hana kolohe, ka pīhoihoi, ka manaʻo e like me ke kūʻē ʻana o ka poʻe iā ʻoe, a i ʻole nā ​​manaʻo hoʻokaʻawale ʻole.
  • fiva, nāʻiʻo paʻakikī, hoʻololi i ka hanu a i ʻole ka puʻuwai puʻuwai, a huikau paha
  • ka pōkole o ka hanu, ka puʻuwai wikiwiki, ka ʻeha o ka umauma, a me ka puʻupuʻu
  • kūkulu kūkulu ʻeha ʻole e hele

Ua hāʻawi ʻia kekahi holoholona holoholona keʻena hoʻokolohua i apomorphine ma ke ʻano he injection i hoʻomōhala ʻia i ka maʻi maka. ʻAʻole ʻike ʻia inā hoʻonui ka apomorphine sublingual i ka makaʻu o ka maʻi maka i nā kānaka. E kamaʻilio me kāu kauka e pili ana i nā pilikia o ka hoʻohana ʻana i kēia lāʻau.

Hoʻokumu paha ka sublingual ʻo Apomorphine i nā hopena ʻē aʻe. Kāhea i kāu kauka inā loaʻa iā ʻoe kekahi pilikia maʻamau i ka hoʻohana ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Mālama i nā manawa āpau me kāu kauka.

Mai ʻae i kekahi e hoʻohana i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

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Nānā Hou - 07/15/2020

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