ʻO Sonidegib

Anter

• Ma mua o ka lawe ʻana i sonidegib,
• Hoʻokumu ʻo Sonidegib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e pau ka lawe ʻana i sonidegib a kāhea koke aku i kāu kauka:

No nā mea maʻi āpau:

ʻAʻole pono e lawe ʻia ʻo Sonidegib e nā wahine hāpai a hāpai paha. Aia kahi makaʻu nui e lilo ka sonidegib i ka lilo o ka hāpai keiki a i ʻole e hoʻokumu ʻia ka pēpē me nā kīnā hānau (nā pilikia o ke kino i loaʻa i ka wā hānau).

E hāʻawi aku kāu kauka a kauka paha iā ʻoe i ka pepa ʻikepili a ka mea hana (Kauka Lapaʻau) ke hoʻomaka ʻoe i ka lāʻau me sonidegib a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole kipa aku i ka pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

Mai hāʻawi i ke koko a i ʻole nā ​​huahana koko ke lawe ʻoe i sonidegib a no 20 mau mahina ma hope o kāu lapaʻau.

E kamaʻilio me kāu kauka e pili ana i nā pilikia o ka lawe sonidegib.

No nā maʻi wahine:

Inā hiki iā ʻoe ke hāpai, pono ʻoe e hōʻalo i ka hāpai ʻana i ka wā o kāu mālama ʻana me sonidegib. Pono ʻoe i kahi hōʻoia hāpai maikaʻi ʻole ma mua o ka hoʻomaka ʻana o kāu lapaʻau. Pono ʻoe e hoʻohana i nā ʻano ʻoluʻolu o ka kaohi hānau i kou wā e mālama ai a no 20 mau mahina ma hope o ka pau ʻana o kāu lāʻau. E haʻi aku kāu kauka iā ʻoe i ke ʻano o ka kaohi hānau e ʻae ʻia.

Inā manaʻo ʻoe he hāpai ʻoe, e haʻalele i kahi wā menstrual, a i ʻole moekolohe me ka hoʻohana ʻole ʻana i ka kaohi hānau ke lawe ʻoe i sonidegib a i ʻole ma waena o 20 mau mahina ma hope o kāu lapaʻau ʻana, e kāhea koke i kāu kauka.

No nā maʻi kāne:

Pono ʻoe e hoʻohana i kahi pale condom, ʻoiai inā ua loaʻa iā ʻoe kahi vasectomy (ʻoki kino e pale aku ai i ka sperm mai ka haʻalele ʻana i kou kino a hāpai i ka hāpai ʻana), i kēlā me kēia manawa ke moe kolohe ʻoe me kahi wahine hāpai a hiki paha i ka hāpai ʻana ke lawe ʻoe i sonidegib, a ma ka liʻiliʻi he 8 mau mahina ma hope o kāu lapaʻau. E haʻi koke i kāu kauka inā ua moe kolohe ʻole ʻoe me kahi wahine i hiki ke hāpai a i ʻole manaʻo ʻoe no kekahi kumu ua hāpai kāu hoa. Mai hāʻawi manawaleʻa i ka wā e lawe ana ʻoe i ka sonidegib a i ʻole ma waena o 8 mau mahina ma hope o kāu lapaʻau ʻana.

Hoʻohana ʻia ʻo Sonidegib e mālama i ka carcinoma basal cell (BCC; kahi ʻano o ka maʻi ʻaʻai ʻili) i nā mākua me ka maʻi ʻaʻai i hoʻi mai ma hope o ke kaha ʻana a i ʻole ka radiation, a i ʻole nā ​​mākua hiki ʻole ke mālama ʻia me ke kahakaha a me ka radiation. Aia ʻo Sonidegib i loko o ka papa o nā lāʻau i kapa ʻia he hedgehog pathway inhibitors. Hana ia ma ka pale ʻana i ka hana o kahi protein i hōʻailona i nā hunaola maʻi ʻaʻa e hoʻonui. Kōkua kēia i ka hōʻoki a hoʻolohi paha i ka hoʻolaha ʻana o nā hunaola maʻi ʻaʻai a kōkua i ka hōʻemi i nā tumors.

