Mea Kākau: Marcus Baldwin
Lā O Ka Hana: 15 Iune 2021
HōʻAno Hou I Ka Lā: 1 Kekemapa 2024
Anonim
Ocrelizumab: What to Know About the First Agent Approved for Primary Progressive MS
Wikiō: Ocrelizumab: What to Know About the First Agent Approved for Primary Progressive MS

Anter

Hoʻohana ʻia ka hoʻopili ʻana o Ocrelizumab e mālama i nā mākua me nā ʻano like ʻole o ka sclerosis maha (MS; kahi maʻi kahi e holo pono ʻole ai nā ʻalalā a ʻike paha ka poʻe i ka nāwaliwali, numbness, nalo ʻana o ka hoʻohui ʻana o nā mākala, a me nā pilikia me ka hihiʻo, ka ʻōlelo, a me ka mālama ʻana i ka maʻi ʻaʻa) me:

  • ke ʻano mua-holomua (nā ʻōuli e hele a hewa i ka manawa) o MS,
  • maʻi hoʻokaʻawale clinically (CIS; nā ʻōuli ʻōuli nerve e kū ma ka liʻiliʻi he 24 mau hola),
  • relapsing-remitting forms (papa o ka maʻi kahi e ʻō ai nā ʻōuli mai kēlā me kēia manawa), a i ʻole
  • nā papa holomua holomua (papa o ka maʻi kahi e hoʻi pinepine ai ka hoʻi ʻana).

ʻO Ocrelizumab i kahi papa o nā lāʻau i kapa ʻia he monoclonal antibodies. Hana ia ma ke kāohi ʻana i kekahi mau pūnaewele o ka ʻōnaehana pale maʻi mai ke kumu o ka hōʻino ʻana.

ʻO ke kūpikipiki ʻo Ocrelizumab ma ke ʻano he hopena (wai) e injected intravenously (i kahi aa) e ke kauka a kahu hānai paha. Hāʻawi pinepine ʻia hoʻokahi manawa i kēlā me kēia 2 mau pule no nā mahele mua ʻelua (ma ka pule 0 a me ka pule 2), a laila hāʻawi ʻia nā infusions i kēlā me kēia 6 mahina.


Hoʻokumu paha ka pahu o Ocrelizumab i nā hopena koʻikoʻi i ka wā o ka infusion a hiki i kahi lā ma hope o ka loaʻa ʻana o ka infusion. Hāʻawi ʻia ʻoe i nā lāʻau ʻē aʻe e mālama a kōkua i ka pale ʻana i nā hopena i ka ocrelizumab. E nānā pono kahi kauka a kahu hānai paha iā ʻoe ke loaʻa nei ka infusion a no ka liʻiliʻi he 1 mau hola ma hope e hāʻawi i ka lāʻau i ke ʻano o nā hopena ʻē aʻe i ka lāʻau. Kāohi paha kāu kauka i kahi manawa a kūloko paha i kāu lāʻau lapaʻau a hoʻēmi paha i ka lāʻau, inā ʻike ʻoe i kekahi mau hopena ʻaoʻao. E haʻi i kāu kauka a kahu hānai paha inā ʻike ʻoe i kekahi o kēia mau mea i loko a i ʻole ma waena o 24 mau hola ma hope o kou hoʻokomo ʻia ʻana: ʻeleʻele; ʻumeʻume; hives; ʻulaʻula ma ke kahua o ka pahu kui; pilikia i ka hanu ʻana a i ʻole ke ale ʻana; uā; ʻūhā; ʻehu; nawaliwali ka manaʻo; huhū o ka puʻu; ʻeha ka waha a ʻeha paha; pokole o ka hanu; pehu o ka maka, maka, waha, ʻāʻī, elelo, a i ʻole mau lehelehe; pāheʻe; kuni; luhi; luhi; ʻeha poʻo; ʻūpā; nausea; aiʻole kahi puʻuwai puʻuwai. Kāhea koke i kāu kauka a i ʻole e kiʻi koke i ka lāʻau olakino pilikia inā ʻike ʻoe i kekahi o kēia mau ʻōuli ma hope o kou haʻalele ʻana i ke keʻena o kāu kauka a i ʻole kahi keʻena olakino.


Hiki paha i ka Ocrelizumab ke kōkua i ka mālama ʻana i nā hōʻailona sclerosis he nui akā ʻaʻole ia e hoʻōla iā lākou.E nānā pono kāu kauka iā ʻoe e ʻike i ka maikaʻi o ka hana a ka ocrelizumab iā ʻoe. He mea nui e haʻi i kāu kauka i kou ʻano i kou wā e mālama ai.

