Neratinib

Anter

• Ma mua o ka lawe neratinib,
• Hoʻokumu paha ʻo Neratinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻĀLU MAKAHIKI kūikawā, e kāhea koke i kāu kauka:
• Hiki i nā ʻōuli o ka overdose ke hoʻopili i kēia mau mea:

Hoʻohana ʻia ʻo Neratinib e mālama i kekahi ʻano o ke kanulau maʻi maʻi maʻi maikaʻi (ka maʻi ʻaʻai umauma e pili ana i nā homone e like me ka ulu ʻana o ka estrogen) i nā mākua ma hope o ka mālama ʻana me trastuzumab (Herceptin) a me nā lāʻau ʻē aʻe. Hoʻohana ʻia ʻo Neratinib me capecitabine (Xeloda) e mālama ai i kekahi ʻano o ka loaʻa ʻana o ka hormone holomua-ʻo ka maʻi ʻaʻai umauma maikaʻi a i ʻole ka maʻi ʻaʻai umauma i pāhola ʻia i nā ʻāpana ʻē aʻe o ke kino ma hope o ka lapaʻau ʻana me ʻelua mau lāʻau ʻē aʻe. Aia ʻo Neratinib i ka papa o nā lāʻau i kapa ʻia nā kinase inhibitors. Hana ia ma ke kāpae ʻana i ka hana o kahi protein pono ʻole e hōʻailona ai i nā hunaola maʻi ʻaʻai e hoʻonui. Kōkua kēia i ka hoʻolohi a hoʻopau paha i ka hoʻolaha ʻana o nā hunaola maʻi ʻaʻai.

Hele mai ʻo Neratinib ma ke ʻano he papa e lawe ma ka waha. Ke lawe hoʻokahi ʻia ʻo neratinib e mālama i ka maʻi ʻaʻai o ka umauma, lawe mau ʻia me ka meaʻai hoʻokahi i kēlā me kēia lā no hoʻokahi makahiki. Ke lawe ʻia ʻo neratinib me capecitabine e mālama ai i ka maʻi ʻaʻai umauma holomua a i ʻole ka maʻi ʻaʻai umauma i pāhola ʻia i nā ʻāpana ʻē aʻe o ke kino, lawe pinepine ʻia ia i kēlā me kēia lā me ka meaʻai i nā lā 1 a 21 o kahi pōʻaiapuni 21 lā a hiki i kou wā e ʻino ai a ulu paha ʻoe nā hopena koʻikoʻi. Lawe i ka neratinib ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono i ka neratinib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā papa holoʻokoʻa; mai hoʻokaʻawale, a nau aku, a hoka ʻole iā lākou.

Hiki i kāu kauka ke hōʻemi i kāu lāʻau a i ʻole no ka manawa kūloko a paʻa mau paha i kāu mālama ʻana iā neratinib i kāu mālama ʻana. Aia kēia i ka maikaʻi o ka hana ʻana o ka lāʻau iā ʻoe a me nā hopena ʻē aʻe āu e ʻike ai. E kamaʻilio me kāu kauka e pili ana i kou ʻano i kāu mālama ʻana. E hoʻomau i ka lawe neratinib ʻoiai ʻoe e ʻoluʻolu. Mai hōʻoki i ka lawe ʻana i neratinib me ke kamaʻilio ʻole ʻana me kāu kauka.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe neratinib,

