Olaparib

Anter

• Ma mua o ka lawe ʻana i ka olaparib,
• Hoʻokumu paha ʻo Olaparib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka:

Hoʻohana ʻia nā papa Olaparib e kōkua e mālama i ka pane o kekahi ʻano ovarian (nā mea hānau wahine kahi e hoʻokumu ʻia ai nā hua manu), tuba fallopian (paipu e lawe i nā hua i hoʻokuʻu ʻia e nā ovaries i ka kōpū), a me peritoneal (ʻāpana o nā aʻa e kū ana i ka ʻōpū. ) Ka maʻi ʻaʻai i ka poʻe i pane piha a pane hapa paha i kā lākou mua a ma hope lāʻau chemotherapy. Hoʻohana pū ʻia ʻo Olaparib papa e mālama i kekahi ʻano o ka maʻi ʻaʻai o ka umauma i pāhola ʻia i nā ʻāpana ʻē aʻe o ke kino a ʻaʻole i hoʻomaikaʻi a i ʻole i hoʻomāhuahua ma hope o ka mālama ʻana me nā lāʻau ʻē aʻe. Hoʻohana ʻia nā papa Olaparib e mālama i kekahi ʻano o ka maʻi ʻaʻai prostate i pāhola ʻia i nā ʻāpana ʻē aʻe o ke kino, ʻaʻole pane hou i nā lāʻau lapaʻau a lāʻau ʻoki lāʻau paha e hoʻohaʻahaʻa i nā pae testosterone, a ua holomua ma hope o ka mālama ʻana me enzalutamide (Xtandi) a i ʻole abiraterone (Yonsa , Zytiga). Hoʻohana ʻia nā papa Olaparib a me nā capsule e mālama i ka maʻi ʻaʻai ovarian i hoʻomaikaʻi ʻole a i ʻole worsened ma hope o ka mālama ʻana me ʻekolu mau lapaʻau ʻē aʻe. Hoʻohana ʻia nā papa Olaparib e kōkua i ka mālama ʻana i ka pane o kekahi ʻano maʻi ʻaʻai pancreatic ʻaʻole i pālahalaha a holomua paha ma hope o ka mua chemotherapy. ʻO Olaparib kahi polyadenosine 5'-diphosphoribose polymerase (PARP) mea hoʻoheheʻe enzyme. Hana ia ma ka luku ʻana i nā hunaola maʻi ʻaʻai.

Hele mai ʻo Olaparib ma ke ʻano he papa a i ʻole he capsule e lawe ma ka waha i ʻelua mau manawa i kēlā me kēia lā me ka ʻole o ka meaʻai. E hoʻāʻo e hoʻokaʻawale i kāu kau ma kahi o 12 mau hola ke kaʻawale. E lawe i ka olaparib ma nā manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe i ka olaparib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i ka papa a i ʻole ka capsule holoʻokoʻa; mai hoʻopīpī i ka nau, māhele, a hoʻonā iā lākou.

Loaʻa ʻo Olaparib ma ke ʻano he papa a ma ke ʻano he capsule. Aia nā papa a me nā capsule i nā huina olaparib like ʻole a ʻaʻole pono e pānaʻi ʻia kekahi i kekahi. E kamaʻilio me kāu kauka a kauka paha inā he nīnau kāu e pili ana i ka hoʻomākaukau papa a me ka capsule.

Hiki i kāu kauka ke hōʻemi i kāu lāʻau olaparib a i ʻole e haʻi iā ʻoe e haʻalele i ka lawe ʻana i ka olaparib no kekahi manawa i ka wā o kāu mālama ʻana. E pili kēia i ka maikaʻi o ka hana ʻana o ka lāʻau iā ʻoe a me nā hopena ʻē aʻe āu e ʻike ai. E haʻi pono i kāu kauka i kou ʻano i kou wā e mālama ai me ka olaparib.

E hāʻawi aku kāu kauka a mea kauka paha iā ʻoe i ka palapala ʻike hoʻomanawanui o ka mea hana (Medication Guide) ke hoʻomaka ʻoe i ka lāʻau me ka olaparib. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) e kiʻi i ke alakaʻi Medication.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka olaparib,

