ʻO Dabrafenib

Anter

• Ma mua o ka lawe ʻana i ka dabrafenib,
• Hoʻokumu paha ʻo Dabrafenib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli e kāhea koke i kāu kauka:

Hoʻohana hoʻokahi ʻia ʻo Dabrafenib a i ʻole hui pū ʻia me trametinib (Mekinist) e mālama i kekahi ʻano melanoma (kahi ʻano maʻi ʻili o ka ʻili) ʻaʻole hiki ke mālama ʻia me ke ʻoki a i pāhola paha i nā ʻāpana ʻē aʻe o ke kino. Hoʻohana pū ʻia me trametinib e mālama a pale i ka hoʻi ʻana o kekahi ʻano melanoma ma hope o ke kaha ʻana e wehe iā ia a me nā lymph node i hoʻopili ʻia. Hoʻohana pū ʻia ʻo Dabrafenib me ka trametinib e mālama ai i kekahi ʻano maʻi ʻaʻai liʻiliʻi liʻiliʻi liʻiliʻi (NSCLC) i pāhola ʻia i nā mea kokoke a i ʻole nā ​​ʻāpana ʻē aʻe o ke kino. Hoʻohana ʻia ia e mālama i kekahi ʻano o ka maʻi ʻaʻai thyroid i pālahalaha ʻia i nā mea kokoke a i ʻole nā ​​ʻāpana ʻē aʻe o ke kino i pane ʻole i nā lapaʻau ma mua. Aia ʻo Dabrafenib i kahi papa o nā lāʻau i kapa ʻia nā kinase inhibitors. Hana ia ma ke kāpae ʻana i ka hana o kahi protein pono ʻole e hōʻailona ai i nā hunaola maʻi ʻaʻai e hoʻonui. Kōkua kēia i ka hōʻoki ʻana i nā hunaola maʻi ʻaʻai.

Hele mai ʻo Dabrafenib ma ke ʻano he capsule e lawe ma ka waha. Lawe ʻia ia i ʻelua mau manawa i ka lā ma ka ʻōpū hakahaka, 1 hola ma mua a i ʻole 2 mau hola ma hope o ka pāʻina ʻana. Lawe iā dabrafenib ma kahi o 12 mau hola ma kahi o nā manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono iā dabrafenib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka. Mai hōʻoki i ka lawe ʻana i ka dabrafenib me ke kamaʻilio ʻole ʻana me kāu kauka.

E ale i nā capsule holoʻokoʻa; mai wehe, wāwahi, a wāwahi paha iā lākou.

Hiki i kāu kauka ke hoʻoponopono i kāu lāʻau a i ʻole manawa kūmau a paʻa mau paha i kāu lāʻau lapaʻau e like me kāu pane i ka lāʻau a me nā hopena ʻē aʻe āu e ʻike ai. E kamaʻilio me kāu kauka e pili ana i kou ʻano i kāu mālama ʻana.

E hāʻawi aku kāu kauka a mea kauka paha iā ʻoe i ka palapala ʻike hoʻomanawanui o ka mea hana (Kauka Lapaʻau) ke hoʻomaka ʻoe i ka lāʻau me dabrafenib a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka dabrafenib,