• e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka neratinib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā papa neratinib. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E kuhikuhi pono i kekahi o kēia mau mea: kekahi antibiotic me ka ciprofloxacin (Cipro), clarithromycin (Biaxin, ma Prevpac), erythromycin (E.E.S., E-Mycin, Erythrocin), a me troleandomycin (ʻaʻole i loaʻa i U.S.). kekahi mau antifungals me ka clotrimazole (Mycelex), fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), a me voriconazole (Vfend); aprepitant (Emend); bosentan (Tracleer); kekahi mau poloka alalai kalipika e like me diltiazem (Cardizem, Tiazac, kekahi) a me verapamil (Calan, Verelan, a me nā mea ʻē aʻe); cobicistat (Tybost); konivaptan (Vaprisol); crizotinib (Xalkori); cyclosporine (Gengraf, Neoral, Sandimmune); dabigatran (Pradaxa); digoxin (Lanoxin); dronedarone (Multaq); enzalutamide (Xtandi); fexofenadine (Allegra); fluvoxamine (Luvox); idelalisib (Zydelig); imatinib (Gleevec); kekahi mau lāʻau no ka hepatitis C me ka boceprevir (ʻaʻole loaʻa hou ma U.S., Victrelis), dasabuvir (i Viekira Pak), ombitasvir (i Technivie, ma Viekira XR), a me paritaprevir (i Technivie, i Viekira XR); kekahi mau lāʻau no ka maʻi pale maʻi (HIV) a i ʻole loaʻa i ka maʻi maʻi maʻi maʻi (AIDS) me efavirenz (Sustiva, i Atripla), elvitegravir (i Genvoya, i Stribild), etravirine (Intelence), indinavir (Crixivan), lopinavir (i Kaletra), nelfinavir (Viracept), ritonavir (Norvir, ma Kaletra), saquinavir (Invirase), a me tipranavir (Aptivus); mitotane (Lysodren); modafinil (Provigil); nefazodone; nā mea pale proton e like me esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), a me rabeprazole (AcipHex); rifampin (Rifadin, Rimactane, ma Rifater); a me kekahi mau lāʻau no ka hopu ʻana me ka carbamazepine (Carbatrol, Epitol, Tegretol) a me phenytoin (Dilantin, Phenytek). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Nui paha nā lāʻau ʻē aʻe e launa pū me neratinib, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• inā ʻoe e lawe i kahi antacid, lawe ma ka liʻiliʻi he 3 mau hola ma mua a i ʻole 3 mau hola ma hope o ka lawe ʻana i neratinib.
• inā ʻoe e lawe nei i ka neratinib a me kahi lāʻau no ka palaka ʻole ʻana, ka puʻuwai puʻuwai, a i ʻole nā ​​maʻi puʻupuʻu (kahi H₂ blocker) e like me ka cimetidine, famotidine (Pepcid, ma Duexis), nizatidine (Axid), a i ʻole ranitidine (Zantac), e lawe i ka neratinib ma kahi o 2 mau hola ma mua a i ʻole 10 mau hola ma hope o ka lawe ʻana i ka H₂ poloka.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St.
• e haʻi i kāu kauka inā loaʻa a loaʻa paha ʻoe i ka maʻi ate.
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a inā ʻoe e hoʻolālā i ka hānau keiki ʻana. ʻAʻole pono ʻoe e hāpai i ka wā e lawe ana ʻoe i neratinib. Inā he wahine ʻoe, pono ʻoe e lawe i kahi hōʻike hāpai ma mua o kou hoʻomaka ʻana i ka lāʻau lapaʻau a pono e hoʻohana i ka kaohi hānau e pale ai i ka hāpai ʻana i ka wā o kāu mālama ʻana me neratinib a no ka liʻiliʻi o 1 mau mahina ma hope o ka lawe ʻana i ka hopena hope loa. Inā he kāne ʻoe, pono ʻoe a me kāu hoa wahine e hoʻohana i ka kaohi hānau i ka wā o kāu mālama ʻana me neratinib a hoʻomau no 3 mau mahina ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā ʻano hana hānau hiki iā ʻoe ke hoʻohana i kāu wā o kāu mālama ʻana. Inā hāpai ʻoe i ka lawe ʻana i neratinib, e kāhea koke i kāu kauka. Hoʻopilikia paha ʻo Neratinib i ka fetus.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū a i ʻole hoʻolālā e hānai. ʻAʻole pono ʻoe e hānai i ka wā e lawe ana i ka neratinib a no 1 mahina ma hope o kāu hopena hope loa.
• pono ʻoe e ʻike ʻo ka neratinib ke kumu pinepine o ka maʻi diarrhea, a hiki ke koʻikoʻi. E haʻi paha kāu kauka iā ʻoe e lawe i ka loperamide (Imodium AD), kahi lāʻau anti-diarrhea, e pale ai i ka make wai (ka nalowale o ka wai he nui mai kou kino) no nā lā 56 mua o kāu mālama ʻana me neratinib. Ma hope o 56 mau lā o ka mālama ʻana, e hoʻoponopono kāu kauka i kāu mahele lāʻau loperamide i loaʻa iā ʻoe he 1 a 2 mau ʻōpū i kēlā me kēia lā ke lawe nei i neratinib. E haʻi aku paha kāu kauka iā ʻoe e inu i nā wai he nui, e hoʻololi i kāu papaʻai, a i ʻole lawe i nā lāʻau ʻē aʻe e kāohi i ka palahī. Kāhea koke i kāu kauka inā loaʻa ʻoe i ka maʻi nui loa (ʻoi aku ma mua o 2 neʻe o ka ʻōpū i 1 lā a i ʻole diarrhea e kū ʻole) a i ʻole diarrhea me ka nāwaliwali, dizziness, a i ʻole ke kuni ke lawe ʻoe i neratinib. Kāhea koke i kāu kauka inā ʻike ʻoe i kekahi o nā ʻōuli ma hope o ka make wai: make wai loa, waha maloʻo a me / a i ʻole ʻili, hoʻemi i ka urination, a me ka puʻuwai wikiwiki.

Mai ʻai i ka hua waina a i ʻole inu i ka wai huaʻulu i ka wā e lawe ana i kēia lāʻau.

E haʻalele i ka lāʻau i haʻalele ʻia a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu paha ʻo Neratinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• pāhoehoe
• ʻeha ka ʻōpū
• puʻuwai puʻuwai
• ʻōhūhū
• ulcer waha
• nalo ʻai ʻole
• Kaumaha emi
• kahe ʻana ka ihu
• nā pilikia kui a i ʻole nā ​​loli
• ʻūpē mākala

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻĀLU MAKAHIKI kūikawā, e kāhea koke i kāu kauka:

• melemele nā ​​maka a me ka ʻili
• mimi ʻeleʻele
• ʻeha a hōʻoluʻolu ʻole paha ma ka ʻaoʻao ʻōpū o luna pono
• luhi
• nausea
• ka luaʻi
• hūwī
• fiva, paʻakikī i ka mimi, ʻeha ke hele i ka mimi, a me nā ʻōuli ʻē aʻe o ka maʻi

Hoʻokumu paha ʻo Neratinib i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Hiki i nā ʻōuli o ka overdose ke hoʻopili i kēia mau mea:

• pāhoehoe
• nausea
• ka luaʻi
• ʻeha ka ʻōpū

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua lab e nānā i ka pane o kou kino i ka neratinib.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Nerlynx^®