E hāʻawi aku kāu kauka a kauka paha iā ʻoe i ka palapala ʻikepili a ka mea hana (Kauka Lapaʻau) ke hoʻomaka ʻoe i ka lāʻau me ka injection ocrelizumab a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Ka ʻAina a me nā lāʻau lapaʻau (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm)or a i ʻole ka pūnaewele o ka mea hana e kiʻi i ke alakaʻi Medication.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka loaʻa ʻana o ka ocrelizumab injection,

  • e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka ocrelizumab, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i ka ocrelizumab injection. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E hoʻomaopopo pono i nā lāʻau e kāohi i kāu ʻōnaehana pale e like me kēia: corticosteroids me dexamethasone, methylprednisolone (Medrol), a me prednisone (Rayos); cyclosporine (Gengraf, Neoral, Sandimmune); daclizumab (Zinbryta); fingolimod (Gilenya); mitoxantrone; natalizumab (Tysabri); tacrolimus (Astagraf, Prograf); a i ʻole teriflunomide (Aubagio). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
  • e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole he hepatitis B (HBV; kahi maʻi ʻino e hoʻopili i ke akepaʻa a e hōʻeha paha i ka ate a i ʻole ke kanesa ate). E haʻi paha kāu kauka iā ʻoe ʻaʻole e loaʻa ka ocrelizumab.
  • e haʻi i kāu kauka inā loaʻa kekahi ʻano maʻi iā ʻoe ma mua o kou hoʻomaka ʻana i kāu lāʻau me ka injection ocrelizumab.
  • E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. E hoʻohana i ka kaohi hānau kūpono i kāu mālama ʻana me ka ocrelizumab a no 6 mau mahina ma hope o ka hopena hope loa. Inā hāpai ʻoe i ka loaʻa ʻana iā ocrelizumab, kāhea i kāu kauka. Inā loaʻa ʻoe i ka ocrelizumab injection i kou wā hāpai, e kamaʻilio pono me ke kauka o kāu pēpē e pili ana i kēia ma hope o ka hānau ʻana o kāu pēpē. Pono paha e hoʻopaneʻe kāu pēpē i ka loaʻa ʻana o kekahi lāʻau āpau iā ʻoe.
  • e haʻi i kāu kauka inā loaʻa iā ʻoe kahi lāʻau lapaʻau hou a i ʻole hoʻonohonoho ʻia e loaʻa nā lāʻau āpau. Pono ʻoe e loaʻa i kekahi ʻano o nā lāʻau āpau ma ka liʻiliʻi he 4 mau pule ma mua a ʻo nā mea ʻē aʻe ma ka liʻiliʻi he 2 mau pule ma mua o kou hoʻomaka ʻana i ka lāʻau me ka ʻoki ocrelizumab. ʻAʻohe o nā lāʻau āpau me ke kamaʻilio ʻole ʻana me kāu kauka i kou wā e mālama ai.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.


Inā haʻalele ʻoe i kahi manawa e loaʻa ai kahi ocrelizumab, kāhea koke i kāu kauka e hoʻonohonoho hou i kāu manawa i koho ai.

Hiki i ka Ocrelizumab ke hana i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • pehu a ʻeha paha ma nā lima, nā lima, nā wāwae, a me nā wāwae
  • pāhoehoe

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻaoʻao HOW, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

  • ke kuni, ke anu, ka ʻū mau, a i ʻole nā ​​hōʻailona ʻē aʻe o ka maʻi
  • ʻeha nā waha
  • shingles (kahi hū e hiki ke hana i ka poʻe i loaʻa i ka paukū i ka wā i hala)
  • ʻo nā ʻeha a puni ka genital a i ʻole ka polū
  • maʻi maʻi ʻili
  • nāwaliwali ma kekahi ʻaoʻao o ke kino; clumsiness o nā lima a me nā wāwae; loli ka hihiʻo; nā hoʻololi i ka noʻonoʻo, ka hoʻomanaʻo, a me ka hoʻonohonoho ʻana; huikau; a i ʻole hoʻololi i ke ʻano

Hiki i ka Ocrelizumab ke hoʻonui i kou makaʻi i kekahi mau maʻi ʻaʻai, me ka maʻi ʻaʻai umauma. E kamaʻilio me kāu kauka e pili ana i ka makaʻu o ka loaʻa ʻana o kēia lāʻau.

Hoʻokumu paha ʻo Ocrelizumab i nā hopena ʻē aʻe. Kāhea i kāu kauka inā loaʻa iā ʻoe kekahi pilikia maʻamau i ka loaʻa ʻana o kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua lab a ma mua a i kou wā e mālama ai e nānā i ka pane o kou kino i ka ocrelizumab injection.

E noi i kāu kauka lāʻau i nā nīnau āu e pili ana i ka ocrelizumab injection.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

  • ʻO Ocrevus®
Nānā Hou - 07/24/2019

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