Hele mai ʻo Sonidegib ma ke ʻano he capsule e lawe ma ka waha. Lawe ʻia ia i hoʻokahi manawa i ka lā ma ka ʻōpū hakahaka, ma ka liʻiliʻi he 1 hola ma mua a i ʻole 2 mau hola ma hope o ka pāʻina ʻana. Lawe i ka sonidegib ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono i ka sonidegib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

Pono paha kāu kauka e hoʻopau a hoʻopau paha i kāu lāʻau e pili ana i kāu pane i sonidegib a me nā hopena ʻē aʻe āu e ʻike ai.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i sonidegib,

• e haʻi aku i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka sonidegib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā capsule sonidegib. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau he aha nā lāʻau lapaʻau a me nā lāʻau ʻole i kuhikuhi ʻia, nā wikamina a me nā mea hoʻopihaʻaiʻai āu e lawe nei a hoʻolālā paha e lawe. E haʻi pono i kekahi o kēia mau mea: atazanavir (Reyataz); kekahi mau antifungals e like me fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), a me voriconazole (Vfend); diltiazem (Cardizem, Cartia, Tiazac, nā mea ʻē aʻe); efavirenz (Sustiva, i Atripla); modafinil (Provigil); nefazodone; rifabutin (Mycobutin); rifampin (Rifadin, Rifamate, Rifater, Rimactane); saquinavir (Hoʻokele); kekahi mau lāʻau no ka hopu ʻana e like me ka carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), phenobarbital, a me phenytoin (Dilantin, Phenytek); a me telithromycin (Ketek). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Nui paha nā lāʻau ʻē aʻe e launa pū me sonidegib, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St. E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe i ka wort a St. John i ka lawe ʻana i sonidegib.
• e haʻi i kāu kauka inā loaʻa ʻoe a i ʻole loaʻa i ka maʻi mākala.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū. ʻ telllelo paha kāu kauka iā ʻoe ʻaʻole e hānai i ka wā e lawe ana ʻoe i sonidegib a no 20 mau mahina ma hope o kāu lapaʻau.

E kamaʻilio me kāu kauka e pili ana i ka ʻai ʻana i ka huaʻōlau a me ka inu ʻana i ka wai momona a ke lawe nei ʻoe i kēia lāʻau.

E haʻalele i ka lāʻau i haʻalele ʻia a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu ʻo Sonidegib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• pāhoehoe
• abdominal eha
• nalo ʻai ʻole
• Kaumaha emi
• nausea
• ka luaʻi
• hoʻololi i ka hiki ke ʻono i ka meaʻai
• poho lauoho
• ʻūlili
• nāwaliwali
• luhi loa
• ʻeha
• hala ha awina

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e pau ka lawe ʻana i sonidegib a kāhea koke aku i kāu kauka:

• ʻūpē mākala
• ʻeha puʻupuʻu i wehewehe ʻole ʻia, palupalu a nāwaliwali paha
• mimi ʻeleʻele a i ʻole cola
• hoʻemi urination
• hiki ʻole ke mimī

Hiki i Sonidegib ke hoʻemi i ka momona i nā wahine. E kamaʻilio me kāu kauka e pili ana i nā pilikia o ka lawe ʻana i sonidegib inā he hopohopo kāu e pili ana i ka momona.

Hoʻokumu paha ʻo Sonidegib i ka ulu ʻana e kū i kakahiaka nui i nā keiki. ʻAʻole koi ʻia kēia lāʻau no ka hoʻohana ʻana i nā keiki.

Hoʻokumu paha ʻo Sonidegib i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• ʻOdomoma^®