Lorlatinib

Anter

• Ma mua o ka lawe ʻana iā lorlatinib,
• ʻO Lorlatinib paha ke kumu o nā hopena. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

Hoʻohana ʻia ʻo Lorlatinib e mālama i kekahi ʻano maʻi ʻaʻai liʻiliʻi liʻiliʻi liʻiliʻi (NSCLC) i pālahalaha ʻia i nā ʻāpana ʻē aʻe o ke kino a ua ʻoi aku ka maikaʻi ma hope o ka mālama ʻana me nā lāʻau chemotherapy ʻē aʻe. Aia ʻo Lorlatinib i kahi papa o nā lāʻau i kapa ʻia ʻo nā kinase inhibitors. Hana ia ma ke kāpae ʻana i ka hana o ka protein pono ʻole e hōʻailona ai i nā hunaola maʻi ʻaʻai e hoʻonui. Kōkua kēia i mea e hōʻoki a hoʻolohi ai paha i ka hoʻolaha ʻana o nā hunaola maʻi ʻaʻai.

Hele mai ʻo Lorlatinib ma ke ʻano he papa e lawe ma ka waha. Lawe mau ʻia me ka ʻai ʻole a ʻai ʻole hoʻokahi manawa i kēlā me kēia lā. Lawe iā lorlatinib ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono iā lorlatinib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

Inā luaʻi ʻoe ma hope o ka lawe ʻana i ka lāʻau, mai lawe i kahi lāʻau ʻē aʻe. E hoʻomau i kāu papa hana maʻamau.

E ale i nā papa holoʻokoʻa; mai hoʻokaʻawale, a nau aku, a hoka ʻole iā lākou. Mai lawe i nā papa i naha a nahae paha.

Hiki i kāu kauka ke hoʻēmi i kāu lāʻau a i ʻole no ka manawa kūloko a paʻa mau paha i kāu mālama ʻana inā e ʻike ʻoe i nā hopena ʻaoʻao. E haʻi pono i kāu kauka i kou ʻano i kou wā e mālama ai me lorlatinib.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana iā lorlatinib,

