Mea Kākau: Gregory Harris
Lā O Ka Hana: 15 Apelila 2021
HōʻAno Hou I Ka Lā: 17 Nowemapa 2024
Anonim
Tafenoquine: Malaria Drug Development
Wikiō: Tafenoquine: Malaria Drug Development

Anter

Hoʻohana ʻia ʻo Tafenoquine (Krintafel) i mea e pale aku ai i ka hoʻi ʻana o ka malaria (kahi maʻi nui i pāhola ʻia e nā makika i kekahi mau wahi o ka honua a hiki i ka make) i nā kānaka he 16 a ʻoi paha makahiki i loaʻa i nā maʻi a ke loaʻa nei iā chloroquine a i ʻole hydroxychloroquine e mālama malaria. Hoʻohana wale ʻia ʻo Tafenoquine (Arakoda) i mea e pale aku ai i ka malaria i ka poʻe huakaʻi e kipa aku i nā wahi i maʻa mau ka malaria. ʻO Tafenoquine kahi papa o nā lāʻau i kapa ʻia nā antimalarials. Hana ia ma ka luku ʻana i nā meaola i kumu i ka malaria.

Hele mai ʻo Tafenoquine ma ke ʻano he papa e lawe ma ka waha me ka meaʻai. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pololei i ka tafenoquine e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

Inā lawe ʻoe i tafenoquine (Krintafel) e pale i ka hoʻi ʻana o ka malaria, lawe pinepine ʻia ia ma ke ʻano he hoʻokahi mahele lāʻau (2 papa) i ka lā mua a ʻelua paha o kāu lapaʻau me chloroquine a i ʻole hydroxychloroquine.


Inā ʻoe e lawe i tafenoquine (Arakoda) no ka pale ʻana i ka malaria, lawe ʻia hoʻokahi mahele (2 papa) hoʻokahi manawa i kēlā me kēia lā no 3 mau lā, e hoʻomaka ana i 3 mau lā ma mua o ka huakaʻi ʻana i kahi i loaʻa ka malaria. ʻOiai ʻoe ma ia wahi, lawe ʻia hoʻokahi mahele lāʻau (2 papa) i hoʻokahi manawa i ka pule ma ka lā like o ka pule. Ma hope o kou hoʻi ʻana mai kahi mai, lawe mau ʻia hoʻokahi mahele lāʻau (2 papa) 7 mau lā ma hope o ka hopena hope loa i lawe ʻia ma mua o kou hoʻi ʻana. ʻAʻole pono ʻoe e lawe i tafenoquine (Arakoda) no ka pale ʻana i ka malaria ma mua o 6 mau mahina.

E ale i nā papa holoʻokoʻa; mai hoʻokaʻawale, a nau aku, a hoka ʻole iā lākou.

Inā luaʻi ʻoe i loko o hoʻokahi hola ma hope o ka lawe ʻana i tafenoquine (Krintafel), e kāhea i kāu kauka. Pono paha ʻoe e lawe i kahi lāʻau ʻē aʻe o kēia lāʻau.

Lawe i ka tafenoquine a hiki i kou hoʻopau ʻana i ke kuhikuhi, ʻoiai inā ʻoi aku kou maikaʻi. Inā kū ʻoe i ka lawe ʻana i ka tafenoquine ma mua koke a lele paha i nā lāʻau, ʻaʻole e mālama pono ʻia kāu maʻi a i ʻole ʻaʻole pale ʻia ʻoe mai nā maʻi o ka wā e hiki mai ana.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi inā ʻoe e lawe iā Tafenoquine (Krintafel). Inā ʻoe e lawe i tafenoquine (Arakoda), e hāʻawi aku kāu kauka a mea kauka paha iā ʻoe i ka palapala ʻike hoʻomanawanui o ka mea hana (Ke alakaʻi lāʻau) ke hoʻomaka ʻoe i ka lāʻau lapaʻau a i kēlā me kēia manawa e hoʻopiha hou i kāu kuhikuhi. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) e kiʻi i ke alakaʻi Medication.


Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i tafenoquine,

  • e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka tafenoquine, primaquine, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i loko o nā papa tafenoquine.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E mālama pono i kekahi o kēia mau mea: dofetilide (Tikosyn) a me metformin (Fortamet, Glucophage, Riomet, ma Actoplus Met, a me nā mea ʻē aʻe). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
  • e haʻi i kāu kauka inā loaʻa ka glucose-6-phosphate dehydrogenase (G-6-PD) hemahema (kahi maʻi koko hoʻoilina). E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe i tafenoquine. E haʻi pū aku i kāu kauka inā loaʻa a loaʻa paha iā ʻoe kekahi pilikia olakino noʻonoʻo. E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe i tafenoquine.
  • e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole he hemolytic anemia (kahi ʻano me ka helu haʻahaʻa o nā ʻulaʻula o ke koko), methemoglobinemia (kahi ʻano me nā hunaola ʻulaʻula hema i hiki ʻole ke hāpai i ka oxygen i nā aʻa i loko o ke kino), nicotinamide adenine dinucleotide (NADH) hemahema (kahi ʻano kūlohelohe), a i ʻole nā ​​maʻi puʻupaʻa a i ʻole ate.
  • e haʻi i kāu kauka inā hāpai ʻoe a i ʻole hoʻolālā e hāpai. Inā he wahine ʻoe o ka hānau keiki ʻana, pono ʻoe e lawe i kahi hōʻike hāpai keiki ma mua o ka hoʻomaka ʻana i ka lāʻau. Pono ʻoe e hoʻohana i ka kaohi hānau e pale ai i ka hāpai ʻana i kāu mālama ʻana me tafenoquine a no 3 mau mahina ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā ʻano hana o ka kaohi hānau e holo pono nāu. Inā hāpai ʻoe i ka lawe ʻana i tafenoquine, e kāhea koke i kāu kauka. Hiki paha i ka Tafenoquine ke hoʻopōʻino i ka fetus.
  • e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū a i ʻole hoʻolālā e hānai.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.


Kāhea i kāu kauka a kauka paha e nīnau i ka mea e hana ai inā e ʻike ʻoe i kahi mahele o tafenoquine (Arakoda).

Hiki i nā Tafenoquine ke hopena i nā hopena. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • nausea
  • ka luaʻi
  • pāhoehoe
  • paʻakikī e hiamoe a hiamoe paha
  • hopohopo
  • loli i ke ʻano
  • moeʻuhane ʻano ʻole
  • ʻeha poʻo
  • nā pilikia ʻike, me ka ʻike maka a i ʻole ka ʻike i ka malamalama

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

  • hūwī
  • hives
  • pehu o nā maka, maka, lehelehe, alelo, waha, a ʻāʻī paha
  • pilikia i ka hanu ʻana a i ʻole ke ale ʻana
  • pokole o ka hanu
  • ʻālohilohi a paʻa paha i ka ʻāʻī
  • mimi kala ʻeleʻele
  • ʻeleʻele-bluish kala o nā lehelehe a me / a i ʻole ʻili
  • ʻūpā
  • huikau
  • hallucination (ke ʻike nei i nā mea a i ʻole ka lohe ʻana i nā leo i ʻole ola)
  • kuhi hewa (he mau manaʻo ʻano ʻē a kumu paha i kumu ʻole i ka ʻoiaʻiʻo) e like me nā manaʻo e hoʻāʻo nei ka poʻe e hōʻino iā ʻoe inā ʻaʻole lākou
  • ʻālohilohi
  • melemele o ka ʻili a me nā maka

Hoʻokumu paha ʻo Tafenoquine i nā hopena ʻē aʻe.Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha paha kāu kauka i kekahi mau hoʻokolohua lab e nānā i ka pane o kou kino i ka tafenoquine.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

  • Arakoda®
  • Krintafel®
Nānā Hou - 02/15/2021

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