• e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka olaparib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā papa olaparib a i ʻole nā ​​capsule. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E ʻike pono i kekahi o kēia mau mea: antibiotic e like me ciprofloxacin (Cipro), clarithromycin (Biaxin, ma Prevpac), erythromycin (E.E.S., Erythrocin, a me nā mea ʻē aʻe), nafcillin, a me telithromycin (ʻaʻole loaʻa hou ma U.S., Ketek) nā antifungals e like me fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Extina, Nizoral, Xolegel), posaconazole (Noxafil), a me voriconazole (Vfend); aprepitant (Emend); kekahi mau lāʻau e mālama ai i ka hopu ʻana e like me ka carbamazepine (Carbatrol, Epitol, Tegretol, Teril), a me phenytoin (Dilantin, Phenytek); bosentan (Tracleer); crizotinib (Xalkori); diltiazem (Cardizem, Cartia, Tiazac, nā mea ʻē aʻe); kekahi mau lāʻau e mālama ai i ka maʻi hepitis C e like me boceprevir (ʻaʻole i loaʻa hou ma U.S., Victrelis) a me telaprevir (ʻaʻole loaʻa hou ma U.S., Incivek); kekahi mau lāʻau e mālama ai i ka maʻi pale maʻi kanaka (HIV) a i ʻole loaʻa i ka maʻi maʻi maʻi maʻi (AIDS) e like me amprenavir (ʻaʻole i loaʻa hou ma US, Agenerase), atazanavir (Reyataz, ma Evotaz), darunavir (Prezista), efavirenz (Sustiva, i Atripla) , etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir / ritonavir (Kaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); imatinib (Gleevec); modafinil (Provigil); nefazodone; nā lāʻau chemotherapy ʻē aʻe no ka maʻi ʻaʻai, rifampin (Rifadin, Rimactane, ma Rifamate, ma Rifater), a me verapamil (Calan, Verelan, ma Tarka). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St. ʻAʻole pono ʻoe e lawe i ka wort a St. John ʻoiai ʻoe e lawe ana i ka olaparib.
• e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole loaʻa iā ʻoe ka maʻi ākea a me ka hanu ʻana, a i ʻole ka maʻi puʻupaʻa a ate paha.
• e haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole hoʻolālā i ka makua kāne o kahi keiki. Pono ʻoe e loaʻa i kahi hōʻike hāpai ma mua o ka hoʻomaka ʻana i ka lāʻau, ʻaʻole pono ʻoe e hāpai i ka wā e lawe ana ʻoe i ka olaparib. Pono ʻoe e hoʻohana i ka kaohi hānau kūpono e pale ai i ka hāpai ʻana i kāu mālama ʻana me olaparib a no 6 mau mahina ma hope o kāu hopena hope loa. Inā he kāne ʻoe a hiki i kāu pakanā ke hāpai, pono ʻoe e hoʻohana i ka kaohi hānau pono i kāu mālama ʻana me nā papa olaparib a no 3 mau mahina ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā hana kaohi hānau e holo pono nāu. Inā hāpai ʻoe i ka lawe ʻana i ka olaparib, e kāhea koke i kāu kauka. Hoʻopilikia paha ʻo Olaparib i ka ʻōpū.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū. Mai hānai i ka wā e lawe ana ʻoe i ka olaparib a no 1 mau mahina ma hope o kāu hopena hope loa.
• pono ʻoe e ʻike ʻaʻole pono ʻoe e hāʻawi i ka sperm ʻoiai ʻoe e lawe nei i nā papa olaparib a no 3 mau mahina ma hope o kāu hopena hope loa.

Mai ʻai i ka huaʻikuʻi a i nā ʻalani ʻo Seville (hoʻohana ʻia i kekahi manawa i nā marmalades), a i ʻole inu i ka wai huaʻikuʻu a i ʻole wai wai ʻalani Seville ke lawe nei i kēia lāʻau.

E haʻalele i ka lāʻau i haʻalele ʻia a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu paha ʻo Olaparib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• nausea
• ka luaʻi
• pāhoehoe
• kōpaʻa
• puʻuwai puʻuwai
• ʻeha poʻo
• hoʻēmi ʻai
• Muscle, ami, a ʻeha hoʻi
• luhi
• ʻeha o ka ʻōpū a hōʻoluʻolu ʻole paha
• loli ka ʻono
• ʻeha o ka waha a i ʻole ʻeha
• hopohopo
• kaumaha
• ʻili maloʻo
• ʻūlili
• hūwī
• paʻakikī e hiamoe a hiamoe paha
• ʻeha urinary

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka:

• fiva, ka pōkole o ka hanu, kahe, a i ʻole ka hū ʻana
• pokole o ka hanu
• nāwaliwali
• luhi loa
• Kaumaha emi
• ʻāpā ʻaʻano ʻole a hoʻokahe koko paha
• ʻili mae
• ke koko i ka mimi a i ʻole ka noho
• ke kuni, ke anu, ka puʻu, ka ʻāʻī, a i ʻole nā ​​hōʻailona ʻē aʻe o ka maʻi
• ʻeha, palupalu, ʻulaʻula, a i ʻole ka pehu ʻana i hoʻokahi wāwae
• ʻeha o ka umauma a paʻa paha; pokole o ka hanu; ʻū kahe i ke koko; a me ka hanu wikiwiki ʻana

Hoʻokumu paha ʻo Olaparib i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha paha kāu kauka i kahi hoʻokolohua hoʻokolohua ma mua o kou hoʻomaka ʻana i kāu lāʻau e ʻike ai hiki ke mālama ʻia i kāu ʻano me ka olaparib. E kauoha kāu kauka i kekahi mau hoʻokolohua lab i kou wā e mālama ai e nānā i ka pane o kou kino i ka olaparib.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• ʻO Lynparza^®