• e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka lorlatinib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā papa lorlatinib. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• E haʻi i kāu kauka inā lawe ʻoe i ka carbamazepine (Epitol, Equetro, Carbatrol, Tegretol, Teril), efavirenz (Sustiva, ma Atripla), nevirapine (Viramune), phenobarbital, phenytoin (Dilantin, Phenytek), pioglitazone (Actos, in Actoplus ), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, ma Rifamate, Rifater), a i ʻole ʻo John John wort. E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe i ka lorlatinib inā ʻoe e lawe i hoʻokahi a ʻoi paha o kēia mau lāʻau.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E ʻike pono i kekahi o kēia mau mea: alprazolam (Xanax); nā poloka kalipuna e like me amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac), felodipine (Plendil), nifedipine (Adalat, Procardia), nisoldipine (Sular), a me verapamil (Calan, Covera); kekahi mau lāʻau e mālama ai i ke kiʻekiʻe o ke kolako e like me atorvastatin (Lipitor) a me lovastatin (Mevacor); clarithromycin (Biaxin, i Prevpac); cyclosporine (Gengraf, Neoral, Sandimmune); diazepam (Valium); erythromycin (E.E.S, Erytab, Eryped); kekahi mau lāʻau e mālama ai iā HIV me atazanavir (Reyataz, ma Evotaz), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, ma Kaletra, ma Technivie), a i ʻole saquinavir (Invirase); itraconazole (Onmel, Sporanox); ketoconazole; midazolam; nefazodone; nā pale pale waha (nā pā kaohi hānau); quinidine (i Nuedexta); sildenafil (Revatio, Viagra); sirolimus (Rapamune); tacrolimus (Prograf); tadalafil (Adcirca, Cialis); trazodone; triazolam (Halcion); aiʻole vardenafil (Levitra, Staxyn). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Hiki paha i nā lāʻau ʻē aʻe ke launa pū me lorlatinib, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole loaʻa paha i kahi puʻuwai kīnā ʻole, kaumaha, hopu ʻana, nā kiʻekiʻe o ke kolesterol a me nā mea momona ʻē aʻe i loko o ke koko, a i ʻole ka maʻi lolo.
• e haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole hoʻolālā i ka makua kāne o kahi keiki. Hiki iā Lorlatinib ke keʻakeʻa i ka hana o nā kaola pale hormonal (nā lāʻau kaohi hānau, nā pāhoʻi, nā apo, nā implants, a i ʻole nā ​​injection), no laila ʻaʻole pono ʻoe e hoʻohana i kēia mau mea ma ke ʻano he ʻano hana wale no kou kaohi hānau i kāu wā e mālama ai. Pono ʻoe e hoʻohana i kahi kaohi hānau ʻole hormonal e like me ke ʻano pale (kahi mea e ālai i ka sperm mai ke komo ʻana i ka pūpū e like me ka condom a i ʻole diaphragm) E noi i kāu kauka e kōkua iā ʻoe e koho i kahi hana o ka kaohi hānau e holo pono nāu. Inā he wahine ʻoe, pono ʻoe e lawe i kahi hōʻike hāpai ma mua o kou hoʻomaka ʻana i ka lāʻau lapaʻau a pono e hoʻohana i ka kaohi hānau ʻole hormonal e pale ai i ka hāpai ʻana i kāu wā lapaʻau a no 6 mau mahina ma hope o kāu hopena hope loa. Inā he kāne ʻoe, pono ʻoe a me kāu pakanā wahine e hoʻohana i ka kaohi hānau ma kāu wā e mālama ai a no 3 mau mahina ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā ʻano hana hānau hiki iā ʻoe ke hoʻohana i kāu wā o kāu mālama ʻana. Inā hāpai ʻoe a ʻo kāu hoa paha i ka lawe ʻana iā lorlatinib, e kāhea koke i kāu kauka. Hiki iā Lorlatinib ke hōʻeha i ka fetus.
• e haʻi i kāu kauka inā ʻoe e hānai umauma ana. ʻAʻole pono ʻoe e hānai i ka umauma ʻoiai ʻoe e lawe nei iā lorlatinib a no 7 mau lā ma hope o kāu hopena hope loa.
• pono ʻoe e ʻike he hiki i kēia lāʻau ke hōʻemi i ka momona i nā kāne. E kamaʻilio me kāu kauka e pili ana i nā pilikia o ka lawe ʻana iā lorlatinib.

E kamaʻilio me kāu kauka e pili ana i ka ʻai ʻana i ka huaʻōlau a me ka inu ʻana i ka wai momona a ke lawe nei ʻoe i kēia lāʻau.

E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia nō naʻe, inā aia ma loko o 4 mau hola o ka mahele hope aʻe, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

ʻO Lorlatinib paha ke kumu o nā hopena. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• loaʻa kaupaona
• Muscle, ami, a ʻeha hoʻi
• pāhoehoe
• kōpaʻa
• nausea
• ka luaʻi
• luhi
• ʻeha poʻo
• loli ka hihiʻo
• ʻākeʻakeʻa a ʻili ranei

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• pehu i kou mau lima, nā wāwae, nā lima a me nā wāwae
• paʻakikī i ka hanu ʻana
• ka hanu, kahe, a me ke kuni
• numbness a me ke kani i kou mau hono a i ʻole nā ​​lima a me nā wāwae
• paʻakikī i ka noʻonoʻo a huikau paha
• ka hopu ʻana
• ke ʻike nei i nā mea a i ʻole ka lohe ʻana i nā leo i ʻole
• loli i ke ʻano, ke kaumaha a hopohopo paha
• nā pilikia me ka ʻōlelo
• paʻakikī e hiamoe a hiamoe paha
• mau moeʻuhane ʻole a i ʻole nā ​​moemoeā pō ʻole
• ʻino, puʻuwai, a i ʻole puʻuwai puʻuwai ʻole

ʻO Lorlatinib paha ke kumu o nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua lab a me kahi electrocardiogram (ECG; hōʻike e ana i ka hana uila i ka puʻuwai) ma mua a i kāu wā e mālama ai e nānā i ka pane o kou kino iā lorlatinib

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

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