• e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka dabrafenib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i loko o nā capsule dabrafenib. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E kuhikuhi pono i kekahi o kēia mau mea: clarithromycin (Biaxin, i PrevPac); dexamethasone; gemfibrozil (Lopid); ketoconazole; midazolam; nefazodone; rifampin (Rifadin, ma Rifamate, ma Rifater, Rimactane); a me warfarin (Coumadin, Jantoven). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Nui paha nā lāʻau ʻē aʻe e launa pū paha me dabrafenib, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• e haʻi i kāu kauka inā loaʻa ʻoe a i ʻole loaʻa ka maʻi diabetes; glucose-6-phosphate dehydrogenase (G6PD) nele (kahi ʻano kūlohelohe); nā pilikia koko; nā pilikia o ka maka; maikaʻi ʻole o ka puʻuwai a i ʻole nā ​​pilikia puʻuwai ʻē aʻe; ate a me nā maʻi konā; a i ʻole kekahi ʻano olakino ʻē aʻe.
• e haʻi i kāu kauka inā hāpai ʻoe a i ʻole hoʻolālā e hāpai i ka hāpai ʻana, a inā ʻoe e hoʻolālā e makua kāne i kahi keiki. Inā he wahine ʻoe, pono ʻoe e hoʻokolohua hāpai ma mua o kou hoʻomaka ʻana i ka lāʻau, a pono ʻoe e hoʻohana i ka kaohi hānau kūpono e pale ai i ka hāpai ʻana i kāu wā lapaʻau a no 2 mau pule ma hope o kāu hopena hope loa. Inā he kāne ʻoe a hiki i kāu pakanā ke hāpai, pono ʻoe e hoʻohana i kahi condom i ka wā e lawe ana i kēia lāʻau, a no 2 mau pule ma hope o kāu lapaʻau ʻana, ʻoiai inā he vasectomy kāu (ke ʻoki e pale ai i ka sperm mai ka haʻalele ʻana i kou kino a hana i ka hāpai keiki) . Pono ʻoe e ʻike i kēia lāʻau e hoʻemi ai i ka momona i nā kāne a me nā wahine; Eia naʻe, ʻaʻole pono ʻoe e kuhi ʻaʻole hiki iā ʻoe ke hāpai a i ʻole hiki iā ʻoe ke hāpai i kekahi mea ʻē aʻe. Inā hāpai ʻoe a ʻo kāu hoa paha i ka lawe ʻana i ka dabrafenib, e kāhea i kāu kauka. Hoʻopilikia paha ʻo Dabrafenib i ka fetus.
• pono ʻoe e ʻike he hiki i ka dabrafenib ke hoʻemi i ka pono o nā kaola pale hormonal (nā lāʻau kaohi hānau, nā pāhoʻi, nā apo, nā implants, a me nā injection). Pono ʻoe e hoʻohana i kahi hana ʻē aʻe o ka kaohi hānau e pale ai i ka hāpai ʻana i loko ou a i ʻole kāu pakanā i kou wā e mālama ai me dabrafenib a no 2 mau pule ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā hana kaohi hānau e holo pono nāu.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū a i ʻole hoʻolālā e hānai. ʻAʻole pono ʻoe e hānai i ka wā e lawe ana i ka dabrafenib a no 2 mau pule ma hope o kāu hopena hope loa.
• inā ke ʻoki nei ʻoe, e like me ke ʻoki niho, e haʻi i ke kauka a i ʻole kauka niho paha e lawe ana ʻoe i ka dabrafenib.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia nō naʻe, inā ʻoi aku ia ma mua o 6 mau hola a hiki i kāu kau palena hope e hoʻolālā ʻia, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu paha ʻo Dabrafenib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• ʻeha poʻo
• ami, mākala, a i ʻole ʻehaʻeha
• nausea
• pāhoehoe
• kōpaʻa
• nalo ʻai ʻole
• uha, ihu ihu, a ʻeha ʻāʻī paha
• poho lauoho
• luhi

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli e kāhea koke i kāu kauka:

• nā loli i ka ʻili (wart hou, ʻili ʻeha, a ʻulaʻula paha i hoʻokahe ke koko a ʻaʻole maikaʻi)
• e hoʻololi i ka nui a me ke kala o kahi mole
• ʻehu, ʻulaʻula, a i ʻole nā ​​pimples
• fiva
• maule ana
• dizziness, lightheadedness, a nāwaliwali paha
• haʻalulu
• hoʻemi urination
• ka pehu o nā lima, nā wāwae, nā kuʻekuʻe wāwae, a me nā wāwae lalo
• urination pinepine
• hoʻonui ka make wai
• ʻeha ka maka
• ʻulaʻula a pehu paha nā lihilihi maka
• ʻike i ka mālamalama
• hoʻololi i ka hihi a ʻike paha i nā loli, e like me ke ʻike ʻana i ka ʻalalā (ʻōkuhi blurr a puni nā mea) a i ʻole nā ​​kiko kala
• ka pehu ʻana, ka ʻeha, ka ʻulaʻula, a me ka ʻili ʻana o ka ʻili ma nā poho lima a me nā kapuwaʻi o nā wāwae
• ʻeha mau e hoʻomaka i ka wahi o ka ʻōpū akā e pālahalaha paha i ka hope
• kahe koko ʻole ʻana a palapū paha
• koko a ʻeleʻele paha, noho aliʻi
• ʻū ana a luaʻi paha i ke koko a i ʻole mea e like me ke kumu kope
• ʻeha ka umauma
• pokole o ka hanu
• pehu o nā lima, ka wāwae, nā kuʻekuʻe wāwae a i ʻole nā ​​wāwae lalo
• wikiwiki, kūlike ʻole, a kuʻi paha i ka puʻuwai puʻuwai
• melemele o ka ʻili a me nā maka

Hiki i ka Dabrafenib ke hoʻonui i ka makaʻu e hoʻomohala ʻoe i nā maʻi ʻili hou a i ʻole nā ​​maʻi ʻino ʻē aʻe. E kamaʻilio me kāu kauka e pili ana i ka makaʻu i ka lawe ʻana i kēia lāʻau.

Hoʻokumu paha ʻo Dabrafenib i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kahi hoʻokolohua lab ma mua o kou hoʻomaka ʻana i kāu lāʻau e ʻike inā hiki ke mālama ʻia i kou maʻi ʻaʻai me dabrafenib. E kauoha kāu kauka i kekahi mau hoʻokolohua lab a ma mua a i kou wā e mālama ai e nānā i ka pane o kou kino iā dabrafenib. E nānā kāu kauka i kou ʻili no nā loli ma mua, i kēlā me kēia 2 mau mahina i kou wā e hoʻomaʻamaʻa ai, a hiki i 6 mau mahina ma hope o ka lapaʻau.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

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