Mea Kākau: Gregory Harris
Lā O Ka Hana: 7 Apelila 2021
HōʻAno Hou I Ka Lā: 19 Nowemapa 2024
Anonim
Gout - Urate/uric acid Renal Transport - Lesinurad and Probenecid
Wikiō: Gout - Urate/uric acid Renal Transport - Lesinurad and Probenecid

Anter

Hiki i nā Lesinurad ke hana i nā pilikia koʻikoʻi koʻikoʻi. E haʻi i kāu kauka inā mālama ʻia ʻoe me ka dialysis (lapaʻau e hoʻomaʻemaʻe i ke koko ke holo maikaʻi ʻole nā ​​puʻupaʻa), ua loaʻa i kahi transplan kidney, a i ʻole loaʻa paha iā ʻoe i kahi maʻi pākī. ʻOi aku ka makaʻu āu e hoʻomohala ai i nā pilikia koʻikoʻi koʻikoʻi inā ʻoe e lawe nei i ka lesinurad wale nō. Pono e lawe pū ʻia ʻo Lesinurad me kahi mea kāohi xanthine oxidase e like me allopurinol (Lopurin, Zyloprim) a i ʻole febuxostat (Uloric). Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke aku i kāu kauka: nausea, luaʻi, a i ʻole ʻeha o ka ʻōpū ʻākau i luna.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha paha kāu kauka i kekahi mau hoʻokolohua ma mua a i ka wā o ka mālama ʻana e nānā ai i ka pane o kou kino i ka lesinurad.

E hāʻawi aku kāu kauka a kauka paha iā ʻoe i ka pepa ʻikepili a ka mea hana (Kauka Lapaʻau) ke hoʻomaka ʻoe i ka lāʻau me lesinurad a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) e kiʻi i ke alakaʻi Medication.


Hoʻohana ʻia ʻo Lesinurad me kahi mea hōʻoki xanthine oxidase e mālama i ka hyperuricemia (nā pae kiʻekiʻe o ka uric acid) i ka poʻe me ka gout (hoʻouka koke ʻia o ka ʻulaʻula, ka pehu ʻana, ka ʻeha, a me ka wela i hoʻokahi a ʻoi paha o nā hono) nona ka maʻi i kāohi ʻole ʻia me kā lākou i kēia manawa lāʻau lapaʻau. Aia ʻo Lesinurad i kahi papa o nā lāʻau i kapa ʻia nā mea kūpale uric acid reabsorption. Hana ia ma ke kōkua ʻana i nā puʻupaʻa e hemo i ka uric acid mai ke kino.

Hele mai ʻo Lesinurad ma ke ʻano he papa e lawe ma ka waha. Lawe ʻia ia i hoʻokahi manawa i kēlā me kēia lā i ke kakahiaka me ka meaʻai a me ka wai. Lawe i ka lesinurad ma kahi o ka manawa like i kēlā me kēia lā a i ka manawa like āu e lawe ai i kahi mea pale xanthine oxidase e like me allopurinol (Lopurin, Zyloprim) a i ʻole febuxostat (Uloric). E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono i lesinurad e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

Mālama ʻo Lesinurad i ka hyperuricemia i ka poʻe me ka gout akā ʻaʻole ia e hoʻōla iā ia. Pīpī paha kāu gout (ʻehaʻeha, ʻeha pū kekahi) ke hoʻomaka mua ʻoe e lawe i ka lesinurad, akā mai hoʻōki i ka lawe ʻana iā ia. E hāʻawi aku kāu kauka iā ʻoe i nā lāʻau ʻē aʻe e kōkua i ka pale ʻana i ka lapalapa gout. E hoʻomau i ka lawe ʻana i ka lesinurad ʻoiai inā maikaʻi ʻoe a i ʻole he hōʻeha gout. Mai hōʻoki i ka lawe ʻana i ka lesinurad me ke kamaʻilio ʻole ʻana me kāu kauka.


Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i lesinurad,

  • e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka lesinurad, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i loko o nā papa lesinurad. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E hoʻomaopopo pono e ʻōlelo i kekahi o kēia mau mea: amiodarone (Cordarone, Nexterone, Pacerone), amlodipine (Norvasc), aspirin, carbamazepine (Epitol, Equetro, Teril, a me nā mea ʻē aʻe), fluconazole (Diflucan), rifampin (Rifadin, Rimactane, ma Rifamate, i Rifater), sildenafil (Revatio, Viagra), a i ʻole valproic acid (Depakene). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Pili pū paha nā lāʻau ʻē aʻe he nui me lesinurad, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
  • e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole loaʻa i kekahi o nā ʻano i ʻōlelo ʻia i ka ʻARlelo Aʻo IMPORTANT, ka maʻi maʻi lysis (kahi maʻi e wāwahi koke ai nā hunaola maʻi a hoʻokuʻu i nā huahana i loko o ke koko), a i ʻole Lesch-Nyhan Syndrome (kahi hoʻoili maʻi i kumu nā kiʻekiʻe o ka uricʻakika i loko o ke koko). E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe i ka lesinurad.
  • e haʻi i kāu kauka inā ua loaʻa ʻoe i kahi maʻi hahau, kahi puʻuwai puʻuwai, ke koko kiʻekiʻe, nā maʻi puʻuwai, nā kolesterol kiʻekiʻe, a i ʻole nā ​​maʻi ate.
  • e haʻi i kāu kauka inā hāpai ʻoe, hoʻolālā e hāpai, a i ʻole e hānai umauma ana. ʻAʻole hiki ke hana maikaʻi nā mea pale Hormonal (nā lāʻau kaohi hānau, nā pāhoʻi, nā apo, nā kīkō, nā implant, a me nā hāmeʻa intrauterine) ke hoʻohana ʻia me lesinurad a pono ʻole e hoʻohana ʻia ma ke ʻano o kāu kaohi hānau. E kamaʻilio me kāu kauka e pili ana i nā hana kaohi hānau e holo pono nāu. Inā hāpai ʻoe i ka lawe ʻana i lesinurad, kāhea i kāu kauka.

Inu ma kahi o 68 auneke (2 liters) o ka wai a i ʻole nā ​​wai ʻē aʻe i kēlā me kēia 24 hola ke lawe nei ʻoe i ka lesinurad ke ʻole e kuhikuhi ʻia e kāu kauka.


Inā makemake ʻoe e lawe i ka lesinurad i ke kakahiaka, mai hoʻokahe i ka lā ma hope. E hoʻomau i kāu papa hana hana maʻamau i ke kakahiaka aʻe me ka meaʻai a me ka wai. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu ʻo Lesinurad i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • ʻO nā ʻōuli e like me ka flu e like me headache, fever, sweating, muscle aches, a me ka māluhiluhi
  • puʻuwai puʻuwai

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i nā ʻ sectionslelo Aʻo IMPORTANT, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

  • ʻeha o ka umauma, kaomi, a i ʻole hōʻoluʻolu
  • pōkole o ka hanu a i ʻole pilikia i ka hanu ʻana
  • nāwaliwali ma kekahi ʻaoʻao a ʻaoʻao paha o ko lākou kino
  • haʻi waha

Hoʻokumu paha ʻo Lesinurad i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a mamao aku mai ka mālamalama, ka wela a me ka momona o ka wela (ʻaʻole i loko o ka lua